Bioenergetic status modulates motor neuron vulnerability and pathogenesis in a zebrafish model of spinal muscular atrophy

PLoS Genetics

Volumn 13, Issue 4, 2017, Pages

  Boyd, Penelope J ^a,b   Tu, Wen Yo ^c   Shorrock, Hannah K ^a,b   Groen, Ewout J N ^a,b   Carter, Roderick N ^b   Powis, Rachael A ^a,b   Thomson, Sophie R ^b   Thomson, Derek ^b   Graham, Laura C ^d   Motyl, Anna A L ^b   Wishart, Thomas M ^d   Highley, J Robin ^c   Morton, Nicholas M ^b   Becker, Thomas ^a,b   Becker, Catherina G ^a,b   Heath, Paul R ^c   Gillingwater, Thomas H ^a,b  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOGLYCERATE KINASE; PHOSPHOGLYCERATE KINASE 1; TERAZOSIN; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATE; PGK1 PROTEIN, MOUSE; PRAZOSIN; SMN1 PROTEIN, ZEBRAFISH; SURVIVAL MOTOR NEURON PROTEIN 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOENERGY; CONTROLLED STUDY; DISEASE PREDISPOSITION; EMBRYO; EXTENSOR DIGITORUM LONGUS MUSCLE; FEMALE; GASTROCNEMIUS MUSCLE; GENE EXPRESSION PROFILING; IN VIVO STUDY; MALE; MITOCHONDRIAL BIOGENESIS; MOTONEURON; MOUSE; NEUROPATHOLOGY; NONHUMAN; SPINAL MUSCULAR ATROPHY; TIBIALIS ANTERIOR MUSCLE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; AXON; DISEASE MODEL; DRUG EFFECTS; ENERGY METABOLISM; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; METABOLISM; MITOCHONDRION; PATHOLOGY; PATHOPHYSIOLOGY; SKELETAL MUSCLE; SPINAL CORD; ZEBRA FISH;

ADENOSINE TRIPHOSPHATE; ANIMALS; AXONS; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; ENERGY METABOLISM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MICE; MITOCHONDRIA; MOTOR NEURONS; MUSCLE, SKELETAL; MUSCULAR ATROPHY, SPINAL; PHOSPHOGLYCERATE KINASE; PRAZOSIN; SPINAL CORD; SURVIVAL OF MOTOR NEURON 1 PROTEIN; ZEBRAFISH;

EID: 85018371495     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1006744     Document Type: Article

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