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Volumn 4 DEC, Issue , 2013, Pages

Clinical pharmacology and pharmacokinetics of levetiracetam

Author keywords

Epilepsy; Levetiracetam; Pharmacokinetics

Indexed keywords

ETIRACETAM;

EID: 84891649144     PISSN: None     EISSN: 16642295     Source Type: Journal    
DOI: 10.3389/fneur.2013.00192     Document Type: Review
Times cited : (81)

References (43)
  • 1
    • 84891654774 scopus 로고    scopus 로고
    • Keppra Injection (Levetiracetam) Package Insert. Smyrna, GA: UCB Pharma, Inc.
    • Keppra Injection (Levetiracetam) Package Insert. Smyrna, GA: UCB Pharma, Inc (2013).
    • (2013)
  • 2
    • 4344639324 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of levetiracetam
    • doi:10.2165/00003088-200443110-00002
    • Patsolos PN. Clinical pharmacokinetics of levetiracetam. Clin Pharmacokinet (2004) 43:707-24. doi:10.2165/00003088-200443110-00002.
    • (2004) Clin Pharmacokinet , vol.43 , pp. 707-724
    • Patsolos, P.N.1
  • 3
    • 33846002757 scopus 로고    scopus 로고
    • Towards better brain management: nootropics
    • doi:10.2174/092986707779313408
    • Malik R, Sangwan A, Saihgal R, Kindal DP, Piplani P. Towards better brain management: nootropics. Curr Med Chem (2007) 14:123-31. doi:10.2174/092986707779313408.
    • (2007) Curr Med Chem , vol.14 , pp. 123-131
    • Malik, R.1    Sangwan, A.2    Saihgal, R.3    Kindal, D.P.4    Piplani, P.5
  • 4
    • 84855427080 scopus 로고    scopus 로고
    • Adjunctive levetriacetam in children, adolescents, and adults with primary generalized seizures: open-label, noncomparative, multicenter, long-term follow-up study
    • doi:10.1111/j.1528-1167.2011.03300.x
    • Delanty N, Jones J, Tonner F. Adjunctive levetriacetam in children, adolescents, and adults with primary generalized seizures: open-label, noncomparative, multicenter, long-term follow-up study. Epilepsia (2012) 53:111-9. doi:10.1111/j.1528-1167.2011.03300.x.
    • (2012) Epilepsia , vol.53 , pp. 111-119
    • Delanty, N.1    Jones, J.2    Tonner, F.3
  • 5
    • 66749161081 scopus 로고    scopus 로고
    • Intravenous levetiracetam in critically ill children with status epilepticus or acute repetitive seizures
    • doi:10.1097/PCC.0b013e3181a0e1cf
    • Abend NS, Monk H, Licht DJ, Dlugos DJ. Intravenous levetiracetam in critically ill children with status epilepticus or acute repetitive seizures. Pediatr Crit Care Med (2009) 10:505-10. doi:10.1097/PCC.0b013e3181a0e1cf.
    • (2009) Pediatr Crit Care Med , vol.10 , pp. 505-510
    • Abend, N.S.1    Monk, H.2    Licht, D.J.3    Dlugos, D.J.4
  • 6
    • 70349780480 scopus 로고    scopus 로고
    • New Treatment options in status epilepticus: a critical review on intravenous levetiracetam
    • doi:10.1177/1756285608100460
    • Trinka E, Dobesberger J. New Treatment options in status epilepticus: a critical review on intravenous levetiracetam. Ther Adv Neurol Disord (2009) 2:79-91. doi:10.1177/1756285608100460.
    • (2009) Ther Adv Neurol Disord , vol.2 , pp. 79-91
    • Trinka, E.1    Dobesberger, J.2
  • 7
    • 0035169113 scopus 로고    scopus 로고
    • Levetiracetam: a novel antiepileptic drug
    • doi:10.1592/phco.21.17.1375.34432
    • Hovinga CA. Levetiracetam: a novel antiepileptic drug. Pharmacotherapy (2001) 21:1375-88. doi:10.1592/phco.21.17.1375.34432.
