Update on bioactive peptides after milk and cheese digestion

Current Opinion in Food Science

Volumn 14, Issue , 2017, Pages 116-121

  Egger, Lotti ^a   Ménard, Olivia ^b  

^a AGROSCOPE   (Switzerland)

^b AGROCAMPUS OUEST   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85017413498     PISSN: 22147993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cofs.2017.03.003     Document Type: Review

References (45)

1. 1 Pessione, E., Cirrincione, S., Bioactive molecules released in food by lactic acid bacteria: encrypted peptides and biogenic amines. Front. Microbiol., 7, 2016, 876.
2. 2 Boutrou, R., Gaudichon, C., Dupont, D., Jardin, J., Airinei, G., Marsset-Baglieri, A., et al. Sequential release of milk protein-derived bioactive peptides in the jejunum in healthy humans. Am. J. Clin. Nutr. 97 (2013), 1314–1323.
3. 3 Boutrou, R., Henry, G., Sanchez-Rivera, L., On the trail of milk bioactive peptides in human and animal intestinal tracts during digestion: a review. Dairy Sci. Technol. 95 (2015), 815–829.
4. 4 Capriotti, A.L., Cavaliere, C., Piovesana, S., Samperi, R., Lagana, A., Recent trends in the analysis of bioactive peptides in milk and dairy products. Anal. Bioanal. Chem. 408 (2016), 2677–2685.
5. 5 Kopf-Bolanz, K.A., Schwander, F., Gijs, M., Vergères, G., Portmann, R., Egger, L., Impact of milk processing on the generation of peptides during digestion. Int. Dairy J. 35 (2014), 130–138.
6. 6 Barbé, F., Le Feunteun, S., Rémond, D., Ménard, O., Jardin, J., Henry, G., et al. Tracking the in vivo release of bioactive peptides in the gut during digestion: mass spectrometry peptidomic characterization of effluents collected in the gut of dairy matrix fed mini-pigs. Food Res. Int. 63:Pt. B (2014), 147–156.
7. 7 Picariello, G., Iacomino, G., Mamone, G., Ferranti, P., Fierro, O., Gianfrani, C., et al. Transport across Caco-2 monolayers of peptides arising from in vitro digestion of bovine milk proteins. Food Chem. 139 (2013), 203–212.
8. 8 Regazzo, D., Molle, D., Gabai, G., Tome, D., Dupont, D., Leonil, J., et al. The (193–209) 17-residues peptide of bovine beta-casein is transported through Caco-2 monolayer. Mol. Nutr. Food Res. 54 (2010), 1428–1435.
9. 9 Segura-Campos, M., Chel-Guerrero, L., Betancur-Ancona, D., Hernandez-Escalante, V.M., Bioavailability of bioactive peptides. Food Rev. Int. 27 (2011), 213–226.
10. 10 Wang, B., Li, B., Effect of molecular weight on the transepithelial transport and peptidase degradation of casein-derived peptides by using Caco-2 cell model. Food Chem. 218 (2017), 1–8.
11. 11 Sanchez-Rivera, L., Ares, I., Miralles, B., Gomez-Ruiz, J.A., Recio, I., Martinez-Larranaga, M.R., et al. Bioavailability and kinetics of the antihypertensive casein-derived peptide HLPLP in rats. J. Agric. Food Chem. 62 (2014), 11869–11875.
12. 12•• Caira, S., Pinto, G., Vitaglione, P., Dal Piaz, F., Ferranti, P., Addeo, F., Identification of casein peptides in plasma of subjects after a cheese-enriched diet. Food Res. Int. 84 (2016), 108–112 Although the study is rather small and comprises only four human subjects, it is one of the still rare reports on bioavailability of bioactive peptides in humans performed after ingestion of complex food.
13. 13 Vij, R., Reddi, S., Kapila, S., Kapila, R., Transepithelial transport of milk derived bioactive peptide VLPVPQK. Food Chem. 190 (2016), 681–688.
14. 14•• Sánchez-Rivera, L., Santos, P.F., Miralles, B., Carrón, R., José Montero, M., Recio, I., Peptide fragments from β-casein f(134–138), HLPLP, generated by the action of ratblood plasma peptidases show potent antihypertensive activity. Food Res. Int. 88 (2016), 348–353 This is one of the few studies on bioavailability and pharmacokinetics of bioactive peptides in vivo in a rat model.
