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1
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74549208765
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Heredity with reference to carcinoma as shown by the study of the cases examined in the pathological laboratory of the University of Michigan, 1895-1913
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This is the first published paper describing what has become known as LS
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Warthin, A. S. Heredity with reference to carcinoma as shown by the study of the cases examined in the pathological laboratory of the University of Michigan, 1895-1913. Arch. Intern. Med. 12, 546-555 (1913). This is the first published paper describing what has become known as LS.
-
(1913)
Arch. Intern. Med.
, vol.12
, pp. 546-555
-
-
Warthin, A.S.1
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3
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0033828829
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Recurrent germline mutation in MSH2 arises frequently de novo
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Desai, D. C. et al. Recurrent germline mutation in MSH2 arises frequently de novo. J. Med. Genet. 37, 646-652 (2000).
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(2000)
J. Med. Genet.
, vol.37
, pp. 646-652
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-
Desai, D.C.1
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4
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0013878809
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Hereditary factors in cancer: Study of two large Midwestern kindreds
-
This paper reopened interest in LS, which had been dormant since the work of Warthin
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Lynch, H. T., Shaw, M. W., Magnuson, C. W., Larsen, A. L. & Krush, A. J. Hereditary factors in cancer: study of two large Midwestern kindreds. Arch. Intern. Med. 117, 206-212 (1966). This paper reopened interest in LS, which had been dormant since the work of Warthin.
-
(1966)
Arch. Intern. Med.
, vol.117
, pp. 206-212
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-
Lynch, H.T.1
Shaw, M.W.2
Magnuson, C.W.3
Larsen, A.L.4
Krush, A.J.5
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5
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0015077284
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Cancer family "G" revisited: 1895-1970
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Lynch, H. T. & Krush, A. J. Cancer family "G" revisited: 1895-1970. Cancer 27, 1505-1511 (1971).
-
(1971)
Cancer
, vol.27
, pp. 1505-1511
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-
Lynch, H.T.1
Krush, A.J.2
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6
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27644482922
-
History and molecular genetics of Lynch syndrome in family G: A century later
-
Douglas, J. A. et al. History and molecular genetics of Lynch syndrome in Family G: a century later. JAMA 294, 2195-2202 (2005).
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(2005)
JAMA
, vol.294
, pp. 2195-2202
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-
Douglas, J.A.1
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7
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-
0015016127
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The cancer family syndrome and cancer control
-
This report details early cancer diagnosis through increased surveillance in CFS
-
Lynch, H. T. & Krush, A. J. The cancer family syndrome and cancer control. Surg. Gynecol. Obstet. 132, 247-250 (1971). This report details early cancer diagnosis through increased surveillance in CFS.
-
(1971)
Surg. Gynecol. Obstet.
, vol.132
, pp. 247-250
-
-
Lynch, H.T.1
Krush, A.J.2
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8
-
-
0021328985
-
Familial colonic cancer without antecedent polyposis
-
This was the first paper to suggest the term LS for CFS
-
Boland, C. R. & Troncale, F. J. Familial colonic cancer without antecedent polyposis. Ann. Intern. Med. 100, 700-701 (1984). This was the first paper to suggest the term LS for CFS.
-
(1984)
Ann. Intern. Med.
, vol.100
, pp. 700-701
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-
Boland, C.R.1
Troncale, F.J.2
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9
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0021247284
-
Serum and hair selenium levels in hereditary nonpolyposis colorectal cancer
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Tempero, M. A., Jacobs, M. M., Lynch, H. T., Graham, C. L. & Blotcky, A. J. Serum and hair selenium levels in hereditary nonpolyposis colorectal cancer. Biol. Trace Element Res. 6, 51-55 (1984).
-
(1984)
Biol. Trace Element Res.
, vol.6
, pp. 51-55
-
-
Tempero, M.A.1
Jacobs, M.M.2
Lynch, H.T.3
Graham, C.L.4
Blotcky, A.J.5
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10
-
-
84923633312
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Adenomas in Lynch syndrome: Don't be fooled by the "non" in hereditary nonpolyposis colorectal cancer
-
This is a recent study demonstrating an excess of adenomas in LS
-
Kalady, M. F., Kravochuck, S., LaGuardia, L., O'Malley, M. & Church, J. M. Adenomas in Lynch syndrome: don't be fooled by the "non" in hereditary nonpolyposis colorectal cancer. Fam Cancer 12 (Suppl. 2), 53 (2013). This is a recent study demonstrating an excess of adenomas in LS.
