Hypothyroxinemia and TPO-antibody positivity are risk factors for premature delivery: The generation R study

Journal of Clinical Endocrinology and Metabolism

Volumn 98, Issue 11, 2013, Pages 4382-4390

  Korevaar, Tim I M ^a   Schalekamp Timmermans, Sarah ^a,b   De Rijke, Yolanda B ^a   Visser, W Edward ^a   Visser, Willy ^b   De Muinck Keizer Schrama, Sabine M P F ^b   Hofman, Albert ^a   Ross, H Alec ^c   Hooijkaas, Herbert ^a   Tiemeier, Henning ^a,b   Bongers Schokking, Jacoba J ^b   Jaddoe, Vincent W V ^a,b   Visser, Theo J ^a   Steegers, Eric A P ^b   Medici, Marco ^a   Peeters, Robin P ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b SOPHIA CHILDREN S HOSPITAL   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

IODINE; THYROID PEROXIDASE ANTIBODY; THYROTROPIN; THYROXINE;

ADULT; ANTHROPOMETRIC PARAMETERS; ANTIBODY TITER; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; ETHNICITY; FEMALE; FIRST TRIMESTER PREGNANCY; FREE THYROXINE INDEX; HUMAN; HYPOTHYROIDISM; HYPOTHYROXINEMIA; MAJOR CLINICAL STUDY; MATERNAL AGE; MATERNAL SMOKING; PARITY; POPULATION RESEARCH; PREGNANT WOMAN; PREMATURE LABOR; PRIORITY JOURNAL; PROSPECTIVE STUDY; RISK ASSESSMENT; RISK FACTOR; SOCIAL STATUS; SUBCLINICAL HYPERTHYROIDISM; THYROID DISEASE; THYROID FUNCTION; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; URINE LEVEL;

ADULT; AUTOANTIBODIES; FEMALE; FETAL MEMBRANES, PREMATURE RUPTURE; HUMANS; HYPERTHYROIDISM; HYPOTHYROIDISM; INFANT, NEWBORN; IODINE; MALE; PREGNANCY; PREGNANCY OUTCOME; PREMATURE BIRTH; PROSPECTIVE STUDIES; RISK FACTORS; SEROEPIDEMIOLOGIC STUDIES; THYROXINE; YOUNG ADULT;

EID: 84887498828     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2013-2855     Document Type: Article

References (40)

