Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: Effects on obstetrical complications

Journal of Clinical Endocrinology and Metabolism

Volumn 91, Issue 7, 2006, Pages 2587-2591

  Negro, Roberto ^a   Formoso, Gianni ^a   Mangieri, Tiziana ^b   Pezzarossa, Antonio ^c   Dazzi, Davide ^c   Hassan, Haslinda ^d  

^a Azienda Ospedaliera LE/1   (Italy)

^b Casa di Cura Salus ^*  (Italy)

^c Di Vaio Hospital   (Italy)

^d RIPAS HOSPITAL   (Brunei Darussalam)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOTHYROXINE; THYROID PEROXIDASE ANTIBODY;

ADOLESCENT; ADULT; ARTICLE; AUTOIMMUNE DISEASE; CHILDBIRTH; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; EUTHYROIDISM; FEMALE; HOSPITAL DEPARTMENT; HUMAN; MAJOR CLINICAL STUDY; OUTCOME ASSESSMENT; PREGNANCY; PREGNANCY COMPLICATION; PREMATURE LABOR; PRIORITY JOURNAL; PROSPECTIVE STUDY; SPONTANEOUS ABORTION; THYROID DISEASE;

ABORTION, SPONTANEOUS; ADOLESCENT; ADULT; AUTOANTIBODIES; AUTOIMMUNE DISEASES; FEMALE; GESTATIONAL AGE; HUMANS; INFANT, NEWBORN; INFANT, PREMATURE; IODIDE PEROXIDASE; OBSTETRIC LABOR, PREMATURE; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; THYROID DISEASES; THYROID FUNCTION TESTS; THYROTROPIN; THYROXINE;

EID: 33745788166     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-1603     Document Type: Article

References (21)

1. Iijima T, Tada H, Hidaka K, Mitsuda N, Murata Y, Amino N 1997 Effects of autoantibodies on the course of pregnancy and fetal growth. Obstet Gynecol 90:364-369
2. Dendrinos S, Papasteriades C, Tarassi K, Christodoulakos G, Prasinos G, Creatsas G 2000 Thyroid autoimmunity in patients with recurrent spontaneous miscarriages. Gynecol Endocrinol 14:270-274
3. Bagis T, Gokcel A, Saygili ES 2001 Autoimmune thyroid disease in pregnancy and the postpartum period: relationship to spontaneous abortion. Thyroid 11:1049-1053
4. Davis LE, Leveno KJ, Cunningham FG 1988 Hypothyroidism complicating pregnancy. Obstet Gynecol 72:108-112
5. Mizgala L, Lao TT, Hannah ME 1991 Hypothyroidism presenting as hypothermia following pre-eclampsia at 23 weeks gestation. Case report and review of the literature. Br J Obstet Gynecol 98:221-224
6. Leung AS, Millar LK, Koonings PP, Montoro M, Mestman J 1993 Perinatal outcome in hypothyroid pregnancies. Obstet Gynecol 81:349-353
7. Abalovich M, Gutierrez S, Alcaraz G, Maccallini G, Garcia A, Levalle O 2002 Overt and subclinical hypothyroidism complicating pregnancy. Thyroid 12:63-68
8. Glinoer D, Rihi M, Grün JP, Kinthaert J 1994 Risk of subclinical hypothyroidism in pregnant women with asymptomatic autoimmune thyroid disorders. J Clin Endocrinol Metab 79:197-204
9. Pratt DE, Kaberlein G, Dudkiewicz A, Karande V, Gleicher N 1993 The association of thyroid antibodies in euthyroid nonpregnantwomenwith recurrent first trimester abortions in the next pregnancy. Fertil Steril 60:1001-1005
10. Menken J, Trussell J, Larsen U 1986 Age and infertility. Science 233:1389-1394
11. Lejeune B, Grun JP, De Nayer PH, Servais G, Glinoer D 1993 Antithyroid antibodies underlying thyroid abnormalities and miscarriage or pregnancy induced hypertension. Br J Obstet Gynaecol 100:669-672
12. Alexander EK, Marqusee E, Lawrence J, Jarolim P, Fisher GA, Larsen PR 2004 Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism. N Engl J Med 351:241-249
13. Glinoer D 1997 The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocr Rev 18:404-433
14. Casey BM, Dashe JS, Wells CE, McIntire DD, Byrd W, Leveno KJ, Cunningham FG 2005 Subclinical hypothyroidism is associated with premature delivery. Obstet Gynecol 105:239-245
15. Negro R, Mangieri T, Coppola L, Presicce G, Caroli Casavola E, Gismondi R, Locorotondo G, Caroli P. Pezzarossa A, Dazzi D, Hassan H 2005 Levothyroxine treatment in thyroid peroxidase antibody-positive women undergoing assisted reproduction technologies: a prospective study. Hum Reprod 20:1529-1533
16. Dejan CM, Saravan P, Bayly G 2002 Whose normal thyroid function is better: yours or mine? Lancet 360:353-354
17. Calvo RM, Jauniaux E, Gubils B, Asuncìon M, Gervy C, Contemprè B, Morreale de Escobar G 2002 Fetal tissues are exposed to biologically relevant free thyroxine concentrations during early phase of development. J Clin Endocrinol Metab 87:1768-1777
18. Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J, O'Heir CE, Mitchell ML, Hermos RJ, Waisbren SE, Faix JD, Klein RZ 1999 Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med 341:549-555
19. den Ouden AL, Kok JH, Verkerk PH, Brand R, Verloove-Vanhorick SP 1996 The relation between neonatal thyroxine levels and neurodevelopmental outcome at 5 and 9 years in a national cohort of very preterm and/or very low birth weight infants. Pediatr Res 39:142-145
20. Reuss ML, Paneth N, Pinto-Martin JA, Lorenz JM, Susser M 1996 The relation of transient hypothyroxinemia in preterm infants to neurological development at two years of age. N Engl J Med 334:821-827
21. Poppe K, Glinoer D 2003 Thyroid autoimmunity and hypothyroidism before and during pregnancy. Hum Reprod 9:149-161