15. 15•• Cicero, A.F., Fogacci, F., Colletti, A., Potential role of bioactive peptides in prevention and treatment of chronic diseases: a narrative review. Br. J. Pharmacol., 2016 This review gives a good general overview on the most studied bioactivities of peptides from different sources.
16. 16 Giansanti, F., Panella, G., Leboffe, L., Antonini, G., Lactoferrin from milk: nutraceutical and pharmacological properties. Pharmaceuticals, 9, 2016, 61.
17. 17 Aluko, R.E., Antihypertensive peptides from food proteins. Annu. Rev. Food Sci. Technol. 6 (2015), 235–262.
18. 18 Beltran-Barrientos, L.M., Hernandez-Mendoza, A., Torres-Llanez, M.J., Gonzalez-Cordova, A.F., Vallejo-Cordoba, B., Invited review: fermented milk as antihypertensive functional food. J. Dairy Sci. 99 (2016), 4099–4110.
19. 19•• Nongonierma, A.B., FitzGerald, R.J., The scientific evidence for the role of milk protein-derived bioactive peptides in humans: a review. J. Funct. Foods 17 (2015), 640–656 This review is focusing on human studies performed with milk-derived bioactive peptides and gives a good overview in several tables on results from human studies.
20. 20•• Cicero, A.F., Colletti, A., Rosticci, M., Cagnati, M., Urso, R., Giovannini, M., et al. Effect of lactotripeptides (isoleucine-proline-proline/valine-proline-proline) on blood pressure and arterial stiffness changes in subjects with suboptimal blood pressure control and metabolic syndrome: a double-blind, randomized, crossover clinical trial. Metab. Syndr. Relat. Disord. 14 (2016), 161–166 There are only few randomized, double-blind, placebo-controlled clinical studies on bioactive peptides in humans. This study with lactotripeptides included 40 subjects with metabolic syndrome in a, crossover clinical trial during 4 weeks.
21. 21 Yoshikawa, M., Bioactive peptides derived from natural proteins with respect to diversity of their receptors and physiological effects. Peptides 72 (2015), 208–225.
22. 22 Hou, I.C., Suzuki, C., Kanegawa, N., Oda, A., Yamada, A., Yoshikawa, M., et al. beta-Lactotensin derived from bovine beta-lactoglobulin exhibits anxiolytic-like activity as an agonist for neurotensin NTS(2) receptor via activation of dopamine D(1) receptor in mice. J. Neurochem. 119 (2011), 785–790.
23. 23 Santiago-Lopez, L., Hernandez-Mendoza, A., Vallejo-Cordoba, B., Mata-Haro, V., Gonzalez-Cordova, A.F., Food-derived immunomodulatory peptides. J. Sci. Food Agric. 96 (2016), 3631–3641.
24. 24 Bruni, N., Capucchio, M.T., Biasibetti, E., Pessione, E., Cirrincione, S., Giraudo, L., et al. Antimicrobial activity of lactoferrin-related peptides and applications in human and veterinary medicine. Molecules (Basel, Switzerland), 21, 2016.
25. 25 Altmann, K., Wutkowski, A., Klempt, M., Clawin-Rädecker, I., Meisel, H., Lorenzen, P.C., Generation and identification of anti-inflammatory peptides from bovine β-casein using enzyme preparations from cod and hog. J. Sci. Food Agric. 96 (2016), 868–877.
26. 26 Ma, Y., Liu, J., Shi, H., Yu, L.L., Isolation and characterization of anti-inflammatory peptides derived from whey protein. J. Dairy Sci. 99 (2016), 6902–6912.
27. 27 Theodorou, G., Politis, I., Effects of peptides derived from traditional Greek yoghurt on expression of pro- and anti-inflammatory genes by ovine monocytes and neutrophils. Food Agric. Immunol. 27 (2016), 484–495.
28. 28 Roldan, N.R., Jimenez, M., Cervantes-Garcia, D., Marin, E., Salinas, E., Glycomacropeptide administration attenuates airway inflammation and remodeling associated to allergic asthma in rat. Inflamm. Res. 65 (2016), 273–283.
29. 29 Horner, K., Drummond, E., Brennan, L., Bioavailability of milk protein-derived bioactive peptides: a glycaemic management perspective. Nutr. Res. Rev. 29 (2016), 91–101.
