메뉴 건너뛰기




Volumn 46, Issue , 2017, Pages 1-7

Obesity altered T cell metabolism and the response to infection

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PROGRAMMED DEATH 1 RECEPTOR; ADIPOCYTOKINE; BIOLOGICAL MARKER;

EID: 85016163675     PISSN: 09527915     EISSN: 18790372     Source Type: Journal    
DOI: 10.1016/j.coi.2017.03.008     Document Type: Review
Times cited : (72)

References (59)
  • 1
    • 84904443484 scopus 로고    scopus 로고
    • T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization in vivo
    • 1 van Panhuys, N., Klauschen, F., Germain, R.N., T-cell-receptor-dependent signal intensity dominantly controls CD4(+) T cell polarization in vivo. Immunity 41 (2014), 63–74.
    • (2014) Immunity , vol.41 , pp. 63-74
    • van Panhuys, N.1    Klauschen, F.2    Germain, R.N.3
  • 2
    • 84875419278 scopus 로고    scopus 로고
    • T cell receptor signalling networks: branched, diversified and bounded
    • 2 Brownlie, R.J., Zamoyska, R., T cell receptor signalling networks: branched, diversified and bounded. Nat Rev Immunol 13 (2013), 257–269.
    • (2013) Nat Rev Immunol , vol.13 , pp. 257-269
    • Brownlie, R.J.1    Zamoyska, R.2
  • 5
    • 84947591002 scopus 로고    scopus 로고
    • T cell metabolism drives immunity
    • The authors provide a concise and expansive summary of current knowledge on T cell metabolism and its contribution to the adaptive immune response. Topics discussed include metabolic states of T cells by different activation states and subsets as well as substrate utilization and function.
    • 5• Buck, M.D., O'Sullivan, D., Pearce, E.L., T cell metabolism drives immunity. J Exp Med 212 (2015), 1345–1360 The authors provide a concise and expansive summary of current knowledge on T cell metabolism and its contribution to the adaptive immune response. Topics discussed include metabolic states of T cells by different activation states and subsets as well as substrate utilization and function.
    • (2015) J Exp Med , vol.212 , pp. 1345-1360
    • Buck, M.D.1    O'Sullivan, D.2    Pearce, E.L.3
  • 6
    • 84885670616 scopus 로고    scopus 로고
    • Fueling immunity: insights into metabolism and lymphocyte function
    • 6 Pearce, E.L., Poffenberger, M.C., Chang, C.H., Jones, R.G., Fueling immunity: insights into metabolism and lymphocyte function. Science, 342, 2013, 1242454.
    • (2013) Science , vol.342 , pp. 1242454
    • Pearce, E.L.1    Poffenberger, M.C.2    Chang, C.H.3    Jones, R.G.4
  • 7
    • 54249141095 scopus 로고    scopus 로고
    • Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival
    • 7 MacIver, N.J., Jacobs, S.R., Wieman, H.L., Wofford, J.A., Coloff, J.L., Rathmell, J.C., Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. J Leukocyte Biol 84 (2008), 949–957.
    • (2008) J Leukocyte Biol , vol.84 , pp. 949-957
    • MacIver, N.J.1    Jacobs, S.R.2    Wieman, H.L.3    Wofford, J.A.4    Coloff, J.L.5    Rathmell, J.C.6
  • 8
    • 44449165597 scopus 로고    scopus 로고
    • Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways
    • 8 Jacobs, S.R., Herman, C.E., MacIver, N.J., Wofford, J.A., Wieman, H.L., Hammen, J.J., Rathmell, J.C., Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J Immunol 180 (2008), 4476–4486.
    • (2008) J Immunol , vol.180 , pp. 4476-4486
    • Jacobs, S.R.1    Herman, C.E.2    MacIver, N.J.3    Wofford, J.A.4    Wieman, H.L.5    Hammen, J.J.6    Rathmell, J.C.7
  • 9
    • 84876758617 scopus 로고    scopus 로고
    • Metabolic pathways in immune cell activation and quiescence
    • 9 Pearce, E.L., Pearce, E.J., Metabolic pathways in immune cell activation and quiescence. Immunity 38 (2013), 633–643.
