Systematic substitutions at BLIP position 50 result in changes in binding specificity for class A β-lactamases

BMC Biochemistry

Volumn 18, Issue 1, 2017, Pages

  Adamski, Carolyn J ^a   Palzkill, Timothy ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Beatmusic; Binding specificity; Systematic substitutions; lactamase

Indexed keywords

ALANINE; ASPARAGINE; BACTERIAL PROTEIN; BETA LACTAMASE; BETA LACTAMASE INHIBITORY PROTEIN; BETA LACTAMASE TEM 1; BLA1 BETA LACTAMASE; CLASS A BETA LACTAMASE; GLUTAMINE; GLYCINE; KPC 2 BETA LACTAMASE; TYROSINE; UNCLASSIFIED DRUG; BETA-LACTAMASE KPC-2; BETA-LACTAMASE-INHIBITOR PROTEIN, STREPTOMYCES; PROTEIN BINDING; RECOMBINANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPARATIVE STUDY; CONTROLLED STUDY; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; PROTEIN CONFORMATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE, FUNCTION AND VARIABILITY; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; STREPTOMYCES CLAVULIGERUS; STRUCTURAL PLASTICITY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SURFACE CHARGE; WILD TYPE; AMINO ACID SEQUENCE; BACILLUS ANTHRACIS; BIOSYNTHESIS; CHEMISTRY; GENETICS; ISOLATION AND PURIFICATION; KINETICS; METABOLISM; MOLECULAR DYNAMICS; MOLECULAR GENETICS; PROTEIN DOMAIN; PROTEIN TERTIARY STRUCTURE; THERMODYNAMICS;

AMINO ACID SEQUENCE; BACILLUS ANTHRACIS; BACTERIAL PROTEINS; BETA-LACTAMASES; KINETICS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; THERMODYNAMICS;

EID: 85014602466     PISSN: None     EISSN: 14712091     Source Type: Journal    
DOI: 10.1186/s12858-017-0077-1     Document Type: Article

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