30. 30 Marcone, S., Belton, O., Fitzgerald, D.J., Milk-derived bioactive peptides and their health promoting effects: a potential role in atherosclerosis. Br. J. Clin. Pharmacol. 83:1 (2016), 152–162.
31. 31 Gillespie, A.L., Green, B.D., The bioactive effects of casein proteins on enteroendocrine cell health, proliferation and incretin hormone secretion. Food Chem. 211 (2016), 148–159.
32. 32• Nongonierma, A.B., FitzGerald, R.J., Structure activity relationship modelling of milk protein-derived peptides with dipeptidyl peptidase IV (DPP-IV) inhibitory activity. Peptides 79 (2016), 1–7 This study combines very efficiently a theoretical approach (QSAR) with experimental activity studies for the identification of novel bioactive sequences.
33. 33 Blanco-Miguez, A., Gutierrez-Jacome, A., Perez-Perez, M., Perez-Rodriguez, G., Catalan-Garcia, S., Fdez-Riverola, F., et al. From amino acid sequence to bioactivity: the biomedical potential of antitumor peptides. Protein Sci. 25 (2016), 1084–1095.
34. 34 Zhang, Y., Lima, C.F., Rodrigues, L.R., Anticancer effects of lactoferrin: underlying mechanisms and future trends in cancer therapy. Nutr. Rev. 72 (2014), 763–773.
35. 35 Sah, B.N.P., Vasiljevic, T., McKechnie, S., Donkor, O.N., Identification of anticancer peptides from bovine milk proteins and their potential roles in management of cancer: a critical review. Compr. Rev. Food Sci. Food Saf. 14 (2015), 123–138.
36. 36 Zhao, M., Wei, C., Yang, X., Zhou, J., Wang, J., Gu, F., et al. The milk-derived hexapeptide PGPIPN inhibits the invasion and migration of human ovarian cancer cells by regulating the expression of MTA1 and NM23H1 genes. Int. J. Oncol. 48 (2016), 1721–1729.
37. 37 Artym, J., Zimecki, M., Milk-derived proteins and peptides in clinical trials. Postepy Hig. Med. Doswiadczalnej (Online) 67 (2013), 800–816.
38. 38 Fernández-Tomé, S., Martínez-Maqueda, D., Girón, R., Goicoechea, C., Miralles, B., Recio, I., Novel peptides derived from αs1-casein with opioid activity and mucin stimulatory effect on HT29-MTX cells. J. Funct. Foods 25 (2016), 466–476.
39. 39 Théolier, J., Fliss, I., Jean, J., Hammami, R., MilkAMP: a comprehensive database of antimicrobial peptides of dairy origin. Dairy Sci. Technol. 94 (2014), 181–193.
40. 40 Bessette, C., Henry, G., Sekkal, S., Benoit, B., Bruno, J., Meugnier, E., et al. Oral administration of a casein matrix containing β-casofensin protects the intestinal barrier in two preclinical models of gut diseases. J. Funct. Foods 27 (2016), 223–235.
41. 41• McCullough, K.M., Choi, D., Guo, J., Zimmerman, K., Walton, J., Rainnie, D.G., et al. Molecular characterization of Thy1 expressing fear-inhibiting neurons within the basolateral amygdala. Nat. Commun., 7, 2016, 13149 The experimental data give in vivo evidence that the bioactive peptide β-lactotensin has fear suppressing effects. This new data confirm previous reports where β-lactotensin mediated ant-nociception, anxiolysis and fear memory modulation.
42. 42 Yamauchi, R., Wada, E., Yamada, D., Yoshikawa, M., Wada, K., Effect of beta-lactotensin on acute stress and fear memory. Peptides 27 (2006), 3176–3182.
43. 43 Nongonierma, A.B., FitzGerald, R.J., Bioactive properties of milk proteins in humans: a review. Peptides 73 (2015), 20–34.
44. 44 Majumder, K., Mine, Y., Wu, J.P., The potential of food protein-derived anti-inflammatory peptides against various chronic inflammatory diseases. J. Sci. Food Agric. 96 (2016), 2303–2311.
45. 45 Mohanty, D.P., Mohapatra, S., Misra, S., Sahu, P.S., Milk derived bioactive peptides and their impact on human health—a review. Saudi J. Biol. Sci. 23 (2016), 577–583.