Intramolecular cooperativity in a protein binding site assessed by combinatorial shotgun scanning mutagenesis

Journal of Molecular Biology

Volumn 347, Issue 3, 2005, Pages 489-494

  Pál, Gábor ^b   Ultsch, Mark H ^a   Clark, Kevin P ^a   Currell, Bridget ^a   Kossiakoff, Anthony A ^b   Sidhu, Sachdev S ^a  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CHICAGO   (United States)

Author keywords

Additivity; Cooperativity; Growth hormone; Phage display; Protein engineering

Indexed keywords

GROWTH HORMONE RECEPTOR; HUMAN GROWTH HORMONE; MUTANT PROTEIN;

ACCURACY; ANALYTIC METHOD; ARTICLE; BINDING SITE; COMBINATORIAL SHOTGUN ALANINE SCANNING MUTAGENESIS; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; MUTAGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

EID: 14744305626     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2005.01.040     Document Type: Article

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