Obesity accelerates T cell senescence in murine visceral adipose tissue

Journal of Clinical Investigation

Volumn 126, Issue 12, 2016, Pages 4626-4639

  Shirakawa, Kohsuke ^a   Yan, Xiaoxiang ^a,b   Shinmura, Ken ^c   Endo, Jin ^a   Kataoka, Masaharu ^a   Katsumata, Yoshinori ^a   Yamamoto, Tsunehisa ^a   Anzai, Atsushi ^a   Isobe, Sarasa ^a   Yoshida, Naohiro ^a,d   Itoh, Hiroshi ^a   Manabe, Ichiro ^e   Sekai, Miho ^f   Hamazaki, Yoko ^f   Fukuda, Keiichi ^a   Minato, Nagahiro ^f   Sano, Motoaki ^a,g  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c HYOGO COLLEGE OF MEDICINE   (Japan)

^d TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

^f KYOTO UNIVERSITY   (Japan)

^g JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; CD30 LIGAND; CD4 ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; GLUCOSE; HERMES ANTIGEN; INSULIN; INTERFERON; INTERLEUKIN 2; L SELECTIN; OSTEOPONTIN; T LYMPHOCYTE RECEPTOR; FAT INTAKE; LEUKOCYTE ANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR; SPP1 PROTEIN, MOUSE;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; B LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL AGING; CHRONIC INFLAMMATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; IN VITRO STUDY; INSULIN RESISTANCE; INTRAPERITONEAL FAT; LIPID DIET; LYMPHOCYTE FUNCTION; MACROPHAGE; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; T LYMPHOCYTE; ADVERSE EFFECTS; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; FAT INTAKE; GENETICS; IMMUNOLOGY; INFLAMMATION; INTRAABDOMINAL FAT; KNOCKOUT MOUSE; PATHOLOGY; PHARMACOLOGY;

ANIMALS; ANTIGENS, CD; B-LYMPHOCYTES; CD4-POSITIVE T-LYMPHOCYTES; CELL AGING; DIETARY FATS; INFLAMMATION; INTRA-ABDOMINAL FAT; MICE; MICE, KNOCKOUT; OBESITY; OSTEOPONTIN; RECEPTORS, ANTIGEN, T-CELL;

EID: 85002679167     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI88606     Document Type: Article

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