-
(2013)
Fam Cancer
, vol.12
, pp. 53
-
-
Kalady, M.F.1
Kravochuck, S.2
LaGuardia, L.3
O'Malley, M.4
Church, J.M.5
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11
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-
24144493180
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Evolution of the nomenclature for the hereditary colorectal cancer syndromes
-
In the context of the developing nomenclature for LS, this paper gives a succinct summary of the history of hereditary CRC until that time
-
Boland, C. R. Evolution of the nomenclature for the hereditary colorectal cancer syndromes. Fam. Cancer 4, 211-218 (2005). In the context of the developing nomenclature for LS, this paper gives a succinct summary of the history of hereditary CRC until that time.
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(2005)
Fam. Cancer
, vol.4
, pp. 211-218
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-
Boland, C.R.1
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12
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33748328364
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Hereditary non-polyposis colorectal cancer: The rise and fall of a confusing term
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Jass, J. R. Hereditary non-polyposis colorectal cancer: The rise and fall of a confusing term. World J. Gastroenterol. 12, 4943-4950 (2006).
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(2006)
World J. Gastroenterol.
, vol.12
, pp. 4943-4950
-
-
Jass, J.R.1
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13
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0017742257
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Hereditary proximal colonic cancer
-
This was the first paper to note the predilection for the proximal colon of LS-associated CRCs
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Lynch, P. M., Lynch, H. T. & Harris, R. E. Hereditary proximal colonic cancer. Dis. Colon Rectum 20, 661-668 (1977). This was the first paper to note the predilection for the proximal colon of LS-associated CRCs.
-
(1977)
Dis. Colon Rectum
, vol.20
, pp. 661-668
-
-
Lynch, P.M.1
Lynch, H.T.2
Harris, R.E.3
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14
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0027998140
-
Surveillance in Lynch syndrome: How aggressive?
-
This paper calls for complete colonoscopy in surveillance for LS-associated CRCs
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Lanspa, S. J. et al. Surveillance in Lynch syndrome: how aggressive? Am. J. Gastroenterol. 89, 1978-1980 (1994). This paper calls for complete colonoscopy in surveillance for LS-associated CRCs.
-
(1994)
Am. J. Gastroenterol.
, vol.89
, pp. 1978-1980
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-
Lanspa, S.J.1
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15
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84875603280
-
Nonpolypoid colorectal neoplasms: A challenge in endoscopic surveillance of patients with Lynch syndrome
-
Rondagh, E. J. A. et al. Nonpolypoid colorectal neoplasms: a challenge in endoscopic surveillance of patients with Lynch syndrome. Endoscopy 45, 257-264 (2013).
-
(2013)
Endoscopy
, vol.45
, pp. 257-264
-
-
Rondagh, E.J.A.1
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16
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0028034537
-
The tumor spectrum in HNPCC
-
Watson, P. & Lynch, H. T. The tumor spectrum in HNPCC. Anticancer Res. 14, 1635-1640 (1994).
-
(1994)
Anticancer Res
, vol.14
, pp. 1635-1640
-
-
Watson, P.1
Lynch, H.T.2
-
17
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44949202465
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The risk of extra-colonic, extraendometrial cancer in the Lynch syndrome
-
Watson, P. et al. The risk of extra-colonic, extraendometrial cancer in the Lynch syndrome. Int. J. Cancer 123, 444-449 (2008).
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(2008)
Int. J. Cancer
, vol.123
, pp. 444-449
-
-
Watson, P.1
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18
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0019515269
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The cancer family syndrome: Rare cutaneous phenotypic linkage of Torre's syndrome
-
This paper was the first to demonstrate that Muir-Torre syndrome is a variant of LS
-
Lynch, H. T., Lynch, P. M., Pester, J. & Fusaro, R. M. The cancer family syndrome: rare cutaneous phenotypic linkage of Torre's syndrome. Arch. Intern. Med. 141, 607-611 (1981). This paper was the first to demonstrate that Muir-Torre syndrome is a variant of LS.
-
(1981)
Arch. Intern. Med.
, vol.141
, pp. 607-611
-
-
Lynch, H.T.1
Lynch, P.M.2
Pester, J.3
Fusaro, R.M.4
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19
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-
70350733425
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Risk of pancreatic cancer in families with Lynch syndrome
-
Kastrinos, F. et al. Risk of pancreatic cancer in families with Lynch syndrome. JAMA 302, 1790-1795 (2009).
