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Volumn 56, Issue 11, 2017, Pages 1267-1285

Levetiracetam Clinical Pharmacokinetic Monitoring in Pediatric Patients with Epilepsy

Author keywords

[No Author keywords available]

Indexed keywords

LEVETIRACETAM; ANTICONVULSIVE AGENT; ETIRACETAM; PIRACETAM;

EID: 85016124312     PISSN: 03125963     EISSN: 11791926     Source Type: Journal    
DOI: 10.1007/s40262-017-0537-1     Document Type: Review
Times cited : (19)

References (76)
  • 1
    • 0036242374 scopus 로고    scopus 로고
    • Update on the epidemiology and prognosis of pediatric epilepsy
    • PID: 11918462
    • Shinnar S, Pellock JM. Update on the epidemiology and prognosis of pediatric epilepsy. J Child Neurol. 2002;17:S4–17.
    • (2002) J Child Neurol , vol.17 , pp. S4-S17
    • Shinnar, S.1    Pellock, J.M.2
  • 2
    • 84868091762 scopus 로고    scopus 로고
    • Ideal characteristics of an antiepileptic drug: how do these impact treatment decisions for individual patients?
    • COI: 1:CAS:528:DC%2BC3sXivVymtLc%3D
    • Trinka E. Ideal characteristics of an antiepileptic drug: how do these impact treatment decisions for individual patients? Acta Neurol Scand. 2012;126:10–8.
    • (2012) Acta Neurol Scand , vol.126 , pp. 10-18
    • Trinka, E.1
  • 3
    • 62949147825 scopus 로고    scopus 로고
    • Keppra: EPAR – scientific discussion. European Medicines Agency
    • European Medicines Agency. Keppra: EPAR – scientific discussion. European Medicines Agency; 2005. pp. 17–19.
    • (2005) European Medicines Agency , pp. 17-19
  • 4
    • 76249093525 scopus 로고    scopus 로고
    • Levetiracetam: a comprehensive review
    • COI: 1:CAS:528:DC%2BC3cXhsFCmsbY%3D, PID: 20136375
    • Crepeau AZ, Treiman DM. Levetiracetam: a comprehensive review. Expert Rev Neurother. 2010;10:159–71.
    • (2010) Expert Rev Neurother , vol.10 , pp. 159-171
    • Crepeau, A.Z.1    Treiman, D.M.2
  • 5
    • 0033811027 scopus 로고    scopus 로고
    • Multicentre, double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures
    • COI: 1:CAS:528:DC%2BD3cXmvVSks7o%3D, PID: 10999557
    • Shorvon SD, Lowenthal A, Janz D, et al. Multicentre, double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures. Epilepsia. 2000;41:1179–86.
    • (2000) Epilepsia. , vol.41 , pp. 1179-1186
    • Shorvon, S.D.1    Lowenthal, A.2    Janz, D.3
  • 6
    • 0033854805 scopus 로고    scopus 로고
    • Levetiracetam for partial seizures: results of a double-blind, randomized clinical trial
    • COI: 1:CAS:528:DC%2BD3cXlvVymt7o%3D, PID: 10908898
    • Cereghino JJ, Biton V, Bou-Khalil B, et al. Levetiracetam for partial seizures: results of a double-blind, randomized clinical trial. Neurology. 2000;55:236–42.
    • (2000) Neurology. , vol.55 , pp. 236-242
    • Cereghino, J.J.1    Biton, V.2    Bou-Khalil, B.3
  • 7
    • 0033775210 scopus 로고    scopus 로고
    • Efficacy and tolerability of levetiracetam 3000 mg/d in patients with refractory partial seizures: a multi-centre, double-blind, responder selected study evaluating monotherapy
    • Ben-Menachem E, Falter U. Efficacy and tolerability of levetiracetam 3000 mg/d in patients with refractory partial seizures: a multi-centre, double-blind, responder selected study evaluating monotherapy. Epilepsia. 2000;41:1279–83.
    • (2000) Epilepsia. , vol.41 , pp. 1279-1283
    • Ben-Menachem, E.1    Falter, U.2
  • 8
    • 33745665605 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled trial of adjunctive levetiracetam in pediatric partial seizures
    • COI: 1:CAS:528:DC%2BD28Xksl2hs7o%3D, PID: 16641323
    • Glauser TA, Ayala R, Elterman RD, et al. Double-blind, placebo-controlled trial of adjunctive levetiracetam in pediatric partial seizures. Neurology. 2006;66:1654–60.
    • (2006) Neurology. , vol.66 , pp. 1654-1660
    • Glauser, T.A.1    Ayala, R.2    Elterman, R.D.3
  • 9
    • 65549121241 scopus 로고    scopus 로고
    • Adjunctive levetiracetam in infants and young children with refractory partial-onset seizures
    • COI: 1:CAS:528:DC%2BD1MXms1Skt74%3D, PID: 19243423
    • Pina-Garza JE, Nordli DR Jr, Rating D, et al. Adjunctive levetiracetam in infants and young children with refractory partial-onset seizures. Epilepsia. 2009;50:1141–9.
    • (2009) Epilepsia. , vol.50 , pp. 1141-1149
    • Pina-Garza, J.E.1    Nordli, D.R.2    Rating, D.3
  • 11
    • 84891649144 scopus 로고    scopus 로고
    • Clinical pharmacology and pharmacokinetics of levetiracetam
    • PID: 24363651
    • Wright C, Downing J, Mungall D, et al. Clinical pharmacology and pharmacokinetics of levetiracetam. Front Neurol. 2013;4:192.
    • (2013) Front Neurol. , vol.4 , pp. 192
    • Wright, C.1    Downing, J.2    Mungall, D.3
  • 12
    • 0033621925 scopus 로고    scopus 로고
    • Pharmacokinetic profile of levetiracetam: toward ideal characteristics
    • COI: 1:CAS:528:DC%2BD3cXosFSnsA%3D%3D, PID: 10722121
    • Patsalos PN. Pharmacokinetic profile of levetiracetam: toward ideal characteristics. Pharmacol Ther. 2000;85:77–85.
