Nonpsychoactive cannabinoid action on 5-HT3 and glycine receptors

endoCANNABINOIDS: Actions at Non-CB1/CB2 Cannabinoid Receptors

Volumn , Issue , 2013, Pages 199-218

  Zhang, Li ^a   Xiong, Wei ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 85014675627     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4614-4669-9_9     Document Type: Chapter

References (86)

1. Aapro MS, Grunberg SM, Manikhas GM, Olivares G, Suarez T, Tjulandin SA, Bertoli LF, Yunus F, Morrica B, Lordick F, Macciocchi A (2006) A phase III, double-blind, randomized trial of palonosetron compared with ondansetron in preventing chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy. Ann Oncol 17:1441-1449
2. Adermark L, Clarke RB, Olsson T, Hansson E, Soderpalm B, Ericson M (2010) Implications for glycine receptors and astrocytes in ethanol-induced elevation of dopamine levels in the nucleus accumbens. Addict Biol 16:43-54
3. Ahrens J, Demir R, Leuwer M, de la Roche J, Krampfl K, Foadi N, Karst M, Haeseler G (2009a) The nonpsychotropic cannabinoid cannabidiol modulates and directly activates alpha-1 and alpha-1-Beta glycine receptor function. Pharmacology 83(4):217-222
4. Ahrens J, Leuwer M, Demir R, Krampfl K, de la Roche J, Foadi N, Karst M, Haeseler G (2009b) Positive allosteric modulatory effects of ajulemic acid at strychnine-sensitive glycine alpha1- and alpha1beta-receptors. Naunyn Schmiedebergs Arch Pharmacol 379(4):371-378
5. Barann M, Molderings G, Bruss M, Bonisch H, Urban BW, Gothert M (2002) Direct inhibition by cannabinoids of human 5-HT3A receptors: probable involvement of an allosteric modulatory site. Br J Pharmacol 137:589-596
6. Barnes NM, Hales TG, Lummis SC, Peters JA (2009) The 5-HT3 receptor-the relationship between structure and function. Neuropharmacology 56:273-284
7. Becker CM, Hoch W, Betz H (1988) Glycine receptor heterogeneity in rat spinal cord during postnatal development. EMBO J 7:3717-3726
8. Becker CM, Betz H, Schroder H (1993) Expression of inhibitory glycine receptors in postnatal rat cerebral cortex. Brain Res 606:220-226
9. Becker L, von Wegerer J, Schenkel J, Zeilhofer HU, Swandulla D, Weiher H (2002) Disease-specific human glycine receptor alpha1 subunit causes hyperekplexia phenotype and impaired glycine- and GABA(A)-receptor transmission in transgenic mice. J Neurosci 22:2505-2512
10. Betz H, Kuhse J, Schmieden V, Laube B, Kirsch J, Harvey RJ (1999) Structure and functions of inhibitory and excitatory glycine receptors. Ann N Y Acad Sci 868:667-676
11. Bradaia A, Schlichter R, Trouslard J (2004) Role of glial and neuronal glycine transporters in the control of glycinergic and glutamatergic synaptic transmission in lamina X of the rat spinal cord. J Physiol 559:169-186
12. Brady CA, Dover TJ, Massoura AN, Princivalle AP, Hope AG, Barnes NM (2007) Identification of 5-HT3A and 5-HT3B receptor subunits in human hippocampus. Neuropharmacology 52:1284-1290
13. Butt C, Alptekin A, Shippenberg T, Oz M (2008) Endogenous cannabinoid anandamide inhibits nicotinic acetylcholine receptor function in mouse thalamic synaptosomes. J Neurochem 105:1235-1243
14. Chau P, Hoifodt-Lido H, Lof E, Soderpalm B, Ericson M (2009) Glycine receptors in the nucleus accumbens involved in the ethanol intake-reducing effect of acamprosate. Alcohol Clin Exp Res 34:39-45
