-
1
-
-
84873956600
-
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary
-
Vestbo,J. et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am. J. Respir. Crit. Care Med. 187, 347-65 (2013).
-
(2013)
Am. J. Respir. Crit. Care Med.
, vol.187
, pp. 347-365
-
-
Vestbo, J.1
-
2
-
-
80051513023
-
Family history is a risk factor for COPD
-
Hersh, C. P. et al. Family history is a risk factor for COPD. Chest 140, 343-350 (2011).
-
(2011)
Chest
, vol.140
, pp. 343-350
-
-
Hersh, C.P.1
-
3
-
-
0035888763
-
Siblings of patients with severe chronic obstructive pulmonary disease have a significant risk of airflow obstruction
-
McCloskey, S. et al. Siblings of patients with severe chronic obstructive pulmonary disease have a significant risk of airflow obstruction. Am J Respir Crit Care Med 164, 1419-1424 (2001).
-
(2001)
Am J Respir Crit Care Med
, vol.164
, pp. 1419-1424
-
-
McCloskey, S.1
-
4
-
-
85015179089
-
-
eds. Organizer, D. C. & Goode, J. A. (John Wiley & Sons, Ltd)
-
Silverman, E. K. In Chronic Obstructive Pulmonary Disease: Pathogenesis to Treatment (eds. Organizer, D. C. & Goode, J. A.) 45-64 (John Wiley & Sons, Ltd, 2000).
-
(2000)
Chronic Obstructive Pulmonary Disease: Pathogenesis to Treatment
, pp. 45-64
-
-
Silverman, E.K.1
-
5
-
-
0031807729
-
Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis
-
Silverman, E. K. et al. Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. Am. J. Respir. Crit. Care Med. 157, 1770-8 (1998).
-
(1998)
Am. J. Respir. Crit. Care Med.
, vol.157
, pp. 1770-1778
-
-
Silverman, E.K.1
-
6
-
-
77649189442
-
Variants in FAM13A are associated with chronic obstructive pulmonary disease
-
Cho, M. H. et al. Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat. Genet. 42, 200-202 (2010).
-
(2010)
Nat. Genet.
, vol.42
, pp. 200-202
-
-
Cho, M.H.1
-
7
-
-
84856337050
-
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13
-
Cho, M. H. et al. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum. Mol. Genet. 21, 947-57 (2012).
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 947-957
-
-
Cho, M.H.1
-
8
-
-
84895799527
-
Risk loci for chronic obstructive pulmonary disease: A genome-wide association study and meta-analysis
-
Cho, M. H. et al. Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir. Med. 2, 214-25 (2014).
-
(2014)
Lancet Respir. Med.
, vol.2
, pp. 214-225
-
-
Cho, M.H.1
-
9
-
-
61549124380
-
Molecular biomarkers for quantitative and discrete COPD phenotypes
-
Bhattacharya, S. et al. Molecular Biomarkers for Quantitative and Discrete COPD Phenotypes. Am. J. Respir. Cell Mol. Biol. 40, 359-367 (2009).
-
(2009)
Am. J. Respir. Cell Mol. Biol.
, vol.40
, pp. 359-367
-
-
Bhattacharya, S.1
-
10
-
-
84949116161
-
A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK
-
Campbell, J. D. et al. A gene expression signature of emphysema-related lung destruction and its reversal by the tripeptide GHK. Genome Med. 4, 67 (2012).
-
(2012)
Genome Med.
, vol.4
, pp. 67
-
-
Campbell, J.D.1
-
11
-
-
84856045106
-
Gene expression networks in COPD: MicroRNA and mRNA regulation
-
Ezzie, M. E. et al. Gene expression networks in COPD: microRNA and mRNA regulation. Thorax 67, 122-131 (2012).
-
(2012)
Thorax
, vol.67
, pp. 122-131
-
-
Ezzie, M.E.1
-
12
-
-
76249090636
-
Expression profiling identifies genes involved in emphysema severity
-
Francis, S. M. et al. Expression profiling identifies genes involved in emphysema severity. Respir. Res. 10, 81 (2009).
