Oxidative stress contributes to liver damage in a murine model of alpha-1-antitrypsin deficiency

Experimental Biology and Medicine

Volumn 237, Issue 10, 2012, Pages 1163-1172

  Marcus, Nancy Y ^a   Blomenkamp, Keith ^a   Ahmad, Muneeb ^a   Teckman, Jeffrey H ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alpha 1 antitrypsin deficiency; Gene array; Oxidative stress; PiZ mice; Redox regulation

Indexed keywords

CARBONYL REDUCTASE; CARBONYL REDUCTASE 3; GLUTATHIONE TRANSFERASE ALPHA; GLUTATHIONE TRANSFERASE M3; MALONALDEHYDE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; 8 HYDROXYDEOXYGUANOSINE; ALPHA 1 ANTITRYPSIN; CYCLOSPORIN A;

AGE; ALPHA 1 ANTITRYPSIN DEFICIENCY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER DISEASE; MALE; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN CARBONYLATION; UPREGULATION; WILD TYPE; AGING; ANIMAL MODEL; DNA DAMAGE; FIBROSIS; IMMUNOBLOTTING; INFLAMMATION; LIVER CELL CARCINOMA; LIVER CELL DAMAGE; LIVER INJURY; OXIDATION REDUCTION STATE; PROTEIN DETERMINATION; REAL TIME POLYMERASE CHAIN REACTION; YOUNG ADULT;

ALCOHOL OXIDOREDUCTASES; ALPHA 1-ANTITRYPSIN; ALPHA 1-ANTITRYPSIN DEFICIENCY; ANIMALS; DISEASE MODELS, ANIMAL; DNA DAMAGE; GLUTATHIONE; GLUTATHIONE TRANSFERASE; ISOENZYMES; LIVER; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OXIDATIVE STRESS; PHENOTYPE; REACTIVE OXYGEN SPECIES;

MURINAE; MUS;

EID: 84868262757     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1258/ebm.2012.012106     Document Type: Article

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