Erythrocyte NADPH oxidase activity modulated by Rac GTPases, PKC, and plasma cytokines contributes to oxidative stress in sickle cell disease

Blood

Volumn 121, Issue 11, 2013, Pages 2099-2107

  George, Alex ^a   Pushkaran, Suvarnamala ^b   Konstantinidis, Diamantis G ^b   Koochaki, Sebastian ^b   Malik, Punam ^b   Mohandas, Narla ^c   Zheng, Yi ^b   Joiner, Clinton H ^d   Kalfa, Theodosia A ^b  

^a TEXAS CHILDREN S HOSPITAL   (United States)

^b UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^c NEW YORK BLOOD CENTER   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; ENDOTHELIN 1; PROTEIN KINASE C; RAC PROTEIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRANSFORMING GROWTH FACTOR BETA1; CYTOKINE; ISOENZYME;

ARTICLE; BLOOD VESSEL OCCLUSION; CALCIUM CELL LEVEL; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVITY; ERYTHROCYTE; ERYTHROCYTE DEFORMABILITY; ERYTHROCYTE FRAGILITY; HEMOLYSIS; HUMAN; HUMAN CELL; INFLAMMATION; INTRACELLULAR SIGNALING; ORGAN INJURY; OXIDATIVE STRESS; PRIORITY JOURNAL; RETICULOCYTE; SICKLE CELL ANEMIA; BIOLOGICAL MODEL; BLOOD; CELL AGING; CHILD; DRUG EFFECT; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; PATHOLOGY; PHYSIOLOGY;

ANEMIA, SICKLE CELL; CALCIUM; CELL AGING; CHILD; CYTOKINES; ENZYME ACTIVATION; ERYTHROCYTES; HUMANS; ISOENZYMES; MODELS, BIOLOGICAL; NADPH OXIDASE; OXIDATIVE STRESS; PROTEIN KINASE C; RAC GTP-BINDING PROTEINS; REACTIVE OXYGEN SPECIES;

MLCS; MLOWN;

EID: 84877589196     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-07-441188     Document Type: Article

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