Two novel point mutations in clinical Staphylococcus aureus reduce linezolid susceptibility and switch on the stringent response to promote persistent infection

PLoS Pathogens

Volumn 6, Issue 6, 2010, Pages

  Gao, Wei ^a,b,c   Chua, Kyra ^a,b,c   Davies, John K ^a   Newton, Hayley J ^c   Seemann, Torsten ^a   Harrison, Paul F ^a   Holmes, Natasha E ^b   Rhee, Hyun Woo ^d   Hong, Jong In ^d   Hartland, Elizabeth L ^c   Stinear, Timothy P ^a,c   Howden, Benjamin P ^a,b,c  

^a MONASH UNIVERSITY   (Australia)

^b AUSTIN HEALTH   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; CLINDAMYCIN; COTRIMOXAZOLE; DAPTOMYCIN; FUSIDIC ACID; GENTAMICIN; GUANOSINE 3' DIPHOSPHATE 5' DIPHOSPHATE; LINEZOLID; RIFAMPICIN; TEICOPLANIN; TIGECYCLINE; VANCOMYCIN; ACETAMIDE DERIVATIVE; ANTIINFECTIVE AGENT; BIOLOGICAL MARKER; GUANOSINE 3',5' POLYPHOSPHATE SYNTHETASES; GUANOSINE 3',5'-POLYPHOSPHATE SYNTHETASES; LIGASE; MESSENGER RNA; METHYLTRANSFERASE; OXAZOLIDINONE DERIVATIVE; RNA 23S;

ADD ON THERAPY; AGED; ANTIBIOTIC RESISTANCE; ARTICLE; BACTEREMIA; BACTERIAL STRAIN; BACTERIAL VIRULENCE; CASE REPORT; CELLULAR STRESS RESPONSE; COMPARATIVE GENOMIC HYBRIDIZATION; DIAGNOSTIC IMAGING; DRUG SUBSTITUTION; DRUG WITHDRAWAL; ENZYME ACTIVITY; FUNCTIONAL GENOMICS; GALLERIA MELLONELLA; HUMAN; MALE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MICROARRAY ANALYSIS; MOTH; NONHUMAN; NUCLEOTIDE SEQUENCE; PERSISTENT INFECTION; POINT MUTATION; RECURRENT INFECTION; STRINGENT RESPONSE; TREATMENT FAILURE; AMINO ACID SEQUENCE; DNA MICROARRAY; DRUG EFFECT; GENE EXPRESSION PROFILING; GENETICS; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; MOLECULAR GENETICS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; VIRULENCE; WESTERN BLOTTING;

BACTERIA (MICROORGANISMS); GALLERIA MELLONELLA; STAPHYLOCOCCUS AUREUS; STRAWBERRY CRINKLE VIRUS;

ACETAMIDES; AGED; AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BIOLOGICAL MARKERS; BLOTTING, WESTERN; DRUG RESISTANCE, BACTERIAL; GENE EXPRESSION PROFILING; HUMANS; LIGASES; MALE; METHYLTRANSFERASES; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXAZOLIDINONES; POINT MUTATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, RIBOSOMAL, 23S; SEQUENCE HOMOLOGY, AMINO ACID; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VIRULENCE;

EID: 77954680177     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000944     Document Type: Article

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