On the need for universal thyroid screening in pregnant women

European Journal of Endocrinology

Volumn 170, Issue 1, 2014, Pages

  Vila, Lluís ^a   Velasco, Inés ^b   González, Stella ^c   Morales, Francisco ^d   Sánchez, Emilia ^e   Torrejón, Sara ^a   Soldevila, Berta ^f   Stagnaro Green, Alex ^g   Puig Domingo, Manuel ^f  

^a Unidad de Cuidados Intensivos Hospital Sant Joan Despi Moisés Broggi   (Spain)

^b Riotinto Hospital   (Spain)

^c HOSPITAL REGIONAL UNIVERSITARIO DE MÁLAGA   (Spain)

^d HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^e UNIVERSITAT RAMON LLULL   (Spain)

^f UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^g GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOTHYROXINE; THYROTROPIN; THYROXINE;

HIGH RISK POPULATION; HUMAN; HYPOTHYROIDISM; PATIENT SAFETY; PREGNANCY OUTCOME; PREGNANT WOMAN; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; RISK FACTOR; SCREENING TEST; THYROID DISEASE; THYROID SCREENING; ADULT; BLOOD; EVIDENCE BASED MEDICINE; FEMALE; FIRST TRIMESTER PREGNANCY; HEALTH CARE POLICY; HORMONE SUBSTITUTION; MATERNAL SERUM SCREENING TEST; PATHOPHYSIOLOGY; PRACTICE GUIDELINE; PREGNANCY; PREGNANCY COMPLICATIONS; PRENATAL DIAGNOSIS; THYROID GLAND;

ADULT; EVIDENCE-BASED MEDICINE; FEMALE; HEALTH POLICY; HORMONE REPLACEMENT THERAPY; HUMANS; HYPOTHYROIDISM; MATERNAL SERUM SCREENING TESTS; PRACTICE GUIDELINES AS TOPIC; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY TRIMESTER, FIRST; PRENATAL DIAGNOSIS; THYROID GLAND; THYROTROPIN; THYROXINE;

EID: 84893004850     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-13-0561     Document Type: Review

References (133)

1. Glinoer D. The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocrine Reviews 1997 18 404-433. (doi:10.1210/er.18.3.404)
2. Morreale de Escobar G, Obregón MJ & Escobar del Rey F. Maternal thyroid hormones early in pregnancy and fetal brain development. Best Practice & Research. Clinical Endocrinology & Metabolism 2004 18 225-248. (doi:10.1016/j.beem.2004.03.012)
3. Morreale de Escobar G, Obregon MJ & Escobar del Rey F. Is neuropsychological development related tomaternal hypothyroidism or to maternal hypothyroxinemia? Journal of Clinical Endocrinology and Metabolism 2000 85 3975-3987. (doi:10.1210/jc.85.11.3975)
4. Glinoer D. The systematic screening and management of hypothyroidism and hyperthyroidism during pregnancy. Trends in Endocrinology and Metabolism 1998 9 403-411. (doi:10.1016/S1043-2760(98)00095-2)
5. Abalovich M, Amino N, Barbour LA, Cobin RH, De Groot LJ, Glinoer D, Mandel SJ & Stagnaro-Green A. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism 2007 92 S1-47. (doi:10.1210/jc.2007-0141)
6. Poppe K, Velkeniers B & Glinoer D. The role of thyroid autoimmunity in fertility and pregnancy. Nature Clinical Practice. Endocrinology & Metabolism 2008 4 394-405. (doi:10.1038/ncpendmet0846)
7. Velkeniers B, Van Meerhaeghe A, Poppe K, Unuane D, Tournaye H & Haentjens P. Levothyroxine treatment and pregnancy outcome in women with subclinical hypothyroidism undergoing assisted reproduction technologies: systematic review and meta-analysis of RCTs. Human Reproduction Update 2013 19 251-258. (doi:10.1093/humupd/dms052)
8. Negro R. Thyroid autoimmunity and pre-term delivery: brief review and meta-analysis. Journal of Endocrinological Investigation 2011 34 155-158. (doi:10.3275/7610)
9. Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J, O'Heir CE, Mitchell ML, Hermos RJ, Waisbren SE et al . Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. New England Journal of Medicine 1999 341 549-555. (doi:10.1056/ NEJM199908193410801)
10. Lazarus JH. Thyroid disease in pregnancy and childhood. Minerva Endocrinologica 2005 30 71-87.
11. Spong CY. Subclinical hypothyroidism: should all pregnant women be screened? Obstetrics and Gynecology 2005 105 235-236. (doi:10.1097/01.AOG. 0000153143.89006.ac)
12. Committee on Patient Safety and Quality Improvement; Committee on Professional Liability. ACOG Committee opinion no. 381: subclinical hypothyroidism in pregnancy. Obstetrics and Gynecology 2007 110 959-960.
13. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, Nixon A, Pearce EN, Soldin OP, Sullivan S et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid 2011 21 1081-1125. (doi:10.1089/thy.2011.0087)
14. Garber JR, Cobin RH, Gharib H, Hennessey JV, Klein I, Mechanick JI, Pessah-Pollack R, Singer PA & Woeber KA. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocrine Practice 2012 18 988-1028. (doi:10.4158/EP12280.GL)
15. De Groot L, Abalovich M, Alexander EK, Amino N, Barbour L, Cobin RH, Eastman CJ, Lazarus JH, Luton D, Mandel SJ et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. Journal of Clinical Endocrinology and Metabolism 2012 97 2543-2565. (doi:10.1210/jc.2011-2803)
16. Galofré Ferrater JC, Corrales Hérnandez JJ, Pérez Corral B, Cantón Blanco A, Alonso Pedrol N, Pérez Pérez A, Lajo Morales T & Tortosa Henzi F. Guía clínica para el diagnóstico y el tratamiento de la disfunción tiroidea subclínica en la gestación. Endocrinología y Nutrición 2009 56 85-91. (doi:10.1016/S1575-0922(09)70556-X)
17. Vila L, Velasco I, Gonzalez S, Morales F, Sanchez E, Lailla JM, Martinez- Astorquiza T & Puig-Domingo M. Detección de la disfunción tiroidea en la población gestante: está justificado el cribado universal. Endocrinología y Nutrición 2012 59 547-560. (doi:10.1016/j.endonu.2012.06.014)
18. Tortosa F. Subclinical thyroid dysfunction in pregnancy. Endocrinología y Nutrición 2011 58 255-257. (doi:10.1016/j.endonu. 2011.05.001)
19. Stagnaro-Green A. Optimal care of the pregnant woman with thyroid disease. Journal of Clinical Endocrinology and Metabolism 2012 97 2619-2622. (doi:10.1210/jc.2012-2380)
20. Col NF, Surks MI & Daniels GH. Subclinical thyroid disease: clinical applications. Journal of the American Medical Association 2004 291 239-243. (doi:10.1001/jama.291.2.239)
21. Vaidya B, Anthony S, Bilous M, Shields B, Drury J, Hutchison S & Bilous R. Detection of thyroid dysfunction in early pregnancy: universal screening or targeted high-risk case finding? Journal of Clinical Endocrinology and Metabolism 2007 92 203-207. (doi:10.1210/jc.2006-1748)
22. Vaidya B, Hubalewska-Dydejczyk A, Laurberg P, Negro R, Vermiglio F & Poppe K. Treatment and screening of hypothyroidism in pregnancy: results of a European survey. European Journal of Endocrinology 2012 166 49-54. (doi:10.1530/EJE-11-0729)
23. Serra-Majem L, Ribas L, Aranceta J, Perez C, Saavedra P & Pena L. Childhood and adolescent obesity in Spain. Results of the enKid study (1998-2000). Medicina Clínica 2003 121 725-732. (doi:10.1016/S0025- 7753(03)74077-9)
24. Rosario PW. Should pregnant women older than 30 years without risk factors be investigated for thyroid dysfunction? Thyroid 2012 22 445-446. (doi:10.1089/thy.2011.0342)
25. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, Nixon A, Pearce EN, Soldin OP, Sullivan S et al. Response to Rosario. Thyroid 2012 22 446-447. (doi:10.1089/thy.2011.0342.rs)
26. Canaris GJ, Manowitz NR, Mayor G & Ridgway EC. The Colorado thyroid disease prevalence study. Archives of Internal Medicine 2000 160 526-534. (doi:10.1001/archinte.160.4.526)
27. Hollowell JG, Staehling NW, Flanders WD, Hannon WH, Gunter EW, Spencer CA & Braverman LE. Serum TSH, T(4), and thyroid antibodies in the United States population (1988 to 1994): National Health and Nutrition Examination Survey (NHANES III). Journal of Clinical Endocrinology and Metabolism 2002 87 489-499. (doi:10.1210/jc.87.2.489)
28. Wilson JMG & Jugner G. In Principles and Practice of Screening for Disease. WHO Chronicle Geneva: World Health Organization. Public Health Papers, no. 34. 1968 22 (11): 473.
29. Bonita R, Beaglehole R & Kjellström T. In Basic Epidemiology, 2nd edn. Geneva: World Health Organization, 2006.
30. Andermann A, Blancquaert I, Beauchamp S & Déry V. Revisiting Wilson and Jungner in the genomic age: a review of screening criteria over the past 40 years. Bulletin of the World Health Organization 2008 86 317-319. (doi:10.2471/BLT.07.050112)
31. Alexander EK. Here's to you, baby! A step forward in support of universal screening of thyroid function during pregnancy. Journal of Clinical Endocrinology and Metabolism 2010 95 1575-1577. (doi:10.1210/jc.2010-0155)
32. Beaglehole R, Bonita R & Kjellström T. In Basic Epidemiology. Geneva: World Health Organization, 1993.
33. Belmonte S. Subclinic hypothyroidism in pregnant women in the northern area of province of Granada, Spain. Prevalence and perinatal consequences. Doctoral Thesis. Universidad de Granada, 2009.
