Thyroid in pregnancy: From physiology to screening

Critical Reviews in Clinical Laboratory Sciences

Volumn 54, Issue 2, 2017, Pages 102-116

  Springer, Drahomira ^a   Jiskra, Jan ^a   Limanova, Zdenka ^a   Zima, Tomas ^a   Potlukova, Eliska ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

anti thyroperoxidase antibodies; Autoimmune thyroid disease; pregnancy; pregnancy loss; screening; thyroid stimulating hormone

Indexed keywords

IODINE; IODOTHYRONINE; LEVOTHYROXINE; THYROGLOBULIN; THYROID ANTIBODY; THYROID HORMONE; THYROID PEROXIDASE; THYROTROPIN; THYROXINE BINDING GLOBULIN; THYROXINE DEIODINASE;

ADVERSE OUTCOME; AUTOIMMUNITY; BRAIN DEVELOPMENT; CHILD; CZECH REPUBLIC; DISEASE MARKER; EMBRYO DEVELOPMENT; FEMALE; FREE THYROXINE INDEX; HUMAN; HYPERTHYROIDISM; HYPOTHYROIDISM; META ANALYSIS (TOPIC); MULTICENTER STUDY (TOPIC); PHYSIOLOGY; PREGNANCY; PREGNANCY DISORDER; PREMATURE LABOR; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REFERENCE VALUE; REVIEW; SCREENING; SPONTANEOUS ABORTION; SYSTEMATIC REVIEW (TOPIC); THYROID GLAND; THYROTROPIN BLOOD LEVEL; PATHOPHYSIOLOGY; PREGNANCY COMPLICATION; THYROID DISEASE;

FEMALE; HUMANS; PREGNANCY; PREGNANCY COMPLICATIONS; THYROID DISEASES; THYROID GLAND; THYROID HORMONES;

EID: 85014944070     PISSN: 10408363     EISSN: 1549781X     Source Type: Journal    
DOI: 10.1080/10408363.2016.1269309     Document Type: Review

References (147)

1. Krassas GE, Poppe K, Glinoer D., Thyroid function and human reproductive health. Endocr Rev 2010;31:702–55
2. Mandel SJ, Larsen PR, Seely EW, Brent GA., Increased need for thyroxine during pregnancy in women with primary hypothyroidism. N Engl J Med 1990;323:91–6
3. Alexander EK, Marqusee E, Lawrence J, et al. Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism. N Engl J Med 2004;351:241–9
4. Lazarus JH, Kokandi A., Thyroid disease in relation to pregnancy:a decade of change. Clin Endocrinol (Oxf) 2000;53:265–78
5. Medici M, Korevaar TI, Visser WE, et al. Thyroid function in pregnancy:what is normal? Clin Chem 2015;61:704–13
6. Yen PM., Physiological and molecular basis of thyroid hormone action. Physiol Rev 2001;1:1097–142
7. Sirakov M, Skah S, Nadjar J, Plateroti M., Thyroid hormone’s action on progenitor/stem cell biology:new challenge for a classic hormone? Biochimica Et Biophysica Acta 2013;1830:3917–27
8. Forhead AJ, Fowden AL. Thyroid hormones in fetal growth and prepartum maturation. J Endocrinol 2014;221:R87–103
9. Preau L, Fini JB, Morvan-Dubois G, Demeneix B., Thyroid hormone signaling during early neurogenesis and its significance as a vulnerable window for endocrine disruption. Bioch Biophys Act 2015;1849:112–21
10. Kapoor R, Fanibunda SE, Desouza LA, et al. Perspectives on thyroid hormone action in adult neurogenesis. J Neurochem 2015; 133:599–616
11. Brown RS., Disorders of the thyroid gland in infancy, childhood and adolescence. Endotext [Online] 2012;45:735–8. Available from:http://www.ncbi.nlm.nih.gov/books/NBK279032/ [last accessed 12 May 2016]
12. Soldin OP, Soldin D, Sastoque M., Gestation-specific thyroxine and thyroid stimulating hormone levels in the United States and worldwide. Ther Drug Monit 2007;29:553–9
13. Sahay RK, Nagesh V., Hypothyroidism in pregnancy. Indian J Endocrinol Metab 2012;16:364–70
14. Hume R, Simpson J, Delahunty C, et al. Human fetal and cord serum thyroid hormones:developmental trends and interrelationships. J Clin Endocrinol Metab 2004;89:4097–103
