-
1
-
-
84941335453
-
Type 2 diabetes: Multimodal treatment of a complex disease
-
CrossRef]
-
Pournaras, D.J.; le Roux, C.W. Type 2 diabetes: Multimodal treatment of a complex disease. Lancet 2015, 386, 936-937. [CrossRef]
-
(2015)
Lancet
, vol.386
, pp. 936-937
-
-
Pournaras, D.J.1
Le Roux, C.W.2
-
2
-
-
84980397249
-
-
accessed on 11 August 2015
-
Centre for Disease Control (CDC). Available online: http://www.cdc.gov/diabetes/basics/prediabetes.html (accessed on 11 August 2015).
-
-
-
-
3
-
-
0024160877
-
Banting Lecture 1988. Role of insulin resistance in human disease
-
CrossRef] [PubMed]
-
Reaven, G.M. Banting Lecture 1988. Role of insulin resistance in human disease. Diabetes 1988, 37, 1595-1607. [CrossRef] [PubMed]
-
Diabetes
, vol.1988
, Issue.37
, pp. 1595-1607
-
-
Reaven, G.M.1
-
4
-
-
84857861919
-
Integrating mechanisms of insulin resistance: Common threads and missing links
-
CrossRef] [PubMed]
-
Samuel, V.T.; Shulman, G.I. Integrating mechanisms of insulin resistance: Common threads and missing links. Cell 2012, 148, 852-871. [CrossRef] [PubMed]
-
(2012)
Cell
, vol.148
, pp. 852-871
-
-
Samuel, V.T.1
Shulman, G.I.2
-
5
-
-
77953868236
-
Lipid-Induced insulin resistance: Unravelling the mechanism
-
CrossRef]
-
Samuel, V.T.; Petersen, K.-F.; Shulman, G.I. Lipid-Induced insulin resistance: Unravelling the mechanism. Lancet 2010, 375, 2267-2277. [CrossRef]
-
(2010)
Lancet
, vol.375
, pp. 2267-2277
-
-
Samuel, V.T.1
Petersen, K.-F.2
Shulman, G.I.3
-
6
-
-
0025663581
-
Slow glucose removal rate and hyperinsulinemia precede the development of Type II diabetes in the offspring of diabetic patients
-
CrossRef] [PubMed]
-
Warram, J.H.; Martin, B.C.; Krolewski, A.S.; Soeldner, J.S.; Khan, C.R. Slow glucose removal rate and hyperinsulinemia precede the development of Type II diabetes in the offspring of diabetic patients. Ann. Intern. Med. 1990, 113, 909-915. [CrossRef] [PubMed]
-
(1990)
Ann. Intern. Med
, vol.113
, pp. 909-915
-
-
Warram, J.H.1
Martin, B.C.2
Krolewski, A.S.3
Soeldner, J.S.4
Khan, C.R.5
-
7
-
-
75549085755
-
Skeletal muscle insulin resistance is primary defect in Type 2 Diabetes
-
CrossRef] [PubMed]
-
DeFronzo, R.A.; Tripathy, D. Skeletal muscle insulin resistance is primary defect in Type 2 Diabetes. Diabetes Car. 2009, 32 (Suppl. S2), S157-S163. [CrossRef] [PubMed]
-
(2009)
Diabetes Car
, vol.32
, pp. S157-S163
-
-
Defronzo, R.A.1
Tripathy, D.2
-
8
-
-
50749118593
-
The internal secretion of the pancreas
-
Banting, F.G.; Best, C.H. The internal secretion of the pancreas. J. Lab. Clin. Med. 1922, 7, 251-266.
-
(1922)
J. Lab. Clin. Med
, vol.7
, pp. 251-266
-
-
Banting, F.G.1
Best, C.H.2
-
9
-
-
0015103371
-
Insulin receptors in the liver: Specific binding of (125 I) insulin to the plasma membrane and its relation to insulin bioactivity
-
CrossRef] [PubMed]
-
Freychet, P.; Roth, J.; Neville, D.M., Jr. Insulin receptors in the liver: specific binding of (125 I) insulin to the plasma membrane and its relation to insulin bioactivity. Proc. Natl. Acad. Sci. USA 1971, 68, 1833-1837. [CrossRef] [PubMed]
-
(1971)
Proc. Natl. Acad. Sci. USA
, vol.68
, pp. 1833-1837
-
-
Freychet, P.1
Roth, J.2
Neville, D.M.3
-
10
-
-
0027212268
-
Insulin receptor substrate-1 and proteins with SH2 domains
-
CrossRef] [PubMed]
-
Myers, M.G.; White, M.F. Insulin receptor substrate-1 and proteins with SH2 domains. Diabetes 1993, 42, 643-650. [CrossRef] [PubMed]
-
(1993)
Diabetes
, vol.42
, pp. 643-650
-
-
Myers, M.G.1
White, M.F.2
-
11
-
-
0021828496
-
Association of phosphatidylinositol kinase activity with with polyoma middle-T component for transformation
-
CrossRef] [PubMed]
-
Whitman, M.; Kaplan, D.R.; Schaffhausen, B.; Cantley, L.; Roberts, T.M. Association of phosphatidylinositol kinase activity with with polyoma middle-T component for transformation. Nature 1985, 315, 239-242. [CrossRef] [PubMed]
-
(1985)
Nature
, vol.315
, pp. 239-242
-
-
Whitman, M.1
