Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity

Journal of Diabetes Research

Volumn 2016, Issue , 2016, Pages

  Jacobsen, Mette J ^a   Mentzel, Caroline M Junker ^a   Olesen, Ann Sofie ^a   Huby, Thierry ^b,c   Jørgensen, Claus B ^a   Barrès, Romain ^d   Fredholm, Merete ^a   Simar, David ^e  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b SORBONNE UNIVERSITÉ   (France)

^c PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^d Capital Region   (Denmark)

^e UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; LIPID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; AUTACOID;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CELL MIGRATION; CELL POLARITY; CONTROLLED STUDY; DIET INDUCED OBESITY; DISEASE ASSOCIATION; DNA METHYLATION; EPIGENETICS; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; IMMUNOPATHOLOGY; IMPAIRED GLUCOSE TOLERANCE; INFLAMMATION; INTRAABDOMINAL FAT; LEUKOCYTE; LIPID METABOLISM; LYMPHOCYTE ACTIVATION; LYMPHOCYTIC INFILTRATION; MACROPHAGE; MALE; METABOLIC DISORDER; METABOLISM; MOLECULAR PATHOLOGY; NONHUMAN; PORCINE MODEL; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSCRIPTOMICS; ANIMAL; BLOOD; DISEASE MODEL; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; IMMUNOLOGY; NEUTROPHIL CHEMOTAXIS; OBESITY; PANNICULITIS; PIG; TIME FACTOR;

ADIPOSITY; ANIMALS; B-LYMPHOCYTES; CHEMOTAXIS, LEUKOCYTE; DISEASE MODELS, ANIMAL; DNA METHYLATION; EPIGENESIS, GENETIC; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; INFLAMMATION MEDIATORS; INTRA-ABDOMINAL FAT; LIPIDS; MALE; OBESITY; PANNICULITIS; SWINE; T-LYMPHOCYTES; TIME FACTORS;

EID: 84954304881     PISSN: 23146745     EISSN: 23146753     Source Type: Journal    
DOI: 10.1155/2016/8539057     Document Type: Article

References (53)

