A conserved ectodomain-transmembrane domain linker motif tunes the allosteric regulation of cell surface receptors

Journal of Biological Chemistry

Volumn 291, Issue 34, 2016, Pages 17536-17546

  Schmidt, Thomas ^a   Ye, Feng ^b   Situ, Alan J ^a   An, Woojin ^c   Ginsberg, Mark H ^b   Ulmer, Tobias S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; ORGANIC POLYMERS;

ALLOSTERIC REGULATION; CELL SURFACE RECEPTORS; INTEGRIN ACTIVATION; INTEGRIN RECEPTORS; LINKER FLEXIBILITY; MODELING CONSTRUCT; RECEPTOR REGULATION; TRANS-MEMBRANE DOMAINS;

CELL MEMBRANES;

CELL SURFACE RECEPTOR; BETA INTEGRIN; CD131 ANTIGEN;

ALLOSTERISM; ALPHA HELIX; AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; THERMODYNAMICS; ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; GENETICS; HAMSTER; HUMAN; METABOLISM; PHYSIOLOGY;

ALLOSTERIC REGULATION; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; CYTOKINE RECEPTOR COMMON BETA SUBUNIT; HUMANS; INTEGRIN BETA CHAINS; PROTEIN DOMAINS; PROTEIN STRUCTURE, SECONDARY;

EID: 84983740851     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.733683     Document Type: Article

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