Kaplan, D.R.2
Schaffhausen, B.3
Cantley, L.4
Roberts, T.M.5
-
12
-
-
12644301164
-
3-phosphoinositide dependent protein kinase-1 (PDK1): Structural and functional homology with the Drosophila DSTPK61 kinase
-
CrossRef]
-
Allesi, D.R.; Deak, M.; Casamayor, A.; Caudwell, F.B.; Morrice, N.; Norman, D.G.; Gaffney, P.; Reese, C.B.; MacDougal, C.N.; Harbison, D. et al. 3-phosphoinositide dependent protein kinase-1 (PDK1): Structural and functional homology with the Drosophila DSTPK61 kinase. Curr. Biol. 1997, 7, 776-789. [CrossRef]
-
(1997)
Curr. Biol
, vol.7
, pp. 776-789
-
-
Allesi, D.R.1
Deak, M.2
Casamayor, A.3
Caudwell, F.B.4
Morrice, N.5
Norman, D.G.6
Gaffney, P.7
Reese, C.B.8
Macdougal, C.N.9
Harbison, D.10
-
13
-
-
0029079275
-
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase
-
CrossRef]
-
Franke, T.F.; Yang, S.I.; Chan, T.O.; Datta, K.; Kazlauskas, A.; Morrison, D.K.; Kaplan, D.R.; Tsichlis, P.N. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 1995, 81, 727-736. [CrossRef]
-
(1995)
Cell
, vol.81
, pp. 727-736
-
-
Franke, T.F.1
Yang, S.I.2
Chan, T.O.3
Datta, K.4
Kazlauskas, A.5
Morrison, D.K.6
Kaplan, D.R.7
Tsichlis, P.N.8
-
14
-
-
0017155056
-
Guanosine 31:51-Monophosphate-dependent protein kinase from silkworm, properties of a catalytic fragment obtained by limited proteolysis
-
[PubMed]
-
Inoue, M.; Kishimoto, A.; Takai, Y.; Nishizuka, Y. Guanosine 31:51-Monophosphate-dependent protein kinase from silkworm, properties of a catalytic fragment obtained by limited proteolysis. J. Biol. Chem. 1976, 251, 4476-4478. [PubMed]
-
(1976)
J. Biol. Chem
, vol.251
, pp. 4476-4478
-
-
Inoue, M.1
Kishimoto, A.2
Takai, Y.3
Nishizuka, Y.4
-
15
-
-
0037677096
-
Insulin-Stimulated phosphorylation of a Rab GTPase activating protein regulates GLUT4 translocation
-
CrossRef] [PubMed]
-
Sano, H.; Kane, S.; Sano, E.; Minea, C.P.; Asara, J.M.; Lane, W.S.; Garner, C.W.; Lienhard, G.E. Insulin-Stimulated phosphorylation of a Rab GTPase activating protein regulates GLUT4 translocation. J. Biol. Chem. 2003, 278, 14599-14602. [CrossRef] [PubMed]
-
(2003)
J. Biol. Chem
, vol.278
, pp. 14599-14602
-
-
Sano, H.1
Kane, S.2
Sano, E.3
Minea, C.P.4
Asara, J.M.5
Lane, W.S.6
Garner, C.W.7
Lienhard, G.E.8
-
16
-
-
0023882706
-
Insulin regulatable tissues express a unique insulin-sensitive glucose transport protein
-
CrossRef] [PubMed]
-
James, D.E.; Brown, R.; Navarro, J.; Pilch, P.F. Insulin regulatable tissues express a unique insulin-sensitive glucose transport protein. Nature 1988, 333, 183-185. [CrossRef] [PubMed]
-
(1988)
Nature
, vol.333
, pp. 183-185
-
-
James, D.E.1
Brown, R.2
Navarro, J.3
Pilch, P.F.4
-
17
-
-
0022802645
-
Fuel selection in animals
-
CrossRef]
-
Randle, P.J. Fuel selection in animals. Biochem. Soc. Trans. 1985, 14, 799-806. [CrossRef]
-
(1985)
Biochem. Soc. Trans
, vol.14
, pp. 799-806
-
-
Randle, P.J.1
-
18
-
-
84863617800
-
In vivo, fatty acid translocase (CD36) critically regulates skeletal muscle fuel selection, exercise performance, and training-induced adaptation of fatty acid oxidation
-
CrossRef] [PubMed]
-
McFarlan, J.T.; Yoshida, Y.; Jain, S.S.; Han, X.X.; Snook, L.A.; Lally, J.; Smith, B.K.; Glatz, J.F.; Luiken, J.J.; Sayer, R.A. et al. In vivo, fatty acid translocase (CD36) critically regulates skeletal muscle fuel selection, exercise performance, and training-induced adaptation of fatty acid oxidation. J. Biol. Chem. 2012, 287, 23502-23516. [CrossRef] [PubMed]
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 23502-23516
-
-
McFarlan, J.T.1
Yoshida, Y.2
Jain, S.S.3
Han, X.X.4
Snook, L.A.5
Lally, J.6
Smith, B.K.7
Glatz, J.F.8
Luiken, J.J.9
Sayer, R.A.10
-
19
-
-
0002315239
-
Regulation of plasma free fatty acid turnover
-
[PubMed]
-
Armstrong, D.T.; Steele, R.; Altszuker, N.; Dunn, A.; Bishop, J.S.; DeBodo, R.C. Regulation of plasma free fatty acid turnover. Am. J. Physiol. 1961, 201, 9-15. [PubMed]
-
(1961)
Am. J. Physiol
, vol.201
