Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells

Journal of Hematology and Oncology

Volumn 10, Issue 1, 2017, Pages

  Qin, Le ^a   Lai, Yunxin ^a   Zhao, Ruocong ^a   Wei, Xinru ^a   Weng, Jianyu ^b   Lai, Peilong ^b   Li, Baiheng ^a   Lin, Simiao ^a   Wang, Suna ^a   Wu, Qiting ^a   Liang, Qiubin ^c   Li, Yangqiu ^d   Zhang, Xuchao ^b   Wu, Yilong ^b   Liu, Pentao ^e   Yao, Yao ^a   Pei, Duanqing ^a   Du, Xin ^b   Li, Peng ^a  

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^b GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^c InVivo Biomedicine Co Ltd   (China)

^d MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^e WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

CAR T cell; CD19; CD4+ T cell; Expansion; Hinge domain; Mesothelin

Indexed keywords

CD19 ANTIGEN; CHIMERIC ANTIGEN RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; LENTIVIRUS VECTOR; MESOTHELIN; MUCIN 1; PROSTATE STEM CELL ANTIGEN; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; CYTOKINE; ERBB2 PROTEIN, HUMAN; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; MUC1 PROTEIN, HUMAN; PSCA PROTEIN, HUMAN; TUMOR ANTIGEN; TUMOR PROTEIN;

ADOPTIVE TRANSFER; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; CD4+ T LYMPHOCYTE; CELL EXPANSION; CELL GROWTH; CELL INVASION; CELL KINETICS; CELL MEDIATED CYTOTOXICITY; CELL MIGRATION ASSAY; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFICACY PARAMETERS; HINGE REGION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA; LYMPHOCYTE COUNT; LYMPHOCYTE CULTURE; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; T LYMPHOCYTE; TUMOR XENOGRAFT; ADOPTIVE IMMUNOTHERAPY; ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; CYTOLOGY; CYTOTOXICITY; GENETICS; IMMUNOLOGY; PROCEDURES; PROTEIN DOMAIN; PROTEIN ENGINEERING; TUMOR CELL LINE; XENOGRAFT;

ANIMALS; ANTIGENS, CD19; ANTIGENS, NEOPLASM; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOKINES; CYTOTOXICITY, IMMUNOLOGIC; GPI-LINKED PROTEINS; HETEROGRAFTS; HUMANS; IMMUNOTHERAPY, ADOPTIVE; MICE; MUCIN-1; NEOPLASM PROTEINS; PROTEIN DOMAINS; PROTEIN ENGINEERING; RECEPTOR, ERBB-2; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 85015245388     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/s13045-017-0437-8     Document Type: Article

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