메뉴 건너뛰기




Volumn 10, Issue 2, 2010, Pages 159-171

Levetiracetam: A comprehensive review

Author keywords

Anticonvulsant; Antiepileptic drug; Epilepsy; Keppra ; Kindling model; Levetiracetam; Pyrrolidine; Seizure; Status epilepticus; Synaptic vesicle protein 2a

Indexed keywords

CARBAMAZEPINE; ETIRACETAM; FELBAMATE; GABAPENTIN; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PLACEBO; SELETRACETAM; TOPIRAMATE; VALPROIC ACID; ANTICONVULSIVE AGENT; DRUG DERIVATIVE; PIRACETAM;

EID: 76249093525     PISSN: 14737175     EISSN: 17448360     Source Type: Journal    
DOI: 10.1586/ern.10.3     Document Type: Review
Times cited : (104)

References (108)
  • 1
    • 32944457671 scopus 로고    scopus 로고
    • Epidemiology of idiopathic generalized epilepsies
    • Jallon P, Latour P. Epidemiology of idiopathic generalized epilepsies. Epilepsia 46(Suppl.), 910-914 (2005).
    • (2005) Epilepsia , vol.46 , Issue.SUPPL. , pp. 910-914
    • Jallon, P.1    Latour, P.2
  • 2
    • 84866763338 scopus 로고    scopus 로고
    • Genetic and chromosomal disorders in epilepsy
    • Wheless JW, Willmore LJ, Brumback RA Eds, People's Medical Publishing House, CT, USA
    • Treiman LJ, Treiman DM. Genetic and chromosomal disorders in epilepsy. In: Advanced Therapy in Epilepsy. Wheless JW, Willmore LJ, Brumback RA (Eds). People's Medical Publishing House, CT, USA 67-76 (2009).
    • (2009) Advanced Therapy in Epilepsy , pp. 67-76
    • Treiman, L.J.1    Treiman, D.M.2
  • 4
    • 0026442417 scopus 로고
    • Seizure disorders: The changes with age
    • Hauser WA. Seizure disorders: the changes with age. Epilepsia 33(Suppl. 4), S6-S14 (1992).
    • (1992) Epilepsia , vol.33 , Issue.SUPPL. 4
    • Hauser, W.A.1
  • 5
    • 39749166363 scopus 로고    scopus 로고
    • Levetiracetam for the treatment of idiopathic generalized epilepsy with myoclonic seizures
    • Showed effect on myoclonic seizures, ••
    • Noachtar S, Andermann E, Meyvisch P et al. Levetiracetam for the treatment of idiopathic generalized epilepsy with myoclonic seizures. Neurology 70(8), 607-616 (2008). •• Showed effect on myoclonic seizures.
    • (2008) Neurology , vol.70 , Issue.8 , pp. 607-616
    • Noachtar, S.1    Andermann, E.2    Meyvisch, P.3
  • 8
    • 0034598762 scopus 로고    scopus 로고
    • Early identification of refractory epilepsy
    • Established criteria for medically refractive epilepsy, •
    • Kwan P, Brodie MJ. Early identification of refractory epilepsy. N. Engl. J. Med. 342(5), 314-319 (2000). • Established criteria for medically refractive epilepsy.
    • (2000) N. Engl. J. Med , vol.342 , Issue.5 , pp. 314-319
    • Kwan, P.1    Brodie, M.J.2
  • 9
    • 34247882628 scopus 로고    scopus 로고
    • Levetiracetam: The profile of a novel anticonvulsant drug-part I: preclinical data
    • De Smedt T, Raedt R, Vonck K, Boon P. Levetiracetam: the profile of a novel anticonvulsant drug-part I: preclinical data. CNS Drug Rev. 13(1), 43-56 (2007).
    • (2007) CNS Drug Rev , vol.13 , Issue.1 , pp. 43-56
    • De Smedt, T.1    Raedt, R.2    Vonck, K.3    Boon, P.4
  • 10
    • 36649032950 scopus 로고    scopus 로고
    • Levetiracetam: The first SV2A ligand for the treatment of epilepsy
    • Klitgaard H, Verdru P. Levetiracetam: the first SV2A ligand for the treatment of epilepsy. Expert Opin. Drug Discov. 2(11), 1537-1545 (2007).
    • (2007) Expert Opin. Drug Discov , vol.2 , Issue.11 , pp. 1537-1545
    • Klitgaard, H.1    Verdru, P.2
  • 11
    • 0032563178 scopus 로고    scopus 로고
    • Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy
    • Showed that levetiracetam (LEV) did not have action in the traditional antiepileptic drug screening animal models, but did have antiseizure activity in the kindling model, ••
    • Klitgaard H, Matagne A, Gobert J, Wulfert E. Evidence for a unique profile of levetiracetam in rodent models of seizures and epilepsy. Eur. J. Pharmacol. 353(2-3), 191-206 (1998). •• Showed that levetiracetam (LEV) did not have action in the traditional antiepileptic drug screening animal models, but did have antiseizure activity in the kindling model.
    • (1998) Eur. J. Pharmacol , vol.353 , Issue.2-3 , pp. 191-206
    • Klitgaard, H.1    Matagne, A.2    Gobert, J.3    Wulfert, E.4
  • 12
    • 34248136001 scopus 로고    scopus 로고
    • Levetiracetam: Part II, the clinical profile of a novel anticonvulsant drug
    • De Smedt T, Raedt R, Vonck K, Boon P. Levetiracetam: part II, the clinical profile of a novel anticonvulsant drug. CNS Drug Rev. 13(1), 57-78 (2007).
    • (2007) CNS Drug Rev , vol.13 , Issue.1 , pp. 57-78
    • De Smedt, T.1    Raedt, R.2    Vonck, K.3    Boon, P.4
  • 13
    • 3042748137 scopus 로고    scopus 로고
    • The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam
    • Described the mechanism of action of LEV for the first time, ••
    • Lynch BA, Lambeng N, Nocka K et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc. Natl Acad. Sci. USA 101(26), 9861-9866 (2004). •• Described the mechanism of action of LEV for the first time.
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , Issue.26 , pp. 9861-9866
    • Lynch, B.A.1    Lambeng, N.2    Nocka, K.3
  • 14
    • 0028825031 scopus 로고
    • The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes
    • Noyer M, Gillard M, Matagne A, Henichart JP, Wulfert E. The novel antiepileptic drug levetiracetam (ucb L059) appears to act via a specific binding site in CNS membranes. Eur. J. Pharmacol. 286(2), 137-146 (1995).