    • (2001) Pharmacotherapy , vol.21 , pp. 1375-1388
    • Hovinga, C.A.1
  • 8
    • 77954481733 scopus 로고    scopus 로고
    • High-dose intravenous levetiracetam for acute seizure exacerbation in children with intractable epilepsy
    • doi:10.1111/j.1528-1167.2010.02519.x
    • Depositario-Cabacar DT, Peters JM, Pong AW, Roth J, Rotenberg A, Viviello JJ Jr., et al. High-dose intravenous levetiracetam for acute seizure exacerbation in children with intractable epilepsy. Epilepsia (2010) 51:1319-22. doi:10.1111/j.1528-1167.2010.02519.x.
    • (2010) Epilepsia , vol.51 , pp. 1319-1322
    • Depositario-Cabacar, D.T.1    Peters, J.M.2    Pong, A.W.3    Roth, J.4    Rotenberg, A.5    Viviello Jr., J.J.6
  • 9
    • 33745974941 scopus 로고    scopus 로고
    • Single-dose bioavailability of levetiracetam intravenous infusion relative to oral tablets and multiple-dose pharmacokinetics and tolerability of levetiracetam intravenous infusion compared with placebo in healthy subjects
    • doi:10.1016/j.clinthera.2006.05.004
    • Ramael S, De Smedt F, Toublanc N, Otoul C, Boulanger P, Riethuisen JM, et al. Single-dose bioavailability of levetiracetam intravenous infusion relative to oral tablets and multiple-dose pharmacokinetics and tolerability of levetiracetam intravenous infusion compared with placebo in healthy subjects. Clin Ther (2006) 28:734-44. doi:10.1016/j.clinthera.2006.05.004.
    • (2006) Clin Ther , vol.28 , pp. 734-744
    • Ramael, S.1    De Smedt, F.2    Toublanc, N.3    Otoul, C.4    Boulanger, P.5    Riethuisen, J.M.6
  • 10
    • 33746115639 scopus 로고    scopus 로고
    • Levetiracetam intravenous infusion: a randomized, placebo-controlled safety and pharmacokinetic study
    • doi:10.1111/j.1528-1167.2006.00586.x
    • Ramael S, Daoust A, Otoul C, Toublanc N, Troenaru M, Lu ZS, et al. Levetiracetam intravenous infusion: a randomized, placebo-controlled safety and pharmacokinetic study. Epilepsia (2006) 47:1128-35. doi:10.1111/j.1528-1167.2006.00586.x.
    • (2006) Epilepsia , vol.47 , pp. 1128-1135
    • Ramael, S.1    Daoust, A.2    Otoul, C.3    Toublanc, N.4    Troenaru, M.5    Lu, Z.S.6
  • 11
    • 77957020271 scopus 로고    scopus 로고
    • Intramuscular and intravenous levetiracetam in humans: safety and pharmacokinetics
    • doi:10.1016/j.eplepsyres.2010.07.016
    • Leppik I, Goel V, Rarick J, Nixdorf D, Cloyd J. Intramuscular and intravenous levetiracetam in humans: safety and pharmacokinetics. Epilepsy Res (2010) 91:289-92. doi:10.1016/j.eplepsyres.2010.07.016.
    • (2010) Epilepsy Res , vol.91 , pp. 289-292
    • Leppik, I.1    Goel, V.2    Rarick, J.3    Nixdorf, D.4    Cloyd, J.5
  • 12
    • 70350703431 scopus 로고    scopus 로고
    • Rapid infusion of a loading dose of intravenous levetiracetam with minimal dilution: a safety study
    • doi:10.1177/0883073808331351
    • Wheless JW, Clarke D, Hovinga CA, Ellis M, Durmeier M, McGregor A, et al. Rapid infusion of a loading dose of intravenous levetiracetam with minimal dilution: a safety study. J Child Neurol (2009) 24:946-51. doi:10.1177/0883073808331351.