    • (2013) Immunity , vol.38 , pp. 633-643
    • Pearce, E.L.1    Pearce, E.J.2
  • 10
    • 84964267895 scopus 로고    scopus 로고
    • Fatty acid metabolism in the regulation of T cell function
    • 10 Lochner, M., Berod, L., Sparwasser, T., Fatty acid metabolism in the regulation of T cell function. Trends Immunol 36 (2015), 81–91.
    • (2015) Trends Immunol , vol.36 , pp. 81-91
    • Lochner, M.1    Berod, L.2    Sparwasser, T.3
  • 12
    • 79953046341 scopus 로고    scopus 로고
    • Inflammatory mechanisms in obesity
    • 12 Gregor, M.F., Hotamisligil, G.S., Inflammatory mechanisms in obesity. Annu Rev Immunol 29 (2011), 415–445.
    • (2011) Annu Rev Immunol , vol.29 , pp. 415-445
    • Gregor, M.F.1    Hotamisligil, G.S.2
  • 13
    • 84875228575 scopus 로고    scopus 로고
    • Obesity and the risk and outcome of infection
    • 13 Huttunen, R., Syrjanen, J., Obesity and the risk and outcome of infection. Int J Obes (Lond) 37 (2013), 333–340.
    • (2013) Int J Obes (Lond) , vol.37 , pp. 333-340
    • Huttunen, R.1    Syrjanen, J.2
  • 14
    • 84860852477 scopus 로고    scopus 로고
    • The impact of obesity on the immune response to infection
    • 14 Milner, J.J., Beck, M.A., The impact of obesity on the immune response to infection. Proc Nutr Soc 71 (2012), 298–306.
    • (2012) Proc Nutr Soc , vol.71 , pp. 298-306
    • Milner, J.J.1    Beck, M.A.2
  • 15
    • 84949093230 scopus 로고    scopus 로고
    • Metabolic regulation of T cell differentiation and function
    • 15 Park, B.V., Pan, F., Metabolic regulation of T cell differentiation and function. Mol Immunol 68 (2015), 497–506.
    • (2015) Mol Immunol , vol.68 , pp. 497-506
    • Park, B.V.1    Pan, F.2
  • 16
    • 77951639702 scopus 로고    scopus 로고
    • IL-7 is essential for homeostatic control of T cell metabolism in vivo
    • 16 Jacobs, S.R., Michalek, R.D., Rathmell, J.C., IL-7 is essential for homeostatic control of T cell metabolism in vivo. J Immunol 184 (2010), 3461–3469.
    • (2010) J Immunol , vol.184 , pp. 3461-3469
    • Jacobs, S.R.1    Michalek, R.D.2    Rathmell, J.C.3
  • 17
    • 84904388553 scopus 로고    scopus 로고
    • Futility sustains memory T cells
    • 17 Weinberg, S.E., Chandel, N.S., Futility sustains memory T cells. Immunity 41 (2014), 1–3.
    • (2014) Immunity , vol.41 , pp. 1-3
    • Weinberg, S.E.1    Chandel, N.S.2
  • 21
    • 84928975351 scopus 로고    scopus 로고
    • IL-7-induced glycerol transport and TAG synthesis promotes memory CD8+ T cell longevity
    • 21 Cui, G., Staron, M.M., Gray, S.M., Ho, P.C., Amezquita, R.A., Wu, J., Kaech, S.M., IL-7-induced glycerol transport and TAG synthesis promotes memory CD8+ T cell longevity. Cell 161 (2015), 750–761.
    • (2015) Cell , vol.161 , pp. 750-761
    • Cui, G.1    Staron, M.M.2    Gray, S.M.3    Ho, P.C.4    Amezquita, R.A.5    Wu, J.6    Kaech, S.M.7
  • 22
    • 84968832518 scopus 로고    scopus 로고
    • Effect of IL-7 and IL-15 on T cell phenotype in myelodysplastic syndromes
    • 22 Dong, W., Ding, T., Wu, L., Ren, X., Epling-Burnette, P.K., Yang, L., Effect of IL-7 and IL-15 on T cell phenotype in myelodysplastic syndromes. Oncotarget 7 (2016), 27479–27488.
    • (2016) Oncotarget , vol.7 , pp. 27479-27488
    • Dong, W.1    Ding, T.2    Wu, L.3    Ren, X.4    Epling-Burnette, P.K.5    Yang, L.6
  • 23
    • 84940955520 scopus 로고    scopus 로고
    • Metabolic plasticity of human T cells: preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2-deoxy-glucose affects effector functions
    • The authors demonstrate alterations in human CD4 and CD8 T cell proliferative and functional responses when challenged with glycolytic and respiratory restriction. This investigation provides evidence linking metabolic flexibility of human T cells to effector functions, like cytokine production, and highlights translational insights from murine models.