-
(2009)
Respir. Res.
, vol.10
, pp. 81
-
-
Francis, S.M.1
-
13
-
-
9744250109
-
Emphysema lung tissue gene expression profiling
-
Golpon, H. A. et al. Emphysema Lung Tissue Gene Expression Profiling. Am. J. Respir. Cell Mol. Biol. 31, 595-600 (2004).
-
(2004)
Am. J. Respir. Cell Mol. Biol.
, vol.31
, pp. 595-600
-
-
Golpon, H.A.1
-
14
-
-
6944222804
-
Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease
-
Ning, W. et al. Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc. Natl. Acad. Sci. USA 101, 14895-14900 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 14895-14900
-
-
Ning, W.1
-
15
-
-
79952676017
-
Genes and gene ontologies common to airflow obstruction and emphysema in the lungs of patients with COPD
-
Savarimuthu Francis, S. M. et al. Genes and Gene Ontologies Common to Airflow Obstruction and Emphysema in the Lungs of Patients with COPD. PLoS ONE 6, e17442 (2011).
-
(2011)
PLoS ONE
, vol.6
, pp. e17442
-
-
Savarimuthu Francis, S.M.1
-
16
-
-
9744246724
-
Gene expression profiling of human lung tissue from smokers with severe emphysema
-
Spira, A. et al. Gene Expression Profiling of Human Lung Tissue from Smokers with Severe Emphysema. Am. J. Respir. Cell Mol. Biol. 31, 601-610 (2004).
-
(2004)
Am. J. Respir. Cell Mol. Biol.
, vol.31
, pp. 601-610
-
-
Spira, A.1
-
17
-
-
39849096188
-
Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer
-
Wang, I.-M. et al. Gene Expression Profiling in Patients with Chronic Obstructive Pulmonary Disease and Lung Cancer. Am. J. Respir. Crit. Care Med. 177, 402-411 (2008).
-
(2008)
Am. J. Respir. Crit. Care Med.
, vol.177
, pp. 402-411
-
-
Wang, I.-M.1
-
18
-
-
57349175524
-
Translating the COPD transcriptome
-
Zeskind, J. E., Lenburg, M. E. & Spira, A. Translating the COPD Transcriptome. Proc. Am. Thorac. Soc. 5, 834-841 (2008).
-
(2008)
Proc. Am. Thorac. Soc.
, vol.5
, pp. 834-841
-
-
Zeskind, J.E.1
Lenburg, M.E.2
Spira, A.3
-
19
-
-
54949132095
-
Identifying targets for COPD treatment through gene expression analyses
-
Chen, Z.-H., Kim, H. P., Ryter, S. W. & Choi, A. M. Identifying targets for COPD treatment through gene expression analyses. Int. J. Chron. Obstruct. Pulmon. Dis. 3, 359 (2008).
-
(2008)
Int. J. Chron. Obstruct. Pulmon. Dis.
, vol.3
, pp. 359
-
-
Chen, Z.-H.1
Kim, H.P.2
Ryter, S.W.3
Choi, A.M.4
-
20
-
-
84908609302
-
Integrative genomics of chronic obstructive pulmonary disease
-
Hobbs, B. D. & Hersh, C. P. Integrative genomics of chronic obstructive pulmonary disease. Biochem. Biophys. Res. Commun. 452, 276-286 (2014).
-
(2014)
Biochem. Biophys. Res. Commun.
, vol.452
, pp. 276-286
-
-
Hobbs, B.D.1
Hersh, C.P.2
-
21
-
-
84879121298
-
A systems biology framework identifies molecular underpinnings of coronary heart disease
-
Huan, T. et al. A systems biology framework identifies molecular underpinnings of coronary heart disease. Arterioscler. Thromb. Vasc. Biol. 33, 1427-1434 (2013).