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(2009)
JAMA
, vol.302
, pp. 1790-1795
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Kastrinos, F.1
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20
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84860605783
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Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: A prospective cohort study
-
Win, A. K. et al. Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: a prospective cohort study. J. Clin. Oncol. 30, 958-964 (2012).
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(2012)
J. Clin. Oncol.
, vol.30
, pp. 958-964
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Win, A.K.1
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21
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79951858605
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Hereditary prostate cancer as a feature of Lynch syndrome
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Bauer, C. M. et al. Hereditary prostate cancer as a feature of Lynch syndrome. Fam. Cancer 10, 37-42 (2011).
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(2011)
Fam. Cancer
, vol.10
, pp. 37-42
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Bauer, C.M.1
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22
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Adrenocortical carcinoma is a Lynch syndrome-associated cancer
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Raymond, V. M. et al. Adrenocortical carcinoma is a Lynch syndrome-associated cancer. J. Clin. Oncol. 31, 3012-3018 (2013).
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(2013)
J. Clin. Oncol.
, vol.31
, pp. 3012-3018
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-
Raymond, V.M.1
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23
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0025848680
-
-
This paper is the source of the Amsterdam I Criteria for LS
-
Vasen, H. F. A., Mecklin, J.-P., Meera Khan, P. & Lynch, H. T. The International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer (ICGHNPCC). Dis. Colon Rectum 34, 424-425 (1991). This paper is the source of the Amsterdam I Criteria for LS.
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(1991)
Dis. Colon Rectum
, vol.34
, pp. 424-425
-
-
Vasen, H.F.A.1
Mecklin, J.-P.2
Meera Khan, P.3
Lynch, H.T.4
-
24
-
-
0033063711
-
New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC
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This is the source of the revised Amsterdam II Criteria
-
Vasen, H. F. A., Watson, P., Mecklin, J.-P. & Lynch, H. T. & ICG-HNPCC. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC. Gastroenterology 116, 1453-1456 (1999). This is the source of the revised Amsterdam II Criteria.
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(1999)
Gastroenterology
, vol.116
, pp. 1453-1456
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-
Vasen, H.F.A.1
Watson, P.2
Mecklin, J.-P.3
Lynch, H.T.4
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25
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0032534069
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A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
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Boland, C. R. et al. A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: development of international criteria for the determination of microsatellite instability in colorectal cancer. Cancer Res. 58, 5248-5257 (1998).
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(1998)
Cancer Res
, vol.58
, pp. 5248-5257
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Boland, C.R.1
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26
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0031551963
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A National Cancer Institute workshop on hereditary nonpolyposis colorectal cancer syndrome: Meeting highlights and Bethesda Guidelines
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Rodriguez-Bigas, M. A. et al. A National Cancer Institute workshop on hereditary nonpolyposis colorectal cancer syndrome: meeting highlights and Bethesda Guidelines. J. Natl Cancer Inst. 89, 1758-1762 (1997).
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(1997)
J. Natl Cancer Inst
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, pp. 1758-1762
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Rodriguez-Bigas, M.A.1
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27
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10744233937
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Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability
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This is the source of the Revised Bethesda Guidelines for MSI testing
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Umar, A. et al. Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J. Natl Cancer Inst. 96, 261-268 (2004). This is the source of the Revised Bethesda Guidelines for MSI testing.
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(2004)
J. Natl Cancer Inst
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, pp. 261-268
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Umar, A.1
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28
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0035980053
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DNA chain length dependence of formation and dynamics of hMutSα.HMutLα.Heteroduplex complexes
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Blackwell, L. J., Wang, S. & Modrich, P. DNA chain length dependence of formation and dynamics of hMutSα.hMutLα.heteroduplex complexes. J. Biol. Chem. 276, 33233-33240 (2001).
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J. Biol. Chem.
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Blackwell, L.J.1
Wang, S.2
Modrich, P.3
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29
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0018242793
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Genetic studies of the lac repressor. VII. On the molecular nature of spontaneous hotspots in the lacl gene of Escherichia coli
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Farabaugh, P. J., Schmeissner, U., Hofer, M. & Miller, J. H. Genetic studies of the lac repressor. VII. On the molecular nature of spontaneous hotspots in the lacl gene of Escherichia coli. J. Mol. Biol. 126, 847-857 (1978).
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J. Mol. Biol.
