To treat or not to treat euthyroid autoimmune disorder during pregnancy?

Gynecologic and Obstetric Investigation

Volumn 67, Issue 3, 2009, Pages 178-182

  Debieve F ^a,b   Duliere S ^a   Bernard, P ^a   Hubinont, C ^a   De Nayer, P ^a   Daumerie, C ^a  

^a CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^b Service d'Obstétrique   (Belgium)

Author keywords

Antiperoxydase antibodies; Hypothyroidism; Pregnancy; Screening

Indexed keywords

LEVOTHYROXINE; THYROID PEROXIDASE ANTIBODY; THYROTROPIN; THYROXINE;

ADOLESCENT; ADULT; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE REDUCTION; FEMALE; FETUS DEATH; HUMAN; INTRAUTERINE GROWTH RETARDATION; MAJOR CLINICAL STUDY; PREECLAMPSIA; PREGNANCY; PREMATURE LABOR; PREVALENCE; PRIORITY JOURNAL; THYROID AUTOIMMUNE DISORDER; THYROID DISEASE; THYROID FUNCTION;

AUTOANTIBODIES; AUTOIMMUNE DISEASES; FEMALE; HUMANS; HYPOTHYROIDISM; IODIDE PEROXIDASE; PREGNANCY; PREGNANCY COMPLICATIONS; RETROSPECTIVE STUDIES; THYROTROPIN; THYROXINE; TREATMENT OUTCOME;

EID: 57649116446     PISSN: 03787346     EISSN: None     Source Type: Journal    
DOI: 10.1159/000185689     Document Type: Article

References (16)

1. Negro R, Formoso G, Mangieri T, Pezzarossa A, Dazzi D, Hassan H: Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications. J Clin Endocrinol Metab 2006; 91: 2587-2591.
2. Glinoer D, Rihi M, Grün JP, Kinthaert J: Risk of subclinical hypothyroidism in pregnant women with asymptomatic autoimmune thyroid disorders. J Clin Endocrinol Metab 1994; 79: 197-204.
3. Glinoer D, Delange F: The potential repercussions of maternal, fetal, and neonatal hypothyroxinemia on the progeny. Thyroid 2000; 10: 871-887.
4. Morrale de Escobar G, Obregon MJ, Escobar del Rey F: Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia? J Clin Endocrinol Metab 2000; 85: 3975-3987.
5. Smallridge RC, Ladenson PW: Hypothyroidism in pregnancy: consequences to neonatal health. J Clin Endocrinol Metab 2001; 86: 2349-2353.
6. Alexander EK, Marqusee E, Lawrence J, Jarolim P, Fisher GA, Larsen PR: Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism. N Engl J Med 2004; 351: 241-249.
7. Glinoer D: The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev 1997; 18: 404-433.
8. Glinoer D, De Nayer Ph, Bourdoux P, Lemone M, Robyn C, Van Steirteghem A, Kinthaert J, Lejeune B: Regulation of maternal thyroid during pregnancy. J Clin Endocrinol Metab 1990; 71: 276-287.
9. Vaidya B, Anthony S, Bilous M, Shields B, Drury J, Hutchison S, Bilous R: Detection of thyroid dysfunction in early pregnancy: universal screening or targeted high-risk case finding? J Clin Endocrinol Metab 2007; 92: 203-207.
10. Iijima T, Tada H, Hidaka Y, Mitsuda N, Murata Y, Amino N: Effects of autoantibodies on the course of pregnancy and fetal growth. Obstet Gynecol 1997; 90: 364-369.
11. Pratt DE, Kaberlein G, Dudkiewicz A, Karande V, Gleicher N: The association of thyroid antibodies in euthyroid nonpregnant women with recurrent first trimester abortions in the next pregnancy. Fertil Steril 1993; 60: 1001-1005.
12. Hershman JM: Physiological and pathological aspects of the effect of human chorionic gonadotropin on the thyroid. Best Pract Res Clin Endocrinol Metab 2004; 18: 249-65.
13. Calvo RM, Jauniaux E, Gubils B, Asuncion M, Gervy C, Contemprè B, Morrale de Escobar G: Fetal tissues are exposed to biologically relevant free thyroxine concentrations during early phase of development. J Clin Endocrinol Metab 2002; 87: 1768-1777.
14. Chan S, Kachiele S, McCabe CJ, Tannahill LA, Gittoes NJL, Visser TJ, Franklyn JA, Kilby MD: Early expression of thyroid hormone deiodinases and receptors in human fetal cerebral cortex. Brain Res 2002; 138: 109-116.
15. Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J, O'Heir CE, Mitchell ML, Hermos RJ, Waisbren SE, Faix JD, Klein RZ: Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 1999; 341: 549-555.
16. Pop VJ, Kuijpens JL, van Baar AL, Verkerk G, van Son MM, de Vijlder JJ, Vulsma T, Wiersinga WM, Drexhage HA, Vader HL: Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clin Endocrinol (Oxf) 1999; 50: 149-155.