메뉴 건너뛰기




Volumn 126, Issue 3, 2015, Pages 386-396

The LSD1 inhibitor RN-1 induces fetal hemoglobin synthesis and reduces disease pathology in sickle cell mice

Author keywords

[No Author keywords available]

Indexed keywords

CD71 ANTIGEN; ENZYME INHIBITOR; HEMOGLOBIN; HEMOGLOBIN F; HEMOGLOBIN GAMMA CHAIN; LYSINE SPECIFIC DEMETHYLASE 1 INHIBITOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; UNCLASSIFIED DRUG; AOF2 PROTEIN, MOUSE; HEMOGLOBIN BETA CHAIN; HISTONE DEMETHYLASE; MESSENGER RNA; RHODAMINE; RN1 COMPOUND; SPIRO COMPOUND; THIOPHENE DERIVATIVE;

EID: 84937949127     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-02-626259     Document Type: Article
Times cited : (71)

References (51)
  • 2
    • 5044239523 scopus 로고    scopus 로고
    • Sickle-cell disease
    • Stuart MJ, Nagel RL. Sickle-cell disease. Lancet. 2004;364(9442):1343-1360.
    • (2004) Lancet , vol.364 , Issue.9442 , pp. 1343-1360
    • Stuart, M.J.1    Nagel, R.L.2
  • 3
    • 0023859033 scopus 로고
    • Levels of fetal hemoglobin necessary for treatment of sickle cell disease
    • Noguchi CT, Rodgers GP, Serjeant G, Schechter AN. Levels of fetal hemoglobin necessary for treatment of sickle cell disease. N Engl J Med. 1988;318(2):96-99.
    • (1988) N Engl J Med , vol.318 , Issue.2 , pp. 96-99
    • Noguchi, C.T.1    Rodgers, G.P.2    Serjeant, G.3    Schechter, A.N.4
  • 4
    • 0033536288 scopus 로고    scopus 로고
    • The beta-thalassemias
    • Olivieri NF. The beta-thalassemias. N Engl J Med. 1999;341(2):99-109.
    • (1999) N Engl J Med , vol.341 , Issue.2 , pp. 99-109
    • Olivieri, N.F.1
  • 5
    • 0022354852 scopus 로고
    • Stimulation of F-cell production in patients with sickle-cell anemia treated with cytarabine or hydroxyurea
    • Veith R, Galanello R, Papayannopoulou T, Stamatoyannopoulos G. Stimulation of F-cell production in patients with sickle-cell anemia treated with cytarabine or hydroxyurea. N Engl J Med. 1985;313(25):1571-1575.
    • (1985) N Engl J Med , vol.313 , Issue.25 , pp. 1571-1575
    • Veith, R.1    Galanello, R.2    Papayannopoulou, T.3    Stamatoyannopoulos, G.4
  • 6
    • 84862254136 scopus 로고    scopus 로고
    • Hydroxyurea for the treatment of sickle cell disease: Efficacy, barriers, toxicity, and management in children
    • Strouse JJ, Heeney MM. Hydroxyurea for the treatment of sickle cell disease: efficacy, barriers, toxicity, and management in children. Pediatr Blood Cancer. 2012;59(2):365-371.
    • (2012) Pediatr Blood Cancer , vol.59 , Issue.2 , pp. 365-371
    • Strouse, J.J.1    Heeney, M.M.2
  • 7
    • 84878154737 scopus 로고    scopus 로고
    • Optimizing Hydroxyurea use in children with sickle cell disease: Low dose regimen is effective
    • Sharef SW, Al-Hajri M, Beshlawi I, et al. Optimizing Hydroxyurea use in children with sickle cell disease: low dose regimen is effective. Eur J Haematol. 2013;90(6):519-524.