    • (1995) Eur. J. Pharmacol , vol.286 , Issue.2 , pp. 137-146
    • Noyer, M.1    Gillard, M.2    Matagne, A.3    Henichart, J.P.4    Wulfert, E.5
  • 15
    • 0033592991 scopus 로고    scopus 로고
    • Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)
    • Crowder KM, Gunther JM, Jones TA et al. Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A). Proc. Natl Acad. Sci. USA 96(26), 15268-15273 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , Issue.26 , pp. 15268-15273
    • Crowder, K.M.1    Gunther, J.M.2    Jones, T.A.3
  • 16
    • 0033398955 scopus 로고    scopus 로고
    • SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release
    • Janz R, Goda Y, Geppert M, Missler M, Sudhof TC. SV2A and SV2B function as redundant Ca2+ regulators in neurotransmitter release. Neuron 24(4), 1003-1016 (1999).
    • (1999) Neuron , vol.24 , Issue.4 , pp. 1003-1016
    • Janz, R.1    Goda, Y.2    Geppert, M.3    Missler, M.4    Sudhof, T.C.5
  • 17
    • 67649992215 scopus 로고    scopus 로고
    • Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam
    • Epub ahead of print
    • Kaminski RM, Gillard M, Leclercq K et al. Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam. Epilepsia (2009) (Epub ahead of print).
    • (2009) Epilepsia
    • Kaminski, R.M.1    Gillard, M.2    Leclercq, K.3
  • 18
    • 0035933671 scopus 로고    scopus 로고
    • Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices
    • Niespodziany I, Klitgaard H, Margineanu DG. Levetiracetam inhibits the high-voltage-activated Ca(2+) current in pyramidal neurones of rat hippocampal slices. Neurosci. Lett. 306(1-2), 5-8 (2001).
    • (2001) Neurosci. Lett , vol.306 , Issue.1-2 , pp. 5-8
    • Niespodziany, I.1    Klitgaard, H.2    Margineanu, D.G.3
  • 19
    • 0036193683 scopus 로고    scopus 로고
    • Selective blockade of N-type calcium channels by levetiracetam
    • Lukyanetz EA, Shkryl VM, Kostyuk PG. Selective blockade of N-type calcium channels by levetiracetam. Epilepsia 43(1), 9-18 (2002).
    • (2002) Epilepsia , vol.43 , Issue.1 , pp. 9-18
    • Lukyanetz, E.A.1    Shkryl, V.M.2    Kostyuk, P.G.3
  • 20
    • 0345700624 scopus 로고    scopus 로고
    • Levetiracetam reduces caffeine-induced Ca2+ transients and epileptiform potentials in hippocampal neurons
    • Angehagen M, Margineanu DG, Ben-Menachem E et al. Levetiracetam reduces caffeine-induced Ca2+ transients and epileptiform potentials in hippocampal neurons. Neuroreport 14(3), 471-475 (2003).
    • (2003) Neuroreport , vol.14 , Issue.3 , pp. 471-475
    • Angehagen, M.1    Margineanu, D.G.2    Ben-Menachem, E.3
  • 21
    • 18044370863 scopus 로고    scopus 로고
    • The antiepileptic drug levetiracetam decreases the inositol 1,4,5-trisphosphate- dependent Ca2+I increase induced by ATP and bradykinin in PC12 cells
    • Cataldi M, Lariccia V, Secondo A, di Renzo G, Annunziato L. The antiepileptic drug levetiracetam decreases the inositol 1,4,5-trisphosphate- dependent Ca2+I increase induced by ATP and bradykinin in PC12 cells. J. Pharmacol. Exp. Ther. 313(2), 720-730 (2005).
    • (2005) J. Pharmacol. Exp. Ther , vol.313 , Issue.2 , pp. 720-730
    • Cataldi, M.1    Lariccia, V.2    Secondo, A.3    di Renzo, G.4    Annunziato, L.5
  • 22
    • 0035987775 scopus 로고    scopus 로고
    • The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents
    • Rigo JM, Hans G, Nguyen L et al. The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents. Br. J. Pharmacol. 136(5), 659-672 (2002).
    • (2002) Br. J. Pharmacol , vol.136 , Issue.5 , pp. 659-672
    • Rigo, J.M.1    Hans, G.2    Nguyen, L.3
  • 23
    • 47249120395 scopus 로고    scopus 로고
    • Development of tolerance to levetiracetam in rats with chronic epilepsy
    • van Vliet EA, van SR, Edelbroek PM et al. Development of tolerance to levetiracetam in rats with chronic epilepsy. Epilepsia 49(7), 1151-1159 (2008).
    • (2008) Epilepsia , vol.49 , Issue.7 , pp. 1151-1159
    • van Vliet1    EA, V.S.2    Edelbroek, P.M.3
  • 24
    • 61849097125 scopus 로고    scopus 로고
    • Decreased expression of synaptic vesicle protein 2A, the binding site for levetiracetam, during epileptogenesis and chronic epilepsy
    • van Vliet EA, Aronica E, Redeker S, Boer K, Gorter JA. Decreased expression of synaptic vesicle protein 2A, the binding site for levetiracetam, during epileptogenesis and chronic epilepsy. Epilepsia 50(3), 422-433 (2009).
    • (2009) Epilepsia , vol.50 , Issue.3 , pp. 422-433
    • van Vliet, E.A.1    Aronica, E.2    Redeker, S.3    Boer, K.4    Gorter, J.A.5
  • 25
    • 4344639324 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of levetiracetam
    • Patsalos PN. Clinical pharmacokinetics of levetiracetam. Clin. Pharmacokinet. 43(11), 707-724 (2004).
    • (2004) Clin. Pharmacokinet , vol.43 , Issue.11 , pp. 707-724
    • Patsalos, P.N.1
  • 26
    • 0032942934 scopus 로고    scopus 로고
    • Blood and cerebrospinal fluid pharmacokinetics of the novel anticonvulsant levetiracetam (ucb L059) in the rat
    • Doheny HC, Ratnaraj N, Whittington MA, Jefferys JG, Patsalos PN. Blood and cerebrospinal fluid pharmacokinetics of the novel anticonvulsant levetiracetam (ucb L059) in the rat. Epilepsy Res. 34(2-3), 161-168 (1999).
    • (1999) Epilepsy Res , vol.34 , Issue.2-3 , pp. 161-168
    • Doheny, H.C.1    Ratnaraj, N.2    Whittington, M.A.3    Jefferys, J.G.4    Patsalos, P.N.5
  • 27
    • 0034892646 scopus 로고    scopus 로고
    • A microdialysis study of the novel antiepileptic drug levetiracetam: Extracellular pharmacokinetics and effect on taurine in rat brain
    • Tong X, Patsalos PN. A microdialysis study of the novel antiepileptic drug levetiracetam: extracellular pharmacokinetics and effect on taurine in rat brain. Br. J. Pharmacol. 133(6), 867-874 (2001).
