Adaptation of a genotype 3 hepatitis E virus to efficient growth in cell culture depends on an inserted human gene segment acquired by recombination

Journal of Virology

Volumn 86, Issue 10, 2012, Pages 5697-5707

  Shukla, P ^a   Nguyen, H T ^a   Faulk, K ^a   Mather, K ^a   Torian, U ^a   Engle, R E ^a   Emerson, S U ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN; GUANOSINE TRIPHOSPHATASE; PROTEIN S17; RIBOSOME PROTEIN; UNCLASSIFIED DRUG; VIRUS RNA;

AMINO ACID COMPOSITION; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; EVOLUTIONARY ADAPTATION; GENETIC RECOMBINATION; GENOTYPE; HEPATITIS E; HEPATITIS E VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA TRANSCRIPTION; VIRAL GENE DELIVERY SYSTEM; VIRUS GENOME; VIRUS STRAIN;

ANIMALS; CELL LINE, TUMOR; GENOTYPE; HEPATITIS E; HEPATITIS E VIRUS; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; RECOMBINATION, GENETIC; RIBOSOMAL PROTEINS; SWINE;

CRICETINAE; HEPATITIS E VIRUS; SUIDAE;

EID: 84861310004     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.00146-12     Document Type: Article

References (34)

1. Ahmad I, Holla RP, Jameel S. 2011. Molecular virology of hepatitis E virus. Virus Res. doi:10.1016/j.virus res.2011.02.11.
2. Charini WA, Todd S, Gutman GA, Semler BL. 1994. Transduction of a human RNA sequence by poliovirus. J. Virol. 68:6547-6552.
3. Dalton HR, Bendall RP, Keane FE, Tedder RS, Ijaz S. 2009. Persistent carriage of hepatitis E virus in patients with HIV infection. N. Engl. J. Med. 361:1025-1027.
4. Emerson SU, et al. 2004. In vitro replication of hepatitis E virus (HEV) genomes and of an HEV replicon expressing green fluorescent protein. J. Virol. 78:4838-4846.
5. Emerson SU, et al. 2010. Release of genotype 1 hepatitis E virus from cultured hepatoma and polarized intestinal cells depends on open reading frame 3 protein and requires an intact PXXP motif. J. Virol. 84:9059-9069.
6. Emerson SU, et al. 2001. Recombinant hepatitis E virus genomes infectious for primates: importance of capping and discovery of a cis-reactive element. Proc. Natl. Acad. Sci. U. S. A. 98:15270-15275.
7. Emerson SU, Purcell RH. 2007. Hepatitis E virus, p 3047-3058. In Knipe DM, et al. (ed), Fields virology, 5th ed. Lippincott/The Williams&Wilkins Co., Philadelphia, PA.
8. Graff J, et al. 2005. The open reading frame 3 gene of hepatitis E virus contains a cis-reactive element and encodes a protein required for infection of macaques. J. Virol. 79:6680-6689.
9. Graff J, Torian U, Nguyen H, Emerson SU. 2006. A bicistronic subgenomic mRNA encodes both the ORF2 and ORF3 proteins of hepatitis E virus. J. Virol. 80:5919-5926.
10. Kamar N, et al. 2011. Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants. Gastroenterology 140:1481-1489.
11. Kamar N, et al. 2010. Hepatitis E virus-induced neurological symptoms in a kidney-transplant patient with chronic hepatitis. Am. J. Transplant. 10:1321-1324.
12. Kamar N, et al. 2011. Hepatitis E virus and neurologic disorders. Emerg. Infect. Dis. 17:173-179.
13. Karpe YA, Lole KS. 2011. Deubiquitination activity associated with hepatitis E virus putative papain-like cysteine protease. J. Gen. Virol. 92: 2088-2092.
14. Khatchikian D, Orlich M, Rott R. 1989. Increased viral pathogenicity after insertion of a 28S rRNA sequence into the haemagglutinin gene of an influenza virus. Nature 340:156-157.
15. Legrand-Abravanel F, et al. 2009. Hepatitis E virus genotype 3 diversity, France. Emerg. Infect. Dis. http://wwwnc.cdc.gov/eid/article/15/1/08 -0296.htm.
16. Meng XJ. 2010. Hepatitis E virus: animal reservoirs and zoonotic risk. Vet. Microbiol. 140:256-265.
17. Meng XJ. 2010. Recent advances in hepatitis E virus. J. Viral. Hepat. 17:531-536.
18. Meng XJ, et al. 2012. Hepeviridae. In King AMQ (ed), Virus taxonomy: classification and nomenclature of viruses: 9th report of the International Committee on Taxonomy of Viruses, p 991-998. Elsevier, San Diego, CA.
19. Meyers G, Tautz N, Dubovi EJ, Thiel H-J. 1991. Viral cytopathogenicity correlated with integration of ubiquitin coding sequences. Virology 180: 602-616.
20. Nagashima S, et al. 2011. A PSAP motif in the ORF3 protein of hepatitis E virus is necessary for virion release from infected cells. J. Gen. Virol. 92:269-278.
21. Nguyen HT, et al. 2012. A naturally occurring human/hepatitis E recombinant virus predominates in serum but not in feces of a chronic hepatitis E patient and has a growth advantage in cell culture. J. Gen. Virol. 93:526-530.
22. Okamoto H. 2011. Efficient cell culture systems for hepatitis E virus strains in feces and circulating blood. Rev. Med. Virol. 21:18-31.
23. Pavio N, Meng XJ, Renou C. 2010. Zoonotic hepatitis E: animal reservoirs and emerging risks. Vet. Res. 41:46.
24. Peron JM, et al. 2006. Prolonged hepatitis E in an immunocompromised patient. J. Gastroenterol. Hepatol. 21:1223-1224.
25. Pischke S, Wedemeyer H. 2010. Chronic hepatitis E in liver transplant recipients: a significant clinical problem? Minerva Gastroenterol. Dietol 56:121-128.
26. Pudupakam RS, et al. 2011. Mutational analysis of the hypervariable region of hepatitis E virus reveals its involvement in the efficiency of viral RNA replication. J. Virol. 85:10031-10040.
27. Pudupakam RS, et al. 2009. Deletions of the hypervariable region (HVR) in open reading frame 1 of hepatitis E virus do not abolish virus infectivity: evidence for attenuation of HVR deletion mutants in vivo. J. Virol. 83: 384-395.
28. Shukla et al. 2011. Cross-species infections of cultured cells by hepatitis E virus and discovery of an infectious virus-host recombinant. Proc. Natl. Acad. Sci. U. S. A. 108:2438-2443.
29. Tanaka T, Takahashi M, Kusano E, Okamoto H. 2007. Development and evaluation of an efficient cell-culture system for hepatitis E virus. J. Gen. Virol. 88:903-911.
30. Tanaka T, et al. 2009. Development and characterization of a genotype 4 hepatitis E virus cell culture system using a HE-JF5/15F strain recovered from a fulminant hepatitis patient. J. Clin. Microbiol. 47:1906-1910.
31. Wang H, et al. 2010. Recombination analysis reveals a double recombination event in hepatitis E virus. Virol. J. 7:129-134.
32. Yamada K, et al. 2009. Construction of an infectious cDNA clone of hepatitis E virus strain JE03-1760F that can propagate efficiently in cultured cells. J. Gen. Virol. 90:457-462.
33. Yamada K, et al. 2009. ORF3 protein of hepatitis E virus is essential for virion release from infected cells. J. Gen. Virol. 90:1880-1891.
34. Zuker M. 2003. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res. 31:3406-3415.