15. Christie MJ, Vaughan CW (2011) Receptors: cannabis medicine without a high. Nat Chem Biol 7:249-250
16. Davies PA, Pistis M, Hanna MC, Peters JA, Lambert JJ, Hales TG, Kirkness EF (1999) The 5-HT3B subunit is a major determinant of serotonin-receptor function. Nature 397:359-363
17. Delaney AJ, Esmaeili A, Sedlak PL, Lynch JW, Sah P (2009) Differential expression of glycine receptor subunits in the rat basolateral and central amygdala. Neurosci Lett 469:237-242
18. Delvaux M, Louvel D, Mamet JP, Campos-Oriola R, Frexinos J (1998) Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome. Aliment Pharmacol Ther 12:849-855
19. Demir R, Leuwer M, de la Roche J, Krampfl K, Foadi N, Karst M, Dengler R, Haeseler G, Ahrens J (2009) Modulation of glycine receptor function by the synthetic cannabinoid HU210. Pharmacology 83(5):270-274
20. Eulenburg V, Armsen W, Betz H, Gomeza J (2005) Glycine transporters: essential regulators of neurotransmission. Trends Biochem Sci 30:325-333
21. Fan P (1995) Cannabinoid agonists inhibit the activation of 5-HT3 receptors in rat nodose ganglion neurons. J Neurophysiol 73:907-910
22. Fan P, Oz M, Zhang L, Weight FF (1995) Effect of cocaine on the 5-HT3 receptor-mediated ion current in Xenopus oocytes. Brain Res 673:181-184
23. Findlay GS, Wick MJ, Mascia MP, Wallace D, Miller GW, Harris RA, Blednov YA (2002) Transgenic expression of a mutant glycine receptor decreases alcohol sensitivity of mice. J Pharmacol Exp Ther 300:526-534
24. Findlay GS, Phelan R, Roberts MT, Homanics GE, Bergeson SE, Lopreato GF, Mihic SJ, Blednov YA, Harris RA (2003) Glycine receptor knock-in mice and hyperekplexia-like phenotypes: comparisons with the null mutant. J Neurosci 23:8051-8059
25. Findlay GS, Harris RA, Blednov YA (2005) Male transgenic glycine receptor alpha1 (S267Q) mutant mice display a hyperekplexia-like increase in acoustic startle responses. Pharmacol Biochem Behav 82:215-222
26. Foadi N, Leuwer M, Demir R, Dengler R, Buchholz V, de la Roche J, Karst M, Haeseler G, Ahrens J (2010) Lack of positive allosteric modulation of mutated alpha(1)S267I glycine receptors by cannabinoids. Naunyn Schmiedebergs Arch Pharmacol 381(5):477-482
27. Gaddum JH (1953) Tryptamine receptors. J Physiol 119:363-368
28. Godlewski G, Gothert M, Malinowska B (2003) Cannabinoid receptor-independent inhibition by cannabinoid agonists of the peripheral 5-HT3 receptor-mediated von Bezold-Jarisch reflex. Br J Pharmacol 138:767-774
29. Gomeza J, Hulsmann S, Ohno K, Eulenburg V, Szoke K, Richter D, Betz H (2003) Inactivation of the glycine transporter 1 gene discloses vital role of glial glycine uptake in glycinergic inhibition. Neuron 40:785-796
30. Harvey RJ, Depner UB, Wassle H, Ahmadi S, Heindl C, Reinold H, Smart TG, Harvey K, Schutz B, Abo-Salem OM, Zimmer A, Poisbeau P, Welzl H, Wolfer DP, Betz H, Zeilhofer HU, Muller U (2004) GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization. Science 304:884-887
31. Harvey RJ, Topf M, Harvey K, Rees MI (2008) The genetics of hyperekplexia: more than startle! Trends Genet 24:439-447
32. Hejazi N, Zhou C, Oz M, Sun H, Ye JH, Zhang L (2006) {Delta}9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors. Mol Pharmacol 69:991-997