-
(2013)
Arterioscler. Thromb. Vasc. Biol.
, vol.33
, pp. 1427-1434
-
-
Huan, T.1
-
22
-
-
84869073340
-
Synthesizing genome-wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate height
-
Lui, J. C. et al. Synthesizing genome-wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate height. Hum. Mol. Genet. 21, 5193-5201 (2012).
-
(2012)
Hum. Mol. Genet.
, vol.21
, pp. 5193-5201
-
-
Lui, J.C.1
-
23
-
-
84863516095
-
A systems genetics approach identifies genes and pathways for type 2 diabetes in human islets
-
Taneera, J. et al. A Systems Genetics Approach Identifies Genes and Pathways for Type 2 Diabetes in Human Islets. Cell Metab. 16, 122-134 (2012).
-
(2012)
Cell Metab.
, vol.16
, pp. 122-134
-
-
Taneera, J.1
-
24
-
-
79959262465
-
Transcriptomic analysis of autistic brain reveals convergent molecular pathology
-
Voineagu, I. et al. Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature 474, 380-384 (2011).
-
(2011)
Nature
, vol.474
, pp. 380-384
-
-
Voineagu, I.1
-
25
-
-
84865822182
-
Systematic localization of common disease-associated variation in regulatory DNA
-
Maurano, M. T. et al. Systematic Localization of Common Disease-Associated Variation in Regulatory DNA. Science 337, 1190-1195 (2012).
-
(2012)
Science
, vol.337
, pp. 1190-1195
-
-
Maurano, M.T.1
-
26
-
-
78149267111
-
Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes
-
Murphy, A. et al. Mapping of numerous disease-associated expression polymorphisms in primary peripheral blood CD4+ lymphocytes. Hum. Mol. Genet. 19, 4745-4757 (2010).
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 4745-4757
-
-
Murphy, A.1
-
27
-
-
77951439152
-
Trait-Associated SNPs are more likely to Be eQTLs: Annotation to enhance discovery from GWAS
-
Nicolae, D. L. et al. Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS. PLoS Genet 6, e1000888 (2010).
-
(2010)
PLoS Genet
, vol.6
, pp. e1000888
-
-
Nicolae, D.L.1
-
28
-
-
84943376336
-
Molecular mechanisms underlying variations in lung function: A systems genetics analysis
-
Obeidat, M. et al. Molecular mechanisms underlying variations in lung function: a systems genetics analysis. Lancet Respir. Med. 3, 782-795 (2015).
-
(2015)
Lancet Respir. Med.
, vol.3
, pp. 782-795
-
-
Obeidat, M.1
-
29
-
-
84957428592
-
Mitochondrial iron as a therapeutic target for IRP2-regulated cigarette smoke-induced bronchitis and emphysema
-
Cloonan, S. et al. Mitochondrial iron as a therapeutic target for IRP2-regulated cigarette smoke-induced bronchitis and emphysema. Nat. Med. 22, 163-74 (2016)
-
(2016)
Nat. Med.
, vol.22
, pp. 163-174
-
-
Cloonan, S.1
-
30
-
-
84988941641
-
A chronic obstructive pulmonary disease susceptibility gene, FAM13A, regulates protein stability of β -catenin
-
Jiang, Z. et al. A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β -catenin. Am. J. Respir. Crit. Care Med 194, 185-97 (2016).
-
(2016)
Am. J. Respir. Crit. Care Med
, vol.194
, pp. 185-197
-
-
Jiang, Z.1
-
31
-
-
84876418514
-
Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells
-
Zhou, X. et al. Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells. Genomics 101, 263-272 (2013).
-
(2013)
Genomics
, vol.101
, pp. 263-272
-
-
Zhou, X.1
-
32
-
-
84928820273
-
Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring
-
Lao, T. et al. Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring. Genome Med. 7, 12 (2015).
-
(2015)
Genome Med.