15. Zhang X, Li C, Mao J, et al. Gestation-specific changes in maternal thyroglobulin during pregnancy and lactation in an iodine-sufficient region in China:a longitudinal study. Clin Endocrinol (Oxf) 2016. [Epub ahead of print]. doi:10.1111/cen.13175
16. Bilek R, Cerovska J, Zamrazil V., The relationship between iodine intake and serum thyroglobulin in the general population. Physiol Res 2015;64:345–53
17. Ma ZF, Skeaf SA., Thyroglobulin as a biomarker of iodine deficiency:a review. Thyroid 2014;24:1195–209
18. Maia AL, Goemann IM, Meyer EL, Wainer SM., Deiodinases:the balance of thyroid hormone:type 1 iodothyronine deiodinase in human physiology and disease. J Endocrinol 2011;209:283–97
19. Kester MH, Kaptein E, Van Dijk CH, et al. Characterization of iodothyronine sulfatase activities in human and rat liver and placenta. Endocrinology 2002;143:814–19
20. Van der Geyten S, Segers I, Gereben B, et al. Transcriptional regulation of iodothyronine deiodinases during embryonic development. Mol Cell Endocrinol 2001;183:1–9
21. Morreale de Escobar G, Obregon MJ, Escobar del Rey F., Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia? J Clin Endocrinol Metab 2000;85:3975–87
22. Ferreiro B, Bernal J, Goodyer CG, Branchard CL., Estimation of nuclear thyroid hormone receptor saturation in human foetal brain and lung during early gestation. J Clin Endocrinol Metab 1988;67:853–6
23. Stagnaro-Green A, Sullivan S, Pearce EN., Iodine supplementation during pregnancy and lactation. JAMA 2012;308:2463–4
24. Bath SC, Steer CD, Golding J, et al. Effect of inadequate iodine status in UK pregnant women on cognitive outcomes in their children:results from the Avon longitudinal study of parents and children (ALSPAC). Lancet 2013;382:331–7
25. Andersson M, Karumbunathan V, Zimmermann MB., Global iodine status in 2011 and trends over the past decade. J Nutr 2012;142:744–50
26. Zimmermann MB, Gizak M, Abbott K, et al. Iodine deficiency in pregnant women in Europe. Lancet Diabetes Endocrinol 2015;3:672–4
27. Jiskra J, Fait T, Bilek R, et al. Mild iodine deficiency in women after spontaneous abortions living in an iodine-sufficient area of Czech Republic:prevalence and impact on reproductive health. Clin Endocrinol 2014;80:452–8
28. WHO Secretariat, Andersson M, de Benoist B, et al. Prevention and control of iodine deficiency in pregnant and lactating women and in children less than 2-years-old:conclusions and recommendations of the Technical Consultation. Public Health Nutr 2007;10:1606–11
29. Lazarus J, Brown RS, Daumerie C, et al. European Thyroid Association guidelines for the management of subclinical hypothyroidism in pregnancy and in children. Eur Thyroid J 2014;3:76–94
30. De Groot L, Abalovich M, Alexander EK, et al. Management of thyroid dysfunction during pregnancy and postpartum:an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2012;97:2543–65
31. Abalovich M, Gutierrez S, Alcaraz G, et al. Overt and subclinical hypothyroidism complicating pregnancy. Thyroid 2002;12:63–8
32. Allan WC, Haddow JE, Palomaki GE, et al. Maternal thyroid deficiency and pregnancy complications:implications for population screening. J Med Screen 2000;7:127–30
33. Mannisto T, Mendola P, Grewal J, et al. Thyroid diseases and adverse pregnancy outcomes in a contemporary US cohort. J Clin Endocrinol Metab 2013;98:2725–33