    • (2001) Br. J. Pharmacol , vol.133 , Issue.6 , pp. 867-874
    • Tong, X.1    Patsalos, P.N.2
  • 28
    • 1842779114 scopus 로고    scopus 로고
    • Comparative pharmacokinetics and metabolism of levetiracetam, a new anti-epileptic agent, in mouse, rat, rabbit and dog
    • Benedetti MS, Coupez R, Whomsley R et al. Comparative pharmacokinetics and metabolism of levetiracetam, a new anti-epileptic agent, in mouse, rat, rabbit and dog. Xenobiotica 34(3), 281-300 (2004).
    • (2004) Xenobiotica , vol.34 , Issue.3 , pp. 281-300
    • Benedetti, M.S.1    Coupez, R.2    Whomsley, R.3
  • 30
    • 33645813802 scopus 로고    scopus 로고
    • Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein
    • Gillard M, Chatelain P, Fuks B. Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SV2A) in human brain and in CHO cells expressing the human recombinant protein. Eur. J. Pharmacol. 536(1-2), 102-108 (2006).
    • (2006) Eur. J. Pharmacol , vol.536 , Issue.1-2 , pp. 102-108
    • Gillard, M.1    Chatelain, P.2    Fuks, B.3
  • 31
    • 33644789540 scopus 로고    scopus 로고
    • Onset of action of levetiracetam: A RCT trial using therapeutic intensive seizure analysis (TISA)
    • Stefan H, Wang-Tilz Y, Pauli E et al. Onset of action of levetiracetam: a RCT trial using therapeutic intensive seizure analysis (TISA). Epilepsia 47(3), 516-522 (2006).
    • (2006) Epilepsia , vol.47 , Issue.3 , pp. 516-522
    • Stefan, H.1    Wang-Tilz, Y.2    Pauli, E.3
  • 32
    • 0033621925 scopus 로고    scopus 로고
    • Pharmacokinetic profile of levetiracetam: Toward ideal characteristics
    • Patsalos PN. Pharmacokinetic profile of levetiracetam: toward ideal characteristics. Pharmacol. Ther. 85(2), 77-85 (2000).
    • (2000) Pharmacol. Ther , vol.85 , Issue.2 , pp. 77-85
    • Patsalos, P.N.1
  • 34
    • 0032963256 scopus 로고    scopus 로고
    • In vitro evaluation of potential drug interactions with levetiracetam, a new antiepileptic agent
    • Nicolas JM, Collart P, Gerin B et al. In vitro evaluation of potential drug interactions with levetiracetam, a new antiepileptic agent. Drug Metab. Dispos. 27(2), 250-254 (1999).
    • (1999) Drug Metab. Dispos , vol.27 , Issue.2 , pp. 250-254
    • Nicolas, J.M.1    Collart, P.2    Gerin, B.3
  • 35
    • 67649112797 scopus 로고    scopus 로고
    • Pharmacodynamic interactions between antiepileptic drugs: Preclinical data based on isobolography
    • Epub ahead of print
    • Czuczwar SJ, Kaplanski J, Swiderska-Dziewit G et al. Pharmacodynamic interactions between antiepileptic drugs: preclinical data based on isobolography. Expert Opin. Drug Metab. Toxicol. (2009) (Epub ahead of print).
    • (2009) Expert Opin. Drug Metab. Toxicol
    • Czuczwar, S.J.1    Kaplanski, J.2    Swiderska-Dziewit, G.3
  • 36
    • 33645019118 scopus 로고    scopus 로고
    • Pharmacodynamic and pharmacokinetic characterization of interactions between levetiracetam and numerous antiepileptic drugs in the mouse maximal electroshock seizure model: An isobolographic analysis
    • Luszczki JJ, Andres MM, Czuczwar P et al. Pharmacodynamic and pharmacokinetic characterization of interactions between levetiracetam and numerous antiepileptic drugs in the mouse maximal electroshock seizure model: an isobolographic analysis. Epilepsia 47(1), 10-20 (2006).
    • (2006) Epilepsia , vol.47 , Issue.1 , pp. 10-20
    • Luszczki, J.J.1    Andres, M.M.2    Czuczwar, P.3
  • 37
    • 34247096547 scopus 로고    scopus 로고
    • Levetiracetam and felbamate interact both pharmacodynamically and pharmacokinetically: An isobolographic analysis in the mouse maximal electroshock model
    • Luszczki JJ, Andres-Mach MM, Ratnaraj N, Patsalos PN, Czuczwar SJ. Levetiracetam and felbamate interact both pharmacodynamically and pharmacokinetically: an isobolographic analysis in the mouse maximal electroshock model. Epilepsia 48(4), 806-815 (2007).
    • (2007) Epilepsia , vol.48 , Issue.4 , pp. 806-815
    • Luszczki, J.J.1    Andres-Mach, M.M.2    Ratnaraj, N.3    Patsalos, P.N.4    Czuczwar, S.J.5
  • 38
    • 70349484436 scopus 로고    scopus 로고
    • Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6Hz psychomotor seizure model
    • Wojda E, Wlaz A, Patsalos PN, Luszczki JJ. Isobolographic characterization of interactions of levetiracetam with the various antiepileptic drugs in the mouse 6Hz psychomotor seizure model. Epilepsy Res. 86(2-3), 163-174 (2009).
    • (2009) Epilepsy Res , vol.86 , Issue.2-3 , pp. 163-174
    • Wojda, E.1    Wlaz, A.2    Patsalos, P.N.3    Luszczki, J.J.4
  • 39
    • 60349092371 scopus 로고    scopus 로고
    • Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: An isobolographic analysis
    • Dudra-Jastrzebska M, Andres-Mach MM, Sielski M et al. Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis. Eur. J. Pharmacol. 605(1-3), 87-94 (2009).
    • (2009) Eur. J. Pharmacol , vol.605 , Issue.1-3 , pp. 87-94
    • Dudra-Jastrzebska, M.1    Andres-Mach, M.M.2    Sielski, M.3
  • 40
    • 61849098715 scopus 로고    scopus 로고
    • Benefit of combination therapy in epilepsy: A review of the preclinical evidence with levetiracetam
    • Kaminski RM, Matagne A, Patsalos PN, Klitgaard H. Benefit of combination therapy in epilepsy: a review of the preclinical evidence with levetiracetam. Epilepsia 50(3), 387-397 (2009).
    • (2009) Epilepsia , vol.50 , Issue.3 , pp. 387-397
    • Kaminski, R.M.1    Matagne, A.2    Patsalos, P.N.3    Klitgaard, H.4
  • 41
    • 0033811027 scopus 로고    scopus 로고
    • Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures. European Levetiracetam Study Group
    • Randomized control trial established efficacy as adjunct therapy in partial-onset seizures, ••
    • Shorvon SD, Lowenthal A, Janz D, Bielen E, Loiseau P. Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures. European Levetiracetam Study Group. Epilepsia 41(9), 1179-1186 (2000). •• Randomized control trial established efficacy as adjunct therapy in partial-onset seizures.