, pp. 9-15
-
-
Armstrong, D.T.1
Steele, R.2
Altszuker, N.3
Dunn, A.4
Bishop, J.S.5
Debodo, R.C.6
-
20
-
-
0014147895
-
Turnover rate of plasma FFA in humans and dogs
-
CrossRef]
-
Issekutz, B., Jr.; Bortz, W.M.; Miller, H.I.; Paul, P. Turnover rate of plasma FFA in humans and dogs. Metabolism 1967, 16, 1001-1009. [CrossRef]
-
(1967)
Metabolism
, vol.16
, pp. 1001-1009
-
-
Issekutz, B.1
Bortz, W.M.2
Miller, H.I.3
Paul, P.4
-
21
-
-
0026071562
-
Saturation kinetics of palmitate uptake in perfused skeletal muscle
-
CrossRef]
-
Turcotte, L.P.; Kiens, B.; Richter, E.A. Saturation kinetics of palmitate uptake in perfused skeletal muscle. FEBS Lett. 1991, 279, 327-329. [CrossRef]
-
(1991)
FEBS Lett
, vol.279
, pp. 327-329
-
-
Turcotte, L.P.1
Kiens, B.2
Richter, E.A.3
-
22
-
-
0039677490
-
Membrane associated fatty acid binding protein (FABPpm) in human skeletal muscle is increased by endurance training
-
CrossRef] [PubMed]
-
Kiens, B.; Kristiansen, S.; Jensen, P.; Richter, E.A.; Turcotte, L.P. Membrane associated fatty acid binding protein (FABPpm) in human skeletal muscle is increased by endurance training. Biochem. Biophys. Res. Commun. 1997, 231, 463-465. [CrossRef] [PubMed]
-
(1997)
Biochem. Biophys. Res. Commun
, vol.231
, pp. 463-465
-
-
Kiens, B.1
Kristiansen, S.2
Jensen, P.3
Richter, E.A.4
Turcotte, L.P.5
-
23
-
-
74949084316
-
Membrance fatty acid transporters as regulators of lipid metabolism: Implications for metabolic disease
-
CrossRef] [PubMed]
-
Glatz, J.F.C.; Luiken, J.J.F.P.; Bonen, A. Membrance fatty acid transporters as regulators of lipid metabolism: Implications for metabolic disease. Physiol. Rev. 2010, 90, 367-417. [CrossRef] [PubMed]
-
(2010)
Physiol. Rev.
, vol.90
, pp. 367-417
-
-
Glatz, J.F.C.1
Luiken, J.J.F.P.2
Bonen, A.3
-
24
-
-
84859157750
-
Fatty acid transport proteins, implications in physiology and disease
-
CrossRef] [PubMed]
-
Kazantzis, M.; Stahl, A. Fatty acid transport proteins, implications in physiology and disease. Biochim. Biophys. Acta 2012, 1821, 852-857. [CrossRef] [PubMed]
-
(2012)
Biochim. Biophys. Acta
, vol.1821
, pp. 852-857
-
-
Kazantzis, M.1
Stahl, A.2
-
25
-
-
0032958470
-
Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats
-
CrossRef] [PubMed]
-
Aitman, T.J.; Glazier, A.M.; Wallace, C.A.; Cooper, L.D.; Nortsworthy, J.K.; Wahid, F.N.; Al-Majali, K.M.; Trembling, P.M.; Mann, C.J.; Shoulders, C.C. et al. Identification of Cd36 (Fat) as an insulin-resistance gene causing defective fatty acid and glucose metabolism in hypertensive rats. Nat. Genet. 1999, 21, 76-83. [CrossRef] [PubMed]
-
(1999)
Nat. Genet
, vol.21
, pp. 76-83
-
-
Aitman, T.J.1
Glazier, A.M.2
Wallace, C.A.3
Cooper, L.D.4
Nortsworthy, J.K.5
Wahid, F.N.6
Al-Majali, K.M.7
Trembling, P.M.8
Mann, C.J.9
Shoulders, C.C.10
-
26
-
-
0036711133
-
Changes in fatty acid transport and transporters are related to the severity of insulin deficiency
-
CrossRef] [PubMed]
-
Luiken, J.J.; Arumugam, Y.; Bell, R.C.; Calles-Escandon, J.; Tandon, N.N.; Glatz, J.F.; Bonen, A. Changes in fatty acid transport and transporters are related to the severity of insulin deficiency. Am. J. Physiol. Endocrinol. Metab. 2002, 283, E612-E621. [CrossRef] [PubMed]
-
(2002)
Am. J. Physiol. Endocrinol. Metab.
, vol.283
, pp. E612-E621
-
-
Luiken, J.J.1
Arumugam, Y.2
Bell, R.C.3
Calles-Escandon, J.4
Tandon, N.N.5
Glatz, J.F.6
Bonen, A.7
-
27
-
-
84893060758
-
Fatty acid metabolism, energy expenditure and insulin resistance in muscle
-
CrossRef] [PubMed]
-
Turner, N.; Cooney, G.J.; Kraegen, E.W.; Bruce, C.R. Fatty acid metabolism, energy expenditure and insulin resistance in muscle. J. Endocrinol. 2014, 220, T61-T79. [CrossRef] [PubMed]
-
(2014)
J. Endocrinol
, vol.220
, pp. T61-T79
-
-
Turner, N.1
Cooney, G.J.2
Kraegen, E.W.3
Bruce, C.R.4
-
28
-
-
81155128125
-
GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance
-
CrossRef] [PubMed]
-
