Levothyroxine treatment in thyroid peroxidase antibody-positive women undergoing assisted reproduction technologies: A prospective study

Human Reproduction

Volumn 20, Issue 6, 2005, Pages 1529-1533

  Negro, Roberto ^a,d   Mangieri, Tiziana ^a   Coppola, Lamberto ^a   Presicce, Giovanni ^a   Casavola, Eugenio Caroli ^a   Gismondi, Riccardo ^a   Locorotondo, Giancarlo ^a   Caroli, Paolo ^a   Pezzarossa, Antonio ^b   Dazzi, Davide ^b   Hassan, Haslinda ^c  

^a Division of Physiopathology of Human Reproduction   (Italy)

^b Dermatology Department   (Italy)

^c RIPAS HOSPITAL   (Brunei Darussalam)

^d VITO FAZZI HOSPITAL   (Italy)

Author keywords

Assisted reproductive technologies; Autoimmunity; Levothyroxine; Thyroid

Indexed keywords

LEVOTHYROXINE; PLACEBO; THYROID PEROXIDASE ANTIBODY; THYROTROPIN; THYROXINE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DELIVERY; EUTHYROIDISM; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; HUMAN; INFERTILITY THERAPY; INTRACYTOPLASMIC SPERM INJECTION; MAJOR CLINICAL STUDY; MEDICAL ASSESSMENT; OVULATION INDUCTION; PREGNANCY RATE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SPONTANEOUS ABORTION; TREATMENT OUTCOME;

EID: 20744444559     PISSN: 02681161     EISSN: None     Source Type: Journal    
DOI: 10.1093/humrep/deh843     Document Type: Article

References (28)

