GZD824 suppresses the growth of human B cell precursor acute lymphoblastic leukemia cells by inhibiting the SRC kinase and PI3K/AKT pathways

Oncotarget

Volumn 8, Issue 50, 2017, Pages 87002-87015

  Ye, Wei ^a,b   Jiang, Zhiwu ^b   Lu, Xiaoyun ^b   Ren, Xiaomei ^b   Deng, Manman ^c   Lin, Shouheng ^b   Xiao, Yiren ^b   Lin, Simiao ^b   Wang, Suna ^b   Li, Baiheng ^b   Zheng, Yi ^b   Lai, Peilong ^d   Weng, Jianyu ^d   Wu, Donghai ^b   Ma, Yuguo ^e   Chen, Xudong ^f   Wen, Zhesheng ^g   Chen, Yaoyu ^h   Feng, Xiaoyan ⁱ   Li, Yangqiu ^j,k   Liu, Pentao ^l   Du, Xin ^d   Pei, Duanqing ^b   Yao, Yao ^b   Xu, Bing ^c   Ding, Ke ^b   Li, Peng ^b   more..

^a UNIVERSITY OF SCIENCE AND TECHNOLOGY OF CHINA   (China)

^b GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^c THE FIRST AFFILIATED HOSPITAL OF XIAMEN UNIVERSITY   (China)

^d GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^e Yikang Tailai Technology Co Ltd   (China)

^f SHENZHEN PEOPLE'S HOSPITAL   (China)

^g SUN YAT SEN UNIVERSITY CANCER CENTER   (China)

^h THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

ⁱ Chongqing HiChuang Biomedical Corp   (China)

^j MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^k JINAN UNIVERSITY   (China)

^l WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

more..

Author keywords

GZD824; PDX; PI3K AKT; Pre B ALL; SRC

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLIN DEPENDENT KINASE 4; GZD 824; INSULIN RECEPTOR SUBSTRATE 1; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL XL; PROTEIN TYROSINE KINASE; RETINOBLASTOMA PROTEIN; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; AKT SIGNALING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BCL XL GENE; CCKN1A GENE; CCND1 GENE; CDK4 GENE; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; G1 PHASE CELL CYCLE CHECKPOINT; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; UPREGULATION;

EID: 85031736938     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.10881     Document Type: Article

References (37)