34. Stagnaro-Green A, Abalovich M, Alexander E, et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid 2011;21:1081–125
35. Potlukova E, Potluka O, Jiskra J, et al. Is age a risk factor for hypothyroidism in pregnancy? An analysis of 5223 pregnant women. J Clin Endocrinol Metab 2012;97:1945–52
36. Blatt AJ, Nakamoto JM, Kaufman HW., National status of testing for hypothyroidism during pregnancy and postpartum. J Clin Endocrinol Metab 2012;97:777–84
37. Casey BM, Dashe JS, Wells CE, et al. Subclinical hypothyroidism and pregnancy outcomes. Obstet Gynecol 2005;105:239–45
38. Vaidya B, Anthony S, Bilous M, et al. Detection of thyroid dysfunction in early pregnancy:universal screening or targeted high-risk case finding? J Clin Endocrinol Metab 2007;92:203–7
39. Haddow JE, Palomaki GE, Allan WC, et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Eng J Med 1999;341:549–55
40. Morreale de Escobar G, Obregon MJ, Escobar del Rey F., Role of thyroid hormone during early brain development. Eur J Endocrinol 2004;151:U25–37
41. Pop VJ, Brouwers EP, Vader HL, et al. Maternal hypothyroxinaemia during early pregnancy and subsequent child development:a 3-year follow-up study. Clin Endocrinol 2003;59:282–8
42. Henrichs J, Bongers-Schokking JJ, Schenk JJ, et al. Maternal thyroid function during early pregnancy and cognitive functioning in early childhood:the generation R study. J Clin Endocrinol Metab 2010;95:4227–34
43. Lazarus JH, Bestwick JP, Channon S, et al. Antenatal thyroid screening and childhood cognitive function. N Eng J Med 2012;366:493–501
44. Korevaar TI, Muetzel R, Medici M, et al. Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood:a population-based prospective cohort study. Lancet Diabetes Endocrinol 2016;4:35–43
45. Busnelli A, Somigliana E, Benaglia L., Thyroid axis dysregulation during in vitro fertilization in hypothyroid-treated patients. Thyroid 2014;24:1650–5
46. Morelli SS, Mandal M, Goldsmith LT, et al. The maternal immune system during pregnancy and its influence on foetal development. Res Report Biol [Online] 2015;6:171–89. Available from:http://dx.doi.org/10.2147/RRB.S80652 [last accessed 12 May 2016]
47. Kwak-Kim J, Bao S, Lee SK, et al. Immunological modes of pregnancy loss:inflammation, immune effectors, and stress. Am J Reprod Immunol 2014;72:129–40
48. Kim NY, Cho HJ, Kim HY, et al. Thyroid autoimmunity and its association with cellular and humoral immunity in women with reproductive failures. Am J Reprod Immunol 2011;65:78–87
49. Medici M, de Rijke YB, Peeters RP, et al. Maternal early pregnancy and newborn thyroid hormone parameters:the generation R study. J Clin Endocrinol Metab 2012;97:646–52
50. Shields BM, Knight BA, Hill AV, et al. Five-year follow-up for women with subclinical hypothyroidism in pregnancy. J Clin Endocrinol Metab 2013;98:E1941–5
51. Nambiar V, Jagtap VS, Sarathi V, et al. Prevalence and impact of thyroid disorders on maternal outcome in Asian-Indian pregnant women. J Thyroid Res 2011;2011:429097
52. Medici M, Porcu E, Pistis G, et al. Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease. PLoS Genet 2014;10:e1004123
53. Jayaraman M, Verma A, Harikumar KV, et al. Pregnancy outcomes with thyroxine replacement for subclinical hypothyroidism:role of thyroid autoimmunity. Indian J Endocrinol Metab 2013;17:294–7