33. Herges S, Taylor DA (2000) Involvement of 5-HT(3) receptors in the nucleus accumbens in the potentiation of cocaine-induced behaviours in the rat. Br J Pharmacol 131:1294-1302
34. Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG (2002) International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev 54:161-202
35. Hu XQ, Peoples RW (2008) The 5-HT3B subunit confers spontaneous channel opening and altered ligand properties of the 5-HT3 receptor. J Biol Chem 283:6826-6831
36. Huestis MA, Cone EJ (2004) Relationship of delta 9-tetrahydrocannabinol concentrations in oral fluid and plasma after controlled administration of smoked cannabis. J Anal Toxicol 28:394-399
37. Jones RH, Holtmann G, Rodrigo L, Ehsanullah RS, Crompton PM, Jacques LA, Mills JG (1999) Alosetron relieves pain and improves bowel function compared with mebeverine in female nonconstipated irritable bowel syndrome patients. Aliment Pharmacol Ther 13:1419-1427
38. Jonsson S, Kerekes N, Hyytia P, Ericson M, Soderpalm B (2009) Glycine receptor expression in the forebrain of male AA/ANA rats. Brain Res 1305(suppl):S27-S36
39. Karnovsky AM, Gotow LF, McKinley DD, Piechan JL, Ruble CL, Mills CJ, Schellin KA, Slightom JL, Fitzgerald LR, Benjamin CW, Roberds SL (2003) A cluster of novel serotonin receptor 3-like genes on human chromosome 3. Gene 319:137-148
40. Koeppe C, Schneider C, Thieme K, Mense S, Stratz T, Muller W, Flor H (2004) The influence of the 5-HT3 receptor antagonist tropisetron on pain in fibromyalgia: a functional magnetic resonance imaging pilot study. Scand J Rheumatol Suppl 119:24-27
41. Li J, Nie H, Bian W, Dave V, Janak PH, Ye JH (2012) Microinjection of glycine into the ventral tegmental area selectively decreases ethanol consumption. J Pharmacol Exp Ther 341(1):196-204
42. Lozovaya N, Yatsenko N, Beketov A, Tsintsadze T, Burnashev N (2005) Glycine receptors in CNS neurons as a target for nonretrograde action of cannabinoids. J Neurosci 25(33):7499-7506
43. Lozovaya N, Mukhtarov M, Tsintsadze T, Ledent C, Burnashev N, Bregestovski P (2011) Frequency-dependent cannabinoid receptor-independent modulation of glycine receptors by endocannabinoid 2-AG. Front Mol Neurosci 4:13
44. Lundeberg L, El-Nour H, Mohabbati S, Morales M, Azmitia E, Nordlind K (2002) Expression of serotonin receptors in allergic contact eczematous human skin. Arch Dermatol Res 294:393-398
45. Lynch JW (2004) Molecular structure and function of the glycine receptor chloride channel. Physiol Rev 84:1051-1095
46. Lynch JW (2009) Native glycine receptor subtypes and their physiological roles. Neuropharmacology 56:303-309
47. Malosio ML, Marqueze-Pouey B, Kuhse J, Betz H (1991) Widespread expression of glycine receptor subunit mRNAs in the adult and developing rat brain. EMBO J 10:2401-2409
48. Manzke T, Niebert M, Koch UR, Caley A, Vogelgesang S, Hulsmann S, Ponimaskin E, Muller U, Smart TG, Harvey RJ, Richter DW (2010) Serotonin receptor 1A-modulated phosphorylation of glycine receptor alpha3 controls breathing in mice. J Clin Invest 120:4118-4128
49. Maricq AV, Peterson AS, Brake AJ, Myers RM, Julius D (1991) Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science 254:432-437