, vol.7
, pp. 12
-
-
Lao, T.1
-
33
-
-
84870461579
-
Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes
-
Haas, B. E. et al. Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes. BMC Med. Genomics 5 (2012).
-
(2012)
BMC Med. Genomics
, vol.5
-
-
Haas, B.E.1
-
34
-
-
84872112470
-
Network medicine approaches to the genetics of complex diseases
-
Silverman, E. & Loscalzo, J. Network Medicine Approaches to the Genetics of Complex Diseases. Discov. Med. 14, 143-152 (2012).
-
(2012)
Discov. Med.
, vol.14
, pp. 143-152
-
-
Silverman, E.1
Loscalzo, J.2
-
35
-
-
84928008785
-
Identifying a gene expression signature of frequent COPD exacerbations in peripheral blood using network methods
-
Morrow, J. D. et al. Identifying a gene expression signature of frequent COPD exacerbations in peripheral blood using network methods. BMC Med. Genomics 8, 1 (2015).
-
(2015)
BMC Med. Genomics
, vol.8
, pp. 1
-
-
Morrow, J.D.1
-
36
-
-
84894102230
-
Transcriptome-based network analysis reveals a spectrum model of human macrophage activation
-
Xue, J. et al. Transcriptome-based network analysis reveals a spectrum model of human macrophage activation. Immunity 40, 274-88 (2014).
-
(2014)
Immunity
, vol.40
, pp. 274-288
-
-
Xue, J.1
-
37
-
-
77952307233
-
Expression of high-mobility group box 1 and of receptor for advanced glycation end products in chronic obstructive pulmonary disease
-
Ferhani, N. et al. Expression of High-Mobility Group Box 1 and of Receptor for Advanced Glycation End Products in Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. 181, 917-927 (2010).
-
(2010)
Am. J. Respir. Crit. Care Med.
, vol.181
, pp. 917-927
-
-
Ferhani, N.1
-
38
-
-
84886441236
-
Systemic soluble receptor for advanced glycation endproducts is a biomarker of emphysema and associated with AGER genetic variants in patients with chronic obstructive pulmonary disease
-
Cheng, D. T. et al. Systemic Soluble Receptor for Advanced Glycation Endproducts Is a Biomarker of Emphysema and Associated with AGER Genetic Variants in Patients with Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. 188, 948-957 (2013).
-
(2013)
Am. J. Respir. Crit. Care Med.
, vol.188
, pp. 948-957
-
-
Cheng, D.T.1
-
39
-
-
84942248106
-
A genome-wide association study of emphysema and airway quantitative imaging phenotypes
-
Cho, M. H. et al. A Genome-Wide Association Study of Emphysema and Airway Quantitative Imaging Phenotypes. Am. J. Respir. Crit. Care Med. 192, 559-569 (2015).
-
(2015)
Am. J. Respir. Crit. Care Med.
, vol.192
, pp. 559-569
-
-
Cho, M.H.1
-
40
-
-
84894259001
-
Genome-wide study of percent emphysema on computed tomography in the general population. The multi-ethnic study of atherosclerosis lung/SNP health association resource study
-
Manichaikul, A. et al. Genome-Wide Study of Percent Emphysema on Computed Tomography in the General Population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study. Am. J. Respir. Crit. Care Med. 189, 408-418 (2014).
-
(2014)
Am. J. Respir. Crit. Care Med.
, vol.189
, pp. 408-418
-
-
Manichaikul, A.1
-
41
-
-
84910078929
-
UpSet: Visualization of intersecting sets
-
Lex, A., Gehlenborg, N., Strobelt, H., Vuillemot, R. & Pfister, H. UpSet: Visualization of Intersecting Sets. IEEE Trans. Vis. Comput. Graph. 20, 1983-1992 (2014).
-
(2014)
IEEE Trans. Vis. Comput. Graph.
