Terazosin activates Pgk1 and Hsp90 to promote stress resistance

Nature Chemical Biology

Volumn 11, Issue 1, 2015, Pages 19-25

  Chen, Xinping ^a,b   Zhao, Chunyue ^a,b   Li, Xiaolong ^c,d   Wang, Tao ^a,b   Li, Yizhou ^e   Cao, Cheng ^e   Ding, Yuehe ^f   Dong, Mengqiu ^f   Finci, Lorenzo ^d   Wang, Jia Huai ^c,d,g   Li, Xiaoyu ^d,e   Liu, Lei ^b  

^a Peking University   (China)

^b BEIJING INSTITUTE FOR BRAIN DISORDERS   (China)

^c UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^d PEKING UNIVERSITY   (China)

^e PEKING UNIVERSITY   (China)

^f NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

^g HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; CHAPERONE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; PHOSPHOGLYCERATE KINASE 1; PHOSPHOTRANSFERASE; TERAZOSIN; UNCLASSIFIED DRUG; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; CYTOKINE; PGK1 PROTEIN, MOUSE; PHOSPHOGLYCERATE KINASE; PRAZOSIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DNA FRAGMENTATION; DROSOPHILA; DRUG DOSE REDUCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; ENZYMOLOGY; IMMUNOPRECIPITATION; MACROPHAGE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STRESS; X RAY CRYSTALLOGRAPHY; ANALOGS AND DERIVATIVES; ANIMAL; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; INFARCTION, MIDDLE CEREBRAL ARTERY; METABOLISM; PATHOLOGY; PHYSIOLOGICAL STRESS; PROTEIN CONFORMATION; SEPSIS; STROKE;

RODENTIA;

ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS; ANIMALS; APOPTOSIS; CELLS, CULTURED; CYTOKINES; HSP90 HEAT-SHOCK PROTEINS; INFARCTION, MIDDLE CEREBRAL ARTERY; MICE; MODELS, MOLECULAR; PHOSPHOGLYCERATE KINASE; PRAZOSIN; PROTEIN CONFORMATION; RATS; SEPSIS; STRESS, PHYSIOLOGICAL; STROKE;

EID: 84924923805     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1657     Document Type: Article

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