54. Bagis T, Gokcel A, Saygili ES., Autoimmune thyroid disease in pregnancy and the postpartum period:relationship to spontaneous abortion. Thyroid 2001;11:1049–53
55. Feki M, Omar S, Menif O, et al. Thyroid disorders in pregnancy:frequency and association with selected diseases and obstetrical complications in Tunisian women. Clin Biochem 2008;41:927–31
56. Pradhan M, Anand B, Singh N, Mehrotra M., Thyroid peroxidase antibody in hypothyroidism:it’s effect on pregnancy. J Matern Foetal Neonatal Med 2013;26:581–3
57. Rasmussen UF, Bliddal S., TPOAbs as a risk factor in pregnancy. Thyroid Int 2014;3:3–20
58. Toulis KA, Goulis DG, Venetis CA, et al. Risk of spontaneous miscarriage in euthyroid women with thyroid autoimmunity undergoing IVF:a meta-analysis. Eur J Endocrinol 2010;4:643–52
59. Thangaratinam S, Tan A, Knox E, et al. Association between thyroid autoantibodies and miscarriage and preterm birth:meta-analysis of evidence. BMJ 2011;9:d2616
60. Chen LM, Zhang Q, Si GX, et al. Associations between thyroid autoantibody status and abnormal pregnancy outcomes in euthyroid women. Endocrine 2015;48:924–8
61. Kim CH, Ahn JW, Kang SP, et al. Effect of levothyroxine treatment on in vitro fertilization and pregnancy outcome in infertile women with subclinical hypothyroidism undergoing in vitro fertilization/intracytoplasmic sperm injection. Fertil Steril 2011;95:1650–4
62. Taylor PN, Minassian C, Rehman A, et al. TSH levels and risk of miscarriage in women on long-term levothyroxine:a community-based study. J Clin Endocrinol Metab 2014;99:3895–902
63. Stagnaro-Green A, Chen X, Bogden JD, et al. The thyroid and pregnancy:a novel risk factor for very preterm delivery. Thyroid 2005;15:351–7
64. He X, Wang P, Wang Z, et al. Thyroid antibodies and risk of preterm delivery:a meta-analysis of prospective cohort studies. Eur J Endocrinol 2012;167:455–64
65. Debieve F, Duliere S, Bernard P, et al. To treat or not to treat euthyroid autoimmune disorder during pregnancy? Gynecol Obstet Invest 2009;67:178–82
66. Tierney K, Delpachitra P, Grossmann M, et al. Thyroid function and autoantibody status among women who spontaneously deliver under 35 weeks of gestation. Clin Endocrinol (Oxf) 2009;71:892–5
67. Abbassi-Ghanavati M, Casey BM, Spong CY, et al. Pregnancy outcomes in women with thyroid peroxidase antibodies. Obstet Gynecol 2010;116:381–6
68. Cleary-Goldman J, Malone FD, Lambert-Messerlian G, et al. Maternal thyroid hypofunction and pregnancy outcome. Obstet Gynecol 2008;112:85–92
69. Korevaar TI, Schalekamp-Timmermans S, de Rijke YB, et al. Hypothyroxinemia and TPO-antibody positivity are risk factors for premature delivery:the generation R study. J Clin Endocrinol Metab 2013;98:4382–90
70. Negro R, Schwartz A, Gismondi R, et al. Thyroid antibody positivity in the first trimester of pregnancy is associated with negative pregnancy outcomes. J Clin Endocrinol Metab 2011;96:E920–4
71. Haddow JE, Cleary-Goldman J, McClain MR, et al. First- and second-trimester risk of aneuploidy (FASTER) research consortium. Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery. Obstet Gynecol 2010;116:58–62
72. Chen X, Jin B, Xia J, et al. Effects of thyroid peroxidase antibody on maternal and neonatal outcomes in pregnant women in an iodine-sufficient area in China. Int J Endocrinol 2016;2016:6461380
73. Kumru P, Erdogdu E, Arisoy R, et al. Effect of thyroid dysfunction and autoimmunity on pregnancy outcomes in low risk population. Arch Gynecol Obstet 2015;291:1047–54
