Synthesis and preliminary evaluation of [ 18F]-labeled 2-oxoquinoline derivatives for PET imaging of cannabinoid CB 2 receptor

Nuclear Medicine and Biology

Volumn 39, Issue 4, 2012, Pages 593-600

  Turkman, Nashaat ^a   Shavrin, Aleksander ^a   Paolillo, Vincenzo ^a   Yeh, Hsin Hsien ^a   Flores, Leo ^a   Soghomonian, Suren ^a   Rabinovich, Brian ^a   Volgin, Andrei ^a   Gelovani, Juri ^a   Alauddin, Mian ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

18F 2 oxoquinoline derivatives; Cannabinoid receptor CB 2; Positron emission tomography

Indexed keywords

4 CYANO N,N,N TRIMETHYLANILINIUM TRIFLATE; 7 METHOXY 8 ALKOXY 2 OXO 1,2 DIHYDROQUINOLINE 3 CARBOXYLIC ACID (4 FLUOROBENZYL)AMIDE F 18; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; DIAGNOSTIC AGENT; TRIFLUOROMETHANESULFONIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG DISTRIBUTION; DRUG SYNTHESIS; EX VIVO STUDY; FLUORINATION; GLIOBLASTOMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; ISOTOPE LABELING; LIPOPHILICITY; MOUSE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; RADIOISOTOPE DIAGNOSIS; REACTION TIME; RECEPTOR BINDING; TUMOR XENOGRAFT; WILD TYPE;

ANIMALS; AUTORADIOGRAPHY; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; CHEMISTRY TECHNIQUES, SYNTHETIC; FLUORINE RADIOISOTOPES; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; POSITRON-EMISSION TOMOGRAPHY; QUINOLONES; RADIOCHEMISTRY; RECEPTOR, CANNABINOID, CB2;

EID: 84860317168     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2011.10.019     Document Type: Article

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