Heterogeneity of CD34 and CD38 expression in acute B lymphoblastic leukemia cells is reversible and not hierarchically organized

Journal of Hematology and Oncology

Volumn 9, Issue 1, 2016, Pages 1-5

  Jiang, Zhiwu ^a   Deng, Manman ^b,c   Wei, Xinru ^a   Ye, Wei ^a   Xiao, Yiren ^a   Lin, Simiao ^a   Wang, Suna ^a   Li, Baiheng ^a   Liu, Xin ^d   Zhang, Gong ^e   Lai, Peilong ^f   Weng, Jianyu ^f   Wu, Donghai ^a   Chen, Haijia ^g   Wei, Wei ^h   Ma, Yuguo ⁱ   Li, Yangqiu ^b,e   Liu, Pentao ^j   Du, Xin ^f   Pei, Duanqing ^a   Yao, Yao ^a   Xu, Bing ^b,c   Li, Peng ^a   more..

^a GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH   (China)

^b MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^c SOUTHERN MEDICAL UNIVERSITY   (China)

^d University Town of Shenzhen   (China)

^e JINAN UNIVERSITY   (China)

^f GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^g Guangzhou Saliai Stem Cell Science and Technology Co Ltd   (China)

^h Yikang Tailai Technology Co Ltd ^*  (China)

ⁱ Yikang Tailai Technology Co Ltd   (China)

^j WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

more..

Author keywords

B ALL; Heterogeneity; Leukemia stem cell; Xenografts

Indexed keywords

CD34 ANTIGEN; CD38 ANTIGEN;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL ACTIVITY; CELL CULTURE; CELL PROLIFERATION; CELL SUBPOPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; EXOME; HUMAN; HUMAN CELL; IMMUNOPHENOTYPING; LETTER; LEUKEMIA CELL; LEUKEMOGENESIS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SOMATIC CELL GENETICS;

EID: 84994853761     PISSN: None     EISSN: 17568722     Source Type: Journal    
DOI: 10.1186/s13045-016-0310-1     Document Type: Letter

References (12)

1. Liew E, Atenafu EG, Schimmer AD, Yee KW, Schuh AC, Minden MD, Gupta V, Brandwein JM. Outcomes of adult patients with relapsed acute lymphoblastic leukemia following frontline treatment with a pediatric regimen. Leuk Res. 2012;36(12):1517-20.
2. Larson S, Stock W. Progress in the treatment of adults with acute lymphoblastic leukemia. Curr Opin Hematol. 2008;15(4):400-7.
3. Pui CH, Evans WE. Treatment of acute lymphoblastic leukemia. N Engl J Med. 2006;354(2):166-78.
4. Nagafuji K, Miyamoto T, Eto T, Kamimura T, Taniguchi S, Okamura T, Ohtsuka E, Yoshida T, Higuchi M, Yoshimoto G, et al. Monitoring of minimal residual disease (MRD) is useful to predict prognosis of adult patients with Ph-negative ALL: results of a prospective study (ALL MRD2002 Study). J Hematol Oncol. 2013;6:14.
5. Kong Y, Yoshida S, Saito Y, Nagatoshi Y, Fukata M, Saito N, Yang S, Iwamoto C, Okamura J, Liu K. CD34+ CD38+ CD19+ as well as CD34+ CD38-CD19+ cells are leukemia-initiating cells with self-renewal capacity in human B-precursor ALL. Leukemia. 2008;22(6):1207-13.
6. le Viseur C, Hotfilder M, Bomken S, Wilson K, Röttgers S, Schrauder A, Rosemann A, Irving J, Stam RW, Shultz LD. In childhood acute lymphoblastic leukemia, blasts at different stages of immunophenotypic maturation have stem cell properties. Cancer Cell. 2008;14(1):47-58.
7. Ye W, Jiang Z, Li GX, Xiao Y, Lin S, Lai Y, Wang S, Li B, Jia B, Li Y, et al. Quantitative evaluation of the immunodeficiency of a mouse strain by tumor engraftments. J Hematol Oncol. 2015;8:59.
8. Deng M, Jiang Z, Li Y, Zhou Y, Li J, Wang X, Yao Y, Wang W, Li P, Xu B. Effective elimination of adult B-lineage acute lymphoblastic leukemia by disulfiram/copper complex in vitro and in vivo in patient-derived xenograft models. Oncotarget. 2016. Online ISSN: 1949-2553.
9. Xiao Y, Jiang Z, Li Y, Ye W, Jia B, Zhang M, Xu Y, Wu D, Lai L, Chen Y, et al. ANGPTL7 regulates the expansion and repopulation of human hematopoietic stem and progenitor cells. Haematologica. 2015;100(5):585-94.
10. Wang L, Gao L, Xu S, Gong S, Chen L, Lu S, Chen J, Qiu H, Xu X, Ni X, et al. FISH + CD34 + CD38- cells detected in newly diagnosed acute myeloid leukemia patients can predict the clinical outcome. J Hematol Oncol. 2013;6(1):85.
11. Lapidot T, Sirard C, Vormoor J, Murdoch B, Hoang T, Caceres-Cortes J, Minden M, Paterson B, Caligiuri MA, Dick JE. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature. 1994;367(6464):645-48.
12. Woo JS, Alberti MO, Tirado CA. Childhood B-acute lymphoblastic leukemia: a genetic update. Exp Hematol Oncol. 2014;3:16.