Ceramides and glucosylceramides are independent antagonists of insulin signaling

Journal of Biological Chemistry

Volumn 289, Issue 2, 2014, Pages 723-734

  Chavez, Jose A ^a   Siddique, M Mobin ^b   Wang, Siew Tein ^b   Ching, Jianhong ^b   Shayman, James A ^c   Summers, Scott A ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN ACTION; INSULIN RESISTANCE; INSULIN SIGNALING; MECHANISM OF ACTION; METABOLIC DISEASE; SPHINGOLIPIDS; TISSUE SPECIFICITY;

CERAMIDES;

INSULIN;

CERAMIDE; CERAMIDE GLUCOSYLTRANSFERASE; GLUCOSE TRANSPORTER 4; GLUCOSYLCERAMIDE; GLYCOGEN SYNTHASE; GLYCOGEN SYNTHASE KINASE 3; PALMITIC ACID; PROTEIN KINASE B; PROTEIN TBC1D1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GLUCOSE TOLERANCE TEST; GLUCOSE TRANSPORT; GLYCOSYLATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; INSULIN SIGNALING; LIPOGENESIS; MALE; MOUSE; MUSCLE TISSUE; MYOTUBE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY;

CERAMIDE; GLUCOSE TRANSPORT; GLUCOSYLCERAMIDE; GLYCEROSPHINGOLIPID; INSULIN; INSULIN RESISTANCE; LIPOTOXICITY; METABOLISM; SPHINGOLIPID;

3T3-L1 CELLS; ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE; CERAMIDES; DIET, HIGH-FAT; GLUCOSYLCERAMIDES; GLUCOSYLTRANSFERASES; HUMANS; INSULIN; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; MUSCLE FIBERS, SKELETAL; MYOBLASTS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

EID: 84891922939     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.522847     Document Type: Article

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