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Farabaugh, P.J.1
Schmeissner, U.2
Hofer, M.3
Miller, J.H.4
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30
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0021988148
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Mechanisms of spontaneous and induced frameshift mutation in bacteriophage T4
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Streisinger, G. & Owen, J. E. Mechanisms of spontaneous and induced frameshift mutation in bacteriophage T4. Genetics 109, 633-659 (1985).
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Genetics
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Streisinger, G.1
Owen, J.E.2
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31
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0023649836
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High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 in Escherichia coli K-12
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Levinson, G. & Gutman, G. A. High frequencies of short frameshifts in poly-CA/TG tandem repeats borne by bacteriophage M13 in Escherichia coli K-12. Nucleic Acids Res. 15, 5323-5338 (1987).
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Levinson, G.1
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Methyl-directed DNA mismatch correction
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Modrich, P. Methyl-directed DNA mismatch correction. J. Biol. Chem. 264, 6597-6600 (1989).
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J. Biol. Chem.
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Modrich, P.1
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33
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0027306173
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Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair
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Strand, M., Prolla, T. A., Liskay, R. M. & Petes, T. D. Destabilization of tracts of simple repetitive DNA in yeast by mutations affecting DNA mismatch repair. Nature 365, 274-276 (1993).
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(1993)
Nature
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, pp. 274-276
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Strand, M.1
Prolla, T.A.2
Liskay, R.M.3
Petes, T.D.4
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34
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0027158031
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Clues to the pathogenesis of familial colorectal cancer
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This was the first study to link MSI with LS
-
Aaltonen, L. A. et al. Clues to the pathogenesis of familial colorectal cancer. Science 260, 812-816 (1993). This was the first study to link MSI with LS.
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(1993)
Science
, vol.260
, pp. 812-816
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Aaltonen, L.A.1
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35
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0027285475
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Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
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Ionov, Y. M., Peinado, M. A., Malkhosyan, S., Shibata, D. & Perucho, M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 363, 558-561 (1993).
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(1993)
Nature
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, pp. 558-561
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Ionov, Y.M.1
Peinado, M.A.2
Malkhosyan, S.3
Shibata, D.4
Perucho, M.5
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36
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Microsatellite instability in cancer of the proximal colon
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Thibodeau, S. N., Bren, G. & Schaid, D. Microsatellite instability in cancer of the proximal colon. Science 260, 816-819 (1993).
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(1993)
Science
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Thibodeau, S.N.1
Bren, G.2
Schaid, D.3
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37
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0027137935
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Hypermutability and mismatch repair deficiency in RER+ tumor cells
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This is an early description of hypermutability in MSI
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Parsons, R. et al. Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell 75, 1227-1236 (1993). This is an early description of hypermutability in MSI.
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(1993)
Cell
, vol.75
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Parsons, R.1
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38
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Natural history of hereditary non-polyposis colorectal cancer
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Jass, J. R. Natural history of hereditary non-polyposis colorectal cancer. J. Tumor Marker Oncol. 10, 65-71 (1995).
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(1995)
J. Tumor Marker Oncol
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Jass, J.R.1
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Genetic instabilities in human cancers
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Lengauer, C., Kinzler, K. W. & Vogelstein, B. Genetic instabilities in human cancers. Nature 396, 643-649 (1998).
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Nature
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Lengauer, C.1
Kinzler, K.W.2
Vogelstein, B.3
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40
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0027943743
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Pathology of hereditary non-polyposis colorectal cancer
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This was the first comprehensive listing of pathological features found in LS-associated CRCs
-
Jass, J. R. et al. Pathology of hereditary non-polyposis colorectal cancer. Anticancer Res. 14, 1631-1634 (1994). This was the first comprehensive listing of pathological features found in LS-associated CRCs.
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(1994)
Anticancer Res
, vol.14
, pp. 1631-1634
-
-
Jass, J.R.1
-
41
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-
18844464796
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Colorectal carcinoma survival among hereditary nonpolyposis colorectal cancer family members
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This study documents the survival advantage of LS-associated CRC compared with sporadic CRC
-
Watson, P. et al. Colorectal carcinoma survival among hereditary nonpolyposis colorectal cancer family members. Cancer 83, 259-266 (1998). This study documents the survival advantage of LS-associated CRC compared with sporadic CRC.