    • (2009) J Child Neurol , vol.24 , pp. 946-951
    • Wheless, J.W.1    Clarke, D.2    Hovinga, C.A.3    Ellis, M.4    Durmeier, M.5    McGregor, A.6
  • 13
    • 20444458809 scopus 로고    scopus 로고
    • Pharmacokinetics of levetiracetam in patients with moderate to severe liver cirrhosis (Child-Pugh classes A, B, and C): characterization by dynamic liver function tests
    • doi:10.1016/j.clpt.2005.02.003
    • Brockmöller J, Thomsen T, Wittstock M, Coupez R, Lochs H, Roots I. Pharmacokinetics of levetiracetam in patients with moderate to severe liver cirrhosis (Child-Pugh classes A, B, and C): characterization by dynamic liver function tests. Clin Pharmacol Ther (2005) 77:529-41. doi:10.1016/j.clpt.2005.02.003.
    • (2005) Clin Pharmacol Ther , vol.77 , pp. 529-541
    • Brockmöller, J.1    Thomsen, T.2    Wittstock, M.3    Coupez, R.4    Lochs, H.5    Roots, I.6
  • 14
    • 34249776676 scopus 로고    scopus 로고
    • Pharmacokinetics of levetiracetam during pregnancy, delivery, in the neonatal period and lactation
    • doi:10.1111/j.1528-1167.2007.01032.x
    • Tomson T, Palm R, Palm R, Kallen K, Ben-Menachem E, Soderfeldt B, et al. Pharmacokinetics of levetiracetam during pregnancy, delivery, in the neonatal period and lactation. Epilepsia (2007) 48:1111-6. doi:10.1111/j.1528-1167.2007.01032.x.
    • (2007) Epilepsia , vol.48 , pp. 1111-1116
    • Tomson, T.1    Palm, R.2    Palm, R.3    Kallen, K.4    Ben-Menachem, E.5    Soderfeldt, B.6
  • 15
    • 84883540852 scopus 로고    scopus 로고
    • Prospective open-label, single-arm, multicenter, safety, tolerability, and pharmacokinetic studies of intravenous levetiracetam in children with epilepsy
    • doi:10.1177/0883073813480241
    • Weinstock A, Ruiz M, Gerard D, Toublanc N, Stockis A, Farooq O, et al. Prospective open-label, single-arm, multicenter, safety, tolerability, and pharmacokinetic studies of intravenous levetiracetam in children with epilepsy. J Child Neurol (2013) 28:1423-9. doi:10.1177/0883073813480241.
    • (2013) J Child Neurol , vol.28 , pp. 1423-1429
    • Weinstock, A.1    Ruiz, M.2    Gerard, D.3    Toublanc, N.4    Stockis, A.5    Farooq, O.6
  • 16
    • 79958740704 scopus 로고    scopus 로고
    • Pharmacokinetics of levetiracetam in neonates with seizures
    • doi:10.1016/j.jpeds.2011.03.057
    • Merhar SL, Schibler KR, Sherwin CM, Meinzen-Derr J, Shi J, Balmakund T, et al. Pharmacokinetics of levetiracetam in neonates with seizures. J Pediatr (2011) 159:152-4. doi:10.1016/j.jpeds.2011.03.057.
    • (2011) J Pediatr , vol.159 , pp. 152-154
    • Merhar, S.L.1    Schibler, K.R.2    Sherwin, C.M.3    Meinzen-Derr, J.4    Shi, J.5    Balmakund, T.6
  • 17
    • 77953111185 scopus 로고    scopus 로고
    • Intravenous levetiracetam in children with seizures: a prospective safety study
    • doi:10.1177/0883073809348795
    • Ng YT, Hastriter EV, Cardenas JF, Khoury EM, Chapman KE. Intravenous levetiracetam in children with seizures: a prospective safety study. J Child Neurol (2010) 25:551-5. doi:10.1177/0883073809348795.
    • (2010) J Child Neurol , vol.25 , pp. 551-555
    • Ng, Y.T.1    Hastriter, E.V.2    Cardenas, J.F.3    Khoury, E.M.4    Chapman, K.E.5
  • 18
    • 34249807897 scopus 로고    scopus 로고
    • Pharmacokinetics of levetiracetam in infants and young children with epilepsy
    • doi:10.1111/j.1528-1167.2007.01090.x
    • Glauser TA, Mitchell WG, Weinstock A, Bebin M, Chen D, Coupez R, et al. Pharmacokinetics of levetiracetam in infants and young children with epilepsy. Epilepsia (2007) 48:1117-22. doi:10.1111/j.1528-1167.2007.01090.x.