    • (2013) Eur J Haematol , vol.90 , Issue.6 , pp. 519-524
    • Sharef, S.W.1    Al-Hajri, M.2    Beshlawi, I.3
  • 8
    • 78650376704 scopus 로고    scopus 로고
    • Examining the characteristics and beliefs of hydroxyurea users and nonusers among adults with sickle cell disease
    • Haywood C Jr, Beach MC, Bediako S, et al. Examining the characteristics and beliefs of hydroxyurea users and nonusers among adults with sickle cell disease. Am J Hematol. 2011;86(1):85-87.
    • (2011) Am J Hematol , vol.86 , Issue.1 , pp. 85-87
    • Haywood, C.1    Beach, M.C.2    Bediako, S.3
  • 9
    • 80051815757 scopus 로고    scopus 로고
    • Monitoring toxicity, impact, and adherence of hydroxyurea in children with sickle cell disease
    • Brandow AM, Panepinto JA. Monitoring toxicity, impact, and adherence of hydroxyurea in children with sickle cell disease. Am J Hematol. 2011;86(9):804-806.
    • (2011) Am J Hematol , vol.86 , Issue.9 , pp. 804-806
    • Brandow, A.M.1    Panepinto, J.A.2
  • 10
    • 67749114687 scopus 로고    scopus 로고
    • Improvement in hemolysis and pulmonary arterial systolic pressure in adult patients with sickle cell disease during treatment with hydroxyurea
    • Olnes M, Chi A, Haney C, et al. Improvement in hemolysis and pulmonary arterial systolic pressure in adult patients with sickle cell disease during treatment with hydroxyurea. Am J Hematol. 2009;84(8):530-532.
    • (2009) Am J Hematol , vol.84 , Issue.8 , pp. 530-532
    • Olnes, M.1    Chi, A.2    Haney, C.3
  • 11
    • 40449130473 scopus 로고    scopus 로고
    • Clinical effectiveness of decitabine in severe sickle cell disease
    • Saunthararajah Y, Molokie R, Saraf S, et al. Clinical effectiveness of decitabine in severe sickle cell disease. Br J Haematol. 2008;141(1):126-129.
    • (2008) Br J Haematol , vol.141 , Issue.1 , pp. 126-129
    • Saunthararajah, Y.1    Molokie, R.2    Saraf, S.3
  • 12
    • 0034307656 scopus 로고    scopus 로고
    • 2-Deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia
    • Koshy M, Dorn L, Bressler L, et al. 2-deoxy 5-azacytidine and fetal hemoglobin induction in sickle cell anemia. Blood. 2000;96(7):2379-2384.
    • (2000) Blood , vol.96 , Issue.7 , pp. 2379-2384
    • Koshy, M.1    Dorn, L.2    Bressler, L.3
  • 13
    • 34548428815 scopus 로고    scopus 로고
    • Decitabine and sickle cell disease: Molecular therapy for a molecular disease
    • Saunthararajah Y. Decitabine and sickle cell disease: molecular therapy for a molecular disease. Pediatr Hematol Oncol. 2007;24(7):465-468.
    • (2007) Pediatr Hematol Oncol , vol.24 , Issue.7 , pp. 465-468
    • Saunthararajah, Y.1
  • 14
    • 0036625004 scopus 로고    scopus 로고
    • Maintenance of elevated fetal hemoglobin levels by decitabine during dose interval treatment of sickle cell anemia
    • DeSimone J, Koshy M, Dorn L, et al. Maintenance of elevated fetal hemoglobin levels by decitabine during dose interval treatment of sickle cell anemia. Blood. 2002;99(11):3905-3908.
    • (2002) Blood , vol.99 , Issue.11 , pp. 3905-3908
    • DeSimone, J.1    Koshy, M.2    Dorn, L.3
  • 15
    • 0030923438 scopus 로고    scopus 로고
    • Induction of gamma-globin by histone deacetylase inhibitors
    • McCaffrey PG, Newsome DA, Fibach E, Yoshida M, Su MS. Induction of gamma-globin by histone deacetylase inhibitors. Blood. 1997;90(5):2075-2083.