    • (2000) Epilepsia , vol.41 , Issue.9 , pp. 1179-1186
    • Shorvon, S.D.1    Lowenthal, A.2    Janz, D.3    Bielen, E.4    Loiseau, P.5
  • 42
    • 0033775210 scopus 로고    scopus 로고
    • Efficacy and tolerability of levetiracetam 3000 mg/d in patients with refractory partial seizures: A multicenter, double-blind, responder-selected study evaluating monotherapy. European Levetiracetam Study Group
    • Showed efficacy and safety of LEV as monotherapy, •
    • Ben-Menachem E, Falter U. Efficacy and tolerability of levetiracetam 3000 mg/d in patients with refractory partial seizures: a multicenter, double-blind, responder-selected study evaluating monotherapy. European Levetiracetam Study Group. Epilepsia 41(10), 1276-1283 (2000). • Showed efficacy and safety of LEV as monotherapy.
    • (2000) Epilepsia , vol.41 , Issue.10 , pp. 1276-1283
    • Ben-Menachem, E.1    Falter, U.2
  • 43
    • 0033854805 scopus 로고    scopus 로고
    • Levetiracetam for partial seizures: Results of a double-blind, randomized clinical trial
    • Cereghino JJ, Biton V, bou-Khalil B et al. Levetiracetam for partial seizures: results of a double-blind, randomized clinical trial. Neurology 55(2), 236-242 (2000).
    • (2000) Neurology , vol.55 , Issue.2 , pp. 236-242
    • Cereghino, J.J.1    Biton, V.2    bou-Khalil, B.3
  • 44
    • 33745665605 scopus 로고    scopus 로고
    • Double-blind placebo-controlled trial of adjunctive levetiracetam in pediatric partial seizures
    • Glauser TA, Ayala R, Elterman RD et al. Double-blind placebo-controlled trial of adjunctive levetiracetam in pediatric partial seizures. Neurology 66(11), 1654-1660 (2006).
    • (2006) Neurology , vol.66 , Issue.11 , pp. 1654-1660
    • Glauser, T.A.1    Ayala, R.2    Elterman, R.D.3
  • 45
    • 65549121241 scopus 로고    scopus 로고
    • Adjunctive levetiracetam in infants and young children with refractory partial-onset seizures
    • Showed efficacy and safety in the pediatric population, •
    • Piña-Garza JE, Nordli DR Jr, Rating D et al. Adjunctive levetiracetam in infants and young children with refractory partial-onset seizures. Epilepsia 50(5), 1141-1149 (2009). • Showed efficacy and safety in the pediatric population.
    • (2009) Epilepsia , vol.50 , Issue.5 , pp. 1141-1149
    • Piña-Garza, J.E.1    Nordli Jr, D.R.2    Rating, D.3
  • 46
    • 13444254419 scopus 로고    scopus 로고
    • Levetiracetam in the treatment of infantile spasms
    • Lawlor KM, Devlin AM. Levetiracetam in the treatment of infantile spasms. Eur. J. Paediatr. Neurol. 9(1), 19-22 (2005).
    • (2005) Eur. J. Paediatr. Neurol , vol.9 , Issue.1 , pp. 19-22
    • Lawlor, K.M.1    Devlin, A.M.2
  • 47
    • 35348847340 scopus 로고    scopus 로고
    • Levetiracetam monotherapy in newly diagnosed cryptogenic West syndrome
    • Gumus H, Kumandas S, Per H. Levetiracetam monotherapy in newly diagnosed cryptogenic West syndrome. Pediatr. Neurol. 37(5), 350-353 (2007).
    • (2007) Pediatr. Neurol , vol.37 , Issue.5 , pp. 350-353
    • Gumus, H.1    Kumandas, S.2    Per, H.3
  • 48
    • 40349111143 scopus 로고    scopus 로고
    • Response of infantile spasms to levetiracetam
    • Mikati MA, El BD, Sinno D, Mroueh S. Response of infantile spasms to levetiracetam. Neurology 70(7), 574-575 (2008).
    • (2008) Neurology , vol.70 , Issue.7 , pp. 574-575
    • Mikati, M.A.1    El, B.D.2    Sinno, D.3    Mroueh, S.4
  • 49
    • 0034162331 scopus 로고    scopus 로고
    • A multicentre, double-blind, randomized, parallel group study to evaluate the tolerability and efficacy of two oral doses of levetiracetam, 2000 mg daily and 4000 mg daily, without titration in patients with refractory epilepsy
    • Betts T, Waegemans T, Crawford P. A multicentre, double-blind, randomized, parallel group study to evaluate the tolerability and efficacy of two oral doses of levetiracetam, 2000 mg daily and 4000 mg daily, without titration in patients with refractory epilepsy. Seizure 9(2), 80-87 (2000).
    • (2000) Seizure , vol.9 , Issue.2 , pp. 80-87
    • Betts, T.1    Waegemans, T.2    Crawford, P.3
  • 50
    • 33645019934 scopus 로고    scopus 로고
    • Efficacy and safety of levetiracetam (up to 2000 mg/day) in Taiwanese patients with refractory partial seizures: A multicenter, randomized, double-blind, placebo-controlled study
    • Tsai JJ, Yen DJ, Hsih MS et al. Efficacy and safety of levetiracetam (up to 2000 mg/day) in Taiwanese patients with refractory partial seizures: a multicenter, randomized, double-blind, placebo-controlled study. Epilepsia 47(1), 72-81 (2006).
    • (2006) Epilepsia , vol.47 , Issue.1 , pp. 72-81
    • Tsai, J.J.1    Yen, D.J.2    Hsih, M.S.3
  • 51
    • 61849102266 scopus 로고    scopus 로고
    • Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in Chinese patients with refractory partial-onset seizures
    • Wu XY, Hong Z, Wu X et al. Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in Chinese patients with refractory partial-onset seizures. Epilepsia 50(3), 398-405 (2009).
    • (2009) Epilepsia , vol.50 , Issue.3 , pp. 398-405
    • Wu, X.Y.1    Hong, Z.2    Wu, X.3
  • 52
    • 33747848720 scopus 로고    scopus 로고
    • Assessment of a dose-response relationship of levetiracetam
    • Meencke HJ, Buyle S. Assessment of a dose-response relationship of levetiracetam. Eur. J. Neurol. 13(9), 942-946 (2006).
    • (2006) Eur. J. Neurol , vol.13 , Issue.9 , pp. 942-946
    • Meencke, H.J.1    Buyle, S.2
  • 53
    • 35848938482 scopus 로고    scopus 로고
    • Placebo-controlled study of levetiracetam in idiopathic generalized epilepsy
    • Established efficacy in idiopathic generalized epilepsy, ••
    • Berkovic SF, Knowlton RC, Leroy RF, Schiemann J, Falter U. Placebo-controlled study of levetiracetam in idiopathic generalized epilepsy. Neurology 69(18), 1751-1760 (2007). •• Established efficacy in idiopathic generalized epilepsy.