Kampmann, U.; Christensen, B.; Nielsen, T.S.; Pedersen, S.B.; Ørskov, L.; Lund, S.; Møller, N.; Jessen, N. GLUT4 and UBC9 protein expression is reduced in muscle from type 2 diabetic patients with severe insulin resistance. PLoS ONE 2011, 6, e27854. [CrossRef] [PubMed]
-
(2011)
Plos ONE
, vol.6
-
-
Kampmann, U.1
Christensen, B.2
Nielsen, T.S.3
Pedersen, S.B.4
Ørskov, L.5
Lund, S.6
Møller, N.7
Jessen, N.8
-
29
-
-
79960776844
-
Skeletal muscle lipid flux: Running water carries no poison
-
CrossRef] [PubMed]
-
Funai, K.; Semenkovich, C.F. Skeletal muscle lipid flux: Running water carries no poison. Am. J. Physiol. Endocrinol. Metab. 2011, 301, E245-E251. [CrossRef] [PubMed]
-
(2011)
Am. J. Physiol. Endocrinol. Metab
, vol.301
, pp. E245-E251
-
-
Funai, K.1
Semenkovich, C.F.2
-
30
-
-
84911427884
-
Targeting mitochondrial biogenesis to treat insulin resistance
-
CrossRef] [PubMed]
-
Zamora, M.; Josep, A.; Villena, J.A. Targeting mitochondrial biogenesis to treat insulin resistance. Curr. Pharm. Des. 2014, 20, 5527-5557. [CrossRef] [PubMed]
-
(2014)
Curr. Pharm. Des
, vol.20
, pp. 5527-5557
-
-
Zamora, M.1
Josep, A.2
Villena, J.A.3
-
31
-
-
84925871294
-
Mitochondrial biogenesis: Pharmacological approaches
-
CrossRef] [PubMed]
-
Valero, T. Mitochondrial biogenesis: Pharmacological approaches. Curr. Pharm. Des. 2014, 20, 5507-5509. [CrossRef] [PubMed]
-
(2014)
Curr. Pharm. Des
, vol.20
, pp. 5507-5509
-
-
Valero, T.1
-
32
-
-
84947026000
-
Metabolic roles of PGC-α and its implications for type 2 diabetes
-
CrossRef] [PubMed]
-
Besseiche, A.; Riveline, J.-P.; Gautier, J.-F.; Breant, B.; Blondeau, B. Metabolic roles of PGC-α and its implications for type 2 diabetes. Diabetes Metab. 2015, 41, 347-357. [CrossRef] [PubMed]
-
(2015)
Diabetes Metab
, vol.41
, pp. 347-357
-
-
Besseiche, A.1
Riveline, J.-P.2
Gautier, J.-F.3
Breant, B.4
Blondeau, B.5
-
33
-
-
33751011308
-
PGC-1α: A key regulator of energy metabolism
-
CrossRef] [PubMed]
-
Liang, H.; Ward, W.F. PGC-1α: A key regulator of energy metabolism. Adv. Physiol. Educ. 2006, 30, 145-151. [CrossRef] [PubMed]
-
(2006)
Adv. Physiol. Educ
, vol.30
, pp. 145-151
-
-
Liang, H.1
Ward, W.F.2
-
34
-
-
84865405481
-
Muscle mitochondria and insulin resistance: A human perspective
-
CrossRef] [PubMed]
-
Hoeks, J.; Schrauwen, P. Muscle mitochondria and insulin resistance: A human perspective. Trends Endocrinol. Metab. 2012, 23, 444-450. [CrossRef] [PubMed]
-
(2012)
Trends Endocrinol. Metab
, vol.23
, pp. 444-450
-
-
Hoeks, J.1
Schrauwen, P.2
-
35
-
-
63549114784
-
Hypertrophy and/or hyperplasia: Dynamics of adipose tissue growth
-
CrossRef] [PubMed]
-
Jo, J.; Gavrilova, O.; Pack, S.; Jou, W.; Mullen, S.; Summer, A.E.; Cushman, S.W.; Periwal, V. Hypertrophy and/or hyperplasia: Dynamics of adipose tissue growth. PLoS Comput. Biol. 2009, 5, e1000324. [CrossRef] [PubMed]
-
(2009)
Plos Comput. Biol
, vol.5
-
-
Jo, J.1
Gavrilova, O.2
Pack, S.3
Jou, W.4
Mullen, S.5
Summer, A.E.6
Cushman, S.W.7
Periwal, V.8
-
36
-
-
0035217707
-
Skeletal muscle lipid content and insulin resistance: Evidence for a paradox in endurance-trained athletes
-
CrossRef] [PubMed]
-
Goodpaster, B.H.; He, J.; Watkins, S.; Kelley, D.E. Skeletal muscle lipid content and insulin resistance: Evidence for a paradox in endurance-trained athletes. J. Clin. Endocrinol. Metab. 2001, 86, 5755-5761. [CrossRef] [PubMed]
-
(2001)
J. Clin. Endocrinol. Metab
, vol.86
, pp. 5755-5761
-
-
Goodpaster, B.H.1
He, J.2
Watkins, S.3
Kelley, D.E.4
-
37
-
-
45549084515
-
Exercise-Induced alterations in intramyocellular lipids and insulin resistance: The athlete’s paradox revisited
-
CrossRef] [PubMed]
-
Dubé, J.J.; Amati, F.; Stefanovic-Racic, M.; Toledo, F.G.S.; Sauers, S.E.; Goodpaster, B.H. Exercise-Induced alterations in intramyocellular lipids and insulin resistance: The athlete’s paradox revisited. Am. J. Physiol. Endocrinol. Metab. 2008, 294, E882-E888. [CrossRef] [PubMed]
-
(2008)
Am. J. Physiol. Endocrinol. Metab.