    • (1997) Blood , vol.90 , Issue.5 , pp. 2075-2083
    • McCaffrey, P.G.1    Newsome, D.A.2    Fibach, E.3    Yoshida, M.4    Su, M.S.5
  • 16
    • 37549053288 scopus 로고    scopus 로고
    • Pulsed-dosing with oral sodium phenylbutyrate increases hemoglobin F in a patient with sickle cell anemia
    • Hines P, Dover GJ, Resar LM. Pulsed-dosing with oral sodium phenylbutyrate increases hemoglobin F in a patient with sickle cell anemia. Pediatr Blood Cancer. 2008;50(2):357-359.
    • (2008) Pediatr Blood Cancer , vol.50 , Issue.2 , pp. 357-359
    • Hines, P.1    Dover, G.J.2    Resar, L.M.3
  • 17
    • 0036899584 scopus 로고    scopus 로고
    • Induction of fetal hemoglobin synthesis in children with sickle cell anemia on low-dose oral sodium phenylbutyrate therapy
    • Resar LM, Segal JB, Fitzpatric LK, Friedmann A, Brusilow SW, Dover GJ. Induction of fetal hemoglobin synthesis in children with sickle cell anemia on low-dose oral sodium phenylbutyrate therapy. J Pediatr Hematol Oncol. 2002;24(9):737-741.
    • (2002) J Pediatr Hematol Oncol , vol.24 , Issue.9 , pp. 737-741
    • Resar, L.M.1    Segal, J.B.2    Fitzpatric, L.K.3    Friedmann, A.4    Brusilow, S.W.5    Dover, G.J.6
  • 18
    • 0028303870 scopus 로고
    • Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate
    • Dover GJ, Brusilow S, Charache S. Induction of fetal hemoglobin production in subjects with sickle cell anemia by oral sodium phenylbutyrate. Blood. 1994;84(1):339-343.
    • (1994) Blood , vol.84 , Issue.1 , pp. 339-343
    • Dover, G.J.1    Brusilow, S.2    Charache, S.3
  • 20
    • 37049008636 scopus 로고    scopus 로고
    • DNA damage in blood leukocytes of individuals with sickle cell disease treated with hydroxyurea
    • Friedrisch JR, Prá D, Maluf SW, et al. DNA damage in blood leukocytes of individuals with sickle cell disease treated with hydroxyurea. Mutat Res. 2008;649(1-2):213-220.
    • (2008) Mutat Res , vol.649 , Issue.1-2 , pp. 213-220
    • Friedrisch, J.R.1    Prá, D.2    Maluf, S.W.3
  • 21
    • 77954934323 scopus 로고    scopus 로고
    • Assessment of genotoxicity associated with hydroxyurea therapy in children with sickle cell anemia
    • Flanagan JM, Howard TA, Mortier N, et al. Assessment of genotoxicity associated with hydroxyurea therapy in children with sickle cell anemia. Mutat Res. 2010;698(1-2):38-42.
    • (2010) Mutat Res , vol.698 , Issue.1-2 , pp. 38-42
    • Flanagan, J.M.1    Howard, T.A.2    Mortier, N.3
  • 23
    • 0022568850 scopus 로고
    • Hydroxyurea induction of hemoglobin F production in sickle cell disease: Relationship between cytotoxicity and F cell production
    • Dover GJ, Humphries RK, Moore JG, et al. Hydroxyurea induction of hemoglobin F production in sickle cell disease: relationship between cytotoxicity and F cell production. Blood. 1986;67(3):735-738.
    • (1986) Blood , vol.67 , Issue.3 , pp. 735-738
    • Dover, G.J.1    Humphries, R.K.2    Moore, J.G.3
  • 24
    • 0023130331 scopus 로고
    • Hydroxyurea-induced augmentation of fetal hemoglobin production in patients with sickle cell anemia
    • Charache S, Dover GJ, Moyer MA, Moore JW. Hydroxyurea-induced augmentation of fetal hemoglobin production in patients with sickle cell anemia. Blood. 1987;69(1):109-116.