    • (2007) Neurology , vol.69 , Issue.18 , pp. 1751-1760
    • Berkovic, S.F.1    Knowlton, R.C.2    Leroy, R.F.3    Schiemann, J.4    Falter, U.5
  • 54
    • 67349156067 scopus 로고    scopus 로고
    • Levetiracetam as add-on therapy for idiopathic generalized epilepsy syndromes with onset during adolescence: Analysis of two randomized, double-blind, placebo-controlled studies
    • Rosenfeld WE, Benbadis S, Edrich P, Tassinari CA, Hirsch E. Levetiracetam as add-on therapy for idiopathic generalized epilepsy syndromes with onset during adolescence: analysis of two randomized, double-blind, placebo-controlled studies. Epilepsy Res. 85(1), 72-80 (2009).
    • (2009) Epilepsy Res , vol.85 , Issue.1 , pp. 72-80
    • Rosenfeld, W.E.1    Benbadis, S.2    Edrich, P.3    Tassinari, C.A.4    Hirsch, E.5
  • 55
    • 33846850154 scopus 로고    scopus 로고
    • Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy
    • Demonstrated, as monotherapy, noninferiority to controlled-release carbamazepine, •
    • Brodie MJ, Perucca E, Ryvlin P, Ben-Menachem E, Meencke HJ. Comparison of levetiracetam and controlled-release carbamazepine in newly diagnosed epilepsy. Neurology 68(6), 402-408 (2007). • Demonstrated, as monotherapy, noninferiority to controlled-release carbamazepine.
    • (2007) Neurology , vol.68 , Issue.6 , pp. 402-408
    • Brodie, M.J.1    Perucca, E.2    Ryvlin, P.3    Ben-Menachem, E.4    Meencke, H.J.5
  • 56
    • 67650815220 scopus 로고    scopus 로고
    • Quality of life and seizure control in patients with brain tumor-related epilepsy treated with levetiracetam monotherapy: Preliminary data of an open-label study
    • Epub ahead of print
    • Dinapoli L, Maschio M, Jandolo B et al. Quality of life and seizure control in patients with brain tumor-related epilepsy treated with levetiracetam monotherapy: preliminary data of an open-label study. Neurol. Sci. (2009) (Epub ahead of print).
    • (2009) Neurol. Sci
    • Dinapoli, L.1    Maschio, M.2    Jandolo, B.3
  • 57
    • 67349218398 scopus 로고    scopus 로고
    • Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: A randomized phase II pilot study
    • Lim DA, Tarapore P, Chang E et al. Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study. J. Neurooncol. 93(3), 349-354 (2009).
    • (2009) J. Neurooncol , vol.93 , Issue.3 , pp. 349-354
    • Lim, D.A.1    Tarapore, P.2    Chang, E.3
  • 58
    • 33847189603 scopus 로고    scopus 로고
    • Levetiracetam as a treatment option in non-convulsive status epilepticus
    • Rupprecht S, Franke K, Fitzek S, Witte OW, Hagemann G. Levetiracetam as a treatment option in non-convulsive status epilepticus. Epilepsy Res. 73(3), 238-244 (2007).
    • (2007) Epilepsy Res , vol.73 , Issue.3 , pp. 238-244
    • Rupprecht, S.1    Franke, K.2    Fitzek, S.3    Witte, O.W.4    Hagemann, G.5
  • 59
    • 42449088099 scopus 로고    scopus 로고
    • Intravenous levetiracetam in the treatment of benzodiazepine refractory status epilepticus
    • Knake S, Gruener J, Hattemer K et al. Intravenous levetiracetam in the treatment of benzodiazepine refractory status epilepticus. J. Neurol. Neurosurg. Psychiatry. 79(5), 588-589 (2008).
    • (2008) J. Neurol. Neurosurg. Psychiatry , vol.79 , Issue.5 , pp. 588-589
    • Knake, S.1    Gruener, J.2    Hattemer, K.3
  • 60
    • 70349652319 scopus 로고    scopus 로고
    • Intravenous levetiracetam as treatment for status epilepticus
    • Berning S, Boesebeck F, van Baalen A, Kellinghaus C. Intravenous levetiracetam as treatment for status epilepticus. J. Neurol. 256(10), 1634-1642 (2009).
    • (2009) J. Neurol , vol.256 , Issue.10 , pp. 1634-1642
    • Berning, S.1    Boesebeck, F.2    van Baalen, A.3    Kellinghaus, C.4
  • 61
    • 67849084811 scopus 로고    scopus 로고
    • Two years of experience in the treatment of status epilepticus with intravenous levetiracetam
    • Eue S, Grumbt M, Muller M, Schulze A. Two years of experience in the treatment of status epilepticus with intravenous levetiracetam. Epilepsy Behav. 15(4), 467-469 (2009).
    • (2009) Epilepsy Behav , vol.15 , Issue.4 , pp. 467-469
    • Eue, S.1    Grumbt, M.2    Muller, M.3    Schulze, A.4
  • 62
    • 66149129578 scopus 로고    scopus 로고
    • Intravenous levetiracetam: A new treatment alternative for refractory status epilepticus
    • Moddel G, Bunten S, Dobis C et al. Intravenous levetiracetam: a new treatment alternative for refractory status epilepticus. J. Neurol. Neurosurg. Psychiatry. 80(6), 689-692 (2009).
    • (2009) J. Neurol. Neurosurg. Psychiatry , vol.80 , Issue.6 , pp. 689-692
    • Moddel, G.1    Bunten, S.2    Dobis, C.3
  • 63
    • 61849142679 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of intravenous levetiracetam infusion as add-on in status epilepticus
    • Uges JW, van H, Engelsman J et al. Safety and pharmacokinetics of intravenous levetiracetam infusion as add-on in status epilepticus. Epilepsia 50(3), 415-421 (2009).
    • (2009) Epilepsia , vol.50 , Issue.3 , pp. 415-421
    • Uges1    JW, V.H.2    Engelsman, J.3
  • 64
    • 70349329265 scopus 로고    scopus 로고
    • Safety and efficacy of levetiracetam for critically ill patients with seizures
    • Nau KM, Divertie GD, Valentino AK, Freeman WD. Safety and efficacy of levetiracetam for critically ill patients with seizures. Neurocrit. Care 11(1), 34-37 (2009).
    • (2009) Neurocrit. Care , vol.11 , Issue.1 , pp. 34-37
    • Nau, K.M.1    Divertie, G.D.2    Valentino, A.K.3    Freeman, W.D.4
  • 65
    • 0035048478 scopus 로고    scopus 로고
    • Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: Meta-analysis of controlled trials
    • Temkin NR. Antiepileptogenesis and seizure prevention trials with antiepileptic drugs: meta-analysis of controlled trials. Epilepsia 42(4), 515-524 (2001).