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(1998)
Cancer
, vol.83
, pp. 259-266
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Watson, P.1
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42
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77950637012
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Tumor infiltrating lymphocytes: An intriguing player in the survival of colorectal cancer patients
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Deschoolmeester, V. et al. Tumor infiltrating lymphocytes: an intriguing player in the survival of colorectal cancer patients. BMC Immunol. 11, 19 (2010).
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BMC Immunol
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Deschoolmeester, V.1
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84923560621
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Ch. 6 (eds Benson, A. B, Chakravarthy, A., Hamilton, S. R., Sigurdson, E. & Thomas, C. Jr) Demos Medical Publishing, This book chapter gives an up-to-date understanding of pathological features in CRC
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Hamilton, S. R. in Cancers of the Colon and Rectum: A Multidisciplinary Approach to Diagnosis and Management Ch. 6 (eds Benson, A. B, Chakravarthy, A., Hamilton, S. R., Sigurdson, E. & Thomas, C. Jr) 115-128 (Demos Medical Publishing, 2014). This book chapter gives an up-to-date understanding of pathological features in CRC.
-
(2014)
Cancers of the Colon and Rectum: A Multidisciplinary Approach to Diagnosis and Management
, pp. 115-128
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-
Hamilton, S.R.1
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44
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84887957063
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Colorectal adenoma stem-like cell populations: Associations with adenoma characteristics and metachronous colorectal neoplasia
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Bartley, A. N. et al. Colorectal adenoma stem-like cell populations: associations with adenoma characteristics and metachronous colorectal neoplasia. Cancer Prev. Res. 6, 1162-1170 (2013).
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Cancer Prev. Res.
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Bartley, A.N.1
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45
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0027263363
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Genetic mapping of a locus predisposing to human colorectal cancer
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This was the first study to show a germline mutation as a cause of LS
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Peltomäki, P. et al. Genetic mapping of a locus predisposing to human colorectal cancer. Science 260, 810-812 (1993). This was the first study to show a germline mutation as a cause of LS.
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(1993)
Science
, vol.260
, pp. 810-812
-
-
Peltomäki, P.1
-
46
-
-
0027485551
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Genetic mapping of a second locus predisposing to hereditary nonpolyposis colorectal cancer
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This study links LS to a second locus
-
Lindblom, A., Tannergard, P., Werelius, B. & Nordenskjold, M. Genetic mapping of a second locus predisposing to hereditary nonpolyposis colorectal cancer. Nature Genet. 5, 279-282 (1993). This study links LS to a second locus.
-
(1993)
Nature Genet
, vol.5
, pp. 279-282
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-
Lindblom, A.1
Tannergard, P.2
Werelius, B.3
Nordenskjold, M.4
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47
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0027742295
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The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
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Fishel, R. et al. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75, 1027-1038 (1993).
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(1993)
Cell
, vol.75
, pp. 1027-1038
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Fishel, R.1
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48
-
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0027145633
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Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
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References 47 and 48 document the discovery of the connection between MSH2 and LS
-
Leach, F. S. et al. Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell 75, 1215-1225 (1993). References 47 and 48 document the discovery of the connection between MSH2 and LS.
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(1993)
Cell
, vol.75
, pp. 1215-1225
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Leach, F.S.1
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49
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0028350601
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Mutation of a mutL homolog in hereditary colon cancer
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Papadopoulos, N. et al. Mutation of a mutL homolog in hereditary colon cancer. Science 263, 1625-1629 (1994).
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Science
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, pp. 1625-1629
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Papadopoulos, N.1
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50
-
-
0028221943
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Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary nonpolyposis colon cancer
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References 49 and 50 document the discovery of the connection between MLH1 and LS
-
Bronner, C. E. et al. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary nonpolyposis colon cancer. Nature 368, 258-261 (1994). References 49 and 50 document the discovery of the connection between MLH1 and LS.
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(1994)
Nature
, vol.368
, pp. 258-261
-
-
Bronner, C.E.1
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51
-
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0027933070
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Mutations of two PMS homologues in hereditary nonpolyposis colon cancer
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This study was the first to link the PMS genes to LS
-
Nicolaides, N. C. et al. Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature 371, 75-80 (1994). This study was the first to link the PMS genes to LS.
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(1994)
Nature
, vol.371
, pp. 75-80
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Nicolaides, N.C.1
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52
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The role of hPMS1 and hPMS2 in predisposing to colorectal cancer
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Liu, T. et al. The role of hPMS1 and hPMS2 in predisposing to colorectal cancer. Cancer Res. 61, 7798-7802 (2001).
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Cancer Res
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Liu, T.1
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