Predominant cerebral cytokine release syndrome in CD19-directed chimeric antigen receptor-modified T cell therapy

Journal of Hematology and Oncology

Volumn 9, Issue 1, 2016, Pages

  Hu, Yongxian ^a   Sun, Jie ^a   Wu, Zhao ^b   Yu, Jian ^a   Cui, Qu ^c   Pu, Chengfei ^b   Liang, Bin ^d   Luo, Yi ^a   Shi, Jimin ^a   Jin, Aiyun ^a   Xiao, Lei ^b   Huang, He ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Formerly SiDanSai Biotechnology Co   (China)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Acute lymphocytic leukemia; Blood brain barrier; CD19; Chimeric antigen receptor modified T cells; Cytokine release syndrome

Indexed keywords

CD19 ANTIGEN; CHIMERIC ANTIGEN RECEPTOR; CYCLOPHOSPHAMIDE; CYTOKINE; FLUDARABINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 6; LYMPHOCYTE ANTIGEN RECEPTOR; MEPREDNISONE; PREDNISONE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; BLOOD BRAIN BARRIER; BLURRED VISION; BRAIN EDEMA; CASE REPORT; CD3+ T LYMPHOCYTE; CELL THERAPY; CEREBROSPINAL FLUID; CHIMERIC ANTIGEN RECEPTOR MODIFIED T CELLS TARGETING CD19; CONTRAST ENHANCEMENT; CYTOKINE RELEASE SYNDROME; FACIAL NERVE PARALYSIS; FEMALE; FEVER; GENE DOSAGE; HEADACHE; HUMAN; HYPERTENSION; LEUKOCYTE COUNT; NUCLEAR MAGNETIC RESONANCE IMAGING; PAPILLEDEMA; POLYMERASE CHAIN REACTION; PROTEIN BLOOD LEVEL; T LYMPHOCYTE; THERAPY EFFECT; TREMOR; VOMITING; ADOPTIVE IMMUNOTHERAPY; ADULT; CLINICAL TRIAL; COMPLICATION; DIAGNOSTIC IMAGING; GENETICS; IMMUNOLOGY; METABOLISM; PROCEDURES;

ADULT; ANTIGENS, CD19; BLOOD-BRAIN BARRIER; BRAIN EDEMA; CYTOKINES; FEMALE; HUMANS; IMMUNOTHERAPY, ADOPTIVE; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PREDNISONE; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 84982181799     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/s13045-016-0299-5     Document Type: Article

References (10)

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