, vol.20
, pp. 1983-1992
-
-
Lex, A.1
Gehlenborg, N.2
Strobelt, H.3
Vuillemot, R.4
Pfister, H.5
-
43
-
-
60549111634
-
WGCNA: An R package for weighted correlation network analysis
-
Langfelder, P. & Horvath, S. WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics 9, 559 (2008).
-
(2008)
BMC Bioinformatics
, vol.9
, pp. 559
-
-
Langfelder, P.1
Horvath, S.2
-
44
-
-
84971527067
-
Network analysis of lung transcriptomics reveals a distinct B cell signature in emphysema
-
Faner, R. et al. Network Analysis of Lung Transcriptomics Reveals a Distinct B Cell Signature in Emphysema. Am. J. Respir. Crit. Care Med. 193, 1242-53 (2016).
-
(2016)
Am. J. Respir. Crit. Care Med.
, vol.193
, pp. 1242-1253
-
-
Faner, R.1
-
45
-
-
73349143302
-
Genome-wide association study identifies five loci associated with lung function
-
Repapi, E. et al. Genome-wide association study identifies five loci associated with lung function. Nat. Genet. 42, 36-44 (2010).
-
(2010)
Nat. Genet.
, vol.42
, pp. 36-44
-
-
Repapi, E.1
-
46
-
-
84904889111
-
Changes of HMGB1 and sRAGE during the recovery of COPD exacerbation
-
Zhang, Y. et al. Changes of HMGB1 and sRAGE during the recovery of COPD exacerbation. J. Thorac. Dis. 6, 734 (2014).
-
(2014)
J. Thorac. Dis.
, vol.6
, pp. 734
-
-
Zhang, Y.1
-
47
-
-
84892614790
-
High expression of high-mobility group box 1 in the blood and lungs is associated with the development of chronic obstructive pulmonary disease in smokers
-
Ko, H.-K. et al. High expression of high-mobility group box 1 in the blood and lungs is associated with the development of chronic obstructive pulmonary disease in smokers. Respirology 19, 253-261 (2014).
-
(2014)
Respirology
, vol.19
, pp. 253-261
-
-
Ko, H.-K.1
-
48
-
-
79960726338
-
High mobility group protein B1 (HMGB1) in Asthma: Comparison of patients with chronic obstructive pulmonary disease and healthy controls
-
Hou, C. et al. High mobility group protein B1 (HMGB1) in Asthma: comparison of patients with chronic obstructive pulmonary disease and healthy controls. Mol. Med. 17, 807 (2011).
-
(2011)
Mol. Med.
, vol.17
, pp. 807
-
-
Hou, C.1
-
49
-
-
84895083345
-
DAMPs activating innate and adaptive immune responses in COPD
-
Pouwels, S. D. et al. DAMPs activating innate and adaptive immune responses in COPD. Mucosal Immunol. 7, 215-226 (2014).
-
(2014)
Mucosal Immunol.
, vol.7
, pp. 215-226
-
-
Pouwels, S.D.1
-
50
-
-
84907010947
-
Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD
-
Mizumura, K. et al. Mitophagy-dependent necroptosis contributes to the pathogenesis of COPD. J. Clin. Invest. 124, 3987-4003 (2014).
-
(2014)
J. Clin. Invest.
, vol.124
, pp. 3987-4003
-
-
Mizumura, K.1
-
51
-
-
31544455025
-
The SERPINE2 gene is associated with chronic obstructive pulmonary disease
-
DeMeo, D. L. et al. The SERPINE2 Gene Is Associated with Chronic Obstructive Pulmonary Disease. Am. J. Hum. Genet. 78, 253-264 (2006).
-
(2006)
Am. J. Hum. Genet.
, vol.78
, pp. 253-264
-
-
DeMeo, D.L.1
-
52
-
-
80052656636
-
Association of SERPINE2 with asthma
-
Himes, B. E. et al. Association of SERPINE2 with asthma. Chest. 140, 667-674 (2011).
-
(2011)
Chest.
