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Volumn 8, Issue 10, 2016, Pages

Tauroursodeoxycholic acid attenuates renal tubular injury in a mouse model of type 2 diabetes

Author keywords

Apoptosis; Diabetic nephropathy; Endoplasmic reticulum stress; Tauroursodeoxycholic acid

Indexed keywords

CASPASE 12; CASPASE 3; DNA NUCLEOTIDYLEXOTRANSFERASE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; TAUROURSODEOXYCHOLIC ACID; BIOLOGICAL MARKER; TAUROCHENODEOXYCHOLIC ACID;

EID: 85016122409     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu8100589     Document Type: Article
Times cited : (27)

References (37)
  • 2
    • 75649140890 scopus 로고    scopus 로고
    • Diabetic kidney disease: Act now or pay later
    • [CrossRef] [PubMed]
    • Atkins, R.C.; Zimmet, P. Diabetic kidney disease: Act now or pay later. Nephrol. Dial. Transplant. 2010, 25, 331–333. [CrossRef] [PubMed]
    • (2010) Nephrol. Dial. Transplant , vol.25 , pp. 331-333
    • Atkins, R.C.1    Zimmet, P.2
  • 3
    • 79751477368 scopus 로고    scopus 로고
    • Glimpse of various pathogenetic mechanisms of diabetic nephropathy
    • [CrossRef] [PubMed]
    • Kanwar, Y.S.; Sun, L.; Xie, P.; Liu, F.Y.; Chen, S. A glimpse of various pathogenetic mechanisms of diabetic nephropathy. Annu. Rev. Pathol. 2011, 6, 395–423. [CrossRef] [PubMed]
    • (2011) Annu. Rev. Pathol , vol.6 , pp. 395-423
    • Kanwar, Y.S.1    Sun, L.2    Xie, P.3    Liu, F.Y.4    Chen, S.A.5
  • 4
    • 0032731318 scopus 로고    scopus 로고
    • The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury?
    • [CrossRef] [PubMed]
    • Gilbert, R.E.; Cooper, M.E. The tubulointerstitium in progressive diabetic kidney disease: More than an aftermath of glomerular injury? Kidney Int. 1999, 56, 1627–1637. [CrossRef] [PubMed]
    • (1999) Kidney Int , vol.56 , pp. 1627-1637
    • Gilbert, R.E.1    Cooper, M.E.2
  • 5
    • 84922631037 scopus 로고    scopus 로고
    • Elevated cannabinoid receptor 1 and G protein-coupled receptor 55 expression in proximal tubule cells and whole kidney exposed to diabetic conditions
    • [CrossRef] [PubMed]
    • Jenkin, K.A.; McAinch, A.J.; Zhang, Y.; Kelly, D.J.; Hryciw, D.H. Elevated cannabinoid receptor 1 and G protein-coupled receptor 55 expression in proximal tubule cells and whole kidney exposed to diabetic conditions. Clin. Exp. Pharmacol. Physiol. 2015, 42, 256–262. [CrossRef] [PubMed]
    • (2015) Clin. Exp. Pharmacol. Physiol , vol.42 , pp. 256-262
    • Jenkin, K.A.1    McAinch, A.J.2    Zhang, Y.3    Kelly, D.J.4    Hryciw, D.H.5
  • 7
    • 40749161602 scopus 로고    scopus 로고
    • Attenuation of interstitial fibrosis and tubular apoptosis in db/db transgenic mice overexpressing catalase in renal proximal tubular cells
    • [CrossRef] [PubMed]
    • Brezniceanu, M.L.; Liu, F.; Wei, C.C.; Chenier, I.; Godin, N.; Zhang, S.L.; Filep, J.G.; Ingelfinger, J.R.; Chan, J.S. Attenuation of interstitial fibrosis and tubular apoptosis in db/db transgenic mice overexpressing catalase in renal proximal tubular cells. Diabetes 2008, 57, 451–459. [CrossRef] [PubMed]
    • (2008) Diabetes , vol.57 , pp. 451-459
    • Brezniceanu, M.L.1    Liu, F.2    Wei, C.C.3    Chenier, I.4    Godin, N.5    Zhang, S.L.6    Filep, J.G.7    Ingelfinger, J.R.8    Chan, J.S.9
