Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7

EJNMMI Research

Volumn 7, Issue 1, 2017, Pages

  Fantoni, Enrico Raffaele ^a   Dal Ben, Diego ^b   Falzoni, Simonetta ^c   Di Virgilio, Francesco ^c   Lovestone, Simon ^d   Gee, Antony ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b UNIVERSITY OF CAMERINO   (Italy)

^c UNIVERSITY OF FERRARA   (Italy)

^d WARNEFORD HOSPITAL   (United Kingdom)

Author keywords

EFB; F 18; LPS; Molecular modelling; P2X7; Radiosynthesis

Indexed keywords

2 CYANO 1 [4 (18F)FLUOROBENZYL] 3 (QUINOLIN 5 YL)GUANIDINE; A 804598; FLUORINE 18; LIPOPOLYSACCHARIDE; PURINERGIC P2X7 RECEPTOR; RECEPTOR BLOCKING AGENT; TRACER; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; CALCIUM TRANSPORT; CELL CULTURE; CONTROLLED STUDY; GENETIC TRANSFECTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR DOCKING; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; POSITRON EMISSION TOMOGRAPHY-COMPUTED TOMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOCHEMISTRY; RAT; RECEPTOR BINDING; SYNTHESIS; THIN LAYER CHROMATOGRAPHY;

EID: 85017025798     PISSN: None     EISSN: 2191219X     Source Type: Journal    
DOI: 10.1186/s13550-017-0275-2     Document Type: Article

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