34. Rebagliato M, Murcia M, Espada M, Alvarez-Pedrerol M, Bolumar F, Vioque J, Basterrechea M, Blarduni E, Ramon R, GuxensM et al . Iodine intake and maternal thyroid function during pregnancy. Epidemiology 2010 21 62-69. (doi:10.1097/EDE.0b013e3181c1592b)
35. Menéndez E, Sánchez V, Avello N, Aller J, Bellido V & Boix P. Universal screening of thyroid dysfunction in pregnant women leaving in Oviedo, Spain. Endocrinología y Nutrición 2011 58 120-121.
36. Berbel P, Mestre JL, Santamaria A, Palazon I, Franco A, Graells M, Gonzalez-Torga A & Morreale de Escobar G. Delayed neurobehavioral development in children born to pregnant women with mild hypothyroxinemia during the first month of gestation: the importance of early iodine supplementation. Thyroid 2009 19 511-519. (doi:10.1089/thy.2008.0341)
37. Casey BM, Dashe JS, Wells CE, McIntire DD, Byrd W, Leveno KJ & Cunningham FG. Subclinical hypothyroidism and pregnancy outcomes. Obstetrics and Gynecology 2005 105 239-245. (doi:10.1097/01.AOG.0000152345.99421.22)
38. Moleti M, Lo PV, Mattina F, Mancuso A, De Vivo A, Giorgianni G, Di Bella B, Trimarchi F & Vermiglio F. Gestational thyroid function abnormalities in conditions of mild iodine deficiency: early screening versus continuous monitoring of maternal thyroid status. European Journal of Endocrinology 2009 160 611-617. (doi:10.1530/EJE-08-0709)
39. Stagnaro-Green A. Overt hyperthyroidism and hypothyroidism during pregnancy. Clinical Obstetrics and Gynecology 2011 54 478-487. (doi:10.1097/GRF.0b013e3182272f32)
40. Blatt AJ, Nakamoto JM & Kaufman HW. National status of testing for hypothyroidism during pregnancy and postpartum. Journal of Clinical Endocrinology and Metabolism 2012 97 777-784. (doi:10.1210/jc.2011-2038)
41. Altomare M, La Vignera S, Asero P, Recupero D, Condorelli RA, Scollo P, Gulisano A, Magro E, Tumino D, Tumino S et al. High prevalence of thyroid dysfunction in pregnant women. Journal of Endocrinological Investigation 2013 36 407-411. (doi:10.3275/8658)
42. Delange F. Iodine requirements during pregnancy, lactation and the neonatal period and indicators of optimal iodine nutrition. Public Health Nutrition 2007 10 1571-1580. (doi:10.1017/S1368980007360941)
43. Bocos-Terraz JP, Izquierdo-Alvarez S, Bancalero-Flores JL, Alvarez-Lahuerta R, Aznar-Sauca A, Real-Lopez E, Ibanez-Marco R, Bocanegra-Garcia V & Rivera-Sanchez G. Thyroid hormones according to gestational age in pregnant Spanish women. BMC Research Notes 2009 2 237. (doi:10.1186/1756-0500-2-237)
44. Pearce EN, Oken E, GillmanMW, Lee SL, Magnani B, Platek D & Braverman LE. Association offirst-trimester thyroid function test values with thyroperoxidase antibody status, smoking, and multivitamin use. Endocrine Practice 2008 14 33-39. (doi:10.4158/EP.14.1.33)
45. Patil-Sisodia K & Mestman JH. Graves hyperthyroidism and pregnancy: a clinical update. Endocrine Practice 2010 16 118-129. (doi:10.4158/EP09233.RA)
46. Goodwin TM, Montoro M, Mestman JH, Pekary AE & Hershman JM. The role of chorionic gonadotropin in transient hyperthyroidism of hyperemesis gravidarum. Journal of Clinical Endocrinology and Metabolism 1992 75 1333-1337. (doi:10.1210/jc.75.5.1333)
47. Trokoudes KM, Skordis N & Picolos MK. Infertility and thyroid disorders. Current Opinion in Obstetrics & Gynecology 2006 18 446-451. (doi:10.1097/01.gco.0000233941.89919.31)
48. Abalovich M, Mitelberg L, Allami C, Gutierrez S, Alcaraz G, Otero P & Levalle O. Subclinical hypothyroidism and thyroid autoimmunity in women with infertility. Gynecological Endocrinology 2007 23 279-283. (doi:10.1080/ 09513590701259542)
49. Negro R, Formoso G, Coppola L, Presicce G, Mangieri T, Pezzarossa A & Dazzi D. Euthyroid women with autoimmune disease undergoing assisted reproduction technologies: the role of autoimmunity and thyroid function. Journal of Endocrinological Investigation 2007 30 3-8.
