Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [11C]A-740003 as a novel tracer of neuroinflammation

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 57, Issue 8, 2014, Pages 509-516

  Janssen, Bieneke ^a   Vugts, Danielle J ^a   Funke, Uta ^a   Spaans, Arnold ^a   Schuit, Robert C ^a   Kooijman, Esther ^a   Rongen, Marissa ^a   Perk, Lars R ^b   Lammertsma, Adriaan A ^a   Windhorst, Albert D ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY AMSTERDAM   (Netherlands)

Author keywords

A 740003; carbon 11; neuroinflammation; positron emission tomography; radiolabelling

Indexed keywords

CARBON; ELECTRONS; METABOLISM; NEURODEGENERATIVE DISEASES; POSITRONS; RADIOACTIVE TRACERS;

A-740003; BIODISTRIBUTIONS; CARBON-11; IN-VIVO; METABOLIC RATES; MICROGLIA; NEUROINFLAMMATION; RADIOLABELLING; RECEPTOR ANTAGONISTS; SYNTHESISED;

POSITRON EMISSION TOMOGRAPHY;

A 740003; CARBON 11; N [1 [[(CYANOIMINO)(5 QUINOLINYLAMINO)METHYL] AMINO]2,2 DIMETHYLPROPYL) 2 (3,4 DIMETHOXYPHENYL)ACETAMIDE]]; PURINERGIC P2X7 RECEPTOR; PURINERGIC P2X7 RECEPTOR ANTAGONIST; RADIOPHARMACEUTICAL AGENT; TRACER; UNCLASSIFIED DRUG; (N-(1-(((CYANOIMINO)(5-QUINOLINYLAMINO) METHYL) AMINO)-2,2-DIMETHYLPROPYL)-2-(3,4-DIMETHOXYPHENYL)ACETAMIDE); ACETAMIDE DERIVATIVE; CARBON; PURINERGIC P2X RECEPTOR ANTAGONIST; QUINOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG METABOLISM; IN VIVO STUDY; ISOTOPE LABELING; MALE; METABOLIC RATE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; RAT; ANIMAL; BRAIN; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; PATHOLOGY; SYNTHESIS; TISSUE DISTRIBUTION; WISTAR RAT;

RATTUS; RATTUS NORVEGICUS;

ACETAMIDES; ANIMALS; BRAIN; CARBON ISOTOPES; DRUG EVALUATION, PRECLINICAL; MALE; PURINERGIC P2X RECEPTOR ANTAGONISTS; QUINOLINES; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 84905560272     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: 10.1002/jlcr.3206     Document Type: Article

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