    • (2001) Epilepsia , vol.42 , Issue.4 , pp. 515-524
    • Temkin, N.R.1
  • 66
    • 52449103734 scopus 로고    scopus 로고
    • Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery
    • Milligan TA, Hurwitz S, Bromfield EB. Efficacy and tolerability of levetiracetam versus phenytoin after supratentorial neurosurgery. Neurology 71(9), 665-669 (2008).
    • (2008) Neurology , vol.71 , Issue.9 , pp. 665-669
    • Milligan, T.A.1    Hurwitz, S.2    Bromfield, E.B.3
  • 67
    • 0031908063 scopus 로고    scopus 로고
    • Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy
    • Loscher W, Honack D, Rundfeldt C. Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy. J. Pharmacol. Exp. Ther. 284(2), 474-479 (1998).
    • (1998) J. Pharmacol. Exp. Ther , vol.284 , Issue.2 , pp. 474-479
    • Loscher, W.1    Honack, D.2    Rundfeldt, C.3
  • 68
    • 33748633136 scopus 로고    scopus 로고
    • Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage
    • Wang H, Gao J, Lassiter TF et al. Levetiracetam is neuroprotective in murine models of closed head injury and subarachnoid hemorrhage. Neurocrit. Care 5(1), 71-78 (2006).
    • (2006) Neurocrit. Care , vol.5 , Issue.1 , pp. 71-78
    • Wang, H.1    Gao, J.2    Lassiter, T.F.3
  • 69
    • 34547534763 scopus 로고    scopus 로고
    • Prophylactic treatment with levetiracetam after status epilepticus: Lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats
    • Brandt C, Glien M, Gastens AM et al. Prophylactic treatment with levetiracetam after status epilepticus: lack of effect on epileptogenesis, neuronal damage, and behavioral alterations in rats. Neuropharmacology 53(2), 207-221 (2007).
    • (2007) Neuropharmacology , vol.53 , Issue.2 , pp. 207-221
    • Brandt, C.1    Glien, M.2    Gastens, A.M.3
  • 70
    • 33846062827 scopus 로고    scopus 로고
    • Effect of levetiracetam on visual-spatial memory following status epilepticus
    • Zhou JL, Zhao Q, Holmes GL. Effect of levetiracetam on visual-spatial memory following status epilepticus. Epilepsy Res. 73(1), 65-74 (2007).
    • (2007) Epilepsy Res , vol.73 , Issue.1 , pp. 65-74
    • Zhou, J.L.1    Zhao, Q.2    Holmes, G.L.3
  • 71
    • 63849342861 scopus 로고    scopus 로고
    • EEG stage predicts impairment of spatial memory and learning after experimental status epilepticus in the rat
    • Marsh ST, Good LB, Garvey KJ, Treiman DM. EEG stage predicts impairment of spatial memory and learning after experimental status epilepticus in the rat. Epilepsia 47(Suppl. 4), 314-315 (2006).
    • (2006) Epilepsia , vol.47 , Issue.SUPPL. 4 , pp. 314-315
    • Marsh, S.T.1    Good, L.B.2    Garvey, K.J.3    Treiman, D.M.4
  • 72
    • 0034922707 scopus 로고    scopus 로고
    • Neuroprotective properties of the novel antiepileptic drug levetiracetam in the rat middle cerebral artery occlusion model of focal cerebral ischemia
    • Hanon E, Klitgaard H. Neuroprotective properties of the novel antiepileptic drug levetiracetam in the rat middle cerebral artery occlusion model of focal cerebral ischemia. Seizure 10(4), 287-293 (2001).
    • (2001) Seizure , vol.10 , Issue.4 , pp. 287-293
    • Hanon, E.1    Klitgaard, H.2
  • 73
    • 44849130867 scopus 로고    scopus 로고
    • Effects of levetiracetam on tardive dyskinesia: A randomized, double-blind, placebo-controlled study
    • Woods SW, Saksa JR, Baker CB, Cohen SJ, Tek C. Effects of levetiracetam on tardive dyskinesia: a randomized, double-blind, placebo-controlled study. J. Clin. Psychiatry 69(4), 546-554 (2008).
    • (2008) J. Clin. Psychiatry , vol.69 , Issue.4 , pp. 546-554
    • Woods, S.W.1    Saksa, J.R.2    Baker, C.B.3    Cohen, S.J.4    Tek, C.5
  • 74
    • 22844442888 scopus 로고    scopus 로고
    • Use of levetiracetam to treat tics in children and adolescents with Tourette syndrome
    • Awaad Y, Michon AM, Minarik S. Use of levetiracetam to treat tics in children and adolescents with Tourette syndrome. Mov. Disord. 20(6), 714-718 (2005).
    • (2005) Mov. Disord , vol.20 , Issue.6 , pp. 714-718
    • Awaad, Y.1    Michon, A.M.2    Minarik, S.3
  • 75
    • 35348969794 scopus 로고    scopus 로고
    • A double blind randomized placebo control trial of levetiracetam in Tourette syndrome
    • Smith-Hicks CL, Bridges DD, Paynter NP, Singer HS. A double blind randomized placebo control trial of levetiracetam in Tourette syndrome. Mov. Disord. 22(12), 1764-1770 (2007).
    • (2007) Mov. Disord , vol.22 , Issue.12 , pp. 1764-1770
    • Smith-Hicks, C.L.1    Bridges, D.D.2    Paynter, N.P.3    Singer, H.S.4
  • 76
    • 65449137478 scopus 로고    scopus 로고
    • Double-blind, crossover study of clonidine and levetiracetam in Tourette syndrome
    • Hedderick EF, Morris CM, Singer HS. Double-blind, crossover study of clonidine and levetiracetam in Tourette syndrome. Pediatr. Neurol. 40(6), 420-425 (2009).
    • (2009) Pediatr. Neurol , vol.40 , Issue.6 , pp. 420-425
    • Hedderick, E.F.1    Morris, C.M.2    Singer, H.S.3
  • 77
    • 33845206589 scopus 로고    scopus 로고
    • Open-label pilot study of levetiracetam (Keppra) for the treatment of chorea in Huntington's disease
    • Zesiewicz TA, Sullivan KL, Hauser RA, Sanchez-Ramos J. Open-label pilot study of levetiracetam (Keppra) for the treatment of chorea in Huntington's disease. Mov. Disord. 21(11), 1998-2001 (2006).
    • (2006) Mov. Disord , vol.21 , Issue.11 , pp. 1998-2001
    • Zesiewicz, T.A.1    Sullivan, K.L.2    Hauser, R.A.3    Sanchez-Ramos, J.4
  • 78
    • 1642538376 scopus 로고    scopus 로고
    • Levetiracetam improves choreic levodopa-induced dyskinesia in the MPTP-treated macaque
    • Bezard E, Hill MP, Crossman AR et al. Levetiracetam improves choreic levodopa-induced dyskinesia in the MPTP-treated macaque. Eur. J. Pharmacol. 485(1-3), 159-164 (2004).