  • 8
    • 1942474599 scopus 로고    scopus 로고
    • Evidence of apoptosis in human diabetic kidney
    • [CrossRef] [PubMed]
    • Kumar, D.; Robertson, S.; Burns, K.D. Evidence of apoptosis in human diabetic kidney. Mol. Cell. Biochem. 2004, 259, 67–70. [CrossRef] [PubMed]
    • (2004) Mol. Cell. Biochem , vol.259 , pp. 67-70
    • Kumar, D.1    Robertson, S.2    Burns, K.D.3
  • 9
    • 80053371703 scopus 로고    scopus 로고
    • Activation of ER stress and apoptosis by hydrogen peroxide in hela cells: Protective role of mild heat preconditioning at 40 degrees C
    • [CrossRef] [PubMed]
    • Pallepati, P.; Averill-Bates, D.A. Activation of ER stress and apoptosis by hydrogen peroxide in hela cells: Protective role of mild heat preconditioning at 40 degrees C. Biochim. Biophys. Acta 2011, 1813, 1987–1999. [CrossRef] [PubMed]
    • (2011) Biochim. Biophys. Acta , vol.1813 , pp. 1987-1999
    • Pallepati, P.1    Averill-Bates, D.A.2
  • 10
    • 78650169392 scopus 로고    scopus 로고
    • Bcl-2 proteins regulate er membrane permeability to luminal proteins during ER stress-induced apoptosis
    • [CrossRef] [PubMed]
    • Wang, X.; Olberding, K.E.; White, C.; Li, C. Bcl-2 proteins regulate er membrane permeability to luminal proteins during ER stress-induced apoptosis. Cell Death Differ. 2011, 18, 38–47. [CrossRef] [PubMed]
    • (2011) Cell Death Differ , vol.18 , pp. 38-47
    • Wang, X.1    Olberding, K.E.2    White, C.3    Li, C.4
  • 11
    • 33846548110 scopus 로고    scopus 로고
    • ER stress and diseases
    • [CrossRef] [PubMed]
    • Yoshida, H. ER stress and diseases. FEBS J. 2007, 274, 630–658. [CrossRef] [PubMed]
    • (2007) FEBS J , vol.274 , pp. 630-658
    • Yoshida, H.1
  • 12
    • 84879695583 scopus 로고    scopus 로고
    • The intersecting roles of endoplasmic reticulum stress, ubiquitin-proteasome system, and autophagy in the pathogenesis of proteinuric kidney disease
    • [CrossRef] [PubMed]
    • Cybulsky, A.V. The intersecting roles of endoplasmic reticulum stress, ubiquitin-proteasome system, and autophagy in the pathogenesis of proteinuric kidney disease. Kidney Int. 2013, 84, 25–33. [CrossRef] [PubMed]
    • (2013) Kidney Int , vol.84 , pp. 25-33
    • Cybulsky, A.V.1
  • 13
    • 84942800193 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in kidney function and disease
    • [CrossRef] [PubMed]
    • Taniguchi, M.; Yoshida, H. Endoplasmic reticulum stress in kidney function and disease. Curr. Opin. Nephrol. Hypertens. 2015, 24, 345–350. [CrossRef] [PubMed]
    • (2015) Curr. Opin. Nephrol. Hypertens , vol.24 , pp. 345-350
    • Taniguchi, M.1    Yoshida, H.2
  • 14
    • 84938537691 scopus 로고    scopus 로고
    • RTN1 mediates progression of kidney disease by inducing ER stress
    • [CrossRef] [PubMed]
    • Fan, Y.; Xiao, W.; Li, Z.; Li, X.; Chuang, P.Y.; Jim, B.; Zhang, W.; Wei, C.; Wang, N.; Jia, W., et al. RTN1 mediates progression of kidney disease by inducing ER stress. Nat. Commun. 2015, 6, 7841. [CrossRef] [PubMed]
    • (2015) Nat. Commun , vol.6 , pp. 7841
    • Fan, Y.1    Xiao, W.2    Li, Z.3    Li, X.4    Chuang, P.Y.5    Jim, B.6    Zhang, W.7    Wei, C.8    Wang, N.9    Jia, W.10
