Structural and biochemical characterization of the interaction between KPC-2 β-lactamase and β-lactamase inhibitor protein

Biochemistry

Volumn 48, Issue 39, 2009, Pages 9185-9193

  Hanes, Melinda S ^a,b   Jude, Kevin M ^a   Berger, James M ^a   Bonomo, Robert A ^c,d   Handel, Tracy M ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^d CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ANTIBIOTIC RESISTANCE; ASYMMETRIC UNIT; BACTERIAL INFECTIONS; BIOCHEMICAL CHARACTERIZATION; CARBAPENEMS; CLASS A; CRYSTALLOGRAPHIC STRUCTURE; HIGH RESOLUTION; HOMOLOGOUS STRUCTURES; HOT SPOT; INHIBITOR PROTEINS; LACTAMASES; POTENT INHIBITOR; RATIONAL DESIGN;

ENZYMES;

ANTIBIOTICS;

BETA LACTAMASE; BETA LACTAMASE INHIBITOR; CARBAPENEMASE;

ANTIBIOTIC RESISTANCE; ARTICLE; BINDING AFFINITY; BIOCHEMISTRY; CLINICAL TRIAL; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME STRUCTURE; HUMAN; KLEBSIELLA PNEUMONIAE; MULTICENTER STUDY; MUTATION; PLASTICITY; PRIORITY JOURNAL; PROTEIN INTERACTION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BETA-LACTAMASES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; KLEBSIELLA PNEUMONIAE; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION;

BACTERIA (MICROORGANISMS); NEGIBACTERIA;

EID: 70349622039     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9007963     Document Type: Article

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