    • (2000) Pharmacol Ther , vol.85 , pp. 77-85
    • Patsalos, P.N.1
  • 13
    • 0035675738 scopus 로고    scopus 로고
    • Pharmacokinetic study of levetiracetam in children
    • COI: 1:CAS:528:DC%2BD38Xht1OqtLk%3D, PID: 11879369
    • Pellock JM, Glauser TA, Bebin EM, et al. Pharmacokinetic study of levetiracetam in children. Epilepsia. 2001;42:1574–9.
    • (2001) Epilepsia. , vol.42 , pp. 1574-1579
    • Pellock, J.M.1    Glauser, T.A.2    Bebin, E.M.3
  • 14
    • 0031955468 scopus 로고    scopus 로고
    • Clinical pharmacokinetics in the 21st century. Does the evidence support definitive outcomes?
    • COI: 1:STN:280:DyaK1c3jt1Oqsw%3D%3D, PID: 9571300
    • Ensom MHH, Davis GA, Cropp CD, Ensom RJ. Clinical pharmacokinetics in the 21st century. Does the evidence support definitive outcomes? Clin Pharmacokinet. 1998;34:265–79.
    • (1998) Clin Pharmacokinet , vol.34 , pp. 265-279
    • Ensom, M.H.H.1    Davis, G.A.2    Cropp, C.D.3    Ensom, R.J.4
  • 15
    • 78649382910 scopus 로고    scopus 로고
    • Adjunctive levetiracetam in patients aged 1 month to <4 years with parital-onset seizures: subpopulation analysis of a prospective, open-label extension study of up to 48 weeks
    • COI: 1:CAS:528:DC%2BC3cXhsVGisb3K, PID: 21095488
    • Pina-Garza JE, Schiemann-Delgado J, Yang H, et al. Adjunctive levetiracetam in patients aged 1 month to <4 years with parital-onset seizures: subpopulation analysis of a prospective, open-label extension study of up to 48 weeks. Clin Ther. 2010;32:1935–50.
    • (2010) Clin Ther , vol.32 , pp. 1935-1950
    • Pina-Garza, J.E.1    Schiemann-Delgado, J.2    Yang, H.3
  • 16
    • 70350417839 scopus 로고    scopus 로고
    • Neurocognitive effects of adjunctive levetiracetam in children with partial-onset seizures: a randomized double-blind, placebo-controlled, noninferiority trial
    • COI: 1:CAS:528:DC%2BD1MXhsVyisrvJ, PID: 19702752
    • Levisohn PM, Mintz M, Hunter SJ, et al. Neurocognitive effects of adjunctive levetiracetam in children with partial-onset seizures: a randomized double-blind, placebo-controlled, noninferiority trial. Epilepsia. 2009;50:2377–89.
    • (2009) Epilepsia. , vol.50 , pp. 2377-2389
    • Levisohn, P.M.1    Mintz, M.2    Hunter, S.J.3
  • 17
    • 84863022652 scopus 로고    scopus 로고
    • A long-term open-label extension study assessing cognition and behaviour, tolerability, safety, and efficacy of adjunctive levetiracetam in children aged 4 to 16 years with partial-onset seizures
    • PID: 21876066
    • Schiemann-Delgado J, Yang H, de la Loge C, et al. A long-term open-label extension study assessing cognition and behaviour, tolerability, safety, and efficacy of adjunctive levetiracetam in children aged 4 to 16 years with partial-onset seizures. J Child Neurol. 2012;27:80–9.
    • (2012) J Child Neurol , vol.27 , pp. 80-89
    • Schiemann-Delgado, J.1    Yang, H.2    de la Loge, C.3
  • 18
    • 84873137479 scopus 로고    scopus 로고
    • Levetiracetam add-on for drug-resistant focal epilepsy: an updated Cochrane review
    • Mbizvo GK, Dixon P, Hutton JL, Marson AG. Levetiracetam add-on for drug-resistant focal epilepsy: an updated Cochrane review. Cochrane Database Syst Rev. 2012;(9):CD001901. doi:10.1002/14651858.CD001901.pub2
    • (2012) Cochrane Database Syst Rev. , vol.9
    • Mbizvo, G.K.1    Dixon, P.2    Hutton, J.L.3    Marson, A.G.4
  • 19
    • 85027926729 scopus 로고    scopus 로고
    • The LaLiMo trial: lamotrigine compared with levetiracetam in the initial 26 weeks of monotherapy for focal and generalised epilepsy: an open-label, prospective, randomised controlled multicenter study
    • PID: 22595362
    • Rosenow F, Schade-Brittinger C, Burchardi N, et al. The LaLiMo trial: lamotrigine compared with levetiracetam in the initial 26 weeks of monotherapy for focal and generalised epilepsy: an open-label, prospective, randomised controlled multicenter study. J Neurol Neurosurg Psychiatry. 2012;83:1093–8.
    • (2012) J Neurol Neurosurg Psychiatry , vol.83 , pp. 1093-1098
    • Rosenow, F.1    Schade-Brittinger, C.2    Burchardi, N.3
  • 20
    • 84930704306 scopus 로고    scopus 로고
    • Neuropsychological effects of levetiracetam and carbamazepine in children with focal epilepsy
    • COI: 1:CAS:528:DC%2BC2MXpvFSjtr4%3D, PID: 25948717
    • Jung DE, Yu R, Yoon JR, et al. Neuropsychological effects of levetiracetam and carbamazepine in children with focal epilepsy. Neurology. 2015;84:2312–9.
    • (2015) Neurology. , vol.84 , pp. 2312-2319
    • Jung, D.E.1    Yu, R.2    Yoon, J.R.3
  • 21
    • 84865075460 scopus 로고    scopus 로고
    • Levetiracetam extended release conversion to monotherapy for the treatment of patients with partial-onset seizures: A double-blind, randomised, multicentre, historical control study
    • COI: 1:CAS:528:DC%2BC38XlvVSmsb0%3D, PID: 22516508
    • Chung S, Ceja H, Gawłowicz J, Avakyan G, McShea C, Schiemann J, et al. Levetiracetam extended release conversion to monotherapy for the treatment of patients with partial-onset seizures: A double-blind, randomised, multicentre, historical control study. Epilepsy Res. 2012;101:92–102.