    • 23• Renner, K., Geiselhoringer, A.L., Fante, M., Bruss, C., Farber, S., Schonhammer, G., Peter, K., Singer, K., Andreesen, R., Hoffmann, P., et al. Metabolic plasticity of human T cells: preserved cytokine production under glucose deprivation or mitochondrial restriction, but 2-deoxy-glucose affects effector functions. Eur J Immunol 45 (2015), 2504–2516 The authors demonstrate alterations in human CD4 and CD8 T cell proliferative and functional responses when challenged with glycolytic and respiratory restriction. This investigation provides evidence linking metabolic flexibility of human T cells to effector functions, like cytokine production, and highlights translational insights from murine models.
    • (2015) Eur J Immunol , vol.45 , pp. 2504-2516
    • Renner, K.1    Geiselhoringer, A.L.2    Fante, M.3    Bruss, C.4    Farber, S.5    Schonhammer, G.6    Peter, K.7    Singer, K.8    Andreesen, R.9    Hoffmann, P.10
  • 24
    • 84876040340 scopus 로고    scopus 로고
    • Interleukin-21 (IL-21) synergizes with IL-2 to enhance T-cell receptor-induced human T-cell proliferation and counteracts IL-2/transforming growth factor-beta-induced regulatory T-cell development
    • 24 Battaglia, A., Buzzonetti, A., Baranello, C., Fanelli, M., Fossati, M., Catzola, V., Scambia, G., Fattorossi, A., Interleukin-21 (IL-21) synergizes with IL-2 to enhance T-cell receptor-induced human T-cell proliferation and counteracts IL-2/transforming growth factor-beta-induced regulatory T-cell development. Immunology 139 (2013), 109–120.
    • (2013) Immunology , vol.139 , pp. 109-120
    • Battaglia, A.1    Buzzonetti, A.2    Baranello, C.3    Fanelli, M.4    Fossati, M.5    Catzola, V.6    Scambia, G.7    Fattorossi, A.8
  • 25
    • 84929312521 scopus 로고    scopus 로고
    • The immune suppressive function of transforming growth factor-beta (TGF-beta) in human diseases
    • 25 Sheng, J., Chen, W., Zhu, H.J., The immune suppressive function of transforming growth factor-beta (TGF-beta) in human diseases. Growth Factors 33 (2015), 92–101.
    • (2015) Growth Factors , vol.33 , pp. 92-101
    • Sheng, J.1    Chen, W.2    Zhu, H.J.3
  • 26
    • 84891090989 scopus 로고    scopus 로고
    • Leptin metabolically licenses T cells for activation to link nutrition and immunity
    • Here, the authors provide a novel link between lymphocyte activation and nutrition by illucidating leptin's impact on effector T cell metabolism. This finding provides an essential role for leptin in T cell mediated immunity.
    • 26•• Saucillo, D.C., Gerriets, V.A., Sheng, J., Rathmell, J.C., Maciver, N.J., Leptin metabolically licenses T cells for activation to link nutrition and immunity. J Immunol 192 (2014), 136–144 Here, the authors provide a novel link between lymphocyte activation and nutrition by illucidating leptin's impact on effector T cell metabolism. This finding provides an essential role for leptin in T cell mediated immunity.
    • (2014) J Immunol , vol.192 , pp. 136-144
    • Saucillo, D.C.1    Gerriets, V.A.2    Sheng, J.3    Rathmell, J.C.4    Maciver, N.J.5
  • 27
    • 84903277871 scopus 로고    scopus 로고
    • Integrating canonical and metabolic signalling programmes in the regulation of T cell responses
    • 27 Pollizzi, K.N., Powell, J.D., Integrating canonical and metabolic signalling programmes in the regulation of T cell responses. Nat Rev Immunol 14 (2014), 435–446.
    • (2014) Nat Rev Immunol , vol.14 , pp. 435-446
    • Pollizzi, K.N.1    Powell, J.D.2
  • 29
    • 84962949589 scopus 로고    scopus 로고
    • Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants
    • 29 Collaboration NRF, Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19.2 million participants. Lancet 387 (2016), 1377–1396.