74. Jiskra J, Bartakova J, Holinka S, et al. Low concordance between positive antibodies to thyroperoxidase and thyroid ultrasound autoimmune pattern in pregnant women. Endocr J 2011;58:849–59
75. Stagnaro-Green A, Roman SH, Cobin RH, et al. Detection of at-risk pregnancy by means of highly sensitive assays for thyroid autoantibodies. JAMA 1990;264:1422–5
76. Iijima T, Tada H, Hidaka Y, et al. Effects of autoantibodies on the course of pregnancy and fetal growth. Obstet Gynecol 1997;9:364–9
77. Walker JA, Illions EH, Huddleston JF, et al. Racial comparisons of thyroid function and autoimmunity during pregnancy and the postpartum period. Obstet Gynecol 2005;106:1365–71
78. Branch BD, Gibson M, Silver R. Clinical practice. Recurrent miscarriage. N Engl J Med 2010;363:1740–7
79. Negro R, Formoso G, Mangieri T, et al. Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease:effects on obstetrical complications. J Clin Endocrinol Metab 2006;91:2587–91
80. Negro R, Mangieri T, Coppola L, et al. Levothyroxine treatment in thyroid peroxidase antibodypositive women undergoing assisted reproduction technologies:a prospective study. Hum Reprod 2005;20:1529–33
81. Vissenberg R, Fliers E, van der Post JA, et al. Live-birth rate in euthyroid women with recurrent miscarriage and thyroid peroxidase antibodies. Gynecol Endocrinol 2016;32:132–5
82. Bartáková J, Potluková E, Rogalewicz V, et al. Screening for autoimmune thyroid disorders after spontaneous abortion is cost-saving and it improves the subsequent pregnancy rate. BMC Pregnancy Childbirth 2013;13:217
83. Vissenberg R, van Dijk MM, Fliers E, et al. Effect of levothyroxine on live birth rate in euthyroid women with recurrent miscarriage and TPO antibodies (T4-LIFE study). Contemp Clin Trials 2015;5:S1551–7144
84. Pop VJ, de Vries E, van Baar AL, et al. Maternal thyroid peroxidase antibodies during pregnancy:a marker of impaired child development? J Clin Endocrinol Metab 1995;80:3561–6
85. Wasserman EE, Nelson K, Rose NR, et al. Maternal thyroid autoantibodies during the third trimester and hearing deficits in children:an epidemiologic assessment. Am J Epidemiol 2008;167:701–10
86. Li Y, Shan Z, Teng W, et al. Abnormalities of maternal thyroid function during pregnancy affect neuropsychological development of their children at 25–30 months. Clin Endocrinol (Oxf) 2010;72:825–9
87. Williams FL, Watson J, Ogston SA, et al. Maternal and umbilical cord levels of T4, FT4, TSH, TPOAb, and TgAb in term infants and neurodevelopmental outcome at 5.5 years. J Clin Endocrinol Metab 2013;98:829–38
88. Oken E, Braverman LE, Platek D, et al. Neonatal thyroxine, maternal thyroid function, and child cognition. J Clin Endocrinol Metab 2009;94:497–503
89. Wasserman EE, Pillion JP, Duggan A, et al. Childhood IQ, hearing loss, and maternal thyroid autoimmunity in the Baltimore Collaborative Perinatal Project. Pediatr Res 2012;72:525–30
90. Wilson RE, Salihu HM, Groer MW, et al. Impact of maternal thyroperoxidase status on fetal body and brain size. J Thyroid Res 2014;2014:872410
91. Ghassabian A, Bongers-Schokking JJ, de Rijke YB, et al. Maternal thyroid autoimmunity during pregnancy and the risk of attention deficit/hyperactivity problems in children:the Generation R Study. Thyroid 2012;22:178–86