    • (2012) Epilepsy Res , vol.101 , pp. 92-102
    • Chung, S.1    Ceja, H.2    Gawłowicz, J.3    Avakyan, G.4    McShea, C.5    Schiemann, J.6
  • 22
    • 78649286285 scopus 로고    scopus 로고
    • Historical control monotherapy design in the treatment of epilepsy
    • COI: 1:CAS:528:DC%2BC3cXhsVKis73F, PID: 20561024
    • French JA, Wang S, Warnock B, Temkin N. Historical control monotherapy design in the treatment of epilepsy. Epilepsia. 2010;51:1936–43.
    • (2010) Epilepsia. , vol.51 , pp. 1936-1943
    • French, J.A.1    Wang, S.2    Warnock, B.3    Temkin, N.4
  • 23
    • 84958720830 scopus 로고    scopus 로고
    • Levetiracetam extended release for the treatment of patients with partial-onset seizures: a long-term, open-label follow-up study
    • COI: 1:CAS:528:DC%2BC2MXitV2nu7%2FE, PID: 26716580
    • Chung S, Ceja H, Gawłowicz J, McShea C, Schiemann J, Lu S. Levetiracetam extended release for the treatment of patients with partial-onset seizures: a long-term, open-label follow-up study. Epilepsy Res. 2016;120:7–12.
    • (2016) Epilepsy Res , vol.120 , pp. 7-12
    • Chung, S.1    Ceja, H.2    Gawłowicz, J.3    McShea, C.4    Schiemann, J.5    Lu, S.6
  • 24
    • 61849127705 scopus 로고    scopus 로고
    • Once-daily extended-release levetiracetam as adjunctive treatment of partial-onset seizures in patients with epilepsy: a double-blind, randomized, placebo-controlled trial
    • COI: 1:CAS:528:DC%2BD1MXksFyqu7k%3D, PID: 19317886
    • Peltola J, Coetzee C, Jiménez F, Litovchenko T, Ramaratnam S, Zaslavaskiy L, et al. Once-daily extended-release levetiracetam as adjunctive treatment of partial-onset seizures in patients with epilepsy: a double-blind, randomized, placebo-controlled trial. Epilepsia. 2009;50:406–14.
    • (2009) Epilepsia. , vol.50 , pp. 406-414
    • Peltola, J.1    Coetzee, C.2    Jiménez, F.3    Litovchenko, T.4    Ramaratnam, S.5    Zaslavaskiy, L.6
  • 25
    • 33947612119 scopus 로고    scopus 로고
    • Levetiracetam or oxcarbazepine as monotherapy in newly diagnosed benign epilepsy of childhood with centrotemporal spikes (BECTS): an open-label, parallel group trial
    • PID: 17055681
    • Coppola G, Franzoni E, Verrotti A, Garone C, Sarajlija J, Operta FF, et al. Levetiracetam or oxcarbazepine as monotherapy in newly diagnosed benign epilepsy of childhood with centrotemporal spikes (BECTS): an open-label, parallel group trial. Brain Dev. 2007;29:281–4.
    • (2007) Brain Dev. , vol.29 , pp. 281-284
    • Coppola, G.1    Franzoni, E.2    Verrotti, A.3    Garone, C.4    Sarajlija, J.5    Operta, F.F.6
  • 26
    • 84907701558 scopus 로고    scopus 로고
    • Evaluation of levetiracetam and valproic acid as low-dose monotherapies for children with typical benign childhood epilepsy with centrotemporal spikes (BECTS)
    • PID: 24998415
    • Xiao F, An D, Deng H, Chen S, Ren J, Zhou D. Evaluation of levetiracetam and valproic acid as low-dose monotherapies for children with typical benign childhood epilepsy with centrotemporal spikes (BECTS). Seizure. 2014;23:756–61.
    • (2014) Seizure. , vol.23 , pp. 756-761
    • Xiao, F.1    An, D.2    Deng, H.3    Chen, S.4    Ren, J.5    Zhou, D.6
  • 27
    • 79953697098 scopus 로고    scopus 로고
    • A multicenter, randomized, placebo-controlled trial of levetiracetam in children and adolescents with newly diagnosed absence epilepsy
    • COI: 1:CAS:528:DC%2BC3MXmtF2ns7k%3D, PID: 21320119
    • Fattore C, Boniver C, Capovilla G, et al. A multicenter, randomized, placebo-controlled trial of levetiracetam in children and adolescents with newly diagnosed absence epilepsy. Epilepsia. 2011;52:802–9.
    • (2011) Epilepsia. , vol.52 , pp. 802-809
    • Fattore, C.1    Boniver, C.2    Capovilla, G.3
  • 28
    • 39749166363 scopus 로고    scopus 로고
    • Levetiracetam for the treatment of idiopathic generalized epilepsy with myoclonic seizures
    • COI: 1:CAS:528:DC%2BD1cXhs1Krurc%3D, PID: 18285535
    • Noachtar S, Andermann E, Meyvisch P, et al. Levetiracetam for the treatment of idiopathic generalized epilepsy with myoclonic seizures. Neurology. 2008;70:607–16.
    • (2008) Neurology. , vol.70 , pp. 607-616
    • Noachtar, S.1    Andermann, E.2    Meyvisch, P.3
  • 29
    • 35848938482 scopus 로고    scopus 로고
    • Placebo-controlled study of levetiracetam in idiopathic generalized epilepsy
    • COI: 1:CAS:528:DC%2BD2sXht1Shu7jJ, PID: 17625106
    • Berkovic SF, Knowlton RC, Leroy RF, et al. Placebo-controlled study of levetiracetam in idiopathic generalized epilepsy. Neurology. 2007;69:1751–60.