    • (2007) Epilepsia , vol.48 , pp. 1117-1122
    • Glauser, T.A.1    Mitchell, W.G.2    Weinstock, A.3    Bebin, M.4    Chen, D.5    Coupez, R.6
  • 19
    • 36048971625 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interaction of levetiracetam on carbamazepine, valproic acid, topiramate, and lamotrigine in children with epilepsy
    • doi:10.1111/j.1528-1167.2007.01201.x
    • Otoul C, De Smedt H, Stockis A. Lack of pharmacokinetic interaction of levetiracetam on carbamazepine, valproic acid, topiramate, and lamotrigine in children with epilepsy. Epilepsia (2007) 48:2111-5. doi:10.1111/j.1528-1167.2007.01201.x.
    • (2007) Epilepsia , vol.48 , pp. 2111-2115
    • Otoul, C.1    De Smedt, H.2    Stockis, A.3
  • 20
    • 79952439180 scopus 로고    scopus 로고
    • Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy
    • doi:10.1016/j.eplepsyres.2011.01.007
    • Freitas-Lima P, Alexandre V Jr, Pereira LR, Feletti F, Perucca E, Sakamoto AC. Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy. Epilepsy Res (2011) 94:117-20. doi:10.1016/j.eplepsyres.2011.01.007.
    • (2011) Epilepsy Res , vol.94 , pp. 117-120
    • Freitas-Lima, P.1    Alexandre Jr., V.2    Pereira, L.R.3    Feletti, F.4    Perucca, E.5    Sakamoto, A.C.6
  • 21
    • 78650843702 scopus 로고    scopus 로고
    • Efficacy of intravenous levetiracetam as an add-on treatment in status epilepticus: a multicentric observational study
    • doi:10.1016/j.seizure.2010.10.009
    • Aiguabella M, Falip M, Villanueva V, de la Penya P, Molins A, Garcia-Morales I, et al. Efficacy of intravenous levetiracetam as an add-on treatment in status epilepticus: a multicentric observational study. Seizure (2011) 20:60-4. doi:10.1016/j.seizure.2010.10.009.
    • (2011) Seizure , vol.20 , pp. 60-64
    • Aiguabella, M.1    Falip, M.2    Villanueva, V.3    de la Penya, P.4    Molins, A.5    Garcia-Morales, I.6
  • 23
    • 79952549970 scopus 로고    scopus 로고
    • Use of intravenous levetiracetam for management of acute seizures in neonates
    • doi:10.1016/j.pediatrneurol.2010.11.005
    • Khan O, Chang E, Cipriani C, Wright C, Crisp E, Kirmani B. Use of intravenous levetiracetam for management of acute seizures in neonates. Pediatr Neurol (2011) 44:265-9. doi:10.1016/j.pediatrneurol.2010.11.005.
    • (2011) Pediatr Neurol , vol.44 , pp. 265-269
    • Khan, O.1    Chang, E.2    Cipriani, C.3    Wright, C.4    Crisp, E.5    Kirmani, B.6
  • 24
    • 53249090387 scopus 로고    scopus 로고
    • Tolerability and dosing experience of intravenous levetiracetam in children and infants
    • doi:10.1016/j.eplepsyres.2008.05.004
    • Michaelides C, Thibert RL, Shapiro MJ, Kinirons P, John T, Manchharam D, et al. Tolerability and dosing experience of intravenous levetiracetam in children and infants. Epilepsy Res (2008) 81:143-7. doi:10.1016/j.eplepsyres.2008.05.004.
    • (2008) Epilepsy Res , vol.81 , pp. 143-147
    • Michaelides, C.1    Thibert, R.L.2    Shapiro, M.J.3    Kinirons, P.4    John, T.5    Manchharam, D.6
  • 25
    • 77549083859 scopus 로고    scopus 로고
    • Levetiracetam in the treatment of neonatal seizures: a pilot study
    • doi:10.1016/j.seizure.2010.01.003
    • Furwentsches A, Bussman C, Ramantani G, Ebinger F, Philippi H, Poschl J, et al. Levetiracetam in the treatment of neonatal seizures: a pilot study. Seizure (2010) 19:185-9. doi:10.1016/j.seizure.2010.01.003.