  • 15
    • 84874476648 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress response and inflammatory cytokines in type 2 diabetic nephropathy: Role of indoleamine 2, 3-dioxygenase and programmed death-1
    • [CrossRef] [PubMed]
    • Baban, B.; Liu, J.Y.; Mozaffari, M.S. Endoplasmic reticulum stress response and inflammatory cytokines in type 2 diabetic nephropathy: Role of indoleamine 2, 3-dioxygenase and programmed death-1. Exp. Mol. Pathol. 2013, 94, 343–351. [CrossRef] [PubMed]
    • (2013) Exp. Mol. Pathol , vol.94 , pp. 343-351
    • Baban, B.1    Liu, J.Y.2    Mozaffari, M.S.3
  • 16
    • 77949730282 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress as a progression factor for kidney injury
    • [CrossRef] [PubMed]
    • Inagi, R. Endoplasmic reticulum stress as a progression factor for kidney injury. Curr. Opin. Pharmacol. 2010, 10, 156–165. [CrossRef] [PubMed]
    • (2010) Curr. Opin. Pharmacol , vol.10 , pp. 156-165
    • Inagi, R.1
  • 17
    • 33748069813 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
    • [CrossRef] [PubMed]
    • Ozcan, U.; Yilmaz, E.; Ozcan, L.; Furuhashi, M.; Vaillancourt, E.; Smith, R.O.; Gorgun, C.Z.; Hotamisligil, G.S. Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 2006, 313, 1137–1140. [CrossRef] [PubMed]
    • (2006) Science , vol.313 , pp. 1137-1140
    • Ozcan, U.1    Yilmaz, E.2    Ozcan, L.3    Furuhashi, M.4    Vaillancourt, E.5    Smith, R.O.6    Gorgun, C.Z.7    Hotamisligil, G.S.8
  • 18
    • 84974573913 scopus 로고    scopus 로고
    • Chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity
    • [CrossRef] [PubMed]
    • Chen, Y.; Wu, Z.; Zhao, S.; Xiang, R. Chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity. Sci. Rep. 2016, 6, 27486. [CrossRef] [PubMed]
    • (2016) Sci. Rep , vol.6 , pp. 27486
    • Chen, Y.1    Wu, Z.2    Zhao, S.3    Xiang, R.4
  • 19
    • 84962253636 scopus 로고    scopus 로고
    • Protection of tauroursodeoxycholic acid on high glucose-induced human retinal microvascular endothelial cells dysfunction and streptozotocin-induced diabetic retinopathy rats
    • [CrossRef] [PubMed]
    • Wang, C.F.; Yuan, J.R.; Qin, D.; Gu, J.F.; Zhao, B.J.; Zhang, L.; Zhao, D.; Chen, J.; Hou, X.F.; Yang, N., et al. Protection of tauroursodeoxycholic acid on high glucose-induced human retinal microvascular endothelial cells dysfunction and streptozotocin-induced diabetic retinopathy rats. J. Ethnopharmacol. 2016, 185, 162–170. [CrossRef] [PubMed]
    • (2016) J. Ethnopharmacol , vol.185 , pp. 162-170
    • Wang, C.F.1    Yuan, J.R.2    Qin, D.3    Gu, J.F.4    Zhao, B.J.5    Zhang, L.6    Zhao, D.7    Chen, J.8    Hou, X.F.9    Yang, N.10
  • 20
    • 84970998207 scopus 로고    scopus 로고
    • Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy
    • [CrossRef] [PubMed]
    • Cao, A.L.; Wang, L.; Chen, X.; Wang, Y.M.; Guo, H.J.; Chu, S.; Liu, C.; Zhang, X.M.; Peng, W. Ursodeoxycholic acid and 4-phenylbutyrate prevent endoplasmic reticulum stress-induced podocyte apoptosis in diabetic nephropathy. Lab. Investig. 2016, 96, 610–622. [CrossRef] [PubMed]
    • (2016) Lab. Investig , vol.96 , pp. 610-622
    • Cao, A.L.1    Wang, L.2    Chen, X.3    Wang, Y.M.4    Guo, H.J.5    Chu, S.6    Liu, C.7    Zhang, X.M.8    Peng, W.9
