Association of maternal thyroid function during early pregnancy with offspring IQ and brain morphology in childhood: A population-based prospective cohort study

The Lancet Diabetes and Endocrinology

Volumn 4, Issue 1, 2016, Pages 35-43

  Korevaar, Tim I M ^a   Muetzel, Ryan ^a   Medici, Marco ^a   Chaker, Layal ^a   Jaddoe, Vincent W V ^a   de Rijke, Yolanda B ^a   Steegers, Eric A P ^a   Visser, Theo J ^a   White, Tonya ^a   Tiemeier, Henning ^a   Peeters, Robin P ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; THYROID PEROXIDASE ANTIBODY; THYROTROPIN; THYROXINE; ANTIBODY; IODIDE PEROXIDASE;

ADULT; ARTICLE; BLOOD SAMPLING; BRAIN; BRAIN CORTEX; BRAIN DEVELOPMENT; BRAIN SIZE; CHILD; CHILDHOOD; COHORT ANALYSIS; FEMALE; FIRST TRIMESTER PREGNANCY; GRAY MATTER; HUMAN; HYPERTHYROIDISM; HYPOTHYROIDISM; INTELLIGENCE QUOTIENT; INTELLIGENCE TEST; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PREGNANT WOMAN; PRIORITY JOURNAL; PROGENY; PROSPECTIVE STUDY; SUBCLINICAL HYPOTHYROIDISM; THYROID FUNCTION; THYROID FUNCTION TEST; ANATOMY AND HISTOLOGY; BLOOD; FETOMATERNAL TRANSFUSION; FETUS BLOOD; GESTATIONAL AGE; IMMUNOLOGY; INTELLIGENCE; MATERNAL WELFARE; METABOLISM; PHYSIOLOGY; PREGNANCY; PRESCHOOL CHILD; THYROID GLAND;

ANTIBODIES; BRAIN; CHILD; CHILD, PRESCHOOL; FEMALE; FETAL BLOOD; GESTATIONAL AGE; HUMANS; INTELLIGENCE; IODIDE PEROXIDASE; MATERNAL HEALTH; MATERNAL-FETAL EXCHANGE; PREGNANCY; PROSPECTIVE STUDIES; THYROID GLAND; THYROTROPIN; THYROXINE;

EID: 84955259554     PISSN: 22138587     EISSN: 22138595     Source Type: Journal    
DOI: 10.1016/S2213-8587(15)00327-7     Document Type: Article

References (41)