, vol.140
, pp. 667-674
-
-
Himes, B.E.1
-
53
-
-
16344363033
-
Increased peripheral blood T-cell apoptosis and decreased Bcl-2 in chronic obstructive pulmonary disease
-
Hodge, S., Hodge, G., Holmes, M. & Reynolds, P. N. Increased peripheral blood T-cell apoptosis and decreased Bcl-2 in chronic obstructive pulmonary disease. Immunol. Cell Biol. 83, 160-166 (2005).
-
(2005)
Immunol. Cell Biol.
, vol.83
, pp. 160-166
-
-
Hodge, S.1
Hodge, G.2
Holmes, M.3
Reynolds, P.N.4
-
54
-
-
77954596271
-
Deregulation of apoptosis mediators' p53 and bcl2 in lung tissue of COPD patients
-
Siganaki, M. et al. Deregulation of apoptosis mediators' p53 and bcl2 in lung tissue of COPD patients. Respir. Res. 11, 46 (2010).
-
(2010)
Respir. Res.
, vol.11
, pp. 46
-
-
Siganaki, M.1
-
55
-
-
84864245915
-
Apoptosis and Bcl-2 family proteins, taken to chronic obstructive pulmonary disease
-
Zeng, H. et al. Apoptosis and Bcl-2 family proteins, taken to chronic obstructive pulmonary disease. Eur Rev Med Pharmacol Sci 16, 711-727 (2012).
-
(2012)
Eur Rev Med Pharmacol Sci
, vol.16
, pp. 711-727
-
-
Zeng, H.1
-
56
-
-
84922895336
-
Immune activation in α 1 -Antitrypsin-deficiency emphysema. beyond the protease-Antiprotease paradigm
-
Baraldo, S. et al. Immune Activation in α 1 -Antitrypsin-Deficiency Emphysema. Beyond the Protease-Antiprotease Paradigm. Am. J. Respir. Crit. Care Med. 191, 402-409 (2015).
-
(2015)
Am. J. Respir. Crit. Care Med.
, vol.191
, pp. 402-409
-
-
Baraldo, S.1
-
57
-
-
69249128696
-
Lymphoid follicles in (very) severe COPD: Beneficial or harmful?
-
Brusselle, G. G., Demoor, T., Bracke, K. R., Brandsma, C.-A. & Timens, W. Lymphoid follicles in (very) severe COPD: beneficial or harmful? Eur. Respir. J. 34, 219-230 (2009).
-
(2009)
Eur. Respir. J.
, vol.34
, pp. 219-230
-
-
Brusselle, G.G.1
Demoor, T.2
Bracke, K.R.3
Brandsma, C.-A.4
Timens, W.5
-
58
-
-
84904236073
-
Immune response in chronic obstructive pulmonary disease
-
Faner, R., Cruz, T. & Agusti, A. Immune response in chronic obstructive pulmonary disease. Expert Rev. Clin. Immunol. 9, 821-833 (2013).
-
(2013)
Expert Rev. Clin. Immunol.
, vol.9
, pp. 821-833
-
-
Faner, R.1
Cruz, T.2
Agusti, A.3
-
59
-
-
2942720573
-
The nature of small-airway obstruction in chronic obstructive pulmonary disease
-
Hogg, J. C. et al. The nature of small-airway obstruction in chronic obstructive pulmonary disease. N. Engl. J. Med. 350, 2645-2653 (2004).
-
(2004)
N. Engl. J. Med.
, vol.350
, pp. 2645-2653
-
-
Hogg, J.C.1
-
60
-
-
84942242255
-
B cell-Activating factor. An orchestrator of lymphoid follicles in severe chronic obstructive pulmonary disease
-
Polverino, F. et al. B Cell-Activating Factor. An Orchestrator of Lymphoid Follicles in Severe Chronic Obstructive Pulmonary Disease. Am. J. Respir. Crit. Care Med. 192, 695-705 (2015).
-
(2015)
Am. J. Respir. Crit. Care Med.
