Pharmacological inhibition of LSD1 and mTOR reduces mitochondrial retention and associated ROS levels in the red blood cells of sickle cell disease

Experimental Hematology

Volumn 50, Issue , 2017, Pages 46-52

  Jagadeeswaran, Ramasamy ^a,b   Vazquez, Benjamin A ^a   Thiruppathi, Muthusamy ^a   Ganesh, Balaji B ^a   Ibanez, Vinzon ^a,b   Cui, Shuaiying ^c   Engel, James D ^d   Diamond, Alan M ^a   Molokie, Robert E ^a,b   DeSimone, Joseph ^a,b   Lavelle, Donald ^a,b   Rivers, Angela ^a,b  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b JESSE BROWN VA MEDICAL CENTER   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

OXYGENASE INHIBITOR; RAPAMYCIN; REACTIVE OXYGEN METABOLITE; RN 1; UNCLASSIFIED DRUG; HISTONE DEMETHYLASE; KDM1A PROTEIN, HUMAN; RHODAMINE; RN1 COMPOUND; SPIRO COMPOUND; TARGET OF RAPAMYCIN KINASE; THIOPHENE DERIVATIVE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ERYTHROCYTE LIFESPAN; FEMALE; GENE EXPRESSION; HUMAN; MALE; MIDDLE AGED; MITOCHONDRION; MITOPHAGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SICKLE CELL ANEMIA; YOUNG ADULT; ANIMAL; BIOLOGICAL MODEL; DISEASE MODEL; DRUG EFFECTS; ERYTHROCYTE; METABOLISM;

ANEMIA, SICKLE CELL; ANIMALS; DISEASE MODELS, ANIMAL; ERYTHROCYTES; HISTONE DEMETHYLASES; HUMANS; MICE; MITOCHONDRIA; MODELS, BIOLOGICAL; REACTIVE OXYGEN SPECIES; RHODAMINES; SIROLIMUS; SPIRO COMPOUNDS; THIOPHENES; TOR SERINE-THREONINE KINASES;

EID: 85017444576     PISSN: 0301472X     EISSN: 18732399     Source Type: Journal    
DOI: 10.1016/j.exphem.2017.02.003     Document Type: Article

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