, vol.294
, pp. E882-E888
-
-
Dubé, J.J.1
Amati, F.2
Stefanovic-Racic, M.3
Toledo, F.G.S.4
Sauers, S.E.5
Goodpaster, B.H.6
-
38
-
-
0029151863
-
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: Genetic and clinical implications
-
CrossRef] [PubMed]
-
Unger, R.H. Lipotoxicity in the pathogenesis of obesity-dependent NIDDM: Genetic and clinical implications. Diabetes 1995, 44, 863-870. [CrossRef] [PubMed]
-
(1995)
Diabetes
, vol.44
, pp. 863-870
-
-
Unger, R.H.1
-
39
-
-
84868144928
-
Revisiting the diacylglycerol-induced insulin resistance hypothesis
-
CrossRef] [PubMed]
-
Amti, F. Revisiting the diacylglycerol-induced insulin resistance hypothesis. Obes. Rev. 2012, 13 (Suppl. S2), 40-50. [CrossRef] [PubMed]
-
(2012)
Obes. Rev
, vol.13
, pp. 40-50
-
-
Amti, F.1
-
40
-
-
77950543816
-
Diacylglycerol-Mediated insulin resistance
-
CrossRef] [PubMed]
-
Erion, D.M.; Shulman, G.I. Diacylglycerol-Mediated insulin resistance. Nat. Med. 2010, 16, 400-402. [CrossRef] [PubMed]
-
(2010)
Nat. Med
, vol.16
, pp. 400-402
-
-
Erion, D.M.1
Shulman, G.I.2
-
41
-
-
0037184925
-
Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
-
CrossRef] [PubMed]
-
Yu, C.; Chen, Y.; Cline, G.W.; Zhang, D.; Zhong, H.; Wang, Y.; Bergeron, R.; Kim, Y.K.; Cushman, S.W.; Cooney, G.J. et al. Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem. 2002, 277, 50230-50236. [CrossRef] [PubMed]
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 50230-50236
-
-
Yu, C.1
Chen, Y.2
Cline, G.W.3
Zhang, D.4
Zhong, H.5
Wang, Y.6
Bergeron, R.7
Kim, Y.K.8
Cushman, S.W.9
Cooney, G.J.10
-
42
-
-
0345086474
-
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C θ and alterations in insulin signalling cascade
-
CrossRef] [PubMed]
-
Griffin, M.E.; Marcucci, M.J.; Cline, G.W.; Bell, K.; Barucci, N.; Lee, D.; Goodyear, L.J.; Kraegen, E.W.; White, M.F.; Shulman, G.I. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C θ and alterations in insulin signalling cascade. Diabetes 1999, 48, 1270-1274. [CrossRef] [PubMed]
-
(1999)
Diabetes
, vol.48
, pp. 1270-1274
-
-
Griffin, M.E.1
Marcucci, M.J.2
Cline, G.W.3
Bell, K.4
Barucci, N.5
Lee, D.6
Goodyear, L.J.7
Kraegen, E.W.8
White, M.F.9
Shulman, G.I.10
-
43
-
-
0036300538
-
Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkB-α
-
CrossRef] [PubMed]
-
Itani, S.I.; Ruderman, N.B.; Schmieder, F.; Boden, G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkB-α. Diabetes 2002, 51, 2005-2011. [CrossRef] [PubMed]
-
(2002)
Diabetes
, vol.51
, pp. 2005-2011
-
-
Itani, S.I.1
Ruderman, N.B.2
Schmieder, F.3
Boden, G.4
-
44
-
-
84946796497
-
Role of PKCδ in insulin sensitivity and skeletal muscle metabolism
-
CrossRef] [PubMed]
-
Li, M.; Veinberg, S.G.; Bezy, O.; O’Neill, B.T.; Kahn, C.R. Role of PKCδ in insulin sensitivity and skeletal muscle metabolism. Diabetes 2015, 64, 4023-4032. [CrossRef] [PubMed]
-
(2015)
Diabetes
, vol.64
, pp. 4023-4032
-
-
Li, M.1
Veinberg, S.G.2
Bezy, O.3
O’Neill, B.T.4
Kahn, C.R.5
-
45
-
-
79959378791
-
Insulin-Stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: The effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids
-
CrossRef] [PubMed]
-
Lam, Y.Y.; Hatzinikolas, G.; Weir, J.M.; Janovska, A.; McAinch, A.J.; Game, P.; Meikle, P.J.; Wittert, G.A. Insulin-Stimulated glucose uptake and pathways regulating energy metabolism in skeletal muscle cells: The effects of subcutaneous and visceral fat, and long-chain saturated, n-3 and n-6 polyunsaturated fatty acids. Biochim. Biophy. Acta 2011, 1811, 468-475. [CrossRef] [PubMed]
-
(2011)
Biochim. Biophy. Acta
, vol.1811
, pp. 468-475
-
-
Lam, Y.Y.1
Hatzinikolas, G.2
Weir, J.M.3
Janovska, A.4
McAinch, A.J.5
Game, P.6
Meikle, P.J.7
Wittert, G.A.8
-
46
-
-
84954386766
-
The CDP-Ethanolamine pathway regulates skeletal muscle diacylglycerol content and mitochondrial biogenesis without altering insulin sensitivity
-
CrossRef] [PubMed]
-
Selathurai, A.; Kowalski, G.M.; Burch, M.L.; Sepulveda, P.; Risis, S.; Lee-Young, R.S.; Lamon, S.; Meikle, P.J.; Genders, A.J.; McGee, S.L. et al. The CDP-Ethanolamine pathway regulates skeletal muscle diacylglycerol content and mitochondrial biogenesis without altering insulin sensitivity. Cell Metab. 2015, 21, 718-730. [CrossRef] [PubMed]
-
(2015)
Cell Metab
, vol.21
, pp. 718-730
-
-
Selathurai, A.1
Kowalski, G.M.2
Burch, M.L.3
Sepulveda, P.4
Risis, S.5
Lee-Young, R.S.6
Lamon, S.7
Meikle, P.J.8
Genders, A.J.9
McGee, S.L.10
-
47
-
-
84903691827
-
Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans
-
CrossRef] [PubMed]
-