  • 21
    • 0036316997 scopus 로고    scopus 로고
    • The early natural history of nephropathy in type 1 diabetes: II. Early renal structural changes in type 1 diabetes
    • [CrossRef] [PubMed]
    • Drummond, K.; Mauer, M.; International Diabetic Nephropathy Study Group. The early natural history of nephropathy in type 1 diabetes: II. Early renal structural changes in type 1 diabetes. Diabetes 2002, 51, 1580–1587. [CrossRef] [PubMed]
    • (2002) Diabetes , vol.51 , pp. 1580-1587
    • Drummond, K.1    Mauer, M.2
  • 22
    • 70349582699 scopus 로고    scopus 로고
    • Ace-inhibitor suppresses the apoptosis induced by endoplasmic reticulum stress in renal tubular in experimental diabetic rats
    • [CrossRef] [PubMed]
    • Sun, H.L.; Sun, L.; Li, Y.Y.; Shao, M.M.; Cheng, X.Y.; Ge, N.; Lu, J.D.; Li, S.M. Ace-inhibitor suppresses the apoptosis induced by endoplasmic reticulum stress in renal tubular in experimental diabetic rats. Exp. Clin. Endocrinol. Diabetes 2009, 117, 336–344. [CrossRef] [PubMed]
    • (2009) Exp. Clin. Endocrinol. Diabetes , vol.117 , pp. 336-344
    • Sun, H.L.1    Sun, L.2    Li, Y.Y.3    Shao, M.M.4    Cheng, X.Y.5    Ge, N.6    Lu, J.D.7    Li, S.M.8
  • 23
    • 33644789780 scopus 로고    scopus 로고
    • Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction
    • [CrossRef] [PubMed]
    • Docherty, N.G.; O’Sullivan, O.E.; Healy, D.A.; Fitzpatrick, J.M.; Watson, R.W. Evidence that inhibition of tubular cell apoptosis protects against renal damage and development of fibrosis following ureteric obstruction. Am. J. Phys. Ren. Physiol. 2006, 290, F4–F13. [CrossRef] [PubMed]
    • (2006) Am. J. Phys. Ren. Physiol , vol.290 , pp. FF4-F13
    • Docherty, N.G.1    O’Sullivan, O.E.2    Healy, D.A.3    Fitzpatrick, J.M.4    Watson, R.W.5
  • 24
    • 27944432606 scopus 로고    scopus 로고
    • Modulating the endoplasmic reticulum stress response with trans-4, 5-dihydroxy-1, 2-dithiane prevents chemically induced renal injuryin vivo
    • [CrossRef] [PubMed]
    • Asmellash, S.; Stevens, J.L.; Ichimura, T. Modulating the endoplasmic reticulum stress response with trans-4, 5-dihydroxy-1, 2-dithiane prevents chemically induced renal injuryin vivo. Toxicol. Sci. 2005, 88, 576–584. [CrossRef] [PubMed]
    • (2005) Toxicol. Sci , vol.88 , pp. 576-584
    • Asmellash, S.1    Stevens, J.L.2    Ichimura, T.3
  • 25
    • 10444226462 scopus 로고    scopus 로고
    • ER stress and the unfolded protein response
    • [CrossRef] [PubMed]
    • Schroder, M.; Kaufman, R.J. ER stress and the unfolded protein response. Mutat. Res. 2005, 569, 29–63. [CrossRef] [PubMed]
    • (2005) Mutat. Res , vol.569 , pp. 29-63
    • Schroder, M.1    Kaufman, R.J.2
  • 26
    • 10644233167 scopus 로고    scopus 로고
    • Chop induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum
    • [CrossRef] [PubMed]
    • Marciniak, S.J.; Yun, C.Y.; Oyadomari, S.; Novoa, I.; Zhang, Y.; Jungreis, R.; Nagata, K.; Harding, H.P.; Ron, D. Chop induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum. Genes Dev. 2004, 18, 3066–3077. [CrossRef] [PubMed]
    • (2004) Genes Dev , vol.18 , pp. 3066-3077