1. Abalovich M, Gutierrez S, Alcaraz G, Maccallini G, Garcia A and Levalle O (2002) Overt and subclinical hypothyroidism complicating pregnancy. Thyroid 12,63-68.
2. Abramson J and Stagnaro-Green A (2001) Thyroid antibodies and fetal loss: an evolving story. Thyroid 11,57-63.
3. Ando T and Davies TF (2003) Postpartum autoimmune thyroid disease: the potential role of fetal microchimerism. J Clin Endocrinol Metab 88, 2965-2971.
4. Ando T and Davies TF (2004) Self-recognition and the role of fetal microchimerism. Best Pract Res Clin Endocrinol Metab 18,197-211.
5. Bussen SS and Steck T (1997) Thyroid antibodies and their relation to antithrombin antibodies, anticardiolipin antbodies and lupus anticoagulant in women with recurrent spontaneous abortion. Eur J Gynecol Reprod Biol 74,139-143.
6. Calvo RM, Jauniaux E, Gulbis B, Asunción M, Gervy C, Contempré B and Morreale de Escobar G (2002) Fetal tissues are exposed to biologically relevant free thyroxine concentrations during early phases of development. J Clin Endocrinol Metab 87,1768-1777.
7. Geva E, Vardinon N, Lessing JB, Lerner-Geva L, Azem F, Yovel I, Burke M, Yust I, Grunfeld R and Amit A (1996) Organ-specific autoantibodies are possible markers for reproductive failure: a prospective study in an in-vitro fertilization-embryo transfer programme. Hum Reprod 11, 1627-1631.
8. Gleicher N (2002) Some thoughts on the reproductive autoimmune failure syndrome (RAFS) and Th-1 versus Th-2 immune responses. Am J Reprod Immunol 48,252-254.
9. Imaizumi M, Pritsker A, Kita M, Ahmad L, Unger P and Davies TF (2001) Pregnancy and murine thyroiditis: thyroglobulin immunization leads to fetal loss in specific allogeneic pregnancies. Endocrinology 142,823-829.
10. Kim CH, Chae HD, Kang BM and Chang YS (1998) Influence of antithyroid antibodies in euthyroid women on in vitro fertilization-embryo transfer outcome. Am J Reprod Immunol 40,2-8.
11. Knudsen N, Jorgensen T, Rasmussen S, Christiansen E and Perrild H (1999) The prevalence of thyroid dysfunction in a population with borderline iodine deficiency. Clin Endocrinol (Oxf) 51,361-367.
12. Kutteh WH, Schoolcraft WB and Scott RT (1999) Antithyroid antibodies do not affect pregnancy outcome in women undergoing assisted reproduction. Hum Reprod 14,2886-2890.
13. Maruo T, Katayama K, Matuso H, Anwar M and Mochizuki M (1992) The role of maternal thyroid hormones in maintaining early pregnancy in threatened abortion. Acta Endocrinol (Copenh) 127,118-122.
14. Marx A and Bucher HC (2003) Numbers needed to treat derived from meta-analysis: a word of caution. ACP J Club 138,A11-A12.
15. Muller AF, Verhoeff A, Mantel MJ and Berghout A (1999) Thyroid autoimmunity and abortion: a prospective study in women undergoing in vitro fertilization. Fertil Steril 71,30-34.
16. Muller AF, Verhoeff A, Mantel MJ, de Jong FH and Berghout A (2000) Decrease of free thyroxine levels after controlled ovarian hyperstimulation. J Clin Endocrinol Metab 85,545-548.
17. Pedersen IB, Knudsen N, Jorgensen T, Perrild H, Ovesen L and Laurberg P (2003) Thyroid peroxidase and thyroglobulin autoantibodies in a large survey of populations with mild and moderate iodine deficiency. Clin Endocrinol (Oxf) 58,36-42.
18. Poppe K, Glinoer D, Van Steirteghem A, Tournaye H, Devroey P, Schiettecatte J and Velkeniers B (2002) Thyroid dysfunction and autoimmunity in infertile women. Thyroid 12,997-1001.
19. Poppe K, Glinoer D, Tournaye H, Devroey P, van Steirteghem A, Ka L and Velkeniers B (2003) Assisted reproduction and thyroid autoimmunity: an unfortunate combination? J Clin Endocrinol Metab 88,4149-4152.
20. Prummel MF and Wiersinga WM (2004) Thyroid autoimmunity and miscarriage. Eur J Endocrinol 150,751-755.
21. Raber W, Nowotny P, Vytiska-Binstorfer E and Vierhapper H (2003) Thyroxine treatment modified in infertile women according to thyroxine-releasing hormone testing: 5 year follow-up of 283 women referred after exclusion of absolute causes of infertility. Hum Reprod 18,707-714.
22. Roberts J, Jenkins C, Wilson R, Pearson C, Franklin IA, MacLean MA, McKillop JH and Walker JJ (1996) Recurrent miscarriage is associated with increased numbers of CD5/20 positive lymphocytes and an increased incidence of thyroid antibodies. Eur J Endocrinol 134,84-86.
23. Rushworth FH, Backos M, Rai R, Chilcott IT, Baxter N and Regan L (2000) Prospective pregnancy outcome in untreated recurrent miscarriers with thyroid autoantibodies. Hum Reprod 15,1637-1639.
24. Stagnaro-Green A, Roman SH, Cobin RH, el-Harazy E, Wallenstein S and Davies TF (1992) A prospective study of lymphocyte-initiated immunosuppression in normal pregnancy: evidence of a T cell etiology for post partum thyroid dysfunction. J Clin Endocrinol Metab 74,645-653.
25. Stricker RB, Steinleitner A, Bookoff CN, Weckstein LN and Winger EE (2000) Successful treatment of immunologic abortion with low-dose intravenous immunoglobulin. Fertil Steril 73,536-540.
26. Van Voorhis BJ and Stovall DW (1997) Autoantibodies and infertility: a review of the lature. J Reprod Immunol 33,239-256.
27. Vaquero E, Lazzarin N, Valensise H, Menghini S, Di Pierro G, Cesa F and Romanini C (2001) Pregnancy outcome in recurrent spontaneous abortion associated with antiphospholipid antibodies: a comparative study of intravenous immunoglobulin versus prednisone plus low-dose aspirin. Am J Reprod Immunol 45,174-179.
28. Vaquero E, Lazzarin N, De Carolis C, Valensise H, Moretti C and Ramanini C (2002) Mild thyroid abnormalities and recurrent spontaneous abortion: diagnostic and therapeutical approach. Am J Reprod Immunol 43,204-208.