    • (1987) Blood , vol.69 , Issue.1 , pp. 109-116
    • Charache, S.1    Dover, G.J.2    Moyer, M.A.3    Moore, J.W.4
  • 25
    • 79961145533 scopus 로고    scopus 로고
    • Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells
    • Cui S, Kolodziej KE, Obara N, et al. Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic β-type globin promoters in differentiated adult erythroid cells. Mol Cell Biol. 2011;31(16):3298-3311.
    • (2011) Mol Cell Biol , vol.31 , Issue.16 , pp. 3298-3311
    • Cui, S.1    Kolodziej, K.E.2    Obara, N.3
  • 26
    • 11144332565 scopus 로고    scopus 로고
    • Histone demethylation mediated by the nuclear amine oxidase homolog LSD1
    • Shi Y, Lan F, Matson C, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell. 2004;119(7):941-953.
    • (2004) Cell , vol.119 , Issue.7 , pp. 941-953
    • Shi, Y.1    Lan, F.2    Matson, C.3
  • 27
    • 35348812522 scopus 로고    scopus 로고
    • LSD1 and the chemistry of histone demethylation
    • Culhane JC, Cole PA. LSD1 and the chemistry of histone demethylation. Curr Opin Chem Biol. 2007;11(5):561-568.
    • (2007) Curr Opin Chem Biol , vol.11 , Issue.5 , pp. 561-568
    • Culhane, J.C.1    Cole, P.A.2
  • 28
    • 33745187327 scopus 로고    scopus 로고
    • Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications
    • Lee MG, Wynder C, Schmidt DM, McCafferty DG, Shiekhattar R. Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol. 2006;13(6):563-567.
    • (2006) Chem Biol , vol.13 , Issue.6 , pp. 563-567
    • Lee, M.G.1    Wynder, C.2    Schmidt, D.M.3    McCafferty, D.G.4    Shiekhattar, R.5
  • 29
    • 84864856634 scopus 로고    scopus 로고
    • Dietary restrictions and drug interactions with monoamine oxidase inhibitors: An update
    • Flockhart DA. Dietary restrictions and drug interactions with monoamine oxidase inhibitors: an update. J Clin Psychiatry. 2012;73(Suppl 1):17-24.
    • (2012) J Clin Psychiatry , vol.73 , pp. 17-24
    • Flockhart, D.A.1
  • 30
    • 84875230084 scopus 로고    scopus 로고
    • Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction
    • Shi L, Cui S, Engel JD, Tanabe O. Lysine-specific demethylase 1 is a therapeutic target for fetal hemoglobin induction. Nat Med. 2013;19(3):291-294.
    • (2013) Nat Med , vol.19 , Issue.3 , pp. 291-294
    • Shi, L.1    Cui, S.2    Engel, J.D.3    Tanabe, O.4
  • 31
    • 84876239967 scopus 로고    scopus 로고
    • Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A
    • Xu J, Bauer DE, Kerenyi MA, et al. Corepressor-dependent silencing of fetal hemoglobin expression by BCL11A. Proc Natl Acad Sci USA. 2013;110(16):6518-6523.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.16 , pp. 6518-6523
    • Xu, J.1    Bauer, D.E.2    Kerenyi, M.A.3
  • 32
    • 84857241874 scopus 로고    scopus 로고
    • Brain-penetrant LSD1 inhibitors can block memory consolidation
    • Neelamegam R, Ricq EL, Malvaez M, et al. Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem Neurosci. 2012;3(2):120-128.
    • (2012) ACS Chem Neurosci , vol.3 , Issue.2 , pp. 120-128
    • Neelamegam, R.1    Ricq, E.L.2    Malvaez, M.3
  • 33
    • 33747152507 scopus 로고    scopus 로고
    • Correction of sickle cell disease by homologous recombination in embryonic stem cells
    • Wu LC, Sun CW, Ryan TM, Pawlik KM, Ren J, Townes TM. Correction of sickle cell disease by homologous recombination in embryonic stem cells. Blood. 2006;108(4):1183-1188.