Szendroedi, J.; Yoshimura, T.; Phielix, E.; Koliaki, C.; Marucci, M.; Zhang, D.; Jelenik, T.; Muller, J.; Herder, C.; Nowotny, P. et al. Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans. Proc. Natl. Acad. Sci. USA 2014, 111, 9597-9602. [CrossRef] [PubMed]
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 9597-9602
-
-
Szendroedi, J.1
Yoshimura, T.2
Phielix, E.3
Koliaki, C.4
Marucci, M.5
Zhang, D.6
Jelenik, T.7
Muller, J.8
Herder, C.9
Nowotny, P.10
-
48
-
-
84937970971
-
Lipid-Induced muscle insulin resistance: Different fat, different pathways
-
CrossRef] [PubMed]
-
Ritter, O.; Jelenik, T.; Roden, M. Lipid-Induced muscle insulin resistance: different fat, different pathways. J. Mol. Med. 2015, 93, 831-843. [CrossRef] [PubMed]
-
(2015)
J. Mol. Med
, vol.93
, pp. 831-843
-
-
Ritter, O.1
Jelenik, T.2
Roden, M.3
-
49
-
-
0018803639
-
Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system
-
CrossRef]
-
Takai, Y.; Kishimoto, A.; Kikkawa, U.; Mori, T.; Nishizuka, Y. Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system. Biochem. Biophys. Res. Commun. 1979, 91, 1218-1224. [CrossRef]
-
(1979)
Biochem. Biophys. Res. Commun
, vol.91
, pp. 1218-1224
-
-
Takai, Y.1
Kishimoto, A.2
Kikkawa, U.3
Mori, T.4
Nishizuka, Y.5
-
50
-
-
0037303088
-
Discovery and prospect of protein kinase C research: Epilogue
-
CrossRef] [PubMed]
-
Nishizuka, Y. Discovery and prospect of protein kinase C research: Epilogue. J. Biochem. 2003, 133, 155-158. [CrossRef] [PubMed]
-
(2003)
J. Biochem
, vol.133
, pp. 155-158
-
-
Nishizuka, Y.1
-
51
-
-
84878871217
-
Distinct patterns of tissue specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding
-
CrossRef] [PubMed]
-
Turner, N.; Kowalski, G.M.; Leslie, S.J.; Risis, S.; Yang, C.; Lee-Young, R.S.; Babb, J.R.; Meikle, P.J.; Lancaster, G.I.; Hentridge, D.C. et al. Distinct patterns of tissue specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding. Diabetologia 2013, 56, 1638-1648. [CrossRef] [PubMed]
-
(2013)
Diabetologia
, vol.56
, pp. 1638-1648
-
-
Turner, N.1
Kowalski, G.M.2
Leslie, S.J.3
Risis, S.4
Yang, C.5
Lee-Young, R.S.6
Babb, J.R.7
Meikle, P.J.8
Lancaster, G.I.9
Hentridge, D.C.10
-
52
-
-
38549152194
-
Principles of bioactive lipid signalling: Lessons from sphingolipids
-
Yusuf, A.H.; Lina, M.O. Principles of bioactive lipid signalling: Lessons from sphingolipids. Nat. Rev. Mol. Cell Biol. 2008, 9, 139-150.
-
(2008)
Nat. Rev. Mol. Cell Biol
, vol.9
, pp. 139-150
-
-
Yusuf, A.H.1
Lina, M.O.2
-
53
-
-
33646394578
-
Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: Role of intramuscular accumulation of lipid metabolites
-
CrossRef] [PubMed]
-
Lee, J.S.; Pinnamaneni, S.K.; Eo, S.J.; Cho, I.H.; Pyo, J.H.; Kim, C.K.; Sinclair, A.J.; Febrraio, M.A.; Watt, M.J. Saturated, but not n-6 polyunsaturated, fatty acids induce insulin resistance: Role of intramuscular accumulation of lipid metabolites. J. Appl. Physiol. 2006, 100, 1467-1474. [CrossRef] [PubMed]
-
(2006)
J. Appl. Physiol.
, vol.100
, pp. 1467-1474
-
-
Lee, J.S.1
Pinnamaneni, S.K.2
Eo, S.J.3
Cho, I.H.4
Pyo, J.H.5
Kim, C.K.6
Sinclair, A.J.7
Febrraio, M.A.8
Watt, M.J.9
-
54
-
-
84961307736
-
Lipid mixtures containing a very high proportion of saturated fatty acids only modestly impair insulin signalling in cultured muscle cells
-
CrossRef]
-
Newson, S.A.; Everett, A.C.; Park, S.; Van Pelt, D.W.; Hinko, A.; Horowitz, J.F. Lipid mixtures containing a very high proportion of saturated fatty acids only modestly impair insulin signalling in cultured muscle cells. PLoS ONE 2015, 10, e0120871. [CrossRef]
-
(2015)
Plos ONE
, vol.10
-
-
Newson, S.A.1
Everett, A.C.2
Park, S.3
Van Pelt, D.W.4
Hinko, A.5
Horowitz, J.F.6
-
55
-
-
80054079107
-
Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics
-
CrossRef] [PubMed]
-
Merrill, A.H., Jr. Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics. Chem. Rev. 2011, 111, 6387-6422. [CrossRef] [PubMed]
-
(2011)
Chem. Rev
, vol.111
, pp. 6387-6422
-
-
Merrill, A.H.1
-
56
-
-
33847332202
-
Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
-
CrossRef] [PubMed]
-
Holland, W.L.; Brozinick, J.T.; Wang, L.P.; Hawkins, E.D.; Sargent, K.M.; Liu, Y.Q.; Narra, K.; Hoehn, K.L.; Knotts, T.A.; Siesky, A. et al. Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 2007, 5, 167-179. [CrossRef] [PubMed]
-
(2007)
Cell Metab
, vol.5
, pp. 167-179
-
-
Holland, W.L.1
Brozinick, J.T.2
Wang, L.P.3
Hawkins, E.D.4
Sargent, K.M.5
Liu, Y.Q.6
Narra, K.7
Hoehn, K.L.8
Knotts, T.A.9
Siesky, A.10
-
57
-
-
84891922939
-
Ceramides and glucosylceramides are independent antagonists of insulin signaling