    • (2016) Lancet , vol.387 , pp. 1377-1396
    • Collaboration NRF1
  • 30
    • 84988904805 scopus 로고    scopus 로고
    • Prevalence of obesity among adults and youth—United States, 2011–2014
    • 30 Ogden, C.L., Carroll, M.D., Fryar, C.D., Flegal, K.M., Prevalence of obesity among adults and youth—United States, 2011–2014. NCHS Data Brief 219 (2015), 1–8.
    • (2015) NCHS Data Brief , vol.219 , pp. 1-8
    • Ogden, C.L.1    Carroll, M.D.2    Fryar, C.D.3    Flegal, K.M.4
  • 32
  • 36
    • 84925431240 scopus 로고    scopus 로고
    • Obesity impairs gammadelta T cell homeostasis and antiviral function in humans
    • 36 Costanzo, A.E., Taylor, K.R., Dutt, S., Han, P.P., Fujioka, K., Jameson, J.M., Obesity impairs gammadelta T cell homeostasis and antiviral function in humans. PLoS One, 10, 2015, e0120918.
    • (2015) PLoS One , vol.10 , pp. e0120918
    • Costanzo, A.E.1    Taylor, K.R.2    Dutt, S.3    Han, P.P.4    Fujioka, K.5    Jameson, J.M.6
  • 37
    • 47049122578 scopus 로고    scopus 로고
    • Leptin and regulatory T cells in obese patients with asthma
    • 37 Mascitelli, L., Pezzetta, F., Goldstein, M.R., Leptin and regulatory T cells in obese patients with asthma. Thorax, 63, 2008, 659.
    • (2008) Thorax , vol.63 , pp. 659
    • Mascitelli, L.1    Pezzetta, F.2    Goldstein, M.R.3
  • 41
    • 84901299349 scopus 로고    scopus 로고
    • 1H NMR-based profiling reveals differential immune-metabolic networks during influenza virus infection in obese mice
    • 1H NMR-based profiling reveals differential immune-metabolic networks during influenza virus infection in obese mice. PLoS One, 9, 2014, e97238.
    • (2014) PLoS One , vol.9 , pp. e97238
    • Milner, J.J.1    Wang, J.2    Sheridan, P.A.3    Ebbels, T.4    Beck, M.A.5    Saric, J.6
  • 42
    • 84929104776 scopus 로고    scopus 로고
    • Obesity increases mortality and modulates the lung metabolome during pandemic H1N1 influenza virus infection in mice
    • The authors demonstrate that obesity increases mortaltiy and lung inflammation in obese mice during pandemic H1N1 influenza virus infection. Furthermore, they provide a link between alterated metabolic profiles in obese mice and impaired cellular immune response.
    • 42•• Milner, J.J., Rebeles, J., Dhungana, S., Stewart, D.A., Sumner, S.C., Meyers, M.H., Mancuso, P., Beck, M.A., Obesity increases mortality and modulates the lung metabolome during pandemic H1N1 influenza virus infection in mice. J Immunol 194 (2015), 4846–4859 The authors demonstrate that obesity increases mortaltiy and lung inflammation in obese mice during pandemic H1N1 influenza virus infection. Furthermore, they provide a link between alterated metabolic profiles in obese mice and impaired cellular immune response.
    • (2015) J Immunol , vol.194 , pp. 4846-4859
    • Milner, J.J.1    Rebeles, J.2    Dhungana, S.3    Stewart, D.A.4    Sumner, S.C.5    Meyers, M.H.6    Mancuso, P.7    Beck, M.A.8
  • 44
    • 84875280888 scopus 로고    scopus 로고
    • Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation
    • 44 Deng, T., Lyon, C.J., Minze, L.J., Lin, J., Zou, J., Liu, J.Z., Ren, Y., Yin, Z., Hamilton, D.J., Reardon, P.R., et al. Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation. Cell Metab 17 (2013), 411–422.
    • (2013) Cell Metab , vol.17 , pp. 411-422
    • Deng, T.1    Lyon, C.J.2    Minze, L.J.3    Lin, J.4    Zou, J.5    Liu, J.Z.6    Ren, Y.7    Yin, Z.8    Hamilton, D.J.9    Reardon, P.R.10
  • 49
    • 84953362988 scopus 로고    scopus 로고
    • Large adipocytes function as antigen-presenting cells to activate CD4(+) T cells via upregulating MHCII in obesity
    • + T cells. This finding links obesity to adipose tissue inflammation and changes in T cell activation and populations.
