Characterizing the effect of GalNAc and phosphorothioate backbone on binding of antisense oligonucleotides to the asialoglycoprotein receptor

Nucleic Acids Research

Volumn 45, Issue 5, 2017, Pages 2294-2306

  Schmidt, Karsten ^a   Prakash, Thazha P ^a   Donner, Aaron J ^a   Kinberger, Garth A ^a   Gaus, Hans J ^a   Low, Audrey ^a   Østergaard, Michael E ^a   Bell, Melanie ^a   Swayze, Eric E ^a   Seth, Punit P ^a  

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3' GALACTOSE N ACETYLGALACTOSAMINE CONJUGATED ANTISENSE OLIGONUCLEOTIDE; ANTISENSE OLIGONUCLEOTIDE; ASIALOGLYCOPROTEIN RECEPTOR; GALACTOSE; N ACETYLGALACTOSAMINE; PHOSPHOROTHIOIC ACID; TRACER; UNCLASSIFIED DRUG; DNA; GLYCOCONJUGATE; OLIGONUCLEOTIDE PHOSPHOROTHIOATE; PROTEIN BINDING; SINGLE STRANDED DNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FLUORESCENCE POLARIZATION IMMUNOASSAY; HUMAN; IC50; INHIBITION CONSTANT; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DETERMINATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BINDING COMPETITION; BINDING SITE; BIOASSAY; CHEMISTRY; CYTOLOGY; FLUORESCENCE POLARIZATION; GENETICS; KINETICS; KNOCKOUT MOUSE; LIVER; LIVER CELL; LIVER MICROSOME; METABOLISM; NUCLEOTIDE SEQUENCE; PRIMARY CELL CULTURE; STATIC ELECTRICITY; TRANSPORT AT THE CELLULAR LEVEL;

ACETYLGALACTOSAMINE; ANIMALS; ASIALOGLYCOPROTEIN RECEPTOR; BASE SEQUENCE; BINDING SITES; BINDING, COMPETITIVE; BIOLOGICAL ASSAY; BIOLOGICAL TRANSPORT; DNA; DNA, SINGLE-STRANDED; FLUORESCENCE POLARIZATION; GLYCOCONJUGATES; HEPATOCYTES; HUMANS; KINETICS; LIVER; MICE; MICE, KNOCKOUT; MICROSOMES, LIVER; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHOROTHIOATE OLIGONUCLEOTIDES; PRIMARY CELL CULTURE; PROTEIN BINDING; STATIC ELECTRICITY;

EID: 85018303347     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkx060     Document Type: Article

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