-
CrossRef] [PubMed]
-
Chavez, J.A.; Siddique, M.M.; Wang, S.T.; Ching, J.H.; Shayman, J.A.; Summers, S.A. Ceramides and glucosylceramides are independent antagonists of insulin signaling. J. Biol. Chem. 2014, 289, 723-734. [CrossRef] [PubMed]
-
(2014)
J. Biol. Chem
, vol.289
, pp. 723-734
-
-
Chavez, J.A.1
Siddique, M.M.2
Wang, S.T.3
Ching, J.H.4
Shayman, J.A.5
Summers, S.A.6
-
58
-
-
79955487247
-
Lipid-Induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
-
CrossRef] [PubMed]
-
Holland, W.L.; Bikman, B.T.; Wang, L.P.; Yuguang, G.; Sargent, K.M.; Bulchand, S.; Knotts, T.A.; Shui, G.H.; Clegg, D.J.; Wenk, M.R. et al. Lipid-Induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J. Clin. Investig. 2011, 121, 1858-1870. [CrossRef] [PubMed]
-
(2011)
J. Clin. Investig
, vol.121
, pp. 1858-1870
-
-
Holland, W.L.1
Bikman, B.T.2
Wang, L.P.3
Yuguang, G.4
Sargent, K.M.5
Bulchand, S.6
Knotts, T.A.7
Shui, G.H.8
Clegg, D.J.9
Wenk, M.R.10
-
59
-
-
45149106053
-
Sphingolipids, insulin resistance, and metabolic disease: New insights from in vivo manipulation of sphingolipid metabolism
-
CrossRef] [PubMed]
-
Holand, W.L.; Summers, S.A. Sphingolipids, insulin resistance, and metabolic disease: New insights from in vivo manipulation of sphingolipid metabolism. Endocr. Rev. 2008, 29, 381-402. [CrossRef] [PubMed]
-
(2008)
Endocr. Rev
, vol.29
, pp. 381-402
-
-
Holand, W.L.1
Summers, S.A.2
-
60
-
-
77957348390
-
Sphingolipids and insulin resistance: The five Ws
-
CrossRef] [PubMed]
-
Summers, S.A. Sphingolipids and insulin resistance: The five Ws. Curr. Opin. Lipidol. 2010, 21, 128-135. [CrossRef] [PubMed]
-
(2010)
Curr. Opin. Lipidol.
, vol.21
, pp. 128-135
-
-
Summers, S.A.1
-
61
-
-
84860482342
-
A ceramide-centric view of insulin resistance
-
CrossRef] [PubMed]
-
Chavez, J.A.; Summers, S.A. A ceramide-centric view of insulin resistance. Cell Metab. 2012, 15, 585-594. [CrossRef] [PubMed]
-
(2012)
Cell Metab
, vol.15
, pp. 585-594
-
-
Chavez, J.A.1
Summers, S.A.2
-
62
-
-
84942103324
-
Ceramides-Lipotoxic inducers of metabolic disorders
-
CrossRef] [PubMed]
-
Chaurasia, B.; Summers, S.A. Ceramides-Lipotoxic inducers of metabolic disorders. Trends Endocrinol. Metab. 2015, 26, 538-550. [CrossRef] [PubMed]
-
(2015)
Trends Endocrinol. Metab
, vol.26
, pp. 538-550
-
-
Chaurasia, B.1
Summers, S.A.2
-
63
-
-
84940100002
-
Dihydroceramides: From bit players to lead actors
-
CrossRef] [PubMed]
-
Siddique, M.M.; Li, Y.; Chaurasia, B.; Kaddai, V.A.; Summers, S.A. Dihydroceramides: From bit players to lead actors. J. Biol. Chem. 2015, 290, 15371-15379. [CrossRef] [PubMed]
-
(2015)
J. Biol. Chem
, vol.290
, pp. 15371-15379
-
-
Siddique, M.M.1
Li, Y.2
Chaurasia, B.3
Kaddai, V.A.4
Summers, S.A.5
-
64
-
-
0032484132
-
Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression
-
CrossRef] [PubMed]
-
Shimabukuro, M.; Higa, M.; Zhou, Y.T.; Wang, M.Y.; Newgard, C.B.; Unger, R.H. Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression. J. Biol. Chem. 1998, 273, 32487-32490. [CrossRef] [PubMed]
-
(1998)
J. Biol. Chem
, vol.273
, pp. 32487-32490
-
-
Shimabukuro, M.1
Higa, M.2
Zhou, Y.T.3
Wang, M.Y.4
Newgard, C.B.5
Unger, R.H.6
-
65
-
-
59849098608
-
Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells
-
CrossRef] [PubMed]
-
Watson, M.L.; Coghlan, M.; Hundal, H.S. Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells. Biochem. J. 2009, 417, 791-801. [CrossRef] [PubMed]
-
(2009)
Biochem. J
, vol.417
, pp. 791-801
-
-
Watson, M.L.1
Coghlan, M.2
Hundal, H.S.3
-
66
-
-
44749085396
-
Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity
-
CrossRef] [PubMed]
-
Skovbro, M.; Baranowski, M.; Skov-Jensen, C.; Flint, A.; Dela, F.; Gorski, J.; Helge, J.W. Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity. Diabetologia 2008, 51, 1253-1260. [CrossRef] [PubMed]
-
(2008)
Diabetologia
, vol.51
, pp. 1253-1260
-
-
Skovbro, M.1
Baranowski, M.2
Skov-Jensen, C.3
Flint, A.4
Dela, F.5
Gorski, J.6
Helge, J.W.7
-
67
-
-
79251646392
-
Improved glucose tolerance after intensive life style intervention occurs without change in muscle ceramide or triacylglycerol in morbidly obese subjects
-
CrossRef] [PubMed]
-
Helge, J.W.; Stalknectt, B.; Drachmann, T.; Hellgren, L.I.; Jimenez-Jimenez, R.; Andersen, J.L.; Richelsen, B.; Bruun, J.M. Improved glucose tolerance after intensive life style intervention occurs without change in muscle ceramide or triacylglycerol in morbidly obese subjects. Acta Physiol. (Oxf.) 2011, 201, 357-364. [CrossRef] [PubMed]
-
(2011)
Acta Physiol. (Oxf.)