    • + T cells. This finding links obesity to adipose tissue inflammation and changes in T cell activation and populations.
    • (2016) Int J Obes (Lond) , vol.40 , pp. 112-120
    • Xiao, L.1    Yang, X.2    Lin, Y.3    Li, S.4    Jiang, J.5    Qian, S.6    Tang, Q.7    He, R.8    Li, X.9
  • 50
    • 66149107054 scopus 로고    scopus 로고
    • Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR
    • 50 Wang, C.Y., Kim, H.H., Hiroi, Y., Sawada, N., Salomone, S., Benjamin, L.E., Moskowitz, M.A., Liao, J.K., Obesity increases vascular senescence and susceptibility to ischemic injury through chronic activation of Akt and mTOR. Sci Signal 2 (2009), 1–11.
    • (2009) Sci Signal , vol.2 , pp. 1-11
    • Wang, C.Y.1    Kim, H.H.2    Hiroi, Y.3    Sawada, N.4    Salomone, S.5    Benjamin, L.E.6    Moskowitz, M.A.7    Liao, J.K.8
  • 52
    • 85002679167 scopus 로고    scopus 로고
    • Obesity accelerates T cell senescence in murine visceral adipose tissue
    • The authors describe a senescent T cell phenotype in murine visceral adipose tissue (VAT) found in obese mice but not lean controls. This novel population of cells was shown to drive VAT inflammation through osteopontin production, connecting adipose tissue with immune aging.
    • 52• Shirakawa, K., Yan, X., Shinmura, K., Endo, J., Kataoka, M., Katsumata, Y., Yamamoto, T., Anzai, A., Isobe, S., Yoshida, N., et al. Obesity accelerates T cell senescence in murine visceral adipose tissue. J Clin Invest 126 (2016), 4626–4639 The authors describe a senescent T cell phenotype in murine visceral adipose tissue (VAT) found in obese mice but not lean controls. This novel population of cells was shown to drive VAT inflammation through osteopontin production, connecting adipose tissue with immune aging.
    • (2016) J Clin Invest , vol.126 , pp. 4626-4639
    • Shirakawa, K.1    Yan, X.2    Shinmura, K.3    Endo, J.4    Kataoka, M.5    Katsumata, Y.6    Yamamoto, T.7    Anzai, A.8    Isobe, S.9    Yoshida, N.10
  • 53
    • 72449139507 scopus 로고    scopus 로고
    • The role of osteopontin in inflammatory processes
    • 53 Lund, S.A., Giachelli, C.M., Scatena, M., The role of osteopontin in inflammatory processes. J Cell Commun Signal 3 (2009), 311–322.
    • (2009) J Cell Commun Signal , vol.3 , pp. 311-322
    • Lund, S.A.1    Giachelli, C.M.2    Scatena, M.3
  • 55
    • 84879125380 scopus 로고    scopus 로고
    • Programmed death-1 shapes memory phenotype CD8 T cell subsets in a cell-intrinsic manner
    • 55 Charlton, J.J., Chatzidakis, I., Tsoukatou, D., Boumpas, D.T., Garinis, G.A., Mamalaki, C., Programmed death-1 shapes memory phenotype CD8 T cell subsets in a cell-intrinsic manner. J Immunol 190 (2013), 6104–6114.
    • (2013) J Immunol , vol.190 , pp. 6104-6114
    • Charlton, J.J.1    Chatzidakis, I.2    Tsoukatou, D.3    Boumpas, D.T.4    Garinis, G.A.5    Mamalaki, C.6
  • 58
  • 59
    • 84954304881 scopus 로고    scopus 로고
    • Altered methylation profile of lymphocytes is concordant with perturbation of lipids metabolism and inflammatory response in obesity
    • 59 Jacobsen, M.J., Mentzel, C.M., Olesen, A.S., Huby, T., Jorgensen, C.B., Barres, R., Fredholm, M., Simar, D., Altered methylation profile of lymphocytes is concordant with perturbation of lipids metabolism and inflammatory response in obesity. J Diabetes Res, 2016, 2016, 8539057.
    • (2016) J Diabetes Res , vol.2016 , pp. 8539057
    • Jacobsen, M.J.1    Mentzel, C.M.2    Olesen, A.S.3    Huby, T.4    Jorgensen, C.B.5    Barres, R.6    Fredholm, M.7    Simar, D.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.