    • (2007) Neurology. , vol.69 , pp. 1751-1760
    • Berkovic, S.F.1    Knowlton, R.C.2    Leroy, R.F.3
  • 30
    • 84874383369 scopus 로고    scopus 로고
    • Safety and efficacy of levetiracetam for the treatment of partial onset seizures in children from one month of age
    • COI: 1:CAS:528:DC%2BC3sXjslChsr4%3D, PID: 23458993
    • Cormier J, Chu CJ. Safety and efficacy of levetiracetam for the treatment of partial onset seizures in children from one month of age. Neuropsychiatr Dis Treat. 2013;9:295–306.
    • (2013) Neuropsychiatr Dis Treat. , vol.9 , pp. 295-306
    • Cormier, J.1    Chu, C.J.2
  • 31
    • 84893698252 scopus 로고    scopus 로고
    • Initial anticonvulsant monotherapy in routine care of children and adolescents: levetiracetam fails more frequently than valproate and oxcarbazepine due to a lack of effectiveness
    • COI: 1:CAS:528:DC%2BC3sXht12iu7%2FK, PID: 23933673
    • Bertsche A, Neininger MP, Dahse AJ, Syrbe S, Bernhard MK, Frontini R, et al. Initial anticonvulsant monotherapy in routine care of children and adolescents: levetiracetam fails more frequently than valproate and oxcarbazepine due to a lack of effectiveness. Eur J Pediatr. 2014;173:87–92.
    • (2014) Eur J Pediatr , vol.173 , pp. 87-92
    • Bertsche, A.1    Neininger, M.P.2    Dahse, A.J.3    Syrbe, S.4    Bernhard, M.K.5    Frontini, R.6
  • 32
    • 0028044191 scopus 로고
    • High-performance liquid chromatographic and megabore gas—liquid chromatographic determination of levetiracetam (ucb L059) in human serum after solid-phase extraction
    • COI: 1:CAS:528:DyaK2MXitlaiurk%3D
    • Vermeij TAC, Edelbroek PM. High-performance liquid chromatographic and megabore gas—liquid chromatographic determination of levetiracetam (ucb L059) in human serum after solid-phase extraction. J Chromatogr B. 1994;662:134–9.
    • (1994) J Chromatogr B , vol.662 , pp. 134-139
    • Vermeij, T.A.C.1    Edelbroek, P.M.2
  • 33
    • 0029945589 scopus 로고    scopus 로고
    • A micromethod for the determination of the new antiepileptic drug levetiracetam (ucb L059) in serum or plasma by high performance liquid chromatography
    • COI: 1:CAS:528:DyaK28XisVGjsbo%3D, PID: 8721278
    • Ratnaraj N, Doheny HC, Patsalos PN. A micromethod for the determination of the new antiepileptic drug levetiracetam (ucb L059) in serum or plasma by high performance liquid chromatography. Ther Drug Monit. 1996;18:154–7.
    • (1996) Ther Drug Monit , vol.18 , pp. 154-157
    • Ratnaraj, N.1    Doheny, H.C.2    Patsalos, P.N.3
  • 34
    • 22844435537 scopus 로고    scopus 로고
    • Determination of levetiracetam in human plasma with minimal sample pretreatment
    • COI: 1:CAS:528:DC%2BD2MXis1Glu7w%3D
    • Martens-Lobenhoffer J, Bode-Böger SM. Determination of levetiracetam in human plasma with minimal sample pretreatment. J Chromatogr B. 2005;819:197–200.
    • (2005) J Chromatogr B , vol.819 , pp. 197-200
    • Martens-Lobenhoffer, J.1    Bode-Böger, S.M.2
  • 35
    • 33646171308 scopus 로고    scopus 로고
    • Drug monitoring and toxicology: a procedure for the monitoring of levetiracetam and zonisamide by HPLC-UV
    • COI: 1:CAS:528:DC%2BD28Xht1Ojsbg%3D, PID: 16620528
    • Juenke JM, Brown PI, Urry FM, McMillin GA. Drug monitoring and toxicology: a procedure for the monitoring of levetiracetam and zonisamide by HPLC-UV. J Anal Toxicol. 2006;30:27–30.
    • (2006) J Anal Toxicol , vol.30 , pp. 27-30
    • Juenke, J.M.1    Brown, P.I.2    Urry, F.M.3    McMillin, G.A.4
  • 36
    • 50849118789 scopus 로고    scopus 로고
    • Simple and validated HPLC–UV analysis of levetiracetam in deproteinized plasma of patients with epilepsy
    • COI: 1:CAS:528:DC%2BD1cXhtVynsbjI
    • Contin M, Mohamed S, Albani F, Riva R, Baruzzi A. Simple and validated HPLC–UV analysis of levetiracetam in deproteinized plasma of patients with epilepsy. J Chromatogr B. 2008;873:129–32.
    • (2008) J Chromatogr B , vol.873 , pp. 129-132
    • Contin, M.1    Mohamed, S.2    Albani, F.3    Riva, R.4    Baruzzi, A.5
  • 37
    • 84923069908 scopus 로고    scopus 로고
    • Development and validation of a HPLC-UV method for the quantification of antiepileptic drugs in dried plasma spots
    • COI: 1:CAS:528:DC%2BC2MXislSnt70%3D, PID: 25153419
    • Baldelli S, Cattaneo D, Giodini L, Baietto L, Di Perri G, D’Avolio A, et al. Development and validation of a HPLC-UV method for the quantification of antiepileptic drugs in dried plasma spots. Clin Chem Lab Med. 2015;53:435–44.
    • (2015) Clin Chem Lab Med , vol.53 , pp. 435-444
    • Baldelli, S.1    Cattaneo, D.2    Giodini, L.3    Baietto, L.4    Di Perri, G.5    D’Avolio, A.6
  • 38
    • 33748285990 scopus 로고    scopus 로고
    • Determination of levetiracetam in human plasma by liquid chromatography/electrospray tandem mass spectrometry and its application to bioequivalence studies
    • Jain DS, Subbaiah G, Sanyal M, Pal U, Shrivastav PS. Determination of levetiracetam in human plasma by liquid chromatography/electrospray tandem mass spectrometry and its application to bioequivalence studies. Rapid Commun Mass Spectrom. 2006;15(20):2539–47.
