p97 negatively regulates NRF2 by extracting ubiquitylated NRF2 from the KEAP1-CUL3 E3 complex

Molecular and Cellular Biology

Volumn 37, Issue 8, 2017, Pages

  Tao, Shasha ^a,b   Liu, Pengfei ^a   Luo, Gang ^a   de la Vega, Montserrat Rojo ^a   Chen, Heping ^a   Wu, Tongde ^a,c   Tillotson, Joseph ^a   Chapman, Eli ^a   Zhang, Donna D ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Autophagy; Cancer chemoresistance; KEAP1; NRF2; Oxidative stress; P97; Proteasome; Protein quality control; Ubiquitylation

Indexed keywords

ADENOSINE TRIPHOSPHATE; CUL3 E3 PROTEIN; HETERODIMER; KELCH LIKE ECH ASSOCIATED PROTEIN 1; PROTEASOME; PROTEIN P97; TRANSCRIPTION FACTOR NRF2; UBIQUITIN; UBIQUITIN PROTEIN LIGASE E3; UBXN7 PROTEIN; UFD1 PROTEIN; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE; CARRIER PROTEIN; CDC48 PROTEIN; CELL CYCLE PROTEIN; CUL3 PROTEIN, HUMAN; CULLIN; KEAP1 PROTEIN, HUMAN; PROTEIN BINDING; RBX1 PROTEIN, HUMAN;

ARTICLE; AUTOPHAGY; CANCER RESISTANCE; CHROMATIN; COMPLEX FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; UBIQUITINATION; METABOLISM; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATASES; CARRIER PROTEINS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CULLIN PROTEINS; HUMANS; KELCH-LIKE ECH-ASSOCIATED PROTEIN 1; NF-E2-RELATED FACTOR 2; PROTEIN BINDING; PROTEOLYSIS; SIGNAL TRANSDUCTION; UBIQUITIN; UBIQUITINATION;

EID: 85017152943     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.00660-16     Document Type: Article

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