1. Nosarti C, Reichenberg A, Murray RM, et al. Preterm birth and psychiatric disorders in young adult life. ArchGenPsychiatry. 2012; 69:E1-E8.
2. WillemsenRH,de Kort SW, van der Kaay DC, Hokken-Koelega AC. Independent effects of prematurity on metabolic and cardiovascular risk factors in short small-for-gestational-age children. J Clin Endocrinol Metab. 2008;93: 452-458.
3. Vikse BE, Irgens LM, Leivestad T, Hallan S, Iversen BM. Low birth weight increases risk for end-stage renal disease. J Am Soc Nephrol. 2008;19: 151-157.
4. Liu L, Johnson HL, Cousens S, et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012;379: 2151-2161.
5. Blencowe H, Cousens S, Oestergaard MZ, et al. National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet. 2012;379: 2162-2172.
6. Menon R. Spontaneous preterm birth, a clinical dilemma: etiologic, pathophysiologic and genetic heterogeneities and racial disparity. Acta Obstet Gynecol Scand. 2008;87: 590-600.
7. Stagnaro-Green A, Abalovich M, Alexander E, et al. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011;21: 1081-1125.
8. De Groot L, Abalovich M, Alexander EK, et al. Management of thyroid dysfunction during pregnancy and postpartum: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2012;97: 2543-2565.
9. Schneuer FJ, Nassar N, Tasevski V, Morris JM, Roberts CL. Association and predictive accuracy of high TSH serum levels in first trimester and adverse pregnancy outcomes. J Clin Endocrinol Metab. 2012;97: 3115-3122.
10. Stagnaro-Green A, Chen X, Bogden JD, Davies TF, Scholl TO. The thyroid and pregnancy: a novel risk factor for very preterm delivery. Thyroid. 2005;15: 351-357.
11. Allan WC, Haddow JE, Palomaki GE, et al. Maternal thyroid deficiency and pregnancy complications: implications for population screening. J Med Screen. 2000;7: 127-130.
12. Negro R, Schwartz A, Gismondi R, Tinelli A, Mangieri T, Stagnaro- Green A. Increased pregnancy loss rate in thyroid antibody negative women with TSH levels between 2.5 and 5.0 in the first trimester of pregnancy. J Clin Endocrinol Metab. 2010;95:E44-E48.
13. Abalovich M, Gutierrez S, Alcaraz G, Maccallini G, Garcia A, Levalle O. Overt and subclinical hypothyroidism complicating pregnancy. Thyroid. 2002;12: 63-68.
14. Casey BM, Dashe JS, Spong CY, McIntire DD, Leveno KJ, Cunningham GF. Perinatal significance of isolated maternal hypothyroxinemia identified in the first half of pregnancy. Obstet Gynecol. 2007;109: 1129-1135.
15. Leung AS, Millar LK, Koonings PP, Montoro M, Mestman JH. Perinatal outcome in hypothyroid pregnancies. Obstet Gynecol. 1993;81: 349-353.
16. Cleary-Goldman J, Malone FD, Lambert-Messerlian G, et al. Maternal thyroid hypofunction and pregnancy outcome. Obstet Gynecol. 2008;112: 85-92.
17. Männistö T, Vääräsmäki M, Pouta A, et al. Perinatal outcome of children born to mothers with thyroid dysfunction or antibodies: a prospective population-based cohort study. J Clin Endocrinol Metab. 2009;94: 772-779.
18. Karakosta P, Alegakis D, Georgiou V, et al. Thyroid dysfunction and autoantibodies in early pregnancy are associated with increased risk of gestational diabetes and adverse birth outcomes. J Clin Endocrinol Metab. 2012;97:4464-4472
19. Ashoor G, Maiz N, Rotas M, Jawdat F, Nicolaides KH. Maternal thyroid function at 11-13 weeks of gestation and spontaneous preterm delivery. Obstet Gynecol. 2011;117: 293-298.
20. Ghafoor F, Mansoor M, Malik T, et al. Role of thyroid peroxidase antibodies in the outcome of pregnancy. J Coll Physicians Surg Pak. 2006;16: 468-471.
21. Glinoer D, Riahi M, Grün JP, Kinthaert J. Risk of subclinical hypothyroidism in pregnant women with asymptomatic autoimmune thyroid disorders. J Clin Endocrinol Metab. 1994;79: 197-204.
22. Negro R, Formoso G, Mangieri T, Pezzarossa A, Dazzi D, Hassan H. Levothyroxine treatment in euthyroid pregnant women with autoimmune thyroid disease: effects on obstetrical complications. J Clin Endocrinol Metab. 2006;91: 2587-2591.
23. Negro R, Schwartz A, Gismondi R, Tinelli A, Mangieri T, Stagnaro- Green A. Thyroid antibody positivity in the first trimester of pregnancy is associated with negative pregnancy outcomes. J Clin Endocrinol Metab. 2011;96:E920-E924.
24. Haddow JE, Cleary-Goldman J, McClain MR, et al. Thyroperoxidase and thyroglobulin antibodies in early pregnancy and preterm delivery. Obstet Gynecol. 2010;116: 58-62.
25. Iijima T, Tada H, Hidaka Y, Mitsuda N, Murata Y, Amino N. Effects of autoantibodies on the course of pregnancy and fetal growth. Obstet Gynecol. 1997;90: 364-369.
26. Jaddoe VW, van Duijn CM, Franco OH, et al. The Generation R Study: design and cohort update 2012. Eur J Epidemiol. 2012;27: 739-756.
27. Medici M, de Rijke YB, Peeters RP, et al. Maternal early pregnancy and newborn thyroid hormone parameters: the GenerationRStudy. J Clin Endocrinol Metab. 2012;97: 646-652.
28. van Mil NH, Tiemeier H, Bongers-Schokking JJ, et al. Low urinary iodine excretion during early pregnancy is associated with alterations in executive functioning in children. J Nutr. 2012;142:2167- 2174.
29. Korevaar TI, Medici M, de Rijke YB, et al. Ethnic differences in maternal thyroid parameters during pregnancy: the Generation R Study. J Clin Endocrinol Metab. 2013;98: 3678-3686.
30. World Health Organization United Nations Children's Fund, Indoi ternational Council for the Control of Iodine Deficiency Disorders. Assessment of Iodine Deficiency Disorders and Monitoring Their Elimination, 3rd ed. Geneva, Switzerland: World Health Organization, 2007.
31. Pearce EN, AnderssonM,ZimmermannM.Global iodine nutrition: where do we stand in 2013? Thyroid. 2013;23: 523-528.
32. Pearce EN, Lazarus JH, Smyth PP, et al. Perchlorate and thiocyanate exposure and thyroid function in first-trimester pregnant women. J Clin Endocrinol Metab. 2010;95: 3207-3215.
33. Akerlund M. Vasopressin and oxytocin in normal reproduction and in the pathophysiology of preterm labour and primary dysmenorrhoea. Development of receptor antagonists for therapeutic use in these conditions. Rocz Akad Med Bialymst. 2004;49: 18-21.
34. Thornton S, Baldwin PJ, Harris PA, et al. The role of arginine vasopressin in human labour: functional studies, fetal production and localisation of V1a receptor mRNA. BJOG. 2002;109: 57-62.
35. Ciosek J, Drobnik J. Vasopressin and oxytocin release and the thyroid function. J Physiol Pharmacol. 2004;55: 423-441.
36. Condon JC, Jeyasuria P, Faust JM, Mendelson CR. Surfactant protein secreted by the maturing mouse fetal lung acts as a hormone that signals the initiation of parturition. Proc Natl Acad Sci USA. 2004; 101: 4978-4983.
37. Salminen A, Vuolteenaho R, Paananen R, Ojaniemi M, Hallman M. Surfactant protein A modulates the lipopolysaccharide-induced inflammatory response related to preterm birth. Cytokine. 2011;56: 442-449.
38. van Tuyl M, Blommaart PE, de Boer PA, et al. Prenatal exposure to thyroid hormone is necessary for normal postnatal development of murine heart and lungs. Dev Biol. 2004;272: 104-117.
39. Ramadurai SM, Nielsen HC, Chen Y, Hatzis D, Sosenko IR. Differential effects in vivo of thyroid hormone on the expression of surfactant phospholipid, surfactant proteinmRNAand antioxidant enzyme mRNA in fetal rat lung. Exp Lung Res. 1998;24: 641-657.
40. He X, Wang P, Wang Z, He X, Xu D, Wang B. Endocrinology in pregnancy: thyroid antibodies and risk of preterm delivery: a metaanalysis of prospective cohort studies. Eur J Endocrinol. 2012;167: 455-464.