50. Meyer G, Kirsch J, Betz H, Langosch D (1995) Identification of a gephyrin binding motif on the glycine receptor beta subunit. Neuron 15:563-572
51. Mihic SJ, Ye Q, Wick MJ, Koltchine VV, Krasowski MD, Finn SE, Mascia MP, Valenzuela CF, Hanson KK, Greenblatt EP, Harris RA, Harrison NL (1997) Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors. Nature 389:385-389
52. Molander A, Soderpalm B (2005a) Accumbal strychnine-sensitive glycine receptors: an access point for ethanol to the brain reward system. Alcohol Clin Exp Res 29:27-37
53. Molander A, Soderpalm B (2005b) Glycine receptors regulate dopamine release in the rat nucleus accumbens. Alcohol Clin Exp Res 29:17-26
54. Morales M, Battenberg E, Bloom FE (1998) Distribution of neurons expressing immunoreactivity for the 5HT3 receptor subtype in the rat brain and spinal cord. J Comp Neurol 402:385-401
55. Morales M, McCollum N, Kirkness EF (2001) 5-HT(3)-receptor subunits A and B are co-expressed in neurons of the dorsal root ganglion. J Comp Neurol 438:163-172
56. Niesler B, Frank B, Kapeller J, Rappold GA (2003) Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E. Gene 310:101-111
57. Niesler B, Walstab J, Combrink S, Moeller D, Kapeller J, Rietdorf J, Boenisch H, Goethert M, Rappold G, Bruess M (2007) Characterization of the novel human serotonin receptor subunits 5-HT3C, 5-HT3D and 5-HT3E. Mol Pharmacol 72(1):8-17
58. Oz M, Zhang L, Morales M (2002) Endogenous cannabinoid, anandamide, acts as a noncompetitive inhibitor on 5-HT3 receptor-mediated responses in Xenopus oocytes. Synapse 46:150-156
59. Pacher P, Batkai S, Kunos G (2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 58:389-462
60. Przegalinski E, Gothert M, Frankowska M, Filip M (2005) WIN 55,212-2-induced reduction of cocaine hyperlocomotion: possible inhibition of 5-HT(3) receptor function. Eur J Pharmacol 517:68-73
61. Racz I, Bilkei-Gorzo A, Markert A, Stamer F, Gothert M, Zimmer A (2008) Anandamide effects on 5-HT(3) receptors in vivo. Eur J Pharmacol 596:98-101
62. Shiang R, Ryan SG, Zhu YZ, Hahn AF, O'Connell P, Wasmuth JJ (1993) Mutations in the alpha 1 subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia. Nat Genet 5:351-358
63. Sigel E, Baur R, Racz I, Marazzi J, Smart TG, Zimmer A, Gertsch J (2011) The major central endocannabinoid directly acts at GABAA receptors. Proc Natl Acad Sci U S A 108:18150-18155
64. Spath M, Stratz T, Farber L, Haus U, Pongratz D (2004a) Treatment of fibromyalgia with tropisetron-dose and efficacy correlations. Scand J Rheumatol Suppl 119:63-66
65. Spath M, Stratz T, Neeck G, Kotter I, Hammel B, Amberger CC, Haus U, Farber L, Pongratz D, Muller W (2004b) Efficacy and tolerability of intravenous tropisetron in the treatment of fibromyalgia. Scand J Rheumatol 33:267-270
66. Spivak CE, Lupica CR, Oz M (2007) The endocannabinoid anandamide inhibits the function of alpha4beta2 nicotinic acetylcholine receptors. Mol Pharmacol 72:1024-1032
67. Stratz T, Muller W (2004) Treatment of chronic low back pain with tropisetron. Scand J Rheumatol Suppl 119:76-78
68. Thompson AJ, Lummis SC (2007) The 5-HT3 receptor as a therapeutic target. Expert Opin Ther Targets 11:527-540