1. S. D. Pedersen, "Metabolic complications of obesity, " Best Practice & Research: Clinical Endocrinology & Metabolism, vol. 27, no. 2, pp. 179-193, 2013.
2. S. W. P. Koppe, "Obesity and the liver: nonalcoholic fatty liver disease, " Translational Research, vol. 164, no. 4, pp. 312-322, 2014.
3. S. H. Davoodi, T. Malek-Shahabi, A. Malekshahi-Moghadam, R. Shahbazi, and S. Esmaeili, "Obesity as an important risk factor for certain types of cancer, " Iranian Journal of Cancer Prevention, vol. 6, no. 4, pp. 186-194, 2013.
4. S. P. Weisberg, D. McCann, M. Desai, M. Rosenbaum, R. L. Leibel, and A.W. Ferrante Jr., "Obesity is associated with macrophage accumulation in adipose tissue, " The Journal of Clinical Investigation, vol. 112, no. 12, pp. 1796-1808, 2003.
5. J. Aron-Wisnewsky, J. Tordjman, C. Poitou et al., "Human adipose tissue macrophages: M1 and M2 cell surface markers in subcutaneous and omental depots and after weight loss, " The Journal of Clinical Endocrinology & Metabolism, vol. 94, no. 11, pp. 4619-4623, 2009.
6. D. Y. Oh, H. Morinaga, S. Talukdar, E. J. Bae, and J. M. Olefsky, "Increased macrophage migration into adipose tissue in obese mice, " Diabetes, vol. 61, no. 2, pp. 346-354, 2012.
7. J. DeFuria, A. C. Belkina, M. Jagannathan-Bogdan et al., "B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile, " Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 13, pp. 5133-5138, 2013.
8. S. Nishimura, I. Manabe, M. Nagasaki et al., "CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity, " Nature Medicine, vol. 15, no. 8, pp. 914-920, 2009.
9. M. F. Gregor and G. S. Hotamisligil, "Inflammatory mechanisms in obesity, " Annual Review of Immunology, vol. 29, pp. 415-445, 2011.
10. H. Sell and J. Eckel, "Chemotactic cytokines, obesity and type 2 diabetes: in vivo and in vitro evidence for a possible causal correlation?" Proceedings of theNutrition Society, vol. 68, no. 4, pp. 378-384, 2009.
11. V. D. F. de Mello, L. Pulkkinen, M. Lalli, M. Kolehmainen, J. Pihlajamäki, and M. Uusitupa, "DNA methylation in obesity and type 2 diabetes, " Annals of Medicine, vol. 46, no. 3, pp. 103-113, 2014.
12. S. J. van Dijk, P. L. Molloy, H. Varinli et al., "Epigenetics and human obesity, " International Journal of Obesity, vol. 39, no. 1, pp. 85-97, 2015.
13. X. Wang, H. Zhu, H. Snieder et al., "Obesity related methylation changes in DNA of peripheral blood leukocytes, " BMC Medicine, vol. 8, article 87, 2010.
14. D. Simar, S. Versteyhe, I. Donkin et al., "DNA methylation is altered in B and NK lymphocytes in obese and type 2 diabetic human, " Metabolism: Clinical and Experimental, vol. 63, no. 9, pp. 1188-1197, 2014.
15. X. Xu, S. Su, V. A. Barnes et al., "A genome-wide methylation study on obesity: differential variability and differential methylation, " Epigenetics, vol. 8, no. 5, pp. 522-533, 2013.
16. P. C. J. Janson, L. B. Linton, E. A. Bergman et al., "Profiling of CD4+ T cells with epigenetic immune lineage analysis, " Journal of Immunology, vol. 186, no. 1, pp. 92-102, 2011.
17. X. Yang, X. Wang, D. Liu, L. Yu, B. Xue, andH. Shi, "Epigenetic regulation of macrophage polarization by DNA methyltransferase 3b, " Molecular Endocrinology, vol. 28, no. 4, pp. 565-574, 2014.
18. H. Maier, R. Ostraat, H. Gao et al., "Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription, "Nature Immunology, vol. 5, no. 10, pp. 1069-1077, 2004.
19. H. H. Hermsdorff, M. L. Mansego, J. Campión, F. I. Milagro, M. A. Zulet, and J. A. Martínez, "TNF-Alpha promotermethylation in peripheral white blood cells: relationship with circulating TNFalpha, truncal fat and n-6 PUFA intake in young women, " Cytokine, vol. 64, no. 1, pp. 265-271, 2013.
20. M. C. García-Cardona, F. Huang, J.M. García-Vivas et al., "DNA methylation of leptin and adiponectin promoters in children is reduced by the combined presence of obesity and insulin resistance, " International Journal of Obesity, vol. 38, no. 11, pp. 1457-1465, 2014.
21. M. E. Spurlock and N. K. Gabler, "The development of porcine models of obesity and the metabolic syndrome, " The Journal of Nutrition, vol. 138, no. 2, pp. 397-402, 2008.
22. M. A. Groenen, A. L. Archibald, H. Uenishi et al., "Analyses of pig genomes provide insight into porcine demography and evolution, " Nature, vol. 491, no. 7424, pp. 393-398, 2012.
23. H. D. Dawson, "Comparative assessment of the pig, mouse, and human genomes; a structural and functional analysis of genes involved in immunity, " in The Minipig in Biomedical Research P AMcAnulty, A. Dayan and K. Hastings, Eds., p. 11, CRC Press, Taylor & Francis Group, 2011.
24. L. J. A. Kogelman, H.N. Kadarmideen, T. Mark et al., "An F2 pig resource population as a model for genetic studies of obesity and obesity-related diseases in humans: design and genetic parameters, " Frontiers in Genetics, vol. 4, article 29, 2013.
25. B. Christoffersen, V. Golozoubova, G. Pacini, O. Svendsen, and K. Raun, "The young Göttingen minipig as a model of childhood and adolescent obesity: influence of diet and gender, " Obesity, vol. 21, no. 1, pp. 149-158, 2013.
26. W. T. Friedewald, R. I. Levy, and D. S. Fredrickson, "Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge, " Clinical Chemistry, vol. 18, no. 6, pp. 499-502, 1972.