    • (2010) Seizure , vol.19 , pp. 185-189
    • Furwentsches, A.1    Bussman, C.2    Ramantani, G.3    Ebinger, F.4    Philippi, H.5    Poschl, J.6
  • 26
  • 27
    • 78751604631 scopus 로고    scopus 로고
    • Efficacy and tolerability of levetiracetam in children with epilepsy
    • doi:10.1016/j.braindev.2010.03.002
    • Li J, Xiao N, Chen S. Efficacy and tolerability of levetiracetam in children with epilepsy. Brain Dev (2011) 33:145-51. doi:10.1016/j.braindev.2010.03.002.
    • (2011) Brain Dev , vol.33 , pp. 145-151
    • Li, J.1    Xiao, N.2    Chen, S.3
  • 28
    • 66349133603 scopus 로고    scopus 로고
    • Role of intravenous levetiracetam in acute seizure management of children
    • doi:10.1016/j.pediatrneurol.2009.02.016
    • Kirmani BF, Crisp ED, Kayani S, Rajab H. Role of intravenous levetiracetam in acute seizure management of children. Pediatr Neurol (2009) 41:37-9. doi:10.1016/j.pediatrneurol.2009.02.016.
    • (2009) Pediatr Neurol , vol.41 , pp. 37-39
    • Kirmani, B.F.1    Crisp, E.D.2    Kayani, S.3    Rajab, H.4
  • 29
    • 38949184571 scopus 로고    scopus 로고
    • Intravenous levetiracetam in children with epilepsy
    • doi:10.1016/j.pediatrneurol.2007.11.003
    • Goraya JS, Khurana DS, Valencia I, Melvin JJ, Cruz M, Legido A, et al. Intravenous levetiracetam in children with epilepsy. Pediatr Neurol (2008) 38:177-80. doi:10.1016/j.pediatrneurol.2007.11.003.
    • (2008) Pediatr Neurol , vol.38 , pp. 177-180
    • Goraya, J.S.1    Khurana, D.S.2    Valencia, I.3    Melvin, J.J.4    Cruz, M.5    Legido, A.6
  • 30
    • 58149154641 scopus 로고    scopus 로고
    • Levetiracetam in children with refractory status epilepticus
    • doi:10.1016/j.yebeh.2008.09.028
    • Gallentine WB, Hunnicutt AS, Husain AM. Levetiracetam in children with refractory status epilepticus. Epilepsy Behav (2009) 14:215-8. doi:10.1016/j.yebeh.2008.09.028.
    • (2009) Epilepsy Behav , vol.14 , pp. 215-218
    • Gallentine, W.B.1    Hunnicutt, A.S.2    Husain, A.M.3
  • 31
    • 84886719001 scopus 로고    scopus 로고
    • Role of intravenous levetiracetam for acute seizure management in preterm neonates
    • doi:10.1016/j.pediatrneurol.2013.05.008
    • Khan O, Cipriani C, Wright C, Crisp E, Kirmani B. Role of intravenous levetiracetam for acute seizure management in preterm neonates. Pediatr Neurol (2013) 49:340-3. doi:10.1016/j.pediatrneurol.2013.05.008.
    • (2013) Pediatr Neurol , vol.49 , pp. 340-343
    • Khan, O.1    Cipriani, C.2    Wright, C.3    Crisp, E.4    Kirmani, B.5
  • 32
    • 84883535358 scopus 로고    scopus 로고
    • Efficacy and tolerability of intravenous levetiracetam in children
    • doi:10.3389/fneur.2013.00120
    • Aceves J, Khan O, Mungall D, Fonkem E, Wright C, Wenner A, et al. Efficacy and tolerability of intravenous levetiracetam in children. Front Neurol (2013) 4:120. doi:10.3389/fneur.2013.00120.