1. De Groot L, Abalovich M, Alexander EK, et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2012, 97:2543-2565.
2. Lazarus J, Brown RS, Daumerie C, Hubalewska-Dydejczyk A, Negro R, Vaidya B 2014 European Thyroid Association guidelines for the management of subclinical hypothyroidism in pregnancy and in children. Eur Thyroid J 2014, 3:76-94.
3. Stagnaro-Green A, Abalovich M, Alexander E, et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid 2011, 21:1081-1125.
4. Lazarus JH, Bestwick JP, Channon S, et al. Antenatal thyroid screening and childhood cognitive function. N Engl J Med 2012, 366:493-501.
5. Lavado-Autric R, Auso E, Garcia-Velasco JV, et al. Early maternal hypothyroxinemia alters histogenesis and cerebral cortex cytoarchitecture of the progeny. J Clin Invest 2003, 111:1073-1082.
6. Bernal J Thyroid hormones and brain development. Vitam Horm 2005, 71:95-122.
7. Iskaros J, Pickard M, Evans I, Sinha A, Hardiman P, Ekins R Thyroid hormone receptor gene expression in first trimester human fetal brain. J Clin Endocrinol Metab 2000, 85:2620-2623.
8. Thorpe-Beeston JG, Nicolaides KH, Felton CV, Butler J, McGregor AM Maturation of the secretion of thyroid hormone and thyroid-stimulating hormone in the fetus. N Engl J Med 1991, 324:532-536.
9. Luders E, Narr KL, Thompson PM, Toga AW Neuroanatomical correlates of intelligence. Intelligence 2009, 37:156-163.
10. Henrichs J, Ghassabian A, Peeters RP, Tiemeier H Maternal hypothyroxinemia and effects on cognitive functioning in childhood: how and why?. Clin Endocrinol 2013, 79:152-162.
11. Haddow JE, Palomaki GE, Allan WC, et al. Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 1999, 341:549-555.
12. Ghassabian A, El Marroun H, Peeters RP, et al. Downstream effects of maternal hypothyroxinemia in early pregnancy: nonverbal IQ and brain morphology in school-age children. J Clin Endocrinol Metab 2014, 99:2383-2390.
13. Marta CB, Adamo AM, Soto EF, Pasquini JM Sustained neonatal hyperthyroidism in the rat affects myelination in the central nervous system. J Neurosci Res 1998, 53:251-259.
14. Pasquini JM, Adamo AM Thyroid hormones and the central nervous system. Dev Neurosci 1994, 16:1-8.
15. Nicholson JL, Altman J Synaptogenesis in the rat cerebellum: effects of early hypo- and hyperthyroidism. Science 1972, 176:530-532.
16. Nicholson JL, Altman J The effects of early hypo- and hyperthyroidism on the development of the rat cerebellar cortex. II. Synaptogenesis in the molecular layer. Brain Res 1972, 44:25-36.
17. Nicholson JL, Altman J The effects of early hypo- and hyperthyroidism on the development of rat cerebellar cortex. I. Cell proliferation and differentiation. Brain Res 1972, 44:13-23.
18. Lauder JM The effects of early hypo- and hyperthyroidism on the development of rat cerebellar cortex. III. Kinetics of cell proliferation in the external granular layer. Brain Res 1977, 126:31-51.
19. Lauder JM, Altman J, Krebs H Some mechanisms of cerebellar foliation: effects of early hypo- and hyperthyroidism. Brain Res 1974, 76:33-40.
20. Jaddoe VW, van Duijn CM, Franco OH, et al. The Generation R Study: design and cohort update 2012. Eur J Epidemiol 2012, 27:739-756.
21. White T, El Marroun H, Nijs I, et al. Pediatric population-based neuroimaging and the Generation R Study: the intersection of developmental neuroscience and epidemiology. Eur J Epidemiol 2013, 28:99-111.
22. Tellegen PJ, Winkel M, Wijnberg-Williams BJ, Laros JA Snijders-Oomen Niet-Verbale Intelligentie Test. SON-R 1/2-7. Manual and Research Report (accessed Aug 25, 2015). http://www.testresearch.nl/sonr/sonr257manual.pdf.
23. Muir T, Zegarac M Societal costs of exposure to toxic substances: economic and health costs of four case studies that are candidates for environmental causation. Environ Health Perspect 2001, 109(suppl 6):885-903.
24. Batty GD, Deary IJ Early life intelligence and adult health. BMJ 2004, 329:585-586.
25. Lauder JM Effects of early hypo- and hyperthyroidism on development of rat cerebellar cortex. IV. The parallel fibers. Brain Res 1978, 142:25-39.
26. Kester MH, Martinez de Mena R, Obregon MJ, et al. Iodothyronine levels in the human developing brain: major regulatory roles of iodothyronine deiodinases in different areas. J Clin Endocrinol Metab 2004, 89:3117-3128.
27. Bates JM, St Germain DL, Galton VA Expression profiles of the three iodothyronine deiodinases, D1, D2, and D3, in the developing rat. Endocrinology 1999, 140:844-851.
28. Mortimer RH, Galligan JP, Cannell GR, Addison RS, Roberts MS Maternal to fetal thyroxine transmission in the human term placenta is limited by inner ring deiodination. J Clin Endocrinol Metab 1996, 81:2247-2249.
29. Chan S, Kachilele S, Hobbs E, et al. Placental iodothyronine deiodinase expression in normal and growth-restricted human pregnancies. J Clin Endocrinol Metab 2003, 88:4488-4495.
30. Emerson CH, Bambini G, Alex S, Castro MI, Roti E, Braverman LE The effect of thyroid dysfunction and fasting on placenta inner ring deiodinase activity in the rat. Endocrinology 1988, 122:809-816.
31. Haddow JE, Craig WY, Neveux LM, et al. Implications of high free thyroxine (FT4) concentrations in euthyroid pregnancies: the FaSTER trial. J Clin Endocrinol Metab 2014, 99:2038-2044.
32. Medici M, Timmermans S, Visser W, et al. Maternal thyroid hormone parameters during early pregnancy and birth weight: the Generation R Study. J Clin Endocrinol Metab 2013, 98:59-66.
33. Anselmo J, Cao D, Karrison T, Weiss RE, Refetoff S Fetal loss associated with excess thyroid hormone exposure. JAMA 2004, 292:691-695.
34. Willoughby KA, McAndrews MP, Rovet JF Effects of maternal hypothyroidism on offspring hippocampus and memory. Thyroid 2014, 24:576-584.
35. Samadi A, Skocic J, Rovet JF Children born to women treated for hypothyroidism during pregnancy show abnormal corpus callosum development. Thyroid 2015, 25:494-502.
36. Ekinci EI, Lu ZX, Sikaris K, et al. Longitudinal assessment of thyroid function in pregnancy. Ann Clin Biochem 2013, 50(pt 6):595-602.
37. Boas M, Forman JL, Juul A, et al. Narrow intra-individual variation of maternal thyroid function in pregnancy based on a longitudinal study on 132 women. Eur J Endocrinol 2009, 161:903-910.
38. Sapin R, d'Herbomez M Free thyroxine measured by equilibrium dialysis and nine immunoassays in sera with various serum thyroxine-binding capacities. Clin Chem 2003, 49:1531-1535.
39. Bath SC, Steer CD, Golding J, Emmett P, Rayman MP Effect of inadequate iodine status in UK pregnant women on cognitive outcomes in their children: results from the Avon Longitudinal Study of Parents and Children (ALSPAC). Lancet 2013, 382:331-337.
40. Ghassabian A, Steenweg-de Graaff J, Peeters RP, et al. Maternal urinary iodine concentration in pregnancy and children's cognition: results from a population-based birth cohort in an iodine-sufficient area. BMJ Open 2014, 4:e005520.
41. Shi X, Han C, Li C, et al. Optimal and safe upper limits of iodine intake for early pregnancy in iodine-sufficient regions: a cross-sectional study of 7190 pregnant women in China. J Clin Endocrinol Metab 2015, 100:1630-1638.