, vol.201
, pp. 357-364
-
-
Helge, J.W.1
Stalknectt, B.2
Drachmann, T.3
Hellgren, L.I.4
Jimenez-Jimenez, R.5
Andersen, J.L.6
Richelsen, B.7
Bruun, J.M.8
-
68
-
-
79954632229
-
Effects of weight loss and exercise on insulin resistance, and on intramyocellular triacylglycerol, diacylglycerol and ceramide
-
CrossRef] [PubMed]
-
Dubé, J.J.; Amati, F.; Stefanovic-Racic, M.; Rossi, A.; Coen, P.; Goodpaster, B.H. Effects of weight loss and exercise on insulin resistance, and on intramyocellular triacylglycerol, diacylglycerol and ceramide. Diabetologia 2011, 54, 1147-1156. [CrossRef] [PubMed]
-
(2011)
Diabetologia
, vol.54
, pp. 1147-1156
-
-
Dubé, J.J.1
Amati, F.2
Stefanovic-Racic, M.3
Rossi, A.4
Coen, P.5
Goodpaster, B.H.6
-
69
-
-
84907984591
-
CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance
-
CrossRef] [PubMed]
-
Raicur, S.; Wang, T.; Chan, P.W.; Li, Y.; Ching, J.; Chaurasia, B.; Dogra, S.; Ohman, M.K.; Takeda, K.; Sugii, S. et al. CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. Cell Metab. 2014, 20, 687-695. [CrossRef] [PubMed]
-
(2014)
Cell Metab
, vol.20
, pp. 687-695
-
-
Raicur, S.1
Wang, T.2
Chan, P.W.3
Li, Y.4
Ching, J.5
Chaurasia, B.6
Dogra, S.7
Ohman, M.K.8
Takeda, K.9
Sugii, S.10
-
70
-
-
84907978697
-
Obesity-induced Cers6-dependent c16:0 ceramide production promotes weight gain and glucose intolerance
-
CrossRef] [PubMed]
-
Turpin, S.M.; Nicholls, H.T.; Willmes, D.M.; Mourier, A.; Brodesser, S.; Wunderlich, C.M.; Maur, J.; Xu, E.; Hammerschmidt, P.; Bronneke, H.S. et al. Obesity-induced Cers6-dependent c16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab. 2014, 20, 678-686. [CrossRef] [PubMed]
-
(2014)
Cell Metab
, vol.20
, pp. 678-686
-
-
Turpin, S.M.1
Nicholls, H.T.2
Willmes, D.M.3
Mourier, A.4
Brodesser, S.5
Wunderlich, C.M.6
Maur, J.7
Xu, E.8
Hammerschmidt, P.9
Bronneke, H.S.10
-
71
-
-
84959557399
-
Muscle sphingolipids during rest and exercise: C18:0 signature for insulin resistance
-
CrossRef] [PubMed]
-
Bergman, B.C.; Brozinick, J.T.; Straus, A.; Bacon, S.; Kerege, A.; Bui, H.H.; Sanders, P.; Siddall, P.; Wei, T.; Thomas, M.K. et al. Muscle sphingolipids during rest and exercise: C18:0 signature for insulin resistance. Diabetologia 2016, 59, 785-798. [CrossRef] [PubMed]
-
(2016)
Diabetologia
, vol.59
, pp. 785-798
-
-
Bergman, B.C.1
Brozinick, J.T.2
Straus, A.3
Bacon, S.4
Kerege, A.5
Bui, H.H.6
Sanders, P.7
Siddall, P.8
Wei, T.9
Thomas, M.K.10
-
72
-
-
84940002705
-
Skeletal muscle ceramide species in men with abdominal obesity
-
CrossRef] [PubMed]
-
De La Maza, M.P.; Rodriguez, J.M.; Hirsch, S.; Leiva, L.; Barrera, G.; Bunout, D. Skeletal muscle ceramide species in men with abdominal obesity. J. Nutr. Health Aging 2015, 19, 389-396. [CrossRef] [PubMed]
-
(2015)
J. Nutr. Health Aging
, vol.19
, pp. 389-396
-
-
De La Maza, M.P.1
Rodriguez, J.M.2
Hirsch, S.3
Leiva, L.4
Barrera, G.5
Bunout, D.6
-
73
-
-
84933179866
-
Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and Type 2 Diabetes
-
CrossRef] [PubMed]
-
Kasumov, T.; Solomon, T.P.J.; Hwang, K.; Hunag, H.; Haus, J.M.; Zhang, R.; Kirwan, J.P. Improved insulin sensitivity after exercise training is linked to reduced plasma C14:0 ceramide in obesity and Type 2 Diabetes. Obesity 2015, 23, 1414-1421. [CrossRef] [PubMed]
-
(2015)
Obesity
, vol.23
, pp. 1414-1421
-
-
Kasumov, T.1
Solomon, T.P.J.2
Hwang, K.3
Hunag, H.4
Haus, J.M.5
Zhang, R.6
Kirwan, J.P.7
-
74
-
-
84875165515
-
The role of gut microbiota on insulin resistance
-
CrossRef] [PubMed]
-
Caricilli, A.M.; Saad, M.J.A. The role of gut microbiota on insulin resistance. Nutrients 2013, 5, 829-851. [CrossRef] [PubMed]
-
(2013)
Nutrients
, vol.5
, pp. 829-851
-
-
Caricilli, A.M.1
Saad, M.J.A.2
|