mTOR Inhibition improves anaemia and reduces organ damage in a murine model of sickle cell disease

British Journal of Haematology

Volumn 174, Issue 3, 2016, Pages 461-469

  Wang, Jintao ^a   Tran, Jennifer ^a   Wang, Hui ^a   Guo, Chiao ^a   Harro, David ^b   Campbell, Andrew D ^a   Eitzman, Daniel T ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

anaemia; mechanistic target of rapamycin; sickle cell disease; sirolimus; stroke

Indexed keywords

HEMOGLOBIN F; IRON; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; RAPAMYCIN; SAPANISERTIB; BENZOXAZOLE DERIVATIVE; HEMOGLOBIN; MTOR PROTEIN, MOUSE; PYRIMIDINE DERIVATIVE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELL MATURATION; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; ERYTHROCYTE COUNT; ERYTHROCYTE LIFESPAN; ERYTHROID CELL; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; KIDNEY LEVEL; LIVER LEVEL; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NONHUMAN; ORGAN INJURY; PRIORITY JOURNAL; RETICULOCYTE COUNT; SICKLE CELL ANEMIA; SPLEEN SIZE; TISSUE LEVEL; TREATMENT DURATION; ANEMIA; ANEMIA, SICKLE CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; ERYTHROCYTE; SPLENOMEGALY;

ANEMIA; ANEMIA, SICKLE CELL; ANIMALS; BENZOXAZOLES; DISEASE MODELS, ANIMAL; ERYTHROCYTES; HEMATOCRIT; HEMOGLOBINS; MICE; PYRIMIDINES; SIROLIMUS; SPLENOMEGALY; TOR SERINE-THREONINE KINASES;

EID: 84963682621     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.14057     Document Type: Article

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