    • (2004) Eur. J. Pharmacol , vol.485 , Issue.1-3 , pp. 159-164
    • Bezard, E.1    Hill, M.P.2    Crossman, A.R.3
  • 79
    • 34548411328 scopus 로고    scopus 로고
    • Levetiracetam-responding paroxysmal nonkinesigenic dyskinesia
    • Alemdar M, Iseri P, Selekler M, Komsuoglu SS. Levetiracetam-responding paroxysmal nonkinesigenic dyskinesia. Clin. Neuropharmacol. 30(4), 241-244 (2007).
    • (2007) Clin. Neuropharmacol , vol.30 , Issue.4 , pp. 241-244
    • Alemdar, M.1    Iseri, P.2    Selekler, M.3    Komsuoglu, S.S.4
  • 80
    • 34748913843 scopus 로고    scopus 로고
    • An open trial of levetiracetam for segmental and generalized dystonia
    • Hering S, Wenning GK, Seppi K, Poewe W, Mueller J. An open trial of levetiracetam for segmental and generalized dystonia. Mov. Disord. 22(11), 1649-1651 (2007).
    • (2007) Mov. Disord , vol.22 , Issue.11 , pp. 1649-1651
    • Hering, S.1    Wenning, G.K.2    Seppi, K.3    Poewe, W.4    Mueller, J.5
  • 81
    • 2142657939 scopus 로고    scopus 로고
    • Levetiracetam as migraine prophylaxis
    • Cochran JW. Levetiracetam as migraine prophylaxis. Clin. J. Pain 20(3), 198-199 (2004).
    • (2004) Clin. J. Pain , vol.20 , Issue.3 , pp. 198-199
    • Cochran, J.W.1
  • 82
    • 33750918330 scopus 로고    scopus 로고
    • Levetiracetam in the prophylaxis of migraine with aura: A 6-month open-label study
    • Brighina F, Palermo A, Aloisio A et al. Levetiracetam in the prophylaxis of migraine with aura: a 6-month open-label study. Clin. Neuropharmacol. 29(6), 338-342 (2006).
    • (2006) Clin. Neuropharmacol , vol.29 , Issue.6 , pp. 338-342
    • Brighina, F.1    Palermo, A.2    Aloisio, A.3
  • 83
    • 65449130768 scopus 로고    scopus 로고
    • Pilot study to evaluate the efficacy and tolerability of levetiracetam (Keppra) in treatment of patients with trigeminal neuralgia
    • Jorns TP, Johnston A, Zakrzewska JM. Pilot study to evaluate the efficacy and tolerability of levetiracetam (Keppra) in treatment of patients with trigeminal neuralgia. Eur. J. Neurol. 16(6), 740-744 (2009).
    • (2009) Eur. J. Neurol , vol.16 , Issue.6 , pp. 740-744
    • Jorns, T.P.1    Johnston, A.2    Zakrzewska, J.M.3
  • 84
    • 73249135882 scopus 로고    scopus 로고
    • Levetiracetam in spinal cord injury pain: A randomized controlled trial
    • Finnerup NB, Grydehoj J, Bing J et al. Levetiracetam in spinal cord injury pain: a randomized controlled trial. Spinal Cord 47(12), 861-867 (2009).
    • (2009) Spinal Cord , vol.47 , Issue.12 , pp. 861-867
    • Finnerup, N.B.1    Grydehoj, J.2    Bing, J.3
  • 85
    • 60049101455 scopus 로고    scopus 로고
    • Effects of levetiracetam on chronic pain in multiple sclerosis: Results of a pilot, randomized, placebo-controlled study
    • Rossi S, Mataluni G, Codeca C et al. Effects of levetiracetam on chronic pain in multiple sclerosis: results of a pilot, randomized, placebo-controlled study. Eur. J. Neurol. 16(3), 360-366 (2009).
    • (2009) Eur. J. Neurol , vol.16 , Issue.3 , pp. 360-366
    • Rossi, S.1    Mataluni, G.2    Codeca, C.3
  • 86
    • 67650107605 scopus 로고    scopus 로고
    • Levetiracetam for managing neurologic and psychiatric disorders
    • Farooq MU, Bhatt A, Majid A et al. Levetiracetam for managing neurologic and psychiatric disorders. Am. J. Health Syst. Pharm. 66(6), 541-561 (2009).
    • (2009) Am. J. Health Syst. Pharm , vol.66 , Issue.6 , pp. 541-561
    • Farooq, M.U.1    Bhatt, A.2    Majid, A.3
  • 87
    • 67649888794 scopus 로고    scopus 로고
    • A prospective pilot study of levetiracetam for body dysmorphic disorder
    • Phillips KA, Menard W. A prospective pilot study of levetiracetam for body dysmorphic disorder. CNS Spectr. 14(5), 252-260 (2009).
    • (2009) CNS Spectr , vol.14 , Issue.5 , pp. 252-260
    • Phillips, K.A.1    Menard, W.2
  • 88
    • 3042814928 scopus 로고    scopus 로고
    • Levetiracetam-induced thrombocytopenia
    • Kimland E, Hojeberg B, von EM. Levetiracetam-induced thrombocytopenia. Epilepsia 45(7), 877-878 (2004).
    • (2004) Epilepsia , vol.45 , Issue.7 , pp. 877-878
    • Kimland, E.1    Hojeberg, B.2    von, E.M.3
  • 90
    • 52449134453 scopus 로고    scopus 로고
    • Levetiracetam as a possible cause of fulminant liver failure
    • Tan TC, de Boer BW, Mitchell A et al. Levetiracetam as a possible cause of fulminant liver failure. Neurology 71(9), 685-686 (2008).
    • (2008) Neurology , vol.71 , Issue.9 , pp. 685-686
    • Tan, T.C.1    de Boer, B.W.2    Mitchell, A.3
  • 92
    • 0242522159 scopus 로고    scopus 로고
    • Aggressive behavior of epilepsy patients in the course of levetiracetam add-on therapy: Report of 33 mild to severe cases
    • Dinkelacker V, Dietl T, Widman G, Lengler U, Elger CE. Aggressive behavior of epilepsy patients in the course of levetiracetam add-on therapy: report of 33 mild to severe cases. Epilepsy Behav. 4(5), 537-547 (2003).
    • (2003) Epilepsy Behav , vol.4 , Issue.5 , pp. 537-547
    • Dinkelacker, V.1    Dietl, T.2    Widman, G.3    Lengler, U.4    Elger, C.E.5
  • 94
    • 34447635871 scopus 로고    scopus 로고
    • Suicidal ideation in epilepsy and levetiracetam therapy
    • Mula M, Sander JW. Suicidal ideation in epilepsy and levetiracetam therapy. Epilepsy Behav. 11(1), 130-132 (2007).
