Mechanism linking diabetes mellitus and obesity

Diabetes, Metabolic Syndrome and Obesity

Volumn 7, Issue , 2014, Pages 587-591

  Al Goblan, Abdullah S ^a   Al Alfi, Mohammed A ^a   Khan, Muhammad Z ^b  

^a IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY   (Saudi Arabia)

^b Sulaiman AlRajhi Colleges   (Saudi Arabia)

Author keywords

Diabetes mellitus; Insulin resistance; Obesity

Indexed keywords

FATTY ACID; GLUCOSE;

ARTICLE; BODY MASS; DIABETES MELLITUS; DIABETOGENESIS; DISEASE ACTIVITY; DISEASE ASSOCIATION; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PANCREAS ISLET BETA CELL; WEIGHT GAIN;

EID: 84919398877     PISSN: None     EISSN: 11787007     Source Type: Journal    
DOI: 10.2147/DMSO.S67400     Document Type: Article

References (36)

1. Scheen AJ. Pathophysiology of type 2 diabetes. Acta Clin Belg. 2003;58(6):335–341.
2. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care. 2007;30 Suppl 1:S42–S47.
3. Hutton JC, Davidson HW. Cytokine-induced dicing and splicing in the β-Cell and the immune response in Type 1 Diabetes. Diabetes. 2010;59(2):335–336.
4. van Belle TL, Coppieters KT, von Herrath MG. Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiol Rev. 2011;91(1):79–118.
5. Mathieu C, Badenhoop K. Vitamin D and type 1 diabetes mellitus: state of the art. Trends Endocrinol Metab. 2005;16(6):261–266.
6. Philippe M F, Benabadji S, Barbot-Trystram L, Vadrot D, Boitard C, Larger E. Pancreatic volume and endocrine and exocrine functions in patients with diabetes. Pancreas. 2011;40(3):359–363.
7. Joergensen C, Hovind P, Schmedes A, Parving HH, Rossing P. Vitamin D levels, microvascular complications, and mortality in type 1 diabetes. Diabetes Care. 2011;34(5):1081–1085.
8. Ershow AG. Environmental infuences on development of type 2 diabetes and obesity: challenges in personalizing prevention and management. J Diabetes Sci Technol. 2009;3(4):727–734.
9. Wild S, Roglic G, Green A, Sicree R, King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care. 2004;27(5):1047–1053.
10. Kasuga M. Insulin resistance and pancreatic β cell failure. J Clin Invest. 2006;116(7):1756–1760.
11. Røder ME, Porte D, Schwartz RS, Kahn SE. Disproportionately elevated proinsulin levels refect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab. 1998;83(2):604–608.
12. Porte D Jr. Banting lecture 1990. Beta-cells in type II diabetes mellitus. Diabetes. 1991;40(2):166–180.
13. Fowler MJ. Microvascular and Macrovascular Complications of Diabetes. Clinical Diabetes. 2008;26(2):77–82.
14. Haffner SM, D’Agostino R, Mykkänen L, et al. Insulin sensitivity in subjects with type 2 diabetes. Relationship to cardiovascular risk factors: the Insulin Resistance Atherosclerosis Study. Diabetes Care. 1999;22(4):562–568.
15. Naser KA, Gruber A, Thomson GA. The emerging pandemic of obesity and diabetes: are we doing enough to prevent a disaster? Int J Clin Pract. 2006;60(9):1093–1097.
16. Gallagher D, Heymsfield SB, Heo M, Jebb SA, Murgatroyd PR, Sakamoto Y. Healthy percentage body fat ranges: an approach for developing guidelines based on body mass index. Am J Clin Nutr. 2000;72(3):694–701.
17. Arora S. Molecular basis of insulin resistance and its relation to metabolic syndrome. In: Insulin Resistance. Rijeka, Croatia: InTech Europe; 2012. Available from: http://www.intechopen.com/books/insulin-resistance/molecular-basis-of-insulin-resistance-and-its-relation-to-metabolic-syndrome. Accessed September 26, 2014.
18. DIAMOND Project Group. Incidence and trends of childhood type 1 diabetes worldwide 1990–1999. Diabet Med. 2006;23(8):857–866.
19. Harder T, Roepke K, Diller N, Stechling Y, Dudenhausen J W, Plagemann A. Birth weight, early weight gain, and subsequent risk of type 1 diabetes: systematic review and meta-analysis. Am J Epidemiol. 2009;169(12):1428–1436.
20. Baum JD, Ounsted M, Smith MA. Letter: Weight gain in infancy and subsequent development of diabetes mellitus in childhood. Lancet. 1975;2(7940):866.
21. Wilkin TJ. The accelerator hypothesis: weight gain as the missing link between type I and type II diabetes. Diabetologia. 2001;44(7):914–922.
22. Tsai AG, Williamson D F, Glick HA. Direct medical cost of overweight and obesity in the USA: a quantitative systematic review. Obes Rev. 2011;12(1):50–61.
23. McKeigue PM, Shah B, Marmot MG. Relation of central obesity and insulin resistance with high diabetes prevalence and cardiovascular risk in South Asians. Lancet. 1991;337(8738):382–386.
24. Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444(7121): 840–846.
25. Karpe F, Dickmann JR, Frayn KN. Fatty acids, obesity, and insulin resistance: time for a reevaluation. Diabetes. 2011;60(10):2441–2449.
26. Jelic K, Luzio SD, Dunseath G, Colding-Jorgsensen M, Owens DR. A cross-sectional analysis of NEFA levels following standard mixed meal in a population of persons with newly diagnosed type 2 diabetes mellitus across a spectrum of glycemic control [Abstract]. Alexandria, VA: American Diabetes Association; 2007. Available from: http://pro-fessional.diabetes.org/Abstracts_Display.aspx?CID=54998. Accessed September 26, 2014.
27. Roden M, Price TB, Perseghin G, et al. Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest. 1996;97(12): 2859–2865.
28. Fain JN, Madan AK, Hiler ML, Cheema P, Bahouth S W. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology. 2004;145(5):2273–2282.
29. Marcial JM, Altieri PI, Banchs H, Escobales N, Crespo M. Metabolic syndrome among Puerto Ricans and other Hispanic populations. P R Health Sci J. 2011;30(3):145–151.
30. Boden G. Fatty acids and insulin resistance. Diabetes Care. 1996;19(4): 394–395.
31. Kahn SE, Prigeon RL, McCulloch DK, et al. Quantifcation of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function. Diabetes. 1993;42(11): 1663–1672.
32. Kahn SE. Clinical review 135: the importance of beta-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab. 2001;86(9):4047–4058.
33. Wellen KE, Hotamisligil GS. Infammation, stress, and diabetes. J Clin Invest. 2005;115(5):1111–1119.
34. Cnop M, Landchild MJ, Vidal J, et al. The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: distinct metabolic effects of two fat compartments. Diabetes. 2002;51(4):1005–1015.
35. Goran MI, Ball GD, Cruz ML. Obesity and risk of type 2 diabetes and cardiovascular disease in children and adolescents. J Clin Endocrinol Metab. 2003;88(4):1417–1427.
36. Bacha F, Saad R, Gungor N, Arslanian SA. Are obesity-related metabolic risk factors modulated by the degree of insulin resistance in adolescents? Diabetes Care. 2006;29(7):1599-1604.