69. Thompson AJ, Price KL, Lummis SC (2011) Cysteine modification reveals which subunits form the ligand binding site in human heteromeric 5-HT3AB receptors. J Physiol 589:4243-4257
70. van Hooft JA, Yakel JL (2003) 5-HT3 receptors in the CNS: 3B or not 3B? Trends Pharmacol Sci 24:157-160
71. Whitehead KJ, Manning JP, Smith CG, Bowery NG (2001) Determination of the extracellular concentration of glycine in the rat spinal cord dorsal horn by quantitative microdialysis. Brain Res 910:192-194
72. Xiong W, Hosoi M, Koo BN, Zhang L (2008) Anandamide inhibition of 5-HT3A receptors varies with receptor density and desensitization. Mol Pharmacol 73:314-322
73. Xiong W, Koo BN, Morton R, Zhang L (2011a) Psychotropic and nonpsychotropic cannabis derivatives inhibit human 5-HT(3A) receptors through a receptor desensitization-dependent mechanism. Neuroscience 184:28-37
74. Xiong W, Cheng K, Cui T, Godlewski G, Rice KC, Xu Y, Zhang L (2011b) Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia. Nat Chem Biol 7(5):296-303
75. Xiong W, Wu X-W, Lovinger MD, Zhang L (2012) A common molecular basis for exogenous and endogenous cannabinoid potentiation of glycine receptors. J Neurosci 32:5200-5208
76. Xu TL, Gong N (2010) Glycine and glycine receptor signaling in hippocampal neurons: diversity, function and regulation. Prog Neurobiol 91:349-361
77. Yang Z, Aubrey KR, Alroy I, Harvey RJ, Vandenberg RJ, Lynch JW (2008) Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. Biochem Pharmacol 76(8):1014-1023
78. Yang KH, Galadari S, Isaev D, Petroianu G, Shippenberg TS, Oz M (2010a) The nonpsychoactive cannabinoid cannabidiol inhibits 5-hydroxytryptamine3A receptor-mediated currents in Xenopus laevis oocytes. J Pharmacol Exp Ther 333:547-554
79. Yang KH, Isaev D, Morales M, Petroianu G, Galadari S, Oz M (2010b) The effect of Delta9-tetrahydrocannabinol on 5-HT3 receptors depends on the current density. Neuroscience 171:40-49
80. Yatsenko N, Lozovaya N (2007) Effect of cannabinoids on glycine-activated currents in pyramidal neurons of the rat hippocampus. Neurophysiology 39(1):13
81. Yevenes GE, Zeilhofer HU (2011) Molecular sites for the positive allosteric modulation of glycine receptors by endocannabinoids. PLoS One 6:e23886
82. Yevenes GE, Moraga-Cid G, Peoples RW, Schmalzing G, Aguayo LG (2008) A selective G betagamma-linked intracellular mechanism for modulation of a ligand-gated ion channel by ethanol. Proc Natl Acad Sci U S A 105:20523-20528
83. Yevenes GE, Moraga-Cid G, Avila A, Guzman L, Figueroa M, Peoples RW, Aguayo LG (2010) Molecular requirements for ethanol differential allosteric modulation of glycine receptors based on selective Gbetagamma modulation. J Biol Chem 285:30203-30213
84. Zeilhofer HU, Zeilhofer UB (2008) Spinal dis-inhibition in inflammatory pain. Neurosci Lett 437:170-174
85. Zeilhofer HU, Benke D, Yevenes GE (2012) Chronic pain states: pharmacological strategies to restore diminished inhibitory spinal pain control. Annu Rev Pharmacol Toxicol 52:111-133
86. Zeitz KP, Guy N, Malmberg AB, Dirajlal S, Martin WJ, Sun L, Bonhaus DW, Stucky CL, Julius D, Basbaum AI (2002) The 5-HT3 subtype of serotonin receptor contributes to nociceptive processing via a novel subset of myelinated and unmyelinated nociceptors. J Neurosci 22:1010-1019