Development and validation of an analytical method based on high performance thin layer chromatography for the simultaneous determination of lamotrigine, zonisamide and levetiracetam in human plasma

Journal of Pharmaceutical and Biomedical Analysis

Volumn 56, Issue 4, 2011, Pages 763-770

  Antonilli, Letizia ^a   Brusadin, Valentina ^a   Filipponi, Francesca ^a   Guglielmi, Renzo ^b   Nencini, Paolo ^a  

^a POLICLINICO UMBERTO I   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Antiepileptics; HPLC; HPTLC; LC MS MS; Plasma concentrations

Indexed keywords

ETIRACETAM; LAMOTRIGINE; ZONISAMIDE;

ADOLESCENT; ADULT; AGED; ANALYTIC METHOD; ARTICLE; CALIBRATION; CHILD; DENSITOMETRY; DRUG BLOOD LEVEL; DRUG DETERMINATION; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PERFORMANCE THIN LAYER CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; VALIDATION PROCESS;

ANTICONVULSANTS; CALIBRATION; CHROMATOGRAPHY, THIN LAYER; DRUG MONITORING; HUMANS; ISOXAZOLES; LINEAR MODELS; MASS SPECTROMETRY; PIRACETAM; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TRIAZINES;

EID: 81155162541     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2011.07.018     Document Type: Article

References (18)

1. Kwan P., Brodie M.J. Drug treatment of epilelpsy: when does it fail and how to optimize its use?. CNS Spectr. 2004, 9:110-119.
2. Winkler S.R., Luer M.S. Antiepileptic drug review: part 1. Surg. Neurol. 1998, 49:449-452.
3. LaRoche S.M., Helmers S.L. The new antiepileptics drugs: clinical applications. JAMA 2004, 291:615-620.
4. De Spiegeleer B., Van Hoorebeke B.L., De Spiegeleer A., Castelein P., Van Bortel L. The paradox of scored tablets: a cost-saving risk. Pharmazie 2009, 64:550-552.
5. Sankar R., Glauser T.A. Understanding therapeutic equivalence in epilepsy. CNS Spectr. 2010, 15:112-123.
6. Krasowski M.D. Therapeutic drug monitoring of the newer anti-epilepsy medications. Pharmaceuticals (Basel) 2010, 3:1909-1935.
7. Hvidberg E.F., Dam M. Clinical pharmacokinetics of anticonvusants. Clin. Pharmacokinet. 1976, 1:161-188.
8. Klotz U. The role of pharmacogenetics in the metabolism of antiepileptic drug: pharmacokinetic and therapeutic implications. Clin. Pharmacokinet. 2007, 46:271-279.
9. Perucca E. Age-related changes in pharmacokinetics: predictability and assessment methods. Int. Rev. Neurobiol. 2007, 81:183-199.
10. Anderson G.D. Pharmacokinetic, pharmacodynamic and pharmacogenetic targeted therapy of antiepileptic drugs. Ther. Drug Monit. 2008, 30:173-180.
11. Corti P., Cenni A., Corbini G., Dreassi E., Murratzu C., Caricchia A.M. Thin-layer chromatography and densitometry in drug assay: comparison of methods for monitoring valproic acid in plasma. J. Pharm. Biomed. Anal. 1990, 8:431-436.
12. Patil K.M., Bodhankar S.L. High-performance thin-layer chromatographic determination of lamotrigine in serum. J. Chromatogr. B: Analyt. Technol. Biomed. Life Sci. 2005, 823:152-157.
13. Wójciak-Kosior M., Skalska A., Matysik G., Kryska M. Quantitative analysis of phenobarbital in dosage form by thin-layer chromatography combined with densitometry. J. AOAC Int. 2006, 89:995-998.
14. Mennickent S., Fierro R., Vega M., de Diego M., Godoy C.G. Instrumental planar chromatographic method for determination of carbamazepine in human serum. J. Sep. Sci. 2009, 32:1454-1458.
15. US Department of Health and Human Services, Food and Drug Administration, Center for Biologics Evaluation and Research Guidance for Industry: Bioanalytical Method Validation, Rockville, MD 2001, http://www.fda.gov/downloads/Drugs/Guidance ComplianceRegulatoryInformation/Guidances/UCM070107.pdf (accessed 21.01.2010).
16. International Conference on Harmonization Tripartite Guideline ICH Topic Q2, Validation of Analytical Procedures: Text and Methodology, Geneva 2005, http://www.ich.org/cache/compo/276-254-1.html (accessed 21.01.2010).
17. Bland J.M., Altman D.G. Statistical methods for assessing agreement between two methods of clinical measurement. Lancet 1986, 8476:307-310.
18. Renger B., Végh Z., Ferenczi-Fodor K. Validation of thin layer and high performance thin layer chromatographic methods. J. Chromatogr. A 2011, 1218:2712-2721.