    • (2006) Blood , vol.108 , Issue.4 , pp. 1183-1188
    • Wu, L.C.1    Sun, C.W.2    Ryan, T.M.3    Pawlik, K.M.4    Ren, J.5    Townes, T.M.6
  • 34
    • 81755163577 scopus 로고    scopus 로고
    • Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes
    • Campbell AD, Cui S, Shi L, et al. Forced TR2/TR4 expression in sickle cell disease mice confers enhanced fetal hemoglobin synthesis and alleviated disease phenotypes. Proc Natl Acad Sci USA. 2011;108(46):18808-18813.
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.46 , pp. 18808-18813
    • Campbell, A.D.1    Cui, S.2    Shi, L.3
  • 35
    • 84899814457 scopus 로고    scopus 로고
    • PGC-1 coactivator activity is required for murine erythropoiesis
    • Cui S, Tanabe O, Lim KC, et al. PGC-1 coactivator activity is required for murine erythropoiesis. Mol Cell Biol. 2014;34(11):1956-1965.
    • (2014) Mol Cell Biol , vol.34 , Issue.11 , pp. 1956-1965
    • Cui, S.1    Tanabe, O.2    Lim, K.C.3
  • 36
    • 84902189880 scopus 로고    scopus 로고
    • Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression
    • Zhang Y, Berka V, Song A, et al. Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression. J Clin Invest. 2014;124(6):2750-2761.
    • (2014) J Clin Invest , vol.124 , Issue.6 , pp. 2750-2761
    • Zhang, Y.1    Berka, V.2    Song, A.3
  • 37
    • 78651245860 scopus 로고    scopus 로고
    • Detrimental effects of adenosine signaling in sickle cell disease
    • Zhang Y, Dai Y, Wen J, et al. Detrimental effects of adenosine signaling in sickle cell disease. Nat Med. 2011;17(1):79-86.
    • (2011) Nat Med , vol.17 , Issue.1 , pp. 79-86
    • Zhang, Y.1    Dai, Y.2    Wen, J.3
  • 38
    • 69849094491 scopus 로고    scopus 로고
    • A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: Critical determinants for successful correction
    • Perumbeti A, Higashimoto T, Urbinati F, et al. A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction. Blood. 2009;114(6):1174-1185.
    • (2009) Blood , vol.114 , Issue.6 , pp. 1174-1185
    • Perumbeti, A.1    Higashimoto, T.2    Urbinati, F.3
  • 39
    • 84905662103 scopus 로고    scopus 로고
    • Developmental transcriptome analysis of human erythropoiesis
    • Shi L, Lin YH, Sierant MC, et al. Developmental transcriptome analysis of human erythropoiesis. Hum Mol Genet. 2014;23(17):4528-4542.
    • (2014) Hum Mol Genet , vol.23 , Issue.17 , pp. 4528-4542
    • Shi, L.1    Lin, Y.H.2    Sierant, M.C.3
  • 40
    • 34547477270 scopus 로고    scopus 로고
    • In vitro erythropoiesis from bone marrow-derived progenitors provides a physiological assay for toxic and mutagenic compounds
    • Shuga J, Zhang J, Samson LD, Lodish HF, Griffith LG. In vitro erythropoiesis from bone marrow-derived progenitors provides a physiological assay for toxic and mutagenic compounds. Proc Natl Acad Sci USA. 2007;104(21):8737-8742.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.21 , pp. 8737-8742
    • Shuga, J.1    Zhang, J.2    Samson, L.D.3    Lodish, H.F.4    Griffith, L.G.5
  • 41
    • 84937862401 scopus 로고    scopus 로고
    • Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes
    • Cui S, Tanabe O, Sierant M, et al. Compound loss of function of nuclear receptors Tr2 and Tr4 leads to induction of murine embryonic β-type globin genes. Blood. 2015;125(9):1477-1487.