    • Marciniak, S.J.1    Yun, C.Y.2    Oyadomari, S.3    Novoa, I.4    Zhang, Y.5    Jungreis, R.6    Nagata, K.7    Harding, H.P.8    Ron, D.9
  • 27
    • 84855597540 scopus 로고    scopus 로고
    • ER stress and apoptosis: A new mechanism for retinal cell death
    • 2012, [CrossRef] [PubMed]
    • Jing, G.; Wang, J.J.; Zhang, S.X. ER stress and apoptosis: A new mechanism for retinal cell death. Exp. Diabetes Res. 2012, 2012, 589589. [CrossRef] [PubMed]
    • (2012) Exp. Diabetes Res
    • Jing, G.1    Wang, J.J.2    Zhang, S.X.3
  • 28
    • 77952049573 scopus 로고    scopus 로고
    • Induction of diabetes in aged C57B6 mice results in severe nephropathy: An association with oxidative stress, endoplasmic reticulum stress, and inflammation
    • [CrossRef] [PubMed]
    • Wu, J.; Zhang, R.; Torreggiani, M.; Ting, A.; Xiong, H.; Striker, G.E.; Vlassara, H.; Zheng, F. Induction of diabetes in aged C57B6 mice results in severe nephropathy: An association with oxidative stress, endoplasmic reticulum stress, and inflammation. Am. J. Pathol. 2010, 176, 2163–2176. [CrossRef] [PubMed]
    • (2010) Am. J. Pathol , vol.176 , pp. 2163-2176
    • Wu, J.1    Zhang, R.2    Torreggiani, M.3    Ting, A.4    Xiong, H.5    Striker, G.E.6    Vlassara, H.7    Zheng, F.8
  • 29
    • 0034698878 scopus 로고    scopus 로고
    • Cross-talk between two cysteine protease families activation of caspase-12 by calpain in apoptosis
    • [CrossRef] [PubMed]
    • Nakagawa, T.; Yuan, J. Cross-talk between two cysteine protease families activation of caspase-12 by calpain in apoptosis. J. Cell Biol. 2000, 150, 887–894. [CrossRef] [PubMed]
    • (2000) J. Cell Biol , vol.150 , pp. 887-894
    • Nakagawa, T.1    Yuan, J.2
  • 30
    • 0034610743 scopus 로고    scopus 로고
    • Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta
    • [CrossRef] [PubMed]
    • Nakagawa, T.; Zhu, H.; Morishima, N.; Li, E.; Xu, J.; Yankner, B.A.; Yuan, J. Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-beta. Nature 2000, 403, 98–103. [CrossRef] [PubMed]
    • (2000) Nature , vol.403 , pp. 98-103
    • Nakagawa, T.1    Zhu, H.2    Morishima, N.3    Li, E.4    Xu, J.5    Yankner, B.A.6    Yuan, J.7
  • 31
    • 1242269804 scopus 로고    scopus 로고
    • Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12
    • [CrossRef] [PubMed]
    • Hitomi, J.; Katayama, T.; Taniguchi, M.; Honda, A.; Imaizumi, K.; Tohyama, M. Apoptosis induced by endoplasmic reticulum stress depends on activation of caspase-3 via caspase-12. Neurosci. Lett. 2004, 357, 127–130. [CrossRef] [PubMed]
    • (2004) Neurosci. Lett , vol.357 , pp. 127-130
    • Hitomi, J.1    Katayama, T.2    Taniguchi, M.3    Honda, A.4    Imaizumi, K.5    Tohyama, M.6
  • 32
    • 0034652248 scopus 로고    scopus 로고
    • Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (Alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency
    • [CrossRef] [PubMed]
    • Burrows, J.A.; Willis, L.K.; Perlmutter, D.H. Chemical chaperones mediate increased secretion of mutant alpha 1-antitrypsin (alpha 1-AT) Z: A potential pharmacological strategy for prevention of liver injury and emphysema in alpha 1-AT deficiency. Proc. Natl. Acad. Sci. USA 2000, 97, 1796–1801. [CrossRef] [PubMed]
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1796-1801
