Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists

Proceedings of the National Academy of Sciences of the United States of America

Volumn 114, Issue 10, 2017, Pages 2568-2573

  Kim, Soo Kyung ^a   Chen, Yalu ^a   Abrol, Ravinder ^a,c   Goddard, William A ^a   Guthrie, Brian ^b  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b CARGILL INC   (United States)

^c CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

Class C GPCR; GPCR activation; Molecular dynamics; Noncaloric sweetener

Indexed keywords

DISULFIDE; G PROTEIN COUPLED RECEPTOR; HETERODIMER; HOMODIMER; MEMBRANE PROTEIN; METABOTROPIC RECEPTOR 1; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR 5; SWEETENING AGENT; METABOTROPIC RECEPTOR; PROTEIN BINDING; TASTE RECEPTORS, TYPE 1;

ALLOSTERISM; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; STRUCTURAL MODEL; SWEETNESS; TASTE BUD; ANIMAL; CHEMISTRY; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; MUTATION; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; TASTE; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; ANIMALS; CRYSTALLOGRAPHY, X-RAY; HUMANS; MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAINS; PROTEIN MULTIMERIZATION; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, METABOTROPIC GLUTAMATE; SWEETENING AGENTS; TASTE; TASTE PERCEPTION;

EID: 85014624308     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1700001114     Document Type: Article

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