27. P. Decaunes, D. Estève, A. Zakaroff-Girard, C. Sengenès, J. Galitzky, and A. Bouloumié, "Adipose-derived stromal cells: cytokine expression and immune cell contaminants, " Methods in Molecular Biology, vol. 702, pp. 151-161, 2011.
28. S. Cirera, "Highly efficient method for isolation of total RNA from adipose tissue, " BMC Research Notes, vol. 6, article 472, 2013.
29. M. Traini, C. M. Quinn, C. Sandoval et al., "Sphingomyelin phosphodiesterase acid-like 3A (SMPDL3A) is a novel nucleotide phosphodiesterase regulated by cholesterol in human macrophages, " The Journal of Biological Chemistry, vol. 289, no. 47, pp. 32895-32913, 2014.
30. T.M. Foy, A. Aruffo, J.Bajorath, J. E. Buhlmann, andR. J.Noelle, "Immune regulation by CD40 and its ligand GP39, " Annual Review of Immunology, vol. 14, pp. 591-617, 1996.
31. S.Wueest, R. Mueller, M. Bluher et al., "Fas (CD95) expression in myeloid cells promotes obesity-induced muscle insulin resistance, " EMBO Molecular Medicine, vol. 6, no. 1, pp. 43-56, 2014.
32. Y.-T. Huang, J. Z. J. Maccani, N. L. Hawley, R. R.Wing, K. T. Kelsey, and J. M. McCaffery, "Epigenetic patterns in successful weight loss maintainers: a pilot study, " International Journal of Obesity, vol. 39, no. 5, pp. 865-868, 2015.
33. A. E. Newell-Fugate, J. N. Taibl, S. G. Clark, M. Alloosh, M. Sturek, and R. L. Krisher, "Effects of diet-induced obesity on metabolic parameters and reproductive function in female ossabawminipigs, " ComparativeMedicine, vol. 64, no. 1, pp. 44-49, 2014.
34. S. Cirera, M. S. Jensen, V. S. Elbrønd et al., "Expression studies of six human obesity-related genes in seven tissues fromdivergent pig breeds, " Animal Genetics, vol. 45, no. 1, pp. 59-66, 2014.
35. R. J. Faris, R. L. Boddicker, J. Walker-Daniels, J. Li, D. E. Jones, andM. E. Spurlock, "Inflammation in response to n3 fatty acids in a porcine obesity model, " Comparative Medicine, vol. 62, no. 6, pp. 495-503, 2012.
36. A. S. Pawar, X.-Y. Zhu, A. Eirin et al., "Adipose tissue remodeling in a novel domestic porcine model of diet-induced obesity, " Obesity, vol. 23, no. 2, pp. 399-407, 2015.
37. S. U. Amano, J. L. Cohen, P. Vangala et al., "Local proliferation of macrophages contributes to obesity-Associated adipose tissue inflammation, " Cell Metabolism, vol. 19, no. 1, pp. 162-171, 2014.
38. P. S. Patel, E. D. Buras, and A. Balasubramanyam, "The role of the immune systemin obesity and insulin resistance, " Journal of Obesity, vol. 2013, Article ID 616193, 9 pages, 2013.
39. U. Kintscher, M. Hartge, K. Hess et al., "T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 28, no. 7, pp. 1304-1310, 2008.
40. J. Deiuliis, Z. Shah, N. Shah et al., "Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers, " PLoS ONE, vol. 6, no. 1, Article IDe16376, 2011.
41. S. Winer, Y. Chan, G. Paltser et al., "Normalization of obesityassociated insulin resistance through immunotherapy, " Nature Medicine, vol. 15, no. 8, pp. 921-929, 2009.
42. D. Cipolletta, M. Feuerer, A. Li et al., "PPAR-is a major driver of the accumulation and phenotype of adipose tissue T reg cells, " Nature, vol. 486, no. 7404, pp. 549-553, 2012.
43. L. Yao, O. Herlea-Pana, J. Heuser-Baker, Y. Chen, and J. Barlic-Dicen, "Roles of the chemokine system in development of obesity, insulin resistance, and cardiovascular disease, " Journal of Immunology Research, vol. 2014, Article ID 181450, 11 pages, 2014.
44. F. Carbone, C. La Rocca, and G. Matarese, "Immunological functions of leptin and adiponectin, " Biochimie, vol. 94, no. 10, pp. 2082-2088, 2012.
45. S. A. Lund, C. M. Giachelli, and M. Scatena, "The role of osteopontin in inflammatory processes, " Journal of Cell Communication and Signaling, vol. 3, no. 3-4, pp. 311-322, 2009.
46. C. Ingvorsen, A. H. Thysen, D. Fernandez-Twinn et al., "Effects of pregnancy on obesity-induced inflammation in a mouse model of fetal programming, " International Journal of Obesity, 2014.
47. D. Wolf, F. Jehle, N. A. Michel et al., "Coinhibitory suppression ofTcell activation byCD40 protects against obesity and adipose tissue inflammation in mice, " Circulation, vol. 129, no. 23, pp. 2414-2425, 2014.
48. J. Dhein, H. Walczak, C. Baumler, K.-M. Debatin, and P. H. Krammer, "Autocrine T-cell suicide mediated by APO-1/(Fas/CD95), " Nature, vol. 373, no. 6513, pp. 438-441, 1995.
49. L. Catrysse, L. Vereecke, R. Beyaert, and G. van Loo, "A20 in inflammation and autoimmunity, " Trends in Immunology, vol. 35, no. 1, pp. 22-31, 2014.
50. M. Matmati, P. Jacques, J. Maelfait et al., "A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis, " Nature Genetics, vol. 43, no. 9, pp. 908-912, 2011.
51. C.-H. Tsao, M.-Y. Shiau, P.-H. Chuang, Y.-H. Chang, and J. Hwang, "Interleukin-4 regulates lipid metabolism by inhibiting adipogenesis and promoting lipolysis, " Journal of Lipid Research, vol. 55, no. 3, pp. 385-397, 2014.
52. B. R. Lawson, T. Eleftheriadis, V. Tardif et al., "Transmethylation in immunity and autoimmunity, " Clinical Immunology, vol. 143, no. 1, pp. 8-21, 2012.
53. D. A. Winer, S. Winer, L. Shen et al., "B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies, " Nature Medicine, vol. 17, no. 5, pp. 610-617, 2011.