    • Burrows, J.A.1    Willis, L.K.2    Perlmutter, D.H.3
  • 33
    • 57849115277 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress plays a central role in development of leptin resistance
    • [CrossRef] [PubMed]
    • Ozcan, L.; Ergin, A.S.; Lu, A.; Chung, J.; Sarkar, S.; Nie, D.; Myers, M.G., Jr.; Ozcan, U. Endoplasmic reticulum stress plays a central role in development of leptin resistance. Cell Metab. 2009, 9, 35–51. [CrossRef] [PubMed]
    • (2009) Cell Metab , vol.9 , pp. 35-51
    • Ozcan, L.1    Ergin, A.S.2    Lu, A.3    Chung, J.4    Sarkar, S.5    Nie, D.6    Myers, M.G.7    Ozcan, U.8
  • 34
    • 84897126655 scopus 로고    scopus 로고
    • 4-phenylbutyrate inhibits tunicamycin-induced acute kidney injury via chop/gadd153 repression
    • [CrossRef] [PubMed]
    • Carlisle, R.E.; Brimble, E.; Werner, K.E.; Cruz, G.L.; Ask, K.; Ingram, A.J.; Dickhout, J.G. 4-phenylbutyrate inhibits tunicamycin-induced acute kidney injury via chop/gadd153 repression. PLoS ONE 2014, 9, e84663. [CrossRef] [PubMed]
    • (2014) Plos ONE , vol.9
    • Carlisle, R.E.1    Brimble, E.2    Werner, K.E.3    Cruz, G.L.4    Ask, K.5    Ingram, A.J.6    Dickhout, J.G.7
  • 35
    • 84863413520 scopus 로고    scopus 로고
    • The nephroprotective effect of tauroursodeoxycholic acid on ischaemia/reperfusion-induced acute kidney injury by inhibiting endoplasmic reticulum stress
    • [CrossRef] [PubMed]
    • Gao, X.; Fu, L.; Xiao, M.; Xu, C.; Sun, L.; Zhang, T.; Zheng, F.; Mei, C. The nephroprotective effect of tauroursodeoxycholic acid on ischaemia/reperfusion-induced acute kidney injury by inhibiting endoplasmic reticulum stress. Basic Clin. Pharmacol. Toxicol. 2012, 111, 14–23. [CrossRef] [PubMed]
    • (2012) Basic Clin. Pharmacol. Toxicol , vol.111 , pp. 14-23
    • Gao, X.1    Fu, L.2    Xiao, M.3    Xu, C.4    Sun, L.5    Zhang, T.6    Zheng, F.7    Mei, C.8
  • 36
    • 84882621088 scopus 로고    scopus 로고
    • Involvement of endoplasmic reticulum stress in albuminuria induced inflammasome activation in renal proximal tubular cells
    • [CrossRef] [PubMed]
    • Fang, L.; Xie, D.; Wu, X.; Cao, H.; Su, W.; Yang, J. Involvement of endoplasmic reticulum stress in albuminuria induced inflammasome activation in renal proximal tubular cells. PLoS ONE 2013, 8, e72344. [CrossRef] [PubMed]
    • (2013) Plos ONE , vol.8
    • Fang, L.1    Xie, D.2    Wu, X.3    Cao, H.4    Su, W.5    Yang, J.6
  • 37
    • 47549111580 scopus 로고    scopus 로고
    • Effect of taurine-conjugated ursodeoxycholic acid on endoplasmic reticulum stress and apoptosis induced by advanced glycation end products in cultured mouse podocytes
    • [CrossRef] [PubMed]
    • Chen, Y.; Liu, C.P.; Xu, K.F.; Mao, X.D.; Lu, Y.B.; Fang, L.; Yang, J.W.; Liu, C. Effect of taurine-conjugated ursodeoxycholic acid on endoplasmic reticulum stress and apoptosis induced by advanced glycation end products in cultured mouse podocytes. Am. J. Nephrol. 2008, 28, 1014–1022. [CrossRef] [PubMed]
    • (2008) Am. J. Nephrol , vol.28 , pp. 1014-1022
    • Chen, Y.1    Liu, C.P.2    Xu, K.F.3    Mao, X.D.4    Lu, Y.B.5    Fang, L.6    Yang, J.W.7    Liu, C.8


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