, vol.192
, pp. 695-705
-
-
Polverino, F.1
-
61
-
-
33645321836
-
Cigarette smoke-induced emphysema: A role for the B cell?
-
van der Strate, B. W. A. et al. Cigarette Smoke-induced Emphysema: A Role for the B Cell? Am. J. Respir. Crit. Care Med. 173, 751-758 (2006).
-
(2006)
Am. J. Respir. Crit. Care Med.
, vol.173
, pp. 751-758
-
-
Van Der Strate, B.W.A.1
-
62
-
-
0038516237
-
Bcl11a is essential for normal lymphoid development
-
Liu, P. et al. Bcl11a is essential for normal lymphoid development. Nat. Immunol. 4, 525-532 (2003).
-
(2003)
Nat. Immunol.
, vol.4
, pp. 525-532
-
-
Liu, P.1
-
63
-
-
17044440153
-
Contingent gene regulatory networks and B cell fate specification
-
Singh, H., Medina, K. L. & Pongubala, J. M. R. Contingent gene regulatory networks and B cell fate specification. Proc. Natl. Acad. Sci. USA. 102, 4949-4953 (2005).
-
(2005)
Proc. Natl. Acad. Sci. USA.
, vol.102
, pp. 4949-4953
-
-
Singh, H.1
Medina, K.L.2
Pongubala, J.M.R.3
-
64
-
-
84878768846
-
Regulation of Wnt4 in chronic obstructive pulmonary disease
-
Durham, A. L. et al. Regulation of Wnt4 in chronic obstructive pulmonary disease. FASEB J. 27, 2367-2381 (2013).
-
(2013)
FASEB J.
, vol.27
, pp. 2367-2381
-
-
Durham, A.L.1
-
65
-
-
79960851246
-
Biologic phenotyping of the human small airway epithelial response to cigarette smoking
-
Tilley, A. E. et al. Biologic Phenotyping of the Human Small Airway Epithelial Response to Cigarette Smoking. PLoS ONE 6, e22798 (2011).
-
(2011)
PLoS ONE
, vol.6
, pp. e22798
-
-
Tilley, A.E.1
-
66
-
-
0141782722
-
OCA-B regulation of B-cell development and function
-
Teitell, M. A. OCA-B regulation of B-cell development and function. Trends Immunol. 24, 546-553 (2003).
-
(2003)
Trends Immunol.
, vol.24
, pp. 546-553
-
-
Teitell, M.A.1
-
67
-
-
34547140875
-
The human disease network
-
Goh, K.-I. et al. The human disease network. Proc. Natl. Acad. Sci. 104, 8685-8690 (2007).
-
(2007)
Proc. Natl. Acad. Sci.
, vol.104
, pp. 8685-8690
-
-
Goh, K.-I.1
-
68
-
-
84870713668
-
Lung eQTLs to help reveal the molecular underpinnings of asthma
-
Hao, K. et al. Lung eQTLs to Help Reveal the Molecular Underpinnings of Asthma. PLOS Genet 8, e1003029 (2012).
-
(2012)
PLOS Genet
, vol.8
, pp. e1003029
-
-
Hao, K.1
-
69
-
-
12144252928
-
The prediction of small airway dimensions using computed tomography
-
Nakano, Y. et al. The Prediction of Small Airway Dimensions Using Computed Tomography. Am. J. Respir. Crit. Care Med. 171, 142-146 (2005).
-
(2005)
Am. J. Respir. Crit. Care Med.
, vol.171
, pp. 142-146
-
-
Nakano, Y.1
-
70
-
-
46249088370
-
Lumi: A pipeline for processing Illumina microarray
-
Du, P., Kibbe, W. A. & Lin, S. M. lumi: a pipeline for processing Illumina microarray. Bioinformatics 24, 1547-1548 (2008).