    • (2007) Epilepsy Behav , vol.11 , Issue.1 , pp. 130-132
    • Mula, M.1    Sander, J.W.2
  • 95
    • 50849134823 scopus 로고    scopus 로고
    • Pyridoxine supplementation for the treatment of levetiracetam-induced behavior side effects in children: Preliminary results
    • Major P, Greenberg E, Khan A, Thiele EA. Pyridoxine supplementation for the treatment of levetiracetam-induced behavior side effects in children: preliminary results. Epilepsy Behav. 13(3), 557-559 (2008).
    • (2008) Epilepsy Behav , vol.13 , Issue.3 , pp. 557-559
    • Major, P.1    Greenberg, E.2    Khan, A.3    Thiele, E.A.4
  • 96
    • 33846657659 scopus 로고    scopus 로고
    • Suicidality and antiepileptic drugs: Is there a link?
    • Analysis of the relationship between antiepileptic drugs and suicidality, •
    • Kalinin VV. Suicidality and antiepileptic drugs: is there a link? Drug Saf. 30(2), 123-142 (2007). • Analysis of the relationship between antiepileptic drugs and suicidality.
    • (2007) Drug Saf , vol.30 , Issue.2 , pp. 123-142
    • Kalinin, V.V.1
  • 97
    • 18244369989 scopus 로고    scopus 로고
    • Levetiracetam concentrations in serum and in breast milk at birth and during lactation
    • Johannessen SI, Helde G, Brodtkorb E. Levetiracetam concentrations in serum and in breast milk at birth and during lactation. Epilepsia 46(5), 775-777 (2005).
    • (2005) Epilepsia , vol.46 , Issue.5 , pp. 775-777
    • Johannessen, S.I.1    Helde, G.2    Brodtkorb, E.3
  • 98
    • 34249776676 scopus 로고    scopus 로고
    • Pharmacokinetics of levetiracetam during pregnancy, delivery, in the neonatal period, and lactation
    • Tomson T, Palm R, Kallen K et al. Pharmacokinetics of levetiracetam during pregnancy, delivery, in the neonatal period, and lactation. Epilepsia 48(6), 1111-1116 (2007).
    • (2007) Epilepsia , vol.48 , Issue.6 , pp. 1111-1116
    • Tomson, T.1    Palm, R.2    Kallen, K.3
  • 99
    • 80052482229 scopus 로고    scopus 로고
    • Levetiracetam therapy in human pregnancy. Updated experience from the UK Epilepsy and Pregnancy Register
    • Registry data on adverse outcomes while on LEV during pregnancy, •
    • Hunt S, Irwin B, Waddell R et al. Levetiracetam therapy in human pregnancy. Updated experience from the UK Epilepsy and Pregnancy Register. Epilepsia 50(Suppl. 4), 44 (2009). • Registry data on adverse outcomes while on LEV during pregnancy.
    • (2009) Epilepsia , vol.50 , Issue.SUPPL. 4 , pp. 44
    • Hunt, S.1    Irwin, B.2    Waddell, R.3
  • 100
    • 76249107597 scopus 로고    scopus 로고
    • Alekar S, Leppik I, Montouris G, Harden C. UCB Antiepileptic Drug Pregnancy Registry. Epilepsia 50(Suppl. 11), 245 (2009). • Registry data on adverse outcomes while on LEV during pregnancy.
    • Alekar S, Leppik I, Montouris G, Harden C. UCB Antiepileptic Drug Pregnancy Registry. Epilepsia 50(Suppl. 11), 245 (2009). • Registry data on adverse outcomes while on LEV during pregnancy.
  • 102
    • 61849127705 scopus 로고    scopus 로고
    • Once-daily extended-release levetiracetam as adjunctive treatment of partial-onset seizures in patients with epilepsy: A double-blind, randomized, placebo-controlled trial
    • Peltola J, Coetzee C, Jimenez F et al. Once-daily extended-release levetiracetam as adjunctive treatment of partial-onset seizures in patients with epilepsy: a double-blind, randomized, placebo-controlled trial. Epilepsia 50(3), 406-414 (2009).
    • (2009) Epilepsia , vol.50 , Issue.3 , pp. 406-414
    • Peltola, J.1    Coetzee, C.2    Jimenez, F.3
  • 103
    • 57849141134 scopus 로고    scopus 로고
    • Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference EILAT IX
    • Bialer M, Johannessen SI, Levy RH et al. Progress report on new antiepileptic drugs: a summary of the Ninth Eilat Conference (EILAT IX). Epilepsy Res. 83(1), 1-43 (2009).
    • (2009) Epilepsy Res , vol.83 , Issue.1 , pp. 1-43
    • Bialer, M.1    Johannessen, S.I.2    Levy, R.H.3
  • 104
    • 49449094989 scopus 로고    scopus 로고
    • Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A
    • Matagne A, Margineanu DG, Kenda B, Michel P, Klitgaard H. Anti-convulsive and anti-epileptic properties of brivaracetam (ucb 34714), a high-affinity ligand for the synaptic vesicle protein, SV2A. Br. J. Pharmacol. 154(8), 1662-1671 (2008).
    • (2008) Br. J. Pharmacol , vol.154 , Issue.8 , pp. 1662-1671
    • Matagne, A.1    Margineanu, D.G.2    Kenda, B.3    Michel, P.4    Klitgaard, H.5
  • 105
    • 67349156665 scopus 로고    scopus 로고
    • Profile of the new pyrrolidone derivative seletracetam (ucb 44212) in animal models of epilepsy
    • Matagne A, Margineanu DG, Potschka H et al. Profile of the new pyrrolidone derivative seletracetam (ucb 44212) in animal models of epilepsy. Eur. J. Pharmacol. 614(1-3), 30-37 (2009).
    • (2009) Eur. J. Pharmacol , vol.614 , Issue.1-3 , pp. 30-37
    • Matagne, A.1    Margineanu, D.G.2    Potschka, H.3
  • 107
    • 38749128706 scopus 로고    scopus 로고
    • SV2A protein is a broad-spectrum anticonvulsant target: Functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy
    • Kaminski RM, Matagne A, Leclercq K et al. SV2A protein is a broad-spectrum anticonvulsant target: functional correlation between protein binding and seizure protection in models of both partial and generalized epilepsy. Neuropharmacology 54(4), 715-720 (2008).
    • (2008) Neuropharmacology , vol.54 , Issue.4 , pp. 715-720
    • Kaminski, R.M.1    Matagne, A.2    Leclercq, K.3
  • 108
    • 0019509687 scopus 로고
    • Proposal for revised clinical and electroencephalographic classification of epileptic seizures
    • Commission on Classification and Terminology of the International League Against Epilepsy
    • Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. Epilepsia 22(4), 489-501 (1981).
    • (1981) Epilepsia , vol.22 , Issue.4 , pp. 489-501


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.