    • (2013) Front Neurol , vol.4 , pp. 120
    • Aceves, J.1    Khan, O.2    Mungall, D.3    Fonkem, E.4    Wright, C.5    Wenner, A.6
  • 33
    • 73949100798 scopus 로고    scopus 로고
    • Acute seizure management in children
    • doi:10.2217/phe.09.59
    • Kirmani BF. Acute seizure management in children. Pediatric Health (2009) 3:543-9. doi:10.2217/phe.09.59.
    • (2009) Pediatric Health , vol.3 , pp. 543-549
    • Kirmani, B.F.1
  • 34
    • 84867862415 scopus 로고    scopus 로고
    • Levetiracetam-associated aggravation of myoclonic seizure in children
    • doi:10.1016/j.seizure.2012.08.008
    • Liu YH, Wang XL, Deng YC, Zhao G. Levetiracetam-associated aggravation of myoclonic seizure in children. Seizure (2012) 21:807-9. doi:10.1016/j.seizure.2012.08.008.
    • (2012) Seizure , vol.21 , pp. 807-809
    • Liu, Y.H.1    Wang, X.L.2    Deng, Y.C.3    Zhao, G.4
  • 35
    • 84863944843 scopus 로고    scopus 로고
    • Levetiracetam may worsen myoclonus in patients with juvenile myoclonic epilepsy: case reports
    • doi:10.1097/WNF.0b013e31825eed8c
    • Babtain FA. Levetiracetam may worsen myoclonus in patients with juvenile myoclonic epilepsy: case reports. Clin Neuropharmacol (2012) 35:201-2. doi:10.1097/WNF.0b013e31825eed8c.
    • (2012) Clin Neuropharmacol , vol.35 , pp. 201-202
    • Babtain, F.A.1
  • 36
    • 77956193510 scopus 로고    scopus 로고
    • Levetiracetam-induced seizure aggravation associated with continuous spikes and waves during slow sleep in children with refractory epilepsies
    • doi:10.1684/epd.2010.0305
    • Caraballo RH, Cersósimo R, De los Santos C. Levetiracetam-induced seizure aggravation associated with continuous spikes and waves during slow sleep in children with refractory epilepsies. Epileptic Disord (2010) 12:146-50. doi:10.1684/epd.2010.0305.
    • (2010) Epileptic Disord , vol.12 , pp. 146-150
    • Caraballo, R.H.1    Cersósimo, R.2    De los Santos, C.3
  • 38
    • 0038644777 scopus 로고    scopus 로고
    • A systematic review of the behavioral effects of levetiracetam in adults with epilepsy, cognitive disorders, or an anxiety disorder during clinical trials
    • doi:10.1016/S1525-5050(03)00005-2
    • Cramer JA, De Rue K, Devinsky O, Edrich P, Trimble MR. A systematic review of the behavioral effects of levetiracetam in adults with epilepsy, cognitive disorders, or an anxiety disorder during clinical trials. Epilepsy Behav (2003) 4:124-32. doi:10.1016/S1525-5050(03)00005-2.
    • (2003) Epilepsy Behav , vol.4 , pp. 124-132
    • Cramer, J.A.1    De Rue, K.2    Devinsky, O.3    Edrich, P.4    Trimble, M.R.5
  • 39
    • 0035673064 scopus 로고    scopus 로고
    • Levetiracetam psychosis in children with epilepsy
    • doi:10.1046/j.1528-1157.2001.32101.x
    • Kossoff EH, Bergey GK, Freeman JM, Vining EP. Levetiracetam psychosis in children with epilepsy. Epilepsia (2001) 42:1611-3. doi:10.1046/j.1528-1157.2001.32101.x.
    • (2001) Epilepsia , vol.42 , pp. 1611-1613
    • Kossoff, E.H.1    Bergey, G.K.2    Freeman, J.M.3    Vining, E.P.4
  • 42
    • 34447635871 scopus 로고    scopus 로고
    • Suicidal ideation in epilepsy and levetiracetam therapy
    • doi:10.1016/j.yebeh.2007.04.008
    • Mula M, Sander JW. Suicidal ideation in epilepsy and levetiracetam therapy. Epilepsy Behav (2007) 11:130-2. doi:10.1016/j.yebeh.2007.04.008.
    • (2007) Epilepsy Behav , vol.11 , pp. 130-132
    • Mula, M.1    Sander, J.W.2


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