Comprehensive Structure-Activity Relationship of Triantennary N-Acetylgalactosamine Conjugated Antisense Oligonucleotides for Targeted Delivery to Hepatocytes

Journal of Medicinal Chemistry

Volumn 59, Issue 6, 2016, Pages 2718-2733

  Prakash, Thazha P ^a   Yu, Jinghua ^a   Migawa, Michael T ^a   Kinberger, Garth A ^a   Wan, W Brad ^a   Østergaard, Michael E ^a   Carty, Recaldo L ^a   Vasquez, Guillermo ^a   Low, Audrey ^a   Chappell, Alfred ^a   Schmidt, Karsten ^a   Aghajan, Mariam ^a   Crosby, Jeff ^a   Murray, Heather M ^a   Booten, Sheri L ^a   Hsiao, Jill ^a   Soriano, Armand ^a   MacHemer, Todd ^a   Cauntay, Patrick ^a   Burel, Sebastien A ^a   Murray, Susan F ^a   Gaus, Hans ^a   Graham, Mark J ^a   Swayze, Eric E ^a   Seth, Punit P ^a   more..

^a ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; MESSENGER RNA; N ACETYLGALACTOSAMINE; APOLIPOPROTEIN C3; BLOOD CLOTTING FACTOR 11; SCARB1 PROTEIN, MOUSE; SCAVENGER RECEPTOR B;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING ASSAY; CONJUGATE; CONTROLLED STUDY; DRUG BINDING; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG POTENCY; DRUG SYNTHESIS; LIVER CELL; MALE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; ANIMAL; BAGG ALBINO MOUSE; BIOSYNTHESIS; C57BL MOUSE; DRUG EFFECTS; GENETICS; HUMAN; SYNTHESIS; TRANSGENIC MOUSE;

ACETYLGALACTOSAMINE; ANIMALS; APOLIPOPROTEIN C-III; DRUG DELIVERY SYSTEMS; FACTOR XI; HEPATOCYTES; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, TRANSGENIC; OLIGONUCLEOTIDES, ANTISENSE; SCAVENGER RECEPTORS, CLASS B; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84962171168     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01948     Document Type: Article

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