Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1α via the mTOR/p70S6K/4E-BP1 and MAPK pathways

Journal of Ethnopharmacology

Volumn 203, Issue , 2017, Pages 27-38

  Mi, Chunliu ^a   Ma, Juan ^a   Wang, Ke Si ^a   Zuo, Hong Xiang ^a   Wang, Zhe ^a   Li, Ming Yue ^a   Piao, Lian Xun ^a   Xu, Guang Hua ^a   Li, Xuezheng ^a   Quan, Zhe Shan ^a   Jin, Xuejun ^a  

^a YANBIAN UNIVERSITY   (China)

Author keywords

Antitumor; HIF 1 ; Imperatorin; Translation

Indexed keywords

DNA TOPOISOMERASE; EDOXUDINE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PENTOSALEN; S6 KINASE; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; VASCULOTROPIN; ANGIOGENESIS INHIBITOR; ANTINEOPLASTIC AGENT; EIF4EBP1 PROTEIN, HUMAN; FUROCOUMARIN DERIVATIVE; MTOR PROTEIN, HUMAN; PHOSPHOPROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TARGET OF RAPAMYCIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER INHIBITION; CLONOGENIC ASSAY; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; DRUG TARGETING; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; FEMALE; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HCT 116 CELL LINE; HELA CELL LINE; HEP3B CELL LINE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; LIVER CANCER CELL LINE; MALE; MOUSE; MTT ASSAY; NONHUMAN; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR HYPOXIA; WESTERN BLOTTING; ANGELICA; ANIMAL; BAGG ALBINO MOUSE; CELL PROLIFERATION; CHEMISTRY; COLON TUMOR; DRUG EFFECTS; ISOLATION AND PURIFICATION; MAPK SIGNALING; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); NUDE MOUSE; PATHOLOGY; VASCULARIZATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANGELICA; ANGIOGENESIS INHIBITORS; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL PROLIFERATION; COLONIC NEOPLASMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FUROCOUMARINS; HCT116 CELLS; HELA CELLS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHOPROTEINS; RIBOSOMAL PROTEIN S6 KINASES, 70-KDA; TOR SERINE-THREONINE KINASES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 85015822720     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2017.03.033     Document Type: Article

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