Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB

Neurobiology of Disease

Volumn 103, Issue , 2017, Pages 32-44

  Guadagno, Noemi A ^a   Moriconi, Claudia ^a   Licursi, Valerio ^a,b   D'Acunto, Emanuela ^a   Nisi, Paola S ^a   Carucci, Nicoletta ^a   De Jaco, Antonella ^a   Cacci, Emanuele ^a   Negri, Rodolfo ^a,b   Lupo, Giuseppe ^a   Miranda, Elena ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CNR   (Italy)

Author keywords

Familial encephalopathy with neuroserpin inclusion bodies; Neural progenitor cells; Neurodegeneration; Neurons; Neuroserpin; Oxidative stress; Protein conformational disease; Serpin polymers

Indexed keywords

DELTA NEUROSERPIN; G392E NEUROSERPIN; GREEN FLUORESCENT PROTEIN; NEUROSERPIN; POLYMER; UNCLASSIFIED DRUG; NEUROPEPTIDE; SERINE PROTEINASE INHIBITOR;

ALDH1B1 GENE; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOE GENE; ARTICLE; BRAIN CORTEX; CELL INCLUSION; CELL PROLIFERATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DEMENTIA; DOWN REGULATION; EMBRYO; ENDOPLASMIC RETICULUM; ENZYME LINKED IMMUNOSORBENT ASSAY; FAMILIAL ENCEPHALOPATHY WITH NEUROSERPIN INCLUSION BODY; FETUS; GENE; GOLGI COMPLEX; GPX1 GENE; GSTM1 GENE; HUMAN; IMMUNOFLUORESCENCE; IN VITRO STUDY; MOUSE; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; POLYMERIZATION; PRDX6 GENE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RNA SEQUENCE; SCARA3 GENE; SOD2 GENE; UPREGULATION; ANIMAL; CELL CULTURE; CELL SURVIVAL; CHEMICALLY INDUCED; DEMYELINATING DISEASE; DRUG EFFECTS; METABOLISM; MYOCLONUS EPILEPSY; NERVE CELL; PATHOLOGY; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DEMENTIA; EPILEPSIES, MYOCLONIC; HEREDODEGENERATIVE DISORDERS, NERVOUS SYSTEM; HUMANS; MICE; MICE, TRANSGENIC; NEURONS; NEUROPEPTIDES; OXIDATIVE STRESS; POLYMERS; SERPINS;

EID: 85016948857     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2017.03.010     Document Type: Article

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