Cytosolic calcium mediates RIP1/RIP3 complex-dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells

Free Radical Biology and Medicine

Volumn 108, Issue , 2017, Pages 433-444

  Sun, Wen ^a   Wu, Xiaxia ^a   Gao, Hongwei ^a   Yu, Jie ^a   Zhao, Wenwen ^a   Lu, Jin Jian ^a   Wang, Jinhua ^b   Du, Guanhua ^b   Chen, Xiuping ^a  

^a University of Macau   (Macao)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

c Jun N terminal kinase; Calcium; Necroptosis; ROS

Indexed keywords

2 (1H INDOL 3 YL) 3 PENTYLAMINOMALEIMIDE; 2 METHOXY 6 ACETYL 7 METHYLJUGLONE; ADENOSINE TRIPHOSPHATE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; BAPTA AM; CALCIUM CHELATING AGENT; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE INHIBITOR; CYTOTOXIC AGENT; MANGANESE SUPEROXIDE DISMUTASE; N BENZYLOXYCARBONYLVALYLALANYLASPARAGYL FLUROMETHYLKETONE; NECROSTATIN 1S; PROTEIN P53; PROTEIN SERINE THREONINE KINASE INHIBITOR; REACTIVE OXYGEN METABOLITE; RECEPTOR INTERACTING PROTEIN 1; RECEPTOR INTERACTING PROTEIN 3; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; SUCCINATE DEHYDROGENASE (UBIQUINONE); THENOYLTRIFLUOROACETONE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; Z VAD FMK; AGFG1 PROTEIN, HUMAN; CALCIUM; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MULTIPROTEIN COMPLEX; NAPHTHOQUINONE; NECROSTATIN-1; NUCLEOPORIN; RIPK3 PROTEIN, HUMAN; RNA BINDING PROTEIN;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL DEATH; CELL MEMBRANE; CELL MEMBRANE DEPOLARIZATION; CELL MEMBRANE PERMEABILITY; CELL ULTRASTRUCTURE; COLON CANCER; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE SILENCING; HCT 116 CELL LINE; HT-29 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTRACELLULAR SIGNALING; LYSOSOME MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; NECROPTOSIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN PHOSPHORYLATION; TRANSMISSION ELECTRON MICROSCOPY; ANTAGONISTS AND INHIBITORS; COLON TUMOR; GENETICS; METABOLISM; SIGNAL TRANSDUCTION;

CALCIUM; CELL DEATH; COLONIC NEOPLASMS; CYTOSOL; HCT116 CELLS; HUMANS; IMIDAZOLES; INDOLES; MAP KINASE KINASE 4; MITOCHONDRIA; MULTIPROTEIN COMPLEXES; NAPHTHOQUINONES; NUCLEAR PORE COMPLEX PROTEINS; REACTIVE OXYGEN SPECIES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 85017623966     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2017.04.010     Document Type: Article

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