1. Zhou Y, You MJ, Young KH, Lin P, Lu G, Medeiros LJ and Bueso-Ramos CE. Advances in the molecular pathobiology of B-lymphoblastic leukemia. Human pathology. 2012; 43:1347-1362
2. Moorman AV. The clinical relevance of chromosomal and genomic abnormalities in B-cell precursor acute lymphoblastic leukaemia. Blood Rev. 2012; 26:123-135
3. De Braekeleer E, Basinko A, Douet-Guilbert N, Morel F, Le Bris MJ, Berthou C, Morice P, Ferec C and De Braekeleer M. Cytogenetics in pre-B and B-cell acute lymphoblastic leukemia: a study of 208 patients diagnosed between 1981 and 2008. Cancer Genet Cytogen. 2010; 200:8-15
4. Tallen G, Ratei R, Mann G, Kaspers G, Niggli F, Karachunsky A, Ebell W, Escherich G, Schrappe M, Klingebiel T, Fengler R, Henze G and von Stackelberg A. Long-term outcome in children with relapsed acute lymphoblastic leukemia after time-point and site-ofrelapse stratification and intensified short-course multidrug chemotherapy: results of trial ALL-REZ BFM 90. Journal of clinical oncology. 2010; 28:2339-2347
5. Armstrong GT, Sklar CA, Hudson MM and Robison LL. Long-term health status among survivors of childhood cancer: does sex matter? Journal of clinical oncology. 2007; 25:4477-4489
6. Goldman JM and Melo JV. Chronic myeloid leukemia advances in biology and new approaches to treatment. The New England journal of medicine. 2003; 349:1451-1464
7. Drugs of choice for cancer. Treatment guidelines from the Medical Letter. 2003; 1:41-52
8. Xi S, Zhang Q, Dyer KF, Lerner EC, Smithgall TE, Gooding WE, Kamens J and Grandis JR. Src kinases mediate STAT growth pathways in squamous cell carcinoma of the head and neck. The Journal of biological chemistry. 2003; 278:31574-31583
9. Kharas MG, Okabe R, Ganis JJ, Gozo M, Khandan T, Paktinat M, Gilliland DG and Gritsman K. Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice. Blood. 2010; 115:1406-1415
10. Vivanco I and Sawyers CL. The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nature reviews Cancer. 2002; 2:489-501
11. Wong J, Welschinger R, Hewson J, Bradstock KF and Bendall LJ. Efficacy of dual PI-3K and mTOR inhibitors in vitro and in vivo in acute lymphoblastic leukemia. Oncotarget. 2014; 5:10460-10472. doi: 10.18632/oncotarget.2260
12. Ren X, Pan X, Zhang Z, Wang D, Lu X, Li Y, Wen D, Long H, Luo J, Feng Y, Zhuang X, Zhang F, Liu J, Leng F, Lang X, Bai Y, et al. Identification of GZD824 as an orally bioavailable inhibitor that targets phosphorylated and nonphosphorylated breakpoint cluster region-Abelson (Bcr-Abl) kinase and overcomes clinically acquired mutationinduced resistance against imatinib. Journal of medicinal chemistry. 2013; 56:879-894
13. Wang DP, Zhang Z, Lu XY, Feng YB, Luo K, Gan JR, Liu YX, Wan JT, Li XA, Zhang FX, Tu ZC, Cai QA, Ren XM and Ding K. Hybrid compounds as new Bcr/Abl inhibitors. Bioorg Med Chem Lett. 2011; 21:1965-1968
14. Robles-Escajeda E, Lerma D, Nyakeriga AM, Ross JA, Kirken RA, Aguilera RJ and Varela-Ramirez A. Searching in mother nature for anti-cancer activity: anti-proliferative and pro-apoptotic effect elicited by green barley on leukemia/lymphoma cells. PloS one. 2013; 8:e73508
15. Mori T, Hayashi T, Hayashi E and Su TP. Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival. PloS one. 2013; 8
16. Robles-Escajeda E, Das U, Ortega NM, Parra K, Francia G, Dimmock JR, Varela-Ramirez A and Aguilera RJ. A novel curcumin-like dienone induces apoptosis in triple-negative breast cancer cells. Cellular oncology. 2016
17. Fabian MA, Biggs WH, 3rd, Treiber DK, Atteridge CE, Azimioara MD, Benedetti MG, Carter TA, Ciceri P, Edeen PT, Floyd M, Ford JM, Galvin M, Gerlach JL, Grotzfeld RM, Herrgard S, Insko DE, et al. A small molecule-kinase interaction map for clinical kinase inhibitors. Nature biotechnology. 2005; 23:329-336
18. Xiao Y, Jiang Z, Li Y, Ye W, Jia B, Zhang M, Xu Y, Wu D, Lai L, Chen Y, Chang Y, Huang X, Liu H, Qing G, Liu P, Li Y, et al. ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells. Haematologica. 2015; 100:585-594
19. Xiao Y, Wei X, Jiang Z, Wang X, Ye W, Liu X, Zhang M, Xu Y, Wu D, Lai L, Yao H, Liu Z, Cao S, Liu P, Xu B, Li Y, et al. Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells. Journal of hematology & oncology. 2015; 8:7