50. Allan WC, Haddow JE, Palomaki GE, Williams JR, Mitchell ML, Hermos RJ, Faix JD & Klein RZ. Maternal thyroid deficiency and pregnancy complications: implications for population screening. Journal of Medical Screening 2000 7 127-130. (doi:10.1136/jms.7.3.127)
51. Abalovich M, Gutierrez S, Alcaraz G, Maccallini G, Garcia A & Levalle O. Overt and subclinical hypothyroidism complicating pregnancy. Thyroid 2002 12 63-68. (doi:10.1089/105072502753451986)
52. Davis LE, Leveno KJ & Cunningham FG. Hypothyroidism complicating pregnancy. Obstetrics and Gynecology 1988 72 108-112.
53. De Vivo A, Mancuso A, Giacobbe A, Moleti M, Maggio SL, De Dominici R, Priolo AM & Vermiglio F. Thyroid function in women found to have early pregnancy loss. Thyroid 2010 20 633-637. (doi:10.1089/thy.2009.0323)
54. Alvarez-Pedrerol M, Guxens M, Mendez M, Canet Y, Martorell R, Espada M, Plana E, Rebagliato M & Sunyer J. Iodine levels and thyroid hormones in healthy pregnant women and birth weight of their offspring. European Journal of Endocrinology 2009 160 423-429. (doi:10.1530/EJE-08-0716)
55. Wolfberg AJ, Lee-Parritz A, Peller AJ & Lieberman ES. Obstetric and neonatal outcomes associated with maternal hypothyroid disease. Journal of Maternal-Fetal & Neonatal Medicine 2005 17 35-38. (doi:10.1080/ 14767050400028642)
56. Buimer M, van Wassenaer AG, Ganzevoort W, Wolf H, Bleker OP & Kok JH. Transient hypothyroxinemia in severe hypertensive disorders of pregnancy. Obstetrics and Gynecology 2005 106 973-979. (doi:10.1097/01.AOG.0000180395. 06136.b5)
57. Leung AS, Millar LK, Koonings PP, Montoro M & Mestman JH. Perinatal outcome in hypothyroid pregnancies. Obstetrics and Gynecology 1993 81 349-353.
58. Stagnaro-Green A, Chen X, Bogden JD, Davies TF & Scholl TO. The thyroid and pregnancy: a novel risk factor for very preterm delivery. Thyroid 2005 15 351-357. (doi:10.1089/thy.2005.15.351)
59. Cleary-Goldman J, Malone FD, Lambert-Messerlian G, Sullivan L, Canick J, Porter TF, Luthy D, Gross S, Bianchi DW & D'Alton ME. Maternal thyroid hypofunction and pregnancy outcome. Obstetrics and Gynecology 2008 112 85-92. (doi:10.1097/AOG.0b013e3181788dd7)
60. van den Boogaard E, Vissenberg R, Land JA, van Wely M, van der Post JA, Goddijn M & Bisschop PH. Significance of (sub)clinical thyroid dysfunction and thyroid autoimmunity before conception and in early pregnancy: a systematic review. Human Reproduction Update 2011 17 605-619. (doi:10.1093/humupd/dmr024)
61. Li Y, Shan Z, Teng W, Yu X, Li Y, Fan C, Teng X, Guo R, Wang H, Li J et al. Abnormalities of maternal thyroid function during pregnancy affect neuropsychological development of their children at 25-30 months. Clinical Endocrinology 2010 72 825-829. (doi:10.1111/j.1365-2265.2009.03743.x)
62. Pop VJ, Kuijpens JL, van Baar AL, Verkerk G, van Son MM, de Vijlder JJ, Vulsma T, Wiersinga WM, Drexhage HA & Vader HL. Low maternal free thyroxine concentrations during early pregnancy are associated with impaired psychomotor development in infancy. Clinical Endocrinology 1999 50 149-155. (doi:10.1046/j.1365-2265.1999.00639.x)
63. Henrichs J, Bongers-Schokking JJ, Schenk JJ, Ghassabian A, Schmidt HG, Visser TJ, Hooijkaas H, de Muinck Keizer-Schrama SM, Hofman A, Jaddoe VV et al . Maternal thyroid function during early pregnancy and cognitive functioning in early childhood: the generation R study. Journal of Clinical Endocrinology and Metabolism 2010 95 4227-4234. (doi:10.1210/jc.2010-0415)
64. Kooistra L, Crawford S, van Baar AL, Brouwers EP & Pop VJ. Neonatal effects of maternal hypothyroxinemia during early pregnancy. Pediatrics 2006 117 161-167. (doi:10.1542/peds.2005-0227)