92. Pakkila F, Mannisto T, Pouta A, et al. The impact of gestational thyroid hormone concentrations on ADHD symptoms of the child. J Clin Endocrinol Metab 2014;99:E1–8
93. Glinoer D, Rihai M, Grün JP, et al. Risk of subclinical hypothyroidism in pregnant women with asymptomatic autoimmune thyroid disorders. J Clin Endocrinol Metab 1994;79:179–204
94. Lazzarin N, Moretti C, De Felice G, et al. Further evidence on the role of thyroid autoimmunity in women with recurrent miscarriage. Int J Endocrinol 2012;2012:717185
95. Weetman AP., Diseases associated with thyroid autoimmunity:explanations for the expanding spectrum. Clin Endocrinol (Oxf) 2011;74:411–18
96. Baloch Z, Carayon P, Conte-Devolx B, et al. Guidelines committee, National academy of clinical biochemistry. Laboratory medicine practice guidelines. Laboratory support for the diagnosis and monitoring of thyroid disease. Thyroid 2003;13:3–126
97. Stricker R, Echenard M, Eberhart R, et al. Evaluation of maternal thyroid function during pregnancy:the importance of using gestational age-specific reference intervals. Eur J Endocrinol 2007;157:509–14
98. Mannisto T, Surcel HM, Ruokonen A, et al. Early pregnancy reference intervals of thyroid hormone concentrations in a thyroid antibody-negative pregnant population. Thyroid 2011;21:291–8
99. Hershman JM., The role of human chorionic gonadotropin as a thyroid stimulator in normal pregnancy. J Clin Endocrinol Metab 2008;93:3305–6
100. Baskin HJ, Cobin RH, Duick DS, et al. AACE medical guidelines for clinical practice for the evaluation and treatment of hyperthyroidism and hypothyroidism. Endocr Pract 2002;8:457–67
101. La’ulu SL, Roberts WL. Ethnic differences in first-trimester thyroid reference intervals. Clin Chem 2011;57:913–15
102. La’ulu SL, Roberts WL., Second-trimester reference intervals for thyroid tests:the role of ethnicity. Clin Chem 2007;53:1658–64
103. Korevaar TI, Medici M, de Rijke YB, et al. Ethnic differences in maternal thyroid parameters during pregnancy:the generation R study. J Clin Endocrinol Metab 2013;98:3678–86
104. Yan YQ, Dong ZL, Dong L, et al. Trimester- and methodspecific reference intervals for thyroid tests in pregnant Chinese women:methodology, euthyroid definition and iodine status can influence the setting of reference intervals. Clin Endocrinol 2011;74:262–9
105. Bestwick JP, John R, Maina A, et al. Thyroid stimulating hormone and free thyroxine in pregnancy:expressing concentrations as multiples of the median (MoMs). Clin Chim Acta 2014;430:33–7
106. Pearce EN, Oken E, Gillman MW, et al. Association of first-trimester thyroid function test values with thyroperoxidase antibody status, smoking, and multivitamin use. Endocr Pract 2008;14:33–9
107. Springer D, Zima T, Limanova Z., Reference intervals in evaluation of maternal thyroid function during the first trimester of pregnancy. Eur J Endocrinol 2009;160:791–7
108. Shen FX, Xie ZW, Lu SM, et al. Gestational thyroid reference intervals in antibody-negative Chinese women. Clin Biochem 2014;47:673–5
109. Bocos-Terraz JP, Izquierdo-Alvarez S, Bancalero-Flores JL, et al. Thyroid hormones according to gestational age in pregnant Spanish women. BMC Res Notes 2009;2:237
110. Gilbert RM, Hadlow NC, Walsh JP, et al. Assessment of thyroid function during pregnancy:first-trimester (weeks 9-13) reference intervals derived from Western Australian women. Med J Aust 2008;189:250–3