-
(2008)
Bioinformatics
, vol.24
, pp. 1547-1548
-
-
Du, P.1
Kibbe, W.A.2
Lin, S.M.3
-
71
-
-
84983003957
-
Hhip haploinsufficiency sensitizes mice to age-related emphysema
-
Lao, T. et al. Hhip haploinsufficiency sensitizes mice to age-related emphysema. Proc. Natl. Acad. Sci. 113, E4681-E4687 (2016).
-
(2016)
Proc. Natl. Acad. Sci.
, vol.113
, pp. E4681-E4687
-
-
Lao, T.1
-
72
-
-
77952567987
-
Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
-
Heinz, S. et al. Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities. Mol. Cell 38, 576-589 (2010).
-
(2010)
Mol. Cell
, vol.38
, pp. 576-589
-
-
Heinz, S.1
-
73
-
-
0037314331
-
Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung
-
Chuang, P.-T., Kawcak, T. & McMahon, A. P. Feedback control of mammalian Hedgehog signaling by the Hedgehog-binding protein, Hip1, modulates Fgf signaling during branching morphogenesis of the lung. Genes Dev. 17, 342-347 (2003).
-
(2003)
Genes Dev.
, vol.17
, pp. 342-347
-
-
Chuang, P.-T.1
Kawcak, T.2
McMahon, A.P.3
-
74
-
-
34848914038
-
Capturing heterogeneity in gene expression studies by surrogate variable analysis
-
Leek, J. T. & Storey, J. D. Capturing Heterogeneity in Gene Expression Studies by Surrogate Variable Analysis. PLoS Genet 3, e161 (2007).
-
(2007)
PLoS Genet
, vol.3
, pp. e161
-
-
Leek, J.T.1
Storey, J.D.2
-
75
-
-
33644872577
-
-
eds Gentleman, R., Carey, V., Dudoit, S., Irizarry, R. & Huber, W. Springer
-
Smyth, G. K. In Bioinformatics and Computational Biology Solutions Using {R} and Bioconductor (eds Gentleman, R., Carey, V., Dudoit, S., Irizarry, R. & Huber, W.) 397-420 (Springer, 2005).
-
(2005)
Bioinformatics and Computational Biology Solutions Using {R} and Bioconductor
, pp. 397-420
-
-
Smyth, G.K.1
-
76
-
-
77949533751
-
A collection of bioconductor methods to visualize gene-list annotations
-
Feng, G. et al. A collection of bioconductor methods to visualize gene-list annotations. BMC Res. Notes 3, 10-10 (2010).
-
(2010)
BMC Res. Notes
, vol.3
, pp. 10
-
-
Feng, G.1
-
77
-
-
84930213392
-
Second-generation PLINK: Rising to the challenge of larger and richer datasets
-
Chang, C. C. et al. Second-generation PLINK: rising to the challenge of larger and richer datasets. GigaScience 4, 7 (2015).
-
(2015)
GigaScience
, vol.4
, pp. 7
-
-
Chang, C.C.1
-
78
-
-
78149265272
-
Robust relationship inference in genome-wide association studies
-
Manichaikul, A. et al. Robust relationship inference in genome-wide association studies. Bioinformatics 26, 2867-2873 (2010).
-
(2010)
Bioinformatics
, vol.26
, pp. 2867-2873
-
-
Manichaikul, A.1
-
79
-
-
33746512512
-
Principal components analysis corrects for stratification in genome-wide association studies
-
Price, A. L. et al. Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 38, 904-909 (2006).
-
(2006)
Nat. Genet.
, vol.38
, pp. 904-909
-
-
Price, A.L.1
-
80
-
-
84861153094
-
Matrix eQTL: Ultra fast eQTL analysis via large matrix operations
-
Shabalin, A. A. Matrix eQTL: ultra fast eQTL analysis via large matrix operations. Bioinformatics 28, 1353-1358 (2012).
-
(2012)
Bioinformatics
, vol.28
, pp. 1353-1358
-
-
Shabalin, A.A.1
|