    • (2006) Rapid Commun Mass Spectrom , vol.15 , Issue.20 , pp. 2539-2547
    • Jain, D.S.1    Subbaiah, G.2    Sanyal, M.3    Pal, U.4    Shrivastav, P.S.5
  • 39
    • 33750066632 scopus 로고    scopus 로고
    • Determination of levetiracetam in human plasma/serum/saliva by liquid chromatography–electrospray tandem mass spectrometry
    • COI: 1:CAS:528:DC%2BD28XhtFWiu73F, PID: 16914128
    • Guo T, Oswald LM, Mendu DR, Soldin SJ. Determination of levetiracetam in human plasma/serum/saliva by liquid chromatography–electrospray tandem mass spectrometry. Clin Chim Acta. 2007;375:115–8.
    • (2007) Clin Chim Acta , vol.375 , pp. 115-118
    • Guo, T.1    Oswald, L.M.2    Mendu, D.R.3    Soldin, S.J.4
  • 40
    • 53049094637 scopus 로고    scopus 로고
    • Quantification of levetiracetam in human plasma by liquid chromatography–tandem mass spectrometry: application to therapeutic drug monitoring
    • COI: 1:CAS:528:DC%2BD1cXht1ymsL%2FI
    • Matar KM. Quantification of levetiracetam in human plasma by liquid chromatography–tandem mass spectrometry: application to therapeutic drug monitoring. J Pharmaceut Biomed. 2008;48:822–8.
    • (2008) J Pharmaceut Biomed. , vol.48 , pp. 822-828
    • Matar, K.M.1
  • 41
    • 76549114365 scopus 로고    scopus 로고
    • Quantification of levetiracetam in plasma of neonates by ultra performance liquid chromatography–tandem mass spectrometry
    • COI: 1:CAS:528:DC%2BC3cXitlWht7g%3D
    • Blonk MI, van der Nagel BC, Smit LS, Mathot RAA. Quantification of levetiracetam in plasma of neonates by ultra performance liquid chromatography–tandem mass spectrometry. J Chromatogr B. 2010;878:675–81.
    • (2010) J Chromatogr B , vol.878 , pp. 675-681
    • Blonk, M.I.1    van der Nagel, B.C.2    Smit, L.S.3    Mathot, R.A.A.4
  • 42
    • 81155162541 scopus 로고    scopus 로고
    • Development and validation of an analytical method based on high performance thin layer chromatography for the simultaneous determination of lamotrigine, zonisamide and levetiracetam in human plasma
    • COI: 1:CAS:528:DC%2BC3MXhtVKmur3N
    • Antonilli L, Brusadin V, Filipponi F, Guglielmi R, Nencini P. Development and validation of an analytical method based on high performance thin layer chromatography for the simultaneous determination of lamotrigine, zonisamide and levetiracetam in human plasma. J Pharmaceut Biomed. 2011;56:763–70.
    • (2011) J Pharmaceut Biomed. , vol.56 , pp. 763-770
    • Antonilli, L.1    Brusadin, V.2    Filipponi, F.3    Guglielmi, R.4    Nencini, P.5
  • 43
    • 79953186567 scopus 로고    scopus 로고
    • Simultaneous quantification of levetiracetam and gabapentin in plasma by ultra-pressure liquid chromatography coupled with tandem mass spectrometry detection
    • COI: 1:CAS:528:DC%2BC3MXjt1GgsLY%3D, PID: 21297550
    • Juenke JM, Brown PI, Johnson-Davis KL, McMillin GA. Simultaneous quantification of levetiracetam and gabapentin in plasma by ultra-pressure liquid chromatography coupled with tandem mass spectrometry detection. Ther Drug Monit. 2011;33:209–13.
    • (2011) Ther Drug Monit , vol.33 , pp. 209-213
    • Juenke, J.M.1    Brown, P.I.2    Johnson-Davis, K.L.3    McMillin, G.A.4
  • 44
    • 84355163125 scopus 로고    scopus 로고
    • Performance characteristics and patient comparison of the ARK Diagnostics levetiracetam immunoassay with an ultra-high performance liquid chromatography with tandem mass spectrometry detection method
    • COI: 1:CAS:528:DC%2BC3MXhs12hu7vL, PID: 22137980
    • Juenke JM, McGraw JP, McMillin GA, Johnson-Davis KL. Performance characteristics and patient comparison of the ARK Diagnostics levetiracetam immunoassay with an ultra-high performance liquid chromatography with tandem mass spectrometry detection method. Clin Chim Acta. 2012;413:529–31.
    • (2012) Clin Chim Acta , vol.413 , pp. 529-531
    • Juenke, J.M.1    McGraw, J.P.2    McMillin, G.A.3    Johnson-Davis, K.L.4
  • 45
    • 84910654981 scopus 로고    scopus 로고
    • Rapid and simultaneous quantification of levetiracetam and its carboxylic metabolite in human plasma by liquid chromatography tandem mass spectrometry
    • PID: 25375249
    • Yeap L-L, Lo Y-L. Rapid and simultaneous quantification of levetiracetam and its carboxylic metabolite in human plasma by liquid chromatography tandem mass spectrometry. PLoS ONE. 2014;9:e111544.
    • (2014) PLoS ONE , vol.9
    • Yeap, L.-L.1    Lo, Y.-L.2
  • 46
    • 1142263160 scopus 로고    scopus 로고
    • High-performance liquid chromatographic determination of Levetiracetam in human plasma: comparison of different sample clean-up procedures
    • COI: 1:CAS:528:DC%2BD2cXhtlKjtb8%3D
    • Pucci V, Bugamelli F, Mandrioli R, Ferranti A, Kenndler E, Raggi MA. High-performance liquid chromatographic determination of Levetiracetam in human plasma: comparison of different sample clean-up procedures. Biomed Chrom. 2004;18:37–44.