111. Xing J, Yuan E, Li J, et al. Trimester- and assay-specific thyroid reference intervals for pregnant women in china. Int J Endocrinol 2016;2016:3754213
112. Karakosta P, Chatzi L, Bagkeris E, et al. First- and second trimester reference intervals for thyroid hormones during pregnancy in ‘Rhea’ mother-child cohort, Crete, Greece. J Thyroid Res 2011;2011:490783
113. Haddow JE, Knight GJ, Palomaki GE, et al. The reference range and within- person variability of thyroid stimulating hormone during the first and second trimesters of pregnancy. J Med Screen 2004;11:170–4
114. Lambert-Messerlian G, McClain M, Haddow JE, et al. First- and second-trimester thyroid hormone reference data in pregnant women:a FASTER (first- and second-trimester evaluation of risk for aneuploidy) research consortium study. Am J Obstet Gynecol 2008;199:62e1–6
115. Li C, Shan Z, Mao J, et al. Assessment of thyroid function during first-trimester pregnancy:what is the rational upper limit of serum TSH during the first trimester in Chinese pregnant women? J Clin Endocrinol Metab 2014;99:73–9
116. Wang QW, Yu B, Huang R, et al. Assessment of thyroid function during pregnancy:the advantage of self-sequential longitudinal reference intervals. Arch Med Sci 2011;7:679–84
117. Zhang J, Li W, Chen QB, et al. Establishment of trimester-specific thyroid stimulating hormone and free thyroxine reference interval in pregnant Chinese women using the Beckman Coulter UniCelTM DxI 600. Clin Chem Lab Med 2015;53:1409–14
118. Fiddes JC, Goodman HM., The gene encoding the common alpha subunit of the four human glycoprotein hormones. J Mol Appl Genet 1981;1:3–18
119. Glinoer D, de Nayer P, Bourdoux P, et al. Regulation of maternal thyroid during pregnancy. J Clin Endocrinol Metab 1990;71:276–87
120. Stöckl D, Van Uytfanghe K, Van Aelst S, Thienpont LM. A statistical basis for harmonization of thyroid stimulating hormone immunoassays using a robust factor analysis model. Clin Chem Lab Med 2014;52:965–72
121. Anckaert E, Poppe K, Van Uytfanghe K, et al. FT4 immunoassays may display a pattern during pregnancy similar to the equilibrium dialysis ID–LC/tandem MS candidate reference measurement procedure in spite of susceptibility towards binding protein alterations. Clinica Chimica Acta 2010;411:1348–53
122. Soldin JS, Soukhova N, Janicic N, et al. The measurement of free thyroxine by isotope dilution tandem mass spectrometry. Clin Chim Acta 2005;358:113–18
123. Thienpont LM, International Federation of Clinical Chemistry and Laboratory Medicine (IFCC), Scientific Division Working Group for Standardization of Thyroid Function Tests (WG-STFT), et al. Measurement of free thyroxine in laboratory medicine–proposal of measurement definition. Clin Chem Lab Med 2007;45:563–4
124. Thienpont LM, IFCC, Scientific Division Working Group for Standardization of Thyroid Function Tests (WGSTFT), et al. Proposal of a candidate international conventional reference measurement procedure for free thyroxine in serum. Clin Chem Lab Med 2007;45:934–6
125. Thienpont LM, Van Uytfanghe K, Beastall G, et al. Report of the IFCC working group for standardization of thyroid function tests, part 2:free thyroxine and free triiodothyronine. Clin Chem 2010;56:912–20
126. Vila L, Velasco I, Gonzales S, et al. Controversies in endocrinology:on the need for universal thyroid screening in pregnant women. Eur J Endocrinol 2014;170:R17–30