65. Finken MJ, van Eijsden M, Loomans EM, Vrijkotte TG & Rotteveel J. Maternal hypothyroxinemia in early pregnancy predicts reduced performance in reaction time tests in 5- to 6-year-old offspring. Journal of Clinical Endocrinology and Metabolism 2013 98 1417-1426. (doi:10.1210/jc.2012-3389)
66. Julvez J, Alvarez-Pedrerol M, Rebagliato M, Murcia M, Forns J, Garcia- Esteban R, Lertxundi N, Espada M, Tardon A, Riano GI et al. Thyroxine levels during pregnancy in healthy women and early child neurodevelopment. Epidemiology 2013 24 150-157. (doi:10.1097/EDE.0b013e318276ccd3)
67. Craig WY, Allan WC, Kloza EM, Pulkkinen AJ, Waisbren S, Spratt DI, Palomaki GE, Neveux LM & Haddow JE.Mid-gestational maternal free thyroxine concentration and offspring neurocognitive development at age two years. Journal of Clinical Endocrinology and Metabolism 2012 97 E22-E28. (doi:10.1210/jc.2011- 1772)
68. Velasco I, Carreira M, Santiago P, Muela JA, Garcia-Fuentes E, Sanchez-Munoz B, Garriga MJ, Gonzalez-Fernandez MC, Rodriguez A, Caballero FF et al. Effect of iodine prophylaxis during pregnancy on neurocognitive development of children during the first two years of life. Journal of Clinical Endocrinology and Metabolism 2009 94 3234-3241. (doi:10.1210/jc.2008-2652)
69. Mannisto T, Mendola P, Reddy U & Laughon SK. Neonatal outcomes and birth weight in pregnancies complicated by maternal thyroid disease. American Journal of Epidemiology 2013 178 731-740. (doi:10.1093/aje/kwt031)
70. Pakkila F, Mannisto T, Surcel HM, Ruokonen A, Bloigu A, Pouta A, Hartikainen AL, Vaarasmaki M, Jarvelin MR & Suvanto E. Maternal thyroid dysfunction during pregnancy and thyroid function of her child in adolescence. Journal of Clinical Endocrinology and Metabolism 2013 98 965-972. (doi:10.1210/jc.2012-2028)
71. Gratacós E. Medicina Fetal. Barcelona: Panamericana, 2007.
72. Chen I. Prenatal testing of thyroid is debated. The New York Times (http://www.nytimes.com/2009/04/14/health/14thyr.html), 2009.
73. Glinoer D & Spencer CA. Serum TSH determinations in pregnancy: how, when and why? Nature Reviews. Endocrinology 2010 6 526-529. (doi:10.1038/nrendo. 2010.91)
74. Mandel SJ, Spencer CA & Hollowell JG. Are detection and treatment of thyroid insufficiency in pregnancy feasible? Thyroid 2005 15 44-53. (doi:10.1089/thy.2005.15.44)
75. Anckaert E, Poppe K, Van Uytfanghe K, Schiettecatte J, Foulon W & Thienpont LM. FT4 immunoassays may display a pattern during pregnancy similar to the equilibrium dialysis ID-LC/tandem MS candidate reference measurement procedure in spite of susceptibility towards binding protein alterations. Clinica Chimica Acta 2010 411 1348-1353. (doi:10.1016/j.cca.2010.05.032)
76. Kahric-Janicic N, Soldin SJ, Soldin OP, West T, Gu J & Jonklaas J. Tandem mass spectrometry improves the accuracy of free thyroxine measurements during pregnancy. Thyroid 2007 17 303-311. (doi:10.1089/thy.2006.0303)
77. Midgley JE & Hoermann R. Measurement of total rather than free thyroxine in pregnancy: the diagnostic implications. Thyroid 2013 23 259-261. (doi:10.1089/thy.2012.0469)
78. Soldin OP. When thyroidologists agree to disagree: comments on the 2012 Endocrine Society pregnancy and thyroid disease clinical practice guideline. Journal of Clinical Endocrinology and Metabolism 2012 97 2632-2635. (doi:10.1210/jc.2012-2529)
79. 4 immunoassays are flawed during pregnancy. American Journal of Obstetrics and Gynecology 2009 200 260-266. (doi:10.1016/j.ajog.2008.10.042)