    • (2004) Biomed Chrom. , vol.18 , pp. 37-44
    • Pucci, V.1    Bugamelli, F.2    Mandrioli, R.3    Ferranti, A.4    Kenndler, E.5    Raggi, M.A.6
  • 47
    • 76749108393 scopus 로고    scopus 로고
    • LC method for therapeutic drug monitoring of levetiracetam: evaluation of the assay performance and validation of its application in the routine area
    • PID: 19896933
    • Zufía L, Aldaz A, Ibáñez N, Giráldez J, Viteri C. LC method for therapeutic drug monitoring of levetiracetam: evaluation of the assay performance and validation of its application in the routine area. Clin Biochem. 2010;43:473–82.
    • (2010) Clin Biochem , vol.43 , pp. 473-482
    • Zufía, L.1    Aldaz, A.2    Ibáñez, N.3    Giráldez, J.4    Viteri, C.5
  • 48
    • 78751646276 scopus 로고    scopus 로고
    • Performance characteristics of a new levetiracetam immunoassay and method comparison with a high-performance liquid chromatography method
    • COI: 1:CAS:528:DC%2BC3MXlsFagsA%3D%3D, PID: 21157399
    • Reineks EZ, Lawson SE, Lembright KE, Wang S. Performance characteristics of a new levetiracetam immunoassay and method comparison with a high-performance liquid chromatography method. Ther Drug Monit. 2011;33:124–7.
    • (2011) Ther Drug Monit , vol.33 , pp. 124-127
    • Reineks, E.Z.1    Lawson, S.E.2    Lembright, K.E.3    Wang, S.4
  • 49
    • 34447510947 scopus 로고    scopus 로고
    • Saliva and serum levetiracetam concentrations in patients with epilepsy
    • COI: 1:CAS:528:DC%2BD2sXls1yhs74%3D, PID: 17529888
    • Mecarelli O, Voti PL, Pro S, Romolo FS, Rotolo M, Pulitano P, et al. Saliva and serum levetiracetam concentrations in patients with epilepsy. Ther Drug Monit. 2007;29:313–8.
    • (2007) Ther Drug Monit , vol.29 , pp. 313-318
    • Mecarelli, O.1    Voti, P.L.2    Pro, S.3    Romolo, F.S.4    Rotolo, M.5    Pulitano, P.6
  • 50
    • 84907513310 scopus 로고    scopus 로고
    • Development and validation of a GC/MS method for the simultaneous determination of levetiracetam and lamotrigine in whole blood
    • COI: 1:CAS:528:DC%2BC2cXhsFWlurvM
    • Nikolaou P, Papoutsis I, Dona A, Spiliopoulou C, Athanaselis S. Development and validation of a GC/MS method for the simultaneous determination of levetiracetam and lamotrigine in whole blood. J Pharmaceut Biomed. 2015;102:25–32.
    • (2015) J Pharmaceut Biomed. , vol.102 , pp. 25-32
    • Nikolaou, P.1    Papoutsis, I.2    Dona, A.3    Spiliopoulou, C.4    Athanaselis, S.5
  • 51
    • 35548937834 scopus 로고    scopus 로고
    • Drug monitoring: simultaneous analysis of lamotrigine, oxcarbazepine, 10-hydroxycarbazepine, and zonisamide by HPLC-UV and a rapid GC method using a nitrogen-phosphorus detector for levetiracetam
    • COI: 1:CAS:528:DC%2BD2sXht1WnsLzK, PID: 17988451
    • Greiner-Sosanko E, Giannoutsos S, Lower DR, Virji MA, Krasowski MD. Drug monitoring: simultaneous analysis of lamotrigine, oxcarbazepine, 10-hydroxycarbazepine, and zonisamide by HPLC-UV and a rapid GC method using a nitrogen-phosphorus detector for levetiracetam. J Chromatogr Sci. 2007;45:616–22.
    • (2007) J Chromatogr Sci , vol.45 , pp. 616-622
    • Greiner-Sosanko, E.1    Giannoutsos, S.2    Lower, D.R.3    Virji, M.A.4    Krasowski, M.D.5
  • 52
    • 84930178795 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of levetiracetam: comparison of a novel immunoassay with an HPLC method
    • COI: 1:CAS:528:DC%2BC2cXhsFymtLjM, PID: 24577125
    • Bianchi V, Arfini C, Vidali M. Therapeutic drug monitoring of levetiracetam: comparison of a novel immunoassay with an HPLC method. Ther Drug Monit. 2014;36:681–5.
    • (2014) Ther Drug Monit , vol.36 , pp. 681-685
    • Bianchi, V.1    Arfini, C.2    Vidali, M.3
  • 53
    • 77954896142 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of the newer anti-epilepsy medications
    • COI: 1:CAS:528:DC%2BC3cXotV2jtbs%3D
    • Krasowski MD. Therapeutic drug monitoring of the newer anti-epilepsy medications. Pharm J. 2010;3:1909–35.
    • (2010) Pharm J. , vol.3 , pp. 1909-1935
    • Krasowski, M.D.1
  • 54
    • 84939271012 scopus 로고    scopus 로고
    • The efficacy of levetiracetam for focal seizures and its blood levels in children
    • PID: 25579248
    • Iwasaki T, Toki T, Nonoda Y, Ishii M. The efficacy of levetiracetam for focal seizures and its blood levels in children. Brain Dev. 2015;37:773–9.
    • (2015) Brain Dev. , vol.37 , pp. 773-779
    • Iwasaki, T.1    Toki, T.2    Nonoda, Y.3    Ishii, M.4
  • 55
    • 84861670578 scopus 로고    scopus 로고
    • An initial experience with therapeutic drug monitoring of levetiracetam as reported from a pediatric clinical setting in India
    • COI: 1:STN:280:DC%2BC38nlvF2hsA%3D%3D, PID: 22626693
    • Mathew B, Prabha R, Saravanakumar K, Thomas M, Fleming D. An initial experience with therapeutic drug monitoring of levetiracetam as reported from a pediatric clinical setting in India. Neurol India. 2012;60:146.