127. Mandel SJ, Spencer CA, Hollowell JG., Are detection and treatment of thyroid insufficiency in pregnancy feasible? Thyroid 2005;15:44–53
128. Midgley JE, Hoermann R., Measurement of total rather than free thyroxine in pregnancy:the diagnostic implications. Thyroid 2013;23:259–61
129. Madariaga AG, Palacios SS, Guillen-Grima F, Galofre JC., The incidence and prevalence of thyroid dysfunction in Europe:a meta-analysis. J Clin Endocrinol Metab 2010;99:923–31
130. Dosiou C, Giudice LC., Natural killer cells in pregnancy and recurrent pregnancy loss:endocrine and immunologic perspectives. Endocr Rev 2005;26:44
131. Springer D, Bartos V, Zima T., Reference intervals for thyroid markers in early pregnancy determined by 7 different analytical systems. Scand J Clin Lab Invest 2014;74:95–101
132. Zamrazil V, Bilek R, Cerovska J, et al. The elimination of iodine deficiency in the Czech Republic:the steps toward success. Thyroid 2004;14:49–56
133. Vaidya B, Hubalewska-Dydejczyk A, Laurberg P, et al. Treatment and screening of hypothyroidism in pregnancy:results of a European survey. Eur J Endocrinol 2012;166:49–54
134. Vila L, Velasco I, Gonzalez S, et al. [Universal screening of thyroid dysfunction in the pregnant population]. Endocrinol Nutr 2013;60:407–9
135. Reid SM, Middleton P, Cossich MC, et al. Interventions for clinical and subclinical hypothyroidism pre-pregnancy and during pregnancy. Cochrane Database Syst Rev 2013;5:CD007752
136. Dosiou C, Barnes J, Schwartz A, et al. Cost-effectiveness of universal and risk-based screening for autoimmune thyroid disease in pregnant women. J Clin Endocrinol Metab 2012;97:1536–46
137. Thung SF, Funai EF, Grobman WA., The cost-effectiveness of universal screening in pregnancy for subclinical hypothyroidism. Am J Obstet Gynecol 2009;200:267e1
138. Horacek J, Spitalniková S, Dlabalova B, et al. Universal screening detects two-times more thyroid disorders in early pregnancy than targeted high-risk case finding. Eur J Endocrinol 2010;163:645–50
139. Pop VJ., Pregnancy, postpartum and the thyroid:isn’t it time to offer women optimal care? Facts Views Vis Obgyn 2014;6:166–70
140. Stagnaro-Green A., Optimal care of the pregnant woman with thyroid disease. J Clin Endocrinol Metabol 2012;97:2619–22
141. Limanova Z, Springer D., [Thyreopathy examination during pregnancy–results of pilot project]. Casopis Lekaru Ceskych 2011;150:389–93
142. Yang H, Shao M, Chen L, et al. Screening strategies for thyroid disorders in the first and second trimester of pregnancy in China. PLoS One 2014;9:e99611
143. Stagnaro-Green A., Screening pregnant women for overt thyroid disease. JAMA 2015;313:565–6
144. Lepoutre T, Debieve F, Gruson D, Daumerie C., Reduction of miscarriages through universal screening and treatment of thyroid autoimmune diseases. Gynecol Obstet Invest 2012;74:265–73
145. Taylor PN, Okosieme OE, Premawardhana L, Lazarus JH., Should all women be screened for thyroid dysfunction in pregnancy? Womens Health (Lond) 2015;11:295–307
146. Wilson JMG, Jungner G., Principles and Practice of Screening for Disease. Geneva:WHO, 1968. Available from:http://www.who.int/bulletin/volumes/86/4/07-050112BP.pdf
147. Negro R, Schwartz A, Gismondi R, et al. Universal screening versus case finding for detection and treatment of thyroid hormonal dysfunction during pregnancy. J Clin Endocrinol Metab 2010;95:1699–707