80. Glinoer D. Maternal thyroid function in pregnancy. Journal of Endocrinological Investigation 1993 16 374-378.
81. Haddow JE, McClain MR, Palomaki GE, Kloza EM & Williams J. Screening for thyroid disorders during pregnancy: results of a survey in Maine. American Journal of Obstetrics and Gynecology 2006 194 471-474. (doi:10.1016/j.ajog.2005. 07.055)
82. Garcia de Guadiana RL, Gonzalez MM, Martin-Ondarza Gonzalez MC, Martin GE, Martinez UJ, Blazquez AA & Nuevo GJ. Evaluation of thyroid function during pregnancy: first-trimester reference intervals for thyroid-stimulating hormone and free thyroxine. Endocrinología y Nutrición 2010 57 290-295. (doi:10.1016/j.endonu.2010.05.002)
83. Vila L, Serra-Prat M, Palomera E, Casamitjana R, de Castro A, Legaz G, Barrionuevo C, Garcia AJ, Lal S, Muñoz JA et al. Reference values for thyroid function tests in pregnant women living in Catalonia, Spain. Thyroid 2010 20 221-225. (doi:10.1089/thy.2008.0264)
84. Santiago P, Berrio M, Olmedo P, Velasco I, Sanchez B, Garcia E, Martinez J & Soriguer F. Reference values for thyroid hormones in the population of pregnant women in Jaen (Spain). Endocrinología y Nutrición 2011 58 62-67. (doi:10.1016/j.endonu.2010.12.004)
85. Haddow JE, Knight GJ, Palomaki GE, McClain MR & Pulkkinen AJ. The reference range and within-person variability of thyroid stimulating hormone during the first and second trimesters of pregnancy. Journal of Medical Screening 2004 11 170-174. (doi:10.1258/0969141042467340)
86. Panesar NS, Li CY & Rogers MS. Reference intervals for thyroid hormones in pregnant Chinese women. Annals of Clinical Biochemistry 2001 38 329-332. (doi:10.1258/0004563011900830)
87. Negro R, Schwartz A, Gismondi R, Tinelli A, Mangieri T & Stagnaro-Green A. Increased pregnancy loss rate in thyroid antibody negative women with TSH levels between 2.5 and 5.0 in the first trimester of pregnancy. Journal of Clinical Endocrinology and Metabolism 2010 95 E44-E48. (doi:10.1210/jc.2010-0340)
88. Dosiou C, Sanders GD, Araki SS & Crapo LM. Screening pregnant women for autoimmune thyroid disease: a cost-effectiveness analysis. European Journal of Endocrinology 2008 158 841-851. (doi:10.1530/EJE-07-0882)
89. Thung SF, Funai EF & Grobman WA. The cost-effectiveness of universal screening in pregnancy for subclinical hypothyroidism. American Journal of Obstetrics and Gynecology 2009 200 267. (doi:10.1016/j.ajog.2008.10.035)
90. Velasco I. Prenatal anomalies associated with iodine deficiency. Progresos en Diagnóstico y Tratamiento Prenatal 2005 17 123-128.
91. Negro R, Schwartz A, Gismondi R, Tinelli A, Mangieri T & Stagnaro-Green A. Universal screening versus case finding for detection and treatment of thyroid hormonal dysfunction during pregnancy. Journal of Clinical Endocrinology and Metabolism 2010 95 1699-1707. (doi:10.1210/jc.2009-2009)
92. Lazarus JH, Bestwick JP, Channon S, Paradice R, Maina A, Rees R, Chiusano E, John R, Guaraldo V, George LM et al. Antenatal thyroid screening and childhood cognitive function. New England Journal of Medicine 2012 366 493-501. (doi:10.1056/NEJMoa1106104)
93. Negro R. Thoughts about the 'Antenatal Thyroid Screening and Childhood Cognitive Function' Study. European Thyroid Journal 2012 1 132-133. (doi:10.1159/000338349)
94. Negro R, Formoso G, Mangieri T, Pezzarossa A, Dazzi D & Hassan H. Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications. Journal of Clinical Endocrinology and Metabolism 2006 91 2587-2591. (doi:10.1210/jc.2005-1603)
95. Dosiou C, Barnes J, Schwartz A, Negro R, Crapo L & Stagnaro-Green A. Cost-effectiveness of universal and risk-based screening for autoimmune thyroid disease in pregnant women. Journal of Clinical Endocrinology and Metabolism 2012 97 1536-1546. (doi:10.1210/jc.2011-2884)
96. Alexander EK, Marqusee E, Lawrence J, Jarolim P, Fischer GA & Larsen PR. Timing and magnitude of increases in levothyroxine requirements during pregnancy in women with hypothyroidism. New England Journal of Medicine 2004 351 241-249. (doi:10.1056/NEJMoa040079)
97. The International Council for Control of Iodine Deficiency Disorders (ICCIDD). Iodine requirements in pregnancy and infancy. IDD Newsletter, 2007 (http://www.thyroid.org/wp-content/uploads/professionals/education/IDD-NL-Feb07. pdf).