    • (2012) Neurol India. , vol.60 , pp. 146
    • Mathew, B.1    Prabha, R.2    Saravanakumar, K.3    Thomas, M.4    Fleming, D.5
  • 56
    • 69749123287 scopus 로고    scopus 로고
    • Levetiracetam in children with refractory epilepsy: lack of correlation between plasma concentration and efficacy
    • PID: 19546014
    • Giroux PC, Salas-Prato M, Théorêt Y, Carmant L. Levetiracetam in children with refractory epilepsy: lack of correlation between plasma concentration and efficacy. Seizure. 2009;18:559–63.
    • (2009) Seizure. , vol.18 , pp. 559-563
    • Giroux, P.C.1    Salas-Prato, M.2    Théorêt, Y.3    Carmant, L.4
  • 57
    • 84930379465 scopus 로고    scopus 로고
    • Correlation between efficacy of levetiracetam and serum levels among children with refractory epilepsy
    • PID: 25791893
    • Sheinberg R, Heyman E, Dagan Z, Youngster I, Kohn E, Gandelman-Marton R, et al. Correlation between efficacy of levetiracetam and serum levels among children with refractory epilepsy. Pediatr Neurol. 2015;52:624–8.
    • (2015) Pediatr Neurol , vol.52 , pp. 624-628
    • Sheinberg, R.1    Heyman, E.2    Dagan, Z.3    Youngster, I.4    Kohn, E.5    Gandelman-Marton, R.6
  • 58
    • 34848887217 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of levetiracetam by high-performance liquid chromatography with photodiode array ultraviolet detection: preliminary observations on correlation between plasma concentration and clinical response in patients with refractory epilepsy
    • COI: 1:CAS:528:DC%2BD2sXhtVyntbrN, PID: 17898647
    • Lancelin F, Franchon E, Kraoul L, Garciau I, Brovedani S, Tabaouti K, et al. Therapeutic drug monitoring of levetiracetam by high-performance liquid chromatography with photodiode array ultraviolet detection: preliminary observations on correlation between plasma concentration and clinical response in patients with refractory epilepsy. Ther Drug Monit. 2007;29:576–83.
    • (2007) Ther Drug Monit , vol.29 , pp. 576-583
    • Lancelin, F.1    Franchon, E.2    Kraoul, L.3    Garciau, I.4    Brovedani, S.5    Tabaouti, K.6
  • 60
    • 70349705741 scopus 로고    scopus 로고
    • Monitoring antiepileptic drugs: a level-headed approach
    • COI: 1:CAS:528:DC%2BD1MXht1Cjur%2FI, PID: 19949569
    • St Louis EK. Monitoring antiepileptic drugs: a level-headed approach. Curr Neuropharmacol. 2009;7:115–9.
    • (2009) Curr Neuropharmacol , vol.7 , pp. 115-119
    • St Louis, E.K.1
  • 61
    • 0141717605 scopus 로고    scopus 로고
    • Measuring the efficacy of antiepileptic drugs
    • PID: 12967570
    • Mohanraj R, Brodie MJ. Measuring the efficacy of antiepileptic drugs. Seizure. 2003;12:413–43.
    • (2003) Seizure. , vol.12 , pp. 413-443
    • Mohanraj, R.1    Brodie, M.J.2
  • 63
    • 2442711407 scopus 로고    scopus 로고
    • Detection of electrographic seizures with continuous EEG monitoring in critically ill patients
    • COI: 1:STN:280:DC%2BD2c3mtVaqsg%3D%3D, PID: 15159471
    • Claassen J, Mayer SA, Kowalski RG, Emerson RG, Hirsch LJ. Detection of electrographic seizures with continuous EEG monitoring in critically ill patients. Neurology. 2004;62:1743–8.
    • (2004) Neurology. , vol.62 , pp. 1743-1748
    • Claassen, J.1    Mayer, S.A.2    Kowalski, R.G.3    Emerson, R.G.4    Hirsch, L.J.5
  • 64
    • 84916593636 scopus 로고    scopus 로고
    • The benefits of antiepileptic drug (AED) blood level monitoring to complement clinical management of people with epilepsy
    • PID: 25499154
    • Stepanova D, Beran RG. The benefits of antiepileptic drug (AED) blood level monitoring to complement clinical management of people with epilepsy. Epilepsy Behav. 2015;42:7–9.
    • (2015) Epilepsy Behav , vol.42 , pp. 7-9
    • Stepanova, D.1    Beran, R.G.2
  • 65
    • 77956012067 scopus 로고    scopus 로고
    • Efficacy and tolerability of high oral doses of levetiracetam in children with epilepsy
    • COI: 1:CAS:528:DC%2BC3cXhtV2jtbbM, PID: 20663645
    • Obeid M, Pong AW. Efficacy and tolerability of high oral doses of levetiracetam in children with epilepsy. Epilepsy Res. 2010;91:101–5.
    • (2010) Epilepsy Res , vol.91 , pp. 101-105
    • Obeid, M.1    Pong, A.W.2
  • 66
    • 4344639324 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of levetiracetam
    • COI: 1:CAS:528:DC%2BD2cXnvVGms7c%3D, PID: 15301575
    • Patsalos PN. Clinical pharmacokinetics of levetiracetam. Clin Pharmacokinet. 2004;43:707–24.
    • (2004) Clin Pharmacokinet , vol.43 , pp. 707-724
    • Patsalos, P.N.1
  • 67
    • 84978003056 scopus 로고    scopus 로고
    • Developmental pharmacokinetics in pediatric populations
    • PID: 25762871
    • Lu H, Rosenbaum S. Developmental pharmacokinetics in pediatric populations. J Pediatr Pharmacol Ther. 2014;19:262–76.