    • (2015) Blood , vol.125 , Issue.9 , pp. 1477-1487
    • Cui, S.1    Tanabe, O.2    Sierant, M.3
  • 42
    • 48349108293 scopus 로고    scopus 로고
    • Genome-wide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism
    • Li S, Liu C, Li N, et al. Genome-wide coactivation analysis of PGC-1alpha identifies BAF60a as a regulator of hepatic lipid metabolism. Cell Metab. 2008;8(2):105-117.
    • (2008) Cell Metab , vol.8 , Issue.2 , pp. 105-117
    • Li, S.1    Liu, C.2    Li, N.3
  • 43
    • 78650419600 scopus 로고    scopus 로고
    • P-selectin-mediated platelet-neutrophil aggregate formation activates neutrophils in mouse and human sickle cell disease
    • Polanowska-Grabowska R, Wallace K, Field JJ, et al. P-selectin-mediated platelet-neutrophil aggregate formation activates neutrophils in mouse and human sickle cell disease. Arterioscler Thromb Vasc Biol. 2010;30(12):2392-2399.
    • (2010) Arterioscler Thromb Vasc Biol , vol.30 , Issue.12 , pp. 2392-2399
    • Polanowska-Grabowska, R.1    Wallace, K.2    Field, J.J.3
  • 44
    • 33947244845 scopus 로고    scopus 로고
    • PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation
    • Yamane K, Tateishi K, Klose RJ, et al. PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation. Mol Cell. 2007;25(6):801-812.
    • (2007) Mol Cell , vol.25 , Issue.6 , pp. 801-812
    • Yamane, K.1    Tateishi, K.2    Klose, R.J.3
  • 45
    • 33947302685 scopus 로고    scopus 로고
    • The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases
    • Iwase S, Lan F, Bayliss P, et al. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell. 2007;128(6):1077-1088.
    • (2007) Cell , vol.128 , Issue.6 , pp. 1077-1088
    • Iwase, S.1    Lan, F.2    Bayliss, P.3
  • 47
    • 84872130436 scopus 로고    scopus 로고
    • Structural and functional analysis of JMJD2D reveals molecular basis for site-specific demethylation among JMJD2 demethylases
    • Krishnan S, Trievel RC. Structural and functional analysis of JMJD2D reveals molecular basis for site-specific demethylation among JMJD2 demethylases. Structure. 2013;21(1):98-108.
    • (2013) Structure , vol.21 , Issue.1 , pp. 98-108
    • Krishnan, S.1    Trievel, R.C.2
  • 48
    • 84859176881 scopus 로고    scopus 로고
    • FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure
    • Hino S, Sakamoto A, Nagaoka K, et al. FAD-dependent lysine-specific demethylase-1 regulates cellular energy expenditure. Nat Commun. 2012;3:758.
    • (2012) Nat Commun , vol.3 , pp. 758
    • Hino, S.1    Sakamoto, A.2    Nagaoka, K.3
  • 49
    • 15044361698 scopus 로고    scopus 로고
    • The serotonin syndrome
    • Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005;352(11):1112-1120.
    • (2005) N Engl J Med , vol.352 , Issue.11 , pp. 1112-1120
    • Boyer, E.W.1    Shannon, M.2
  • 50
    • 81555205756 scopus 로고    scopus 로고
    • Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing
    • Xu J, Peng C, Sankaran VG, et al. Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science. 2011;334(6058):993-996.
    • (2011) Science , vol.334 , Issue.6058 , pp. 993-996
    • Xu, J.1    Peng, C.2    Sankaran, V.G.3
  • 51
    • 79960974473 scopus 로고    scopus 로고
    • Pomalidomide augments fetal hemoglobin production without the myelosuppressive effects of hydroxyurea in transgenic sickle cell mice
    • Meiler SE, Wade M, Kutlar F, et al. Pomalidomide augments fetal hemoglobin production without the myelosuppressive effects of hydroxyurea in transgenic sickle cell mice. Blood. 2011;118(4):1109-1112.
    • (2011) Blood , vol.118 , Issue.4 , pp. 1109-1112
    • Meiler, S.E.1    Wade, M.2    Kutlar, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.