20. Ye W, Jiang Z, Li GX, Xiao Y, Lin S, Lai Y, Wang S, Li B, Jia B, Li Y, Huang ZL, Li J, Feng F, Li S, Yao H, Liu Z, et al. Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments. Journal of hematology & oncology. 2015; 8:59
21. Li W, Jiang Z, Li T, Wei X, Zheng Y, Wu D, Yang L, Chen S, Xu B, Zhong M, Jiang J, Hu Y, Su H, Zhang M, Huang X, Geng S, et al. Genome-wide analyses identify KLF4 as an important negative regulator in T-cell acute lymphoblastic leukemia through directly inhibiting T-cell associated genes. Molecular cancer. 2015; 14:26
22. Johnson FM, Saigal B, Talpaz M and Donato NJ. Dasatinib (BMS-354825) tyrosine kinase inhibitor suppresses invasion and induces cell cycle arrest and apoptosis of head and neck squamous cell carcinoma and non-small cell lung cancer cells. Clinical cancer research. 2005; 11:6924-6932
23. Sethi G, Chatterjee S, Rajendran P, Li F, Shanmugam MK, Wong KF, Kumar AP, Senapati P, Behera AK, Hui KM, Basha J, Natesh N, Luk JM and Kundu TK. Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo. Molecular cancer. 2014; 13:66
24. Kamran MZ, Patil P and Gude RP. Role of STAT3 in cancer metastasis and translational advances. BioMed research international. 2013; 2013:421821
25. Jo DH, Kim JH, Cho CS, Cho YL, Jun HO, Yu YS, Min JK and Kim JH. STAT3 inhibition suppresses proliferation of retinoblastoma through down-regulation of positive feedback loop of STAT3/miR-17-92 clusters. Oncotarget. 2014; 5:11513-11525. doi: 10.18632/oncotarget.2546
26. Walker MP, Diaugustine RP, Zeringue E, Bunger MK, Schmitt M, Archer TK and Richards RG. An IGF1/insulin receptor substrate-1 pathway stimulates a mitotic kinase (cdk1) in the uterine epithelium during the proliferative response to estradiol. The Journal of endocrinology. 2010; 207:225-235
27. Myers MG, Sun XJ, Cheatham B, Jachna BR, Glasheen EM, Backer JM and White MF. Irs-1 Is a Common Element in Insulin and Insulin-Like Growth Factor-I Signaling to the Phosphatidylinositol 3'-Kinase. Endocrinology. 1993; 132:1421-1430
28. Suman S, Kallakury BVS, Fornace AJ and Datta K. Protracted Upregulation of Leptin and IGF1 is Associated with Activation of PI3K/Akt and JAK2 Pathway in Mouse Intestine after Ionizing Radiation Exposure. Int J Biol Sci. 2015; 11:274-283
29. Melo JV and Deininger MW. Biology of chronic myelogenous leukemia signaling pathways of initiation and transformation. Hematology/oncology clinics of North America. 2004; 18:545-568, vii-viii
30. Ren R. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia. Nature reviews Cancer. 2005; 5:172-183
31. Hu Y, Swerdlow S, Duffy TM, Weinmann R, Lee FY and Li S. Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103:16870-16875
32. Deininger M. Src kinases in Ph+ lymphoblastic leukemia. Nature genetics. 2004; 36:440-441
33. Buchner M, Fuchs S, Prinz G, Pfeifer D, Bartholome K, Burger M, Chevalier N, Vallat L, Timmer J, Gribben JG, Jumaa H, Veelken H, Dierks C and Zirlik K. Spleen Tyrosine Kinase Is Overexpressed and Represents a Potential Therapeutic Target in Chronic Lymphocytic Leukemia. Cancer research. 2009; 69:5424-5432
34. Brandts CH, Sargin B, Rode M, Biermann C, Lindtner B, Schwable J, Buerger H, Muller-Tidow C, Choudhary C, McMahon M, Berdel WE and Serve H. Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation. Cancer research. 2005; 65:9643-9650
35. Sun XJ, Rothenberg P, Kahn CR, Backer JM, Araki E, Wilden PA, Cahill DA, Goldstein BJ and White MF. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature. 1991; 352:73-77
36. Hadari YR, Tzahar E, Nadiv O, Rothenberg P, Roberts CT, Jr., LeRoith D, Yarden Y and Zick Y. Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers. The Journal of biological chemistry. 1992; 267:17483-17486
37. Juric D, Lacayo NJ, Ramsey MC, Racevskis J, Wiernik PH, Rowe JM, Goldstone AH, O'Dwyer PJ, Paietta E and Sikic BI. Differential gene expression patterns and interaction networks in BCR-ABL-positive and-negative adult acute lymphoblastic leukemias. Journal of clinical oncology. 2007; 25:1341-1349