    • (2014) J Pediatr Pharmacol Ther. , vol.19 , pp. 262-276
    • Lu, H.1    Rosenbaum, S.2
  • 68
    • 84880787487 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of new-generation antiepileptic drugs at the extremes of age: an update
    • COI: 1:CAS:528:DC%2BC3sXhvVSnu7jO, PID: 23640503
    • Italiano D, Perucca E. Clinical pharmacokinetics of new-generation antiepileptic drugs at the extremes of age: an update. Clin Pharmacokinet. 2013;52:627–45.
    • (2013) Clin Pharmacokinet , vol.52 , pp. 627-645
    • Italiano, D.1    Perucca, E.2
  • 69
    • 77956589604 scopus 로고    scopus 로고
    • Age and comedications influence levetiracetam pharmacokinetics in children
    • PID: 20837299
    • Dahlin MG, Wide K, Ohman I. Age and comedications influence levetiracetam pharmacokinetics in children. Pediatr Neurol. 2010;43:231–5.
    • (2010) Pediatr Neurol , vol.43 , pp. 231-235
    • Dahlin, M.G.1    Wide, K.2    Ohman, I.3
  • 70
    • 84863827127 scopus 로고    scopus 로고
    • Pharmacokinetic variability of four newer antiepileptic drugs, lamotrigine, levetiracetam, oxcarbazepine, and topiramate: a comparison of the impact of age and comedication
    • Landmark CJ, Baftiu A, Tysse I, Valso B, Larsson PG, Rytter E, et al. Pharmacokinetic variability of four newer antiepileptic drugs, lamotrigine, levetiracetam, oxcarbazepine, and topiramate: a comparison of the impact of age and comedication. Ther Drug Monit. 2012;34:440–5.
    • (2012) Ther Drug Monit , vol.34 , pp. 440-445
    • Landmark, C.J.1    Baftiu, A.2    Tysse, I.3    Valso, B.4    Larsson, P.G.5    Rytter, E.6
  • 71
    • 41949136803 scopus 로고    scopus 로고
    • Retrospective population pharmacokinetic analysis of levetiracetam in children and adolescents with epilepsy
    • COI: 1:CAS:528:DC%2BD1cXntVWgsbY%3D, PID: 18399714
    • Toublanc N, Sargentini-Maier ML, Lacroix B, Jacqmin P, Stockis A. Retrospective population pharmacokinetic analysis of levetiracetam in children and adolescents with epilepsy. Clin Pharmacokinet. 2008;47:333–41.
    • (2008) Clin Pharmacokinet , vol.47 , pp. 333-341
    • Toublanc, N.1    Sargentini-Maier, M.L.2    Lacroix, B.3    Jacqmin, P.4    Stockis, A.5
  • 72
    • 84898489017 scopus 로고    scopus 로고
    • Development of an integrated population pharmacokinetic model for oral levetiracetam in populations of various ages and ethnicities
    • COI: 1:CAS:528:DC%2BC2cXmtlemsbk%3D, PID: 23877106
    • Toublanc N, Lacroix BD, Yamamoto J. Development of an integrated population pharmacokinetic model for oral levetiracetam in populations of various ages and ethnicities. Drug Metab Pharmacokinet. 2014;29:61–8.
    • (2014) Drug Metab Pharmacokinet , vol.29 , pp. 61-68
    • Toublanc, N.1    Lacroix, B.D.2    Yamamoto, J.3
  • 73
    • 84862523622 scopus 로고    scopus 로고
    • Population pharmacokinetics modeling of levetiracetam in Chinese children with epilepsy
    • COI: 1:CAS:528:DC%2BC38XotVOqtrs%3D, PID: 22669118
    • Wang Y, Wang L, Lu W, Shang D, Wei M, Wu Y. Population pharmacokinetics modeling of levetiracetam in Chinese children with epilepsy. Acta Pharmacol Sin. 2012;33:845–51.
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 845-851
    • Wang, Y.1    Wang, L.2    Lu, W.3    Shang, D.4    Wei, M.5    Wu, Y.6
  • 74
    • 65549128284 scopus 로고    scopus 로고
    • Population pharmacokinetics of levetiracetam and dosing recommendation in children with epilepsy
    • COI: 1:CAS:528:DC%2BD1MXms1Skt7w%3D, PID: 19175400
    • Chhun S, Jullien V, Rey E, Dulac O, Chiron C, Pons G. Population pharmacokinetics of levetiracetam and dosing recommendation in children with epilepsy. Epilepsia. 2009;50:1150–7.
    • (2009) Epilepsia. , vol.50 , pp. 1150-1157
    • Chhun, S.1    Jullien, V.2    Rey, E.3    Dulac, O.4    Chiron, C.5    Pons, G.6
  • 75
    • 84928154904 scopus 로고    scopus 로고
    • Evidence-based guideline: management of an unprovoked first seizure in adults
    • PID: 25901057
    • Krumholz A, Wiebe S, Gronseth GS, Gloss DS, Sanchez AM, Kabir AA, et al. Evidence-based guideline: management of an unprovoked first seizure in adults. Neurology. 2015;84:1705–13.
    • (2015) Neurology. , vol.84 , pp. 1705-1713
    • Krumholz, A.1    Wiebe, S.2    Gronseth, G.S.3    Gloss, D.S.4    Sanchez, A.M.5    Kabir, A.A.6
  • 76
    • 45749150011 scopus 로고    scopus 로고
    • Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies
    • COI: 1:CAS:528:DC%2BD1cXpslWmurs%3D, PID: 18397299
    • Patsalos PN, Berry DJ, Bourgeois BFD, Cloyd JC, Glauser TA, Johannessen SI, et al. Antiepileptic drugs—best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies. Epilepsia. 2008;49:1239–79.
    • (2008) Epilepsia. , vol.49 , pp. 1239-1279
    • Patsalos, P.N.1    Berry, D.J.2    Bourgeois, B.F.D.3    Cloyd, J.C.4    Glauser, T.A.5    Johannessen, S.I.6


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