Subinhibitory concentrations of bacteriostatic antibiotics induce relA-dependent and relA-independent tolerance to β-lactams

Antimicrobial Agents and Chemotherapy

Volumn 61, Issue 4, 2017, Pages

  Kudrin, Pavel ^a   Varik, Vallo ^a,b   Oliveira, Sofia Raquel Alves ^a   Beljantseva, Jelena ^a   Del Peso Santos, Teresa ^b   Dzhygyr, Ievgen ^b   Rejman, Dominik ^c   Cava, Felipe ^b   Tenson, Tanel ^a   Hauryliuk, Vasili ^a,b  

^a UNIVERSITY OF TARTU   (Estonia)

^b UMEÅ UNIVERSITY   (Sweden)

^c INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

Author keywords

Antibiotics; Mupirocin; Persistence; ppGpp; RelA; Ribosomes; Thiostrepton; Tolerance; Trimethoprim; lactam

Indexed keywords

AMPICILLIN; ANTIBIOTIC AGENT; BETA LACTAM ANTIBIOTIC; CHLORAMPHENICOL; NORFLOXACIN; PSEUDOMONIC ACID; SYNTHETASE; TETRACYCLINE; THIOSTREPTON; TRANSFER RNA; ADENOSINE 5',5'''-TRIPHOSPHOGUANOSINE-3'''-DIPHOSPHATE; ANTIINFECTIVE AGENT; BETA LACTAM; DIHYDROFOLATE REDUCTASE; GUANOSINE 3' DIPHOSPHATE 5' DIPHOSPHATE; GUANOSINE 3',5'-POLYPHOSPHATE SYNTHETASES; ISOLEUCINE TRANSFER RNA LIGASE; LIGASE; TRIMETHOPRIM;

ARTICLE; BACTERIOSTASIS; BACTERIUM CULTURE; ENZYME ACTIVATION; ENZYME INHIBITION; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RIBOSOME; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CELL FRACTIONATION; CHEMISTRY; DRUG EFFECTS; DRUG INTERACTION; DRUG TOLERANCE; GENETICS; METABOLISM; PROTEIN SYNTHESIS;

ANTI-BACTERIAL AGENTS; BETA-LACTAMS; CHLORAMPHENICOL; DRUG INTERACTIONS; DRUG TOLERANCE; ESCHERICHIA COLI; GUANOSINE TETRAPHOSPHATE; ISOLEUCINE-TRNA LIGASE; LIGASES; MUPIROCIN; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA, TRANSFER; SUBCELLULAR FRACTIONS; TETRACYCLINE; TETRAHYDROFOLATE DEHYDROGENASE; THIOSTREPTON; TRIMETHOPRIM;

EID: 85016798861     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02173-16     Document Type: Article

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