98. Moleti M, Lo PV, Campolo MC, Mattina F, Galletti M, Mandolfino M, Violi MA, Giorgianni G, De Domenico D, Trimarchi F et al. Iodine prophylaxis using iodized salt and risk of maternal thyroid failure in conditions of mild iodine deficiency. Journal of Clinical Endocrinology and Metabolism 2008 93 2616-2621. (doi:10.1210/jc.2008-0352)
99. Soriguer F, Gutierrez-Repiso C, Gonzalez-Romero S, Olveira G, Garriga MJ, Velasco I, Santiago P, Morreale de Escobar G & Garcia-Fuentes E. Iodine concentration in cow's milk and its relation with urinary iodine concentrations in the population. Clinical Nutrition 2011 30 44-48. (doi:10.1016/j.clnu.2010. 07.001)
100. Sahu MT, Das V, Mittal S, Agarwal A & Sahu M. Overt and subclinical thyroid dysfunction among Indian pregnant women and its effect on maternal and fetal outcome. Archives of Gynecology and Obstetrics 2010 281 215-220. (doi:10.1007/s00404-009-1105-1)
101. Stagnaro-Green A. Maternal thyroid disease and preterm delivery. Journal of Clinical Endocrinology and Metabolism 2009 94 21-25. (doi:10.1210/jc.2008- 1288)
102. Casey BM. Subclinical hypothyroidism and pregnancy. Obstetrical & Gynecological Survey 2006 61 415-420. (doi:10.1097/01.ogx.0000223331.51424.9b)
103. Moleti M, Trimarchi F & Vermiglio F. Doubts and concerns about isolated maternal hypothyroxinemia. Journal of Thyroid Research 2011 2011 463029. (doi:10.4061/2011/463029)
104. Pop VJ, Brouwers EP, Vader HL, Vulsma T, van Baar AL & de Vijlder JJ. Maternal hypothyroxinaemia during early pregnancy and subsequent child development: a 3-year follow-up study. Clinical Endocrinology 2003 59 282-288. (doi:10.1046/j.1365-2265.2003.01822.x)
105. Dominguez I, Reviriego S, Rojo-Martinez G, Valdes MJ, Carrasco R, Coronas I, Lopez-Ojeda J, Pacheco M, Garriga MJ, Garcia-Fuentes E et al. Iodine deficiency and thyroid function in healthy pregnant women. Medicina Clínica 2004 122 449-453.
106. Mitchell ML, Klein RZ, Sargent JD, Meter RA, Haddow JE, Waisbren SE & Faix JD. Iodine sufficiency and measurements of thyroid function in maternal hypothyroidism. Clinical Endocrinology 2003 58 612-616. (doi:10.1046/j.1365- 2265.2003.01760.x)
107. Moleti M, Vermiglio F & Trimarchi F. Maternal isolated hypothyroxinemia: to treat or not to treat? Journal of Endocrinological Investigation 2009 32 780-782. (doi:10.3275/6374)
108. Vermiglio F, Lo PV, Moleti M, Sidoti M, Tortorella G, Scaffidi G, Castagna MG, Mattina F, Violi MA, Crisa A et al. Attention deficit and hyperactivity disorders in the offspring of mothers exposed to mild-moderate iodine deficiency: a possible novel iodine deficiency disorder in developed countries. Journal of Clinical Endocrinology and Metabolism 2004 89 6054-6060. (doi:10.1210/jc.2004-0571)
109. Hollowell JG & Haddow JE. The prevalence of iodine deficiency in women of reproductive age in the United States of America. Public Health Nutrition 2007 10 1532-1539. (doi:10.1017/S1368980007360862)
110. Haddow JE, McClain MR, Palomaki GE & Hollowell JG. Urine iodine measurements, creatinine adjustment, and thyroid deficiency in an adult United States population. Journal of Clinical Endocrinology and Metabolism 2007 92 1019-1022. (doi:10.1210/jc.2006-2156)
111. Pearce EN. What do we know about iodine supplementation in pregnancy? Journal of Clinical Endocrinology and Metabolism 2009 94 3188-3190. (doi:10.1210/jc.2009-1512)
112. De Santiago J, Pastor J, Escobar del Rey F & Morreale de Escobar G. Iodine deficiency and thyroid function in pregnant. Endocrinología 1999 46 (Supp Congress) 7.
113. Rebagliato M, Murcia M, Alvarez-Pedrerol M, Espada M, Fernandez-Somoano A, Lertxundi N, Navarrete-Munoz EM, Forns J, Aranbarri A, Llop S et al. Iodine supplementation during pregnancy and infant neuropsychological development: INMA Mother and Child Cohort Study. American Journal of Epidemiology 2013 178 1067-1075. (doi:10.1093/aje/kwt085)
114. Murcia M, Rebagliato M, Iniguez C, Lopez-Espinosa MJ, Estarlich M, Plaza B, Barona-Vilar C, Espada M, Vioque J & Ballester F. Effect of iodine supplementation during pregnancy on infant neurodevelopment at 1 year of age. American Journal of Epidemiology 2011 173 804-812. (doi:10.1093/aje/kwq424)
115. Negro R, Soldin OP, Obregon MJ & Stagnaro-Green A. Hypothyroxinemia and pregnancy. Endocrine Practice 2011 17 422-429. (doi:10.4158/EP10309.RA)
116. Toulis KA, Goulis DG, Venetis CA, Kolibianakis EM, Negro R, Tarlatzis BC & Papadimas I. Risk of spontaneous miscarriage in euthyroid women with thyroid autoimmunity undergoing IVF: a meta-analysis. European Journal of Endocrinology 2010 162 643-652. (doi:10.1530/EJE-09-0850)
117. Jaen Diaz JI, Lopez DC, Cordero GB, Santillana BF, Sastre MJ & Martin DG. Incidence of postpartum thyroiditis and study of possible associated factors. Medicina Clínica 2009 132 569-573. (doi:10.1016/j.medcli.2008. 10.059)
118. Prummel MF & Wiersinga WM. Thyroid autoimmunity and miscarriage. European Journal of Endocrinology 2004 150 751-755. (doi:10.1530/eje.0.1500751)
119. Lepoutre T, Debieve F, Gruson D & Daumerie C. Reduction of miscarriages through universal screening and treatment of thyroid autoimmune diseases. Gynecologic and Obstetric Investigation 2012 74 265-273. (doi:10.1159/000343759)
120. Iijima T, Tada H, Hidaka Y, Mitsuda N, Murata Y & Amino N. Effects of autoantibodies on the course of pregnancy and fetal growth. Obstetrics and Gynecology 1997 90 364-369. (doi:10.1016/S0029-7844(97)〈?A3B2 show $160〉00283-4)
121. Cervera R & Balasch J. Bidirectional effects on autoimmunity and reproduction. Human Reproduction Update 2008 14 359-366. (doi:10.1093/humupd/ dmn013)
122. Toulis KA, Goulis DG, Venetis CA, Kolibianakis EM, Tarlatzis BC & Papadimas I. Thyroid autoimmunity and miscarriages: the corpus luteum hypothesis. Medical Hypotheses 2009 73 1060-1062. (doi:10.1016/j.mehy.2009.05. 012)
123. Millar LK, Wing DA, Leung AS, Koonings PP, Montoro MN & Mestman JH. Low birth weight and preeclampsia in pregnancies complicated by hyperthyroidism. Obstetrics and Gynecology 1994 84 946-949.
124. Gilbert RM, Hadlow NC, Walsh JP, Fletcher SJ, Brown SJ, Stuckey BG & Lim EM. Assessment of thyroid function during pregnancy: first-trimester (weeks 9-13) reference intervals derived from Western Australian women. Medical Journal of Australia 2008 189 250-253.
125. Lambert-Messerlian G, McClain M, Haddow JE, Palomaki GE, Canick JA, Cleary-Goldman J, Malone FD, Porter TF, Nyberg DA, Bernstein P et al. First- and second-trimester thyroid hormone reference data in pregnant women: a FaSTER (First- and Second-Trimester Evaluation of Risk for aneuploidy) Research Consortium study. American Journal of Obstetrics and Gynecology 2008 199 62-66. (doi:10.1016/j.ajog.2007.12.003)
126. Hieronimus S, Bec-Roche M, Ferrari P, Chevalier N, Fenichel P & Brucker-Davis F. Iodine status and thyroid function of 330 pregnant women from Nice area assessed during the second part of pregnancy. Annales d'Endocrinologie 2009 70 218-224. (doi:10.1016/j.ando.2009.03.004)
127. Mannisto T, Surcel HM, Ruokonen A, Vaarasmaki M, Pouta A, Bloigu A, Jarvelin MR, Hartikainen AL & Suvanto E. Early pregnancy reference intervals of thyroid hormone concentrations in a thyroid antibody-negative pregnant population. Thyroid 2011 21 291-298. (doi:10.1089/thy.2010.0337)
128. Haddow JE, Craig WY, Palomaki GE, Neveux LM, Lambert-Messerlian G, Canick JA, Malone FD & D'Alton ME. Impact of adjusting for the reciprocal relationship between maternal weight and free thyroxine during early pregnancy. Thyroid 2013 23 225-230. (doi:10.1089/thy.2012.0440)
129. Medici M, Timmermans S, Visser W, de Muinck Keizer-Schrama SM, Jaddoe VW, Hofman A, Hooijkaas H, de Rijke YB, Tiemeier H, Bongers-Schokking JJ et al. Maternal thyroid hormone parameters during early pregnancy and birth weight: the Generation R Study. Journal of Clinical Endocrinology and Metabolism 2013 98 59-66. (doi:10.1210/jc.2012-2420)
130. 4 reference ranges during pregnancy? Journal of Clinical Endocrinology andMetabolism 2013 98 43-44. (doi:10.1210/jc.2012-4010)
131. Vissenberg R, van den BE, van Wely M, van der Post JA, Bisschop PH & Goddijn M. Treatment of thyroid disorders before conception and in early
132. Reid SM, Middleton P, Cossich MC & Crowther CA. Interventions for clinical and subclinical hypothyroidism in pregnancy. Cochrane Database of Systematic Reviews 2010 7 CD007752.
133. Laurberg P, Andersen SL, Pedersen IB, Andersen S & Carle A. Screening for overt thyroid disease in early pregnancy may be preferable to searching for small aberrations in thyroid function tests. Clinical